Medical Multimodal Foundation Models in Clinical Diagnosis and Treatment: Applications, Challenges, and Future Directions

Recent advancements in deep learning have significantly revolutionized the field of clinical diagnosis and treatment, offering novel approaches to improve diagnostic precision and treatment efficacy across diverse clinical domains, thus driving the pursuit of precision medicine. The growing availability of multi-organ and multimodal datasets has accelerated the development of large-scale Medical Multimodal Foundation Models (MMFMs). These models, known for their strong generalization capabilities and rich representational power, are increasingly being adapted to address a wide range of clinical tasks, from early diagnosis to personalized treatment strategies. This review offers a comprehensive analysis of recent developments in MMFMs, focusing on three key aspects: datasets, model architectures, and clinical applications. We also explore the challenges and opportunities in optimizing multimodal representations and discuss how these advancements are shaping the future of healthcare by enabling improved patient outcomes and more efficient clinical workflows.

Evolutionary Algorithm with Detection Region Method for Constrained Multi-Objective Problems with Binary Constraints

Solving constrained multi-objective optimization problems (CMOPs) is a challenging task. While many practical algorithms have been developed to tackle CMOPs, real-world scenarios often present cases where the constraint functions are unknown or unquantifiable, resulting in only binary outcomes (feasible or infeasible). This limitation reduces the effectiveness of constraint violation guidance, which can negatively impact the performance of existing algorithms that rely on this approach. Such challenges are particularly detrimental for algorithms employing the epsilon-based method, as they hinder effective relaxation of the feasible region. To address these challenges, this paper proposes a novel algorithm called DRMCMO based on the detection region method. In DRMCMO, detection regions dynamic monitor feasible solutions to enhance convergence, helping the population escape local optima. Additionally, these regions collaborate with the neighbor pairing strategy to improve population diversity within narrow feasible areas. We have modified three existing test suites to serve as benchmark test problems for CMOPs with binary constraints(CMOP/BC) and conducted comprehensive comparative experiments with state-of-the-art algorithms on these test suites and real-world problems. The results demonstrate the strong competitiveness of DRMCMO against state-of-the-art algorithms. Given the limited research on CMOP/BC, our study offers a new perspective for advancing this field.

Dropout the High-rate Downsampling: A Novel Design Paradigm for UHD Image Restoration

With the popularization of high-end mobile devices, Ultra-high-definition (UHD) images have become ubiquitous in our lives. The restoration of UHD images is a highly challenging problem due to the exaggerated pixel count, which often leads to memory overflow during processing. Existing methods either downsample UHD images at a high rate before processing or split them into multiple patches for separate processing. However, high-rate downsampling leads to significant information loss, while patch-based approaches inevitably introduce boundary artifacts. In this paper, we propose a novel design paradigm to solve the UHD image restoration problem, called D2Net. D2Net enables direct full-resolution inference on UHD images without the need for high-rate downsampling or dividing the images into several patches. Specifically, we ingeniously utilize the characteristics of the frequency domain to establish long-range dependencies of features. Taking into account the richer local patterns in UHD images, we also design a multi-scale convolutional group to capture local features. Additionally, during the decoding stage, we dynamically incorporate features from the encoding stage to reduce the flow of irrelevant information. Extensive experiments on three UHD image restoration tasks, including low-light image enhancement, image dehazing, and image deblurring, show that our model achieves better quantitative and qualitative results than state-of-the-art methods.

BrainDreamer: Reasoning-Coherent and Controllable Image Generation from EEG Brain Signals via Language Guidance

Can we directly visualize what we imagine in our brain together with what we describe? The inherent nature of human perception reveals that, when we think, our body can combine language description and build a vivid picture in our brain. Intuitively, generative models should also hold such versatility. In this paper, we introduce BrainDreamer, a novel end-to-end language-guided generative framework that can mimic human reasoning and generate high-quality images from electroencephalogram (EEG) brain signals. Our method is superior in its capacity to eliminate the noise introduced by non-invasive EEG data acquisition and meanwhile achieve a more precise mapping between the EEG and image modality, thus leading to significantly better-generated images. Specifically, BrainDreamer consists of two key learning stages: 1) modality alignment and 2) image generation. In the alignment stage, we propose a novel mask-based triple contrastive learning strategy to effectively align EEG, text, and image embeddings to learn a unified representation. In the generation stage, we inject the EEG embeddings into the pre-trained Stable Diffusion model by designing a learnable EEG adapter to generate high-quality reasoning-coherent images. Moreover, BrainDreamer can accept textual descriptions (e.g., color, position, etc.) to achieve controllable image generation. Extensive experiments show that our method significantly outperforms prior arts in terms of generating quality and quantitative performance.

Subequivariant Reinforcement Learning in 3D Multi-Entity Physical Environments

Learning policies for multi-entity systems in 3D environments is far more complicated against single-entity scenarios, due to the exponential expansion of the global state space as the number of entities increases. One potential solution of alleviating the exponential complexity is dividing the global space into independent local views that are invariant to transformations including translations and rotations. To this end, this paper proposes Subequivariant Hierarchical Neural Networks (SHNN) to facilitate multi-entity policy learning. In particular, SHNN first dynamically decouples the global space into local entity-level graphs via task assignment. Second, it leverages subequivariant message passing over the local entity-level graphs to devise local reference frames, remarkably compressing the representation redundancy, particularly in gravity-affected environments. Furthermore, to overcome the limitations of existing benchmarks in capturing the subtleties of multi-entity systems under the Euclidean symmetry, we propose the Multi-entity Benchmark (MEBEN), a new suite of environments tailored for exploring a wide range of multi-entity reinforcement learning. Extensive experiments demonstrate significant advancements of SHNN on the proposed benchmarks compared to existing methods. Comprehensive ablations are conducted to verify the indispensability of task assignment and subequivariance.

EIT-1M: One Million EEG-Image-Text Pairs for Human Visual-textual Recognition and More

Recently, electroencephalography (EEG) signals have been actively incorporated to decode brain activity to visual or textual stimuli and achieve object recognition in multi-modal AI. Accordingly, endeavors have been focused on building EEG-based datasets from visual or textual single-modal stimuli. However, these datasets offer limited EEG epochs per category, and the complex semantics of stimuli presented to participants compromise their quality and fidelity in capturing precise brain activity. The study in neuroscience unveils that the relationship between visual and textual stimulus in EEG recordings provides valuable insights into the brain's ability to process and integrate multi-modal information simultaneously. Inspired by this, we propose a novel large-scale multi-modal dataset, named EIT-1M, with over 1 million EEG-image-text pairs. Our dataset is superior in its capacity of reflecting brain activities in simultaneously processing multi-modal information. To achieve this, we collected data pairs while participants viewed alternating sequences of visual-textual stimuli from 60K natural images and category-specific texts. Common semantic categories are also included to elicit better reactions from participants' brains. Meanwhile, response-based stimulus timing and repetition across blocks and sessions are included to ensure data diversity. To verify the effectiveness of EIT-1M, we provide an in-depth analysis of EEG data captured from multi-modal stimuli across different categories and participants, along with data quality scores for transparency. We demonstrate its validity on two tasks: 1) EEG recognition from visual or textual stimuli or both and 2) EEG-to-visual generation.

Vision-Language Meets the Skeleton: Progressively Distillation with Cross-Modal Knowledge for 3D Action Representation Learning

Supervised and self-supervised learning are two main training paradigms for skeleton-based human action recognition. However, the former one-hot classification requires labor-intensive predefined action categories annotations, while the latter involves skeleton transformations (e.g., cropping) in the pretext tasks that may impair the skeleton structure. To address these challenges, we introduce a novel skeleton-based training framework (C$^2$VL) based on Cross-modal Contrastive learning that uses the progressive distillation to learn task-agnostic human skeleton action representation from the Vision-Language knowledge prompts. Specifically, we establish the vision-language action concept space through vision-language knowledge prompts generated by pre-trained large multimodal models (LMMs), which enrich the fine-grained details that the skeleton action space lacks. Moreover, we propose the intra-modal self-similarity and inter-modal cross-consistency softened targets in the cross-modal contrastive process to progressively control and guide the degree of pulling vision-language knowledge prompts and corresponding skeletons closer. These soft instance discrimination and self-knowledge distillation strategies contribute to the learning of better skeleton-based action representations from the noisy skeleton-vision-language pairs. During the inference phase, our method requires only the skeleton data as the input for action recognition and no longer for vision-language prompts. Extensive experiments show that our method achieves state-of-the-art results on NTU RGB+D 60, NTU RGB+D 120, and PKU-MMD datasets. The code will be available in the future.

Fine-Grained Side Information Guided Dual-Prompts for Zero-Shot Skeleton Action Recognition

Skeleton-based zero-shot action recognition aims to recognize unknown human actions based on the learned priors of the known skeleton-based actions and a semantic descriptor space shared by both known and unknown categories. However, previous works focus on establishing the bridges between the known skeleton representation space and semantic descriptions space at the coarse-grained level for recognizing unknown action categories, ignoring the fine-grained alignment of these two spaces, resulting in suboptimal performance in distinguishing high-similarity action categories. To address these challenges, we propose a novel method via Side information and dual-prompts learning for skeleton-based zero-shot action recognition (STAR) at the fine-grained level. Specifically, 1) we decompose the skeleton into several parts based on its topology structure and introduce the side information concerning multi-part descriptions of human body movements for alignment between the skeleton and the semantic space at the fine-grained level; 2) we design the visual-attribute and semantic-part prompts to improve the intra-class compactness within the skeleton space and inter-class separability within the semantic space, respectively, to distinguish the high-similarity actions. Extensive experiments show that our method achieves state-of-the-art performance in ZSL and GZSL settings on NTU RGB+D, NTU RGB+D 120, and PKU-MMD datasets.

Equivariant Local Reference Frames for Unsupervised Non-rigid Point Cloud Shape Correspondence

Unsupervised non-rigid point cloud shape correspondence underpins a multitude of 3D vision tasks, yet itself is non-trivial given the exponential complexity stemming from inter-point degree-of-freedom, i.e., pose transformations. Based on the assumption of local rigidity, one solution for reducing complexity is to decompose the overall shape into independent local regions using Local Reference Frames (LRFs) that are invariant to SE(3) transformations. However, the focus solely on local structure neglects global geometric contexts, resulting in less distinctive LRFs that lack crucial semantic information necessary for effective matching. Furthermore, such complexity introduces out-of-distribution geometric contexts during inference, thus complicating generalization. To this end, we introduce 1) EquiShape, a novel structure tailored to learn pair-wise LRFs with global structural cues for both spatial and semantic consistency, and 2) LRF-Refine, an optimization strategy generally applicable to LRF-based methods, aimed at addressing the generalization challenges. Specifically, for EquiShape, we employ cross-talk within separate equivariant graph neural networks (Cross-GVP) to build long-range dependencies to compensate for the lack of semantic information in local structure modeling, deducing pair-wise independent SE(3)-equivariant LRF vectors for each point. For LRF-Refine, the optimization adjusts LRFs within specific contexts and knowledge, enhancing the geometric and semantic generalizability of point features. Our overall framework surpasses the state-of-the-art methods by a large margin on three benchmarks. Code and models will be publicly available.

An EnKF-LSTM Assimilation Algorithm for Crop Growth Model

Accurate and timely prediction of crop growth is of great significance to ensure crop yields and researchers have developed several crop models for the prediction of crop growth. However, there are large difference between the simulation results obtained by the crop models and the actual results, thus in this paper, we proposed to combine the simulation results with the collected crop data for data assimilation so that the accuracy of prediction will be improved. In this paper, an EnKF-LSTM data assimilation method for various crops is proposed by combining ensemble Kalman filter and LSTM neural network, which effectively avoids the overfitting problem of existing data assimilation methods and eliminates the uncertainty of the measured data. The verification of the proposed EnKF-LSTM method and the comparison of the proposed method with other data assimilation methods were performed using datasets collected by sensor equipment deployed on a farm.