CPLIP: Zero-Shot Learning for Histopathology with Comprehensive Vision-Language Alignment

This paper proposes Comprehensive Pathology Language Image Pre-training (CPLIP), a new unsupervised technique designed to enhance the alignment of images and text in histopathology for tasks such as classification and segmentation. This methodology enriches vision-language models by leveraging extensive data without needing ground truth annotations. CPLIP involves constructing a pathology-specific dictionary, generating textual descriptions for images using language models, and retrieving relevant images for each text snippet via a pre-trained model. The model is then fine-tuned using a many-to-many contrastive learning method to align complex interrelated concepts across both modalities. Evaluated across multiple histopathology tasks, CPLIP shows notable improvements in zero-shot learning scenarios, outperforming existing methods in both interpretability and robustness and setting a higher benchmark for the application of vision-language models in the field. To encourage further research and replication, the code for CPLIP is available on GitHub at https://cplip.github.io/

3D-TexSeg: Unsupervised Segmentation of 3D Texture using Mutual Transformer Learning

Analysis of the 3D Texture is indispensable for various tasks, such as retrieval, segmentation, classification, and inspection of sculptures, knitted fabrics, and biological tissues. A 3D texture is a locally repeated surface variation independent of the surface's overall shape and can be determined using the local neighborhood and its characteristics. Existing techniques typically employ computer vision techniques that analyze a 3D mesh globally, derive features, and then utilize the obtained features for retrieval or classification. Several traditional and learning-based methods exist in the literature, however, only a few are on 3D texture, and nothing yet, to the best of our knowledge, on the unsupervised schemes. This paper presents an original framework for the unsupervised segmentation of the 3D texture on the mesh manifold. We approach this problem as binary surface segmentation, partitioning the mesh surface into textured and non-textured regions without prior annotation. We devise a mutual transformer-based system comprising a label generator and a cleaner. The two models take geometric image representations of the surface mesh facets and label them as texture or non-texture across an iterative mutual learning scheme. Extensive experiments on three publicly available datasets with diverse texture patterns demonstrate that the proposed framework outperforms standard and SOTA unsupervised techniques and competes reasonably with supervised methods.