How Good is my Histopathology Vision-Language Foundation Model? A Holistic Benchmark

Recently, histopathology vision-language foundation models (VLMs) have gained popularity due to their enhanced performance and generalizability across different downstream tasks. However, most existing histopathology benchmarks are either unimodal or limited in terms of diversity of clinical tasks, organs, and acquisition instruments, as well as their partial availability to the public due to patient data privacy. As a consequence, there is a lack of comprehensive evaluation of existing histopathology VLMs on a unified benchmark setting that better reflects a wide range of clinical scenarios. To address this gap, we introduce HistoVL, a fully open-source comprehensive benchmark comprising images acquired using up to 11 various acquisition tools that are paired with specifically crafted captions by incorporating class names and diverse pathology descriptions. Our Histo-VL includes 26 organs, 31 cancer types, and a wide variety of tissue obtained from 14 heterogeneous patient cohorts, totaling more than 5 million patches obtained from over 41K WSIs viewed under various magnification levels. We systematically evaluate existing histopathology VLMs on Histo-VL to simulate diverse tasks performed by experts in real-world clinical scenarios. Our analysis reveals interesting findings, including large sensitivity of most existing histopathology VLMs to textual changes with a drop in balanced accuracy of up to 25% in tasks such as Metastasis detection, low robustness to adversarial attacks, as well as improper calibration of models evident through high ECE values and low model prediction confidence, all of which can affect their clinical implementation.

A Coarse-to-Fine Pseudo-Labeling Framework for Unsupervised Video Anomaly Detection

Detection of anomalous events in videos is an important problem in applications such as surveillance. Video anomaly detection (VAD) is well-studied in the one-class classification (OCC) and weakly supervised (WS) settings. However, fully unsupervised (US) video anomaly detection methods, which learn a complete system without any annotation or human supervision, have not been explored in depth. This is because the lack of any ground truth annotations significantly increases the magnitude of the VAD challenge. To address this challenge, we propose a simple-but-effective two-stage pseudo-label generation framework that produces segment-level (normal/anomaly) pseudo-labels, which can be further used to train a segment-level anomaly detector in a supervised manner. The proposed coarse-to-fine pseudo-label (C2FPL) generator employs carefully-designed hierarchical divisive clustering and statistical hypothesis testing to identify anomalous video segments from a set of completely unlabeled videos. The trained anomaly detector can be directly applied on segments of an unseen test video to obtain segment-level, and subsequently, frame-level anomaly predictions. Extensive studies on two large-scale public-domain datasets, UCF-Crime and XD-Violence, demonstrate that the proposed unsupervised approach achieves superior performance compared to all existing OCC and US methods , while yielding comparable performance to the state-of-the-art WS methods.