Medchain: Bridging the Gap Between LLM Agents and Clinical Practice through Interactive Sequential Benchmarking

Clinical decision making (CDM) is a complex, dynamic process crucial to healthcare delivery, yet it remains a significant challenge for artificial intelligence systems. While Large Language Model (LLM)-based agents have been tested on general medical knowledge using licensing exams and knowledge question-answering tasks, their performance in the CDM in real-world scenarios is limited due to the lack of comprehensive testing datasets that mirror actual medical practice. To address this gap, we present MedChain, a dataset of 12,163 clinical cases that covers five key stages of clinical workflow. MedChain distinguishes itself from existing benchmarks with three key features of real-world clinical practice: personalization, interactivity, and sequentiality. Further, to tackle real-world CDM challenges, we also propose MedChain-Agent, an AI system that integrates a feedback mechanism and a MCase-RAG module to learn from previous cases and adapt its responses. MedChain-Agent demonstrates remarkable adaptability in gathering information dynamically and handling sequential clinical tasks, significantly outperforming existing approaches. The relevant dataset and code will be released upon acceptance of this paper.

Large Language Models for Lossless Image Compression: Next-Pixel Prediction in Language Space is All You Need

We have recently witnessed that ``Intelligence" and `` Compression" are the two sides of the same coin, where the language large model (LLM) with unprecedented intelligence is a general-purpose lossless compressor for various data modalities. This attribute particularly appeals to the lossless image compression community, given the increasing need to compress high-resolution images in the current streaming media era. Consequently, a spontaneous envision emerges: Can the compression performance of the LLM elevate lossless image compression to new heights? However, our findings indicate that the naive application of LLM-based lossless image compressors suffers from a considerable performance gap compared with existing state-of-the-art (SOTA) codecs on common benchmark datasets. In light of this, we are dedicated to fulfilling the unprecedented intelligence (compression) capacity of the LLM for lossless image compression tasks, thereby bridging the gap between theoretical and practical compression performance. Specifically, we propose P$^{2}$-LLM, a next-pixel prediction-based LLM, which integrates various elaborated insights and methodologies, \textit{e.g.,} pixel-level priors, the in-context ability of LLM, and a pixel-level semantic preservation strategy, to enhance the understanding capacity of pixel sequences for better next-pixel predictions. Extensive experiments on benchmark datasets demonstrate that P$^{2}$-LLM can beat SOTA classical and learned codecs.

Test-time adaptation for image compression with distribution regularization

Current test- or compression-time adaptation image compression (TTA-IC) approaches, which leverage both latent and decoder refinements as a two-step adaptation scheme, have potentially enhanced the rate-distortion (R-D) performance of learned image compression models on cross-domain compression tasks, \textit{e.g.,} from natural to screen content images. However, compared with the emergence of various decoder refinement variants, the latent refinement, as an inseparable ingredient, is barely tailored to cross-domain scenarios. To this end, we aim to develop an advanced latent refinement method by extending the effective hybrid latent refinement (HLR) method, which is designed for \textit{in-domain} inference improvement but shows noticeable degradation of the rate cost in \textit{cross-domain} tasks. Specifically, we first provide theoretical analyses, in a cue of marginalization approximation from in- to cross-domain scenarios, to uncover that the vanilla HLR suffers from an underlying mismatch between refined Gaussian conditional and hyperprior distributions, leading to deteriorated joint probability approximation of marginal distribution with increased rate consumption. To remedy this issue, we introduce a simple Bayesian approximation-endowed \textit{distribution regularization} to encourage learning a better joint probability approximation in a plug-and-play manner. Extensive experiments on six in- and cross-domain datasets demonstrate that our proposed method not only improves the R-D performance compared with other latent refinement counterparts, but also can be flexibly integrated into existing TTA-IC methods with incremental benefits.

Deep Signature: Characterization of Large-Scale Molecular Dynamics

Understanding protein dynamics are essential for deciphering protein functional mechanisms and developing molecular therapies. However, the complex high-dimensional dynamics and interatomic interactions of biological processes pose significant challenge for existing computational techniques. In this paper, we approach this problem for the first time by introducing Deep Signature, a novel computationally tractable framework that characterizes complex dynamics and interatomic interactions based on their evolving trajectories. Specifically, our approach incorporates soft spectral clustering that locally aggregates cooperative dynamics to reduce the size of the system, as well as signature transform that collects iterated integrals to provide a global characterization of the non-smooth interactive dynamics. Theoretical analysis demonstrates that Deep Signature exhibits several desirable properties, including invariance to translation, near invariance to rotation, equivariance to permutation of atomic coordinates, and invariance under time reparameterization. Furthermore, experimental results on three benchmarks of biological processes verify that our approach can achieve superior performance compared to baseline methods.

Towards Data-Centric Face Anti-Spoofing: Improving Cross-domain Generalization via Physics-based Data Synthesis

Face Anti-Spoofing (FAS) research is challenged by the cross-domain problem, where there is a domain gap between the training and testing data. While recent FAS works are mainly model-centric, focusing on developing domain generalization algorithms for improving cross-domain performance, data-centric research for face anti-spoofing, improving generalization from data quality and quantity, is largely ignored. Therefore, our work starts with data-centric FAS by conducting a comprehensive investigation from the data perspective for improving cross-domain generalization of FAS models. More specifically, at first, based on physical procedures of capturing and recapturing, we propose task-specific FAS data augmentation (FAS-Aug), which increases data diversity by synthesizing data of artifacts, such as printing noise, color distortion, moir\'e pattern, \textit{etc}. Our experiments show that using our FAS augmentation can surpass traditional image augmentation in training FAS models to achieve better cross-domain performance. Nevertheless, we observe that models may rely on the augmented artifacts, which are not environment-invariant, and using FAS-Aug may have a negative effect. As such, we propose Spoofing Attack Risk Equalization (SARE) to prevent models from relying on certain types of artifacts and improve the generalization performance. Last but not least, our proposed FAS-Aug and SARE with recent Vision Transformer backbones can achieve state-of-the-art performance on the FAS cross-domain generalization protocols. The implementation is available at https://github.com/RizhaoCai/FAS_Aug.

Image Provenance Analysis via Graph Encoding with Vision Transformer

Recent advances in AI-powered image editing tools have significantly lowered the barrier to image modification, raising pressing security concerns those related to spreading misinformation and disinformation on social platforms. Image provenance analysis is crucial in this context, as it identifies relevant images within a database and constructs a relationship graph by mining hidden manipulation and transformation cues, thereby providing concrete evidence chains. This paper introduces a novel end-to-end deep learning framework designed to explore the structural information of provenance graphs. Our proposed method distinguishes from previous approaches in two main ways. First, unlike earlier methods that rely on prior knowledge and have limited generalizability, our framework relies upon a patch attention mechanism to capture image provenance clues for local manipulations and global transformations, thereby enhancing graph construction performance. Second, while previous methods primarily focus on identifying tampering traces only between image pairs, they often overlook the hidden information embedded in the topology of the provenance graph. Our approach aligns the model training objectives with the final graph construction task, incorporating the overall structural information of the graph into the training process. We integrate graph structure information with the attention mechanism, enabling precise determination of the direction of transformation. Experimental results show the superiority of the proposed method over previous approaches, underscoring its effectiveness in addressing the challenges of image provenance analysis.

Open-Set Deepfake Detection: A Parameter-Efficient Adaptation Method with Forgery Style Mixture

Open-set face forgery detection poses significant security threats and presents substantial challenges for existing detection models. These detectors primarily have two limitations: they cannot generalize across unknown forgery domains and inefficiently adapt to new data. To address these issues, we introduce an approach that is both general and parameter-efficient for face forgery detection. It builds on the assumption that different forgery source domains exhibit distinct style statistics. Previous methods typically require fully fine-tuning pre-trained networks, consuming substantial time and computational resources. In turn, we design a forgery-style mixture formulation that augments the diversity of forgery source domains, enhancing the model's generalizability across unseen domains. Drawing on recent advancements in vision transformers (ViT) for face forgery detection, we develop a parameter-efficient ViT-based detection model that includes lightweight forgery feature extraction modules and enables the model to extract global and local forgery clues simultaneously. We only optimize the inserted lightweight modules during training, maintaining the original ViT structure with its pre-trained ImageNet weights. This training strategy effectively preserves the informative pre-trained knowledge while flexibly adapting the model to the task of Deepfake detection. Extensive experimental results demonstrate that the designed model achieves state-of-the-art generalizability with significantly reduced trainable parameters, representing an important step toward open-set Deepfake detection in the wild.

Imaging Interiors: An Implicit Solution to Electromagnetic Inverse Scattering Problems

Electromagnetic Inverse Scattering Problems (EISP) have gained wide applications in computational imaging. By solving EISP, the internal relative permittivity of the scatterer can be non-invasively determined based on the scattered electromagnetic fields. Despite previous efforts to address EISP, achieving better solutions to this problem has remained elusive, due to the challenges posed by inversion and discretization. This paper tackles those challenges in EISP via an implicit approach. By representing the scatterer's relative permittivity as a continuous implicit representation, our method is able to address the low-resolution problems arising from discretization. Further, optimizing this implicit representation within a forward framework allows us to conveniently circumvent the challenges posed by inverse estimation. Our approach outperforms existing methods on standard benchmark datasets. Project page: https://luo-ziyuan.github.io/Imaging-Interiors

Event Trojan: Asynchronous Event-based Backdoor Attacks

As asynchronous event data is more frequently engaged in various vision tasks, the risk of backdoor attacks becomes more evident. However, research into the potential risk associated with backdoor attacks in asynchronous event data has been scarce, leaving related tasks vulnerable to potential threats. This paper has uncovered the possibility of directly poisoning event data streams by proposing Event Trojan framework, including two kinds of triggers, i.e., immutable and mutable triggers. Specifically, our two types of event triggers are based on a sequence of simulated event spikes, which can be easily incorporated into any event stream to initiate backdoor attacks. Additionally, for the mutable trigger, we design an adaptive learning mechanism to maximize its aggressiveness. To improve the stealthiness, we introduce a novel loss function that constrains the generated contents of mutable triggers, minimizing the difference between triggers and original events while maintaining effectiveness. Extensive experiments on public event datasets show the effectiveness of the proposed backdoor triggers. We hope that this paper can draw greater attention to the potential threats posed by backdoor attacks on event-based tasks. Our code is available at https://github.com/rfww/EventTrojan.

Unraveling the Mechanics of Learning-Based Demonstration Selection for In-Context Learning

Large Language Models (LLMs) have demonstrated impressive in-context learning (ICL) capabilities from few-shot demonstration exemplars. While recent learning-based demonstration selection methods have proven beneficial to ICL by choosing more useful exemplars, their underlying mechanisms are opaque, hindering efforts to address limitations such as high training costs and poor generalization across tasks. These methods generally assume the selection process captures similarities between the exemplar and the target instance, however, it remains unknown what kinds of similarities are captured and vital to performing ICL. To dive into this question, we analyze the working mechanisms of the learning-based demonstration selection methods and empirically identify two important factors related to similarity measurement: 1) The ability to integrate different levels of task-agnostic text similarities between the input of exemplars and test cases enhances generalization power across different tasks. 2) Incorporating task-specific labels when measuring the similarities significantly improves the performance on each specific task. We validate these two findings through extensive quantitative and qualitative analyses across ten datasets and various LLMs. Based on our findings, we introduce two effective yet simplified exemplar selection methods catering to task-agnostic and task-specific demands, eliminating the costly LLM inference overhead.