Efficient Medical Image Retrieval Using DenseNet and FAISS for BIRADS Classification

That datasets that are used in todays research are especially vast in the medical field. Different types of medical images such as X-rays, MRI, CT scan etc. take up large amounts of space. This volume of data introduces challenges like accessing and retrieving specific images due to the size of the database. An efficient image retrieval system is essential as the database continues to grow to save time and resources. In this paper, we propose an approach to medical image retrieval using DenseNet for feature extraction and use FAISS for similarity search. DenseNet is well-suited for feature extraction in complex medical images and FAISS enables efficient handling of high-dimensional data in large-scale datasets. Unlike existing methods focused solely on classification accuracy, our method prioritizes both retrieval speed and diagnostic relevance, addressing a critical gap in real-time case comparison for radiologists. We applied the classification of breast cancer images using the BIRADS system. We utilized DenseNet's powerful feature representation and FAISSs efficient indexing capabilities to achieve high precision and recall in retrieving relevant images for diagnosis. We experimented on a dataset of 2006 images from the Categorized Digital Database for Low Energy and Subtracted Contrast Enhanced Spectral Mammography (CDD-CESM) images available on The Cancer Imaging Archive (TCIA). Our method outperforms conventional retrieval techniques, achieving a precision of 80% at k=5 for BIRADS classification. The dataset includes annotated CESM images and medical reports, providing a comprehensive foundation for our research.

Retrieval-enriched zero-shot image classification in low-resource domains

Low-resource domains, characterized by scarce data and annotations, present significant challenges for language and visual understanding tasks, with the latter much under-explored in the literature. Recent advancements in Vision-Language Models (VLM) have shown promising results in high-resource domains but fall short in low-resource concepts that are under-represented (e.g. only a handful of images per category) in the pre-training set. We tackle the challenging task of zero-shot low-resource image classification from a novel perspective. By leveraging a retrieval-based strategy, we achieve this in a training-free fashion. Specifically, our method, named CoRE (Combination of Retrieval Enrichment), enriches the representation of both query images and class prototypes by retrieving relevant textual information from large web-crawled databases. This retrieval-based enrichment significantly boosts classification performance by incorporating the broader contextual information relevant to the specific class. We validate our method on a newly established benchmark covering diverse low-resource domains, including medical imaging, rare plants, and circuits. Our experiments demonstrate that CORE outperforms existing state-of-the-art methods that rely on synthetic data generation and model fine-tuning.

MS-Glance: Non-semantic context vectors and the applications in supervising image reconstruction

Non-semantic context information is crucial for visual recognition, as the human visual perception system first uses global statistics to process scenes rapidly before identifying specific objects. However, while semantic information is increasingly incorporated into computer vision tasks such as image reconstruction, non-semantic information, such as global spatial structures, is often overlooked. To bridge the gap, we propose a biologically informed non-semantic context descriptor, \textbf{MS-Glance}, along with the Glance Index Measure for comparing two images. A Global Glance vector is formulated by randomly retrieving pixels based on a perception-driven rule from an image to form a vector representing non-semantic global context, while a local Glance vector is a flattened local image window, mimicking a zoom-in observation. The Glance Index is defined as the inner product of two standardized sets of Glance vectors. We evaluate the effectiveness of incorporating Glance supervision in two reconstruction tasks: image fitting with implicit neural representation (INR) and undersampled MRI reconstruction. Extensive experimental results show that MS-Glance outperforms existing image restoration losses across both natural and medical images. The code is available at \url{https://github.com/Z7Gao/MSGlance}.

Efficient Feature Extraction and Classification Architecture for MRI-Based Brain Tumor Detection

Uncontrolled cell division in the brain is what gives rise to brain tumors. If the tumor size increases by more than half, there is little hope for the patient's recovery. This emphasizes the need of rapid and precise brain tumor diagnosis. When it comes to analyzing, diagnosing, and planning therapy for brain tumors, MRI imaging plays a crucial role. A brain tumor's development history is crucial information for doctors to have. When it comes to distinguishing between human soft tissues, MRI scans are superior. In order to get reliable classification results from MRI scans quickly, deep learning is one of the most practical methods. Early human illness diagnosis has been demonstrated to be more accurate when deep learning methods are used. In the case of diagnosing a brain tumor, when even a little misdiagnosis might have serious consequences, accuracy is especially important. Disclosure of brain tumors in medical images is still a difficult task. Brain MRIs are notoriously imprecise in revealing the presence or absence of tumors. Using MRI scans of the brain, a Convolutional Neural Network (CNN) was trained to identify the presence of a tumor in this research. Results from the CNN model showed an accuracy of 99.17%. The CNN model's characteristics were also retrieved. In order to evaluate the CNN model's capability for processing images, we applied the features via the following machine learning models: KNN, Logistic regression, SVM, Random Forest, Naive Bayes, and Perception. CNN and machine learning models were also evaluated using the standard metrics of Precision, Recall, Specificity, and F1 score. The significance of the doctor's diagnosis enhanced the accuracy of the CNN model's assistance in identifying the existence of tumor and treating the patient.

MMCS: A Multimodal Medical Diagnosis System Integrating Image Analysis and Knowledge-based Departmental Consultation

We present MMCS, a system capable of recognizing medical images and patient facial details, and providing professional medical diagnoses. The system consists of two core components: The first component is the analysis of medical images and videos. We trained a specialized multimodal medical model capable of interpreting medical images and accurately analyzing patients' facial emotions and facial paralysis conditions. The model achieved an accuracy of 72.59% on the FER2013 facial emotion recognition dataset, with a 91.1% accuracy in recognizing the happy emotion. In facial paralysis recognition, the model reached an accuracy of 92%, which is 30% higher than that of GPT-4o. Based on this model, we developed a parser for analyzing facial movement videos of patients with facial paralysis, achieving precise grading of the paralysis severity. In tests on 30 videos of facial paralysis patients, the system demonstrated a grading accuracy of 83.3%.The second component is the generation of professional medical responses. We employed a large language model, integrated with a medical knowledge base, to generate professional diagnoses based on the analysis of medical images or videos. The core innovation lies in our development of a department-specific knowledge base routing management mechanism, in which the large language model categorizes data by medical departments and, during the retrieval process, determines the appropriate knowledge base to query. This significantly improves retrieval accuracy in the RAG (retrieval-augmented generation) process. This mechanism led to an average increase of 4 percentage points in accuracy for various large language models on the MedQA dataset.Our code is open-sourced and available at: https://github.com/renllll/MMCS.

MedImageInsight: An Open-Source Embedding Model for General Domain Medical Imaging

In this work, we present MedImageInsight, an open-source medical imaging embedding model. MedImageInsight is trained on medical images with associated text and labels across a diverse collection of domains, including X-Ray, CT, MRI, dermoscopy, OCT, fundus photography, ultrasound, histopathology, and mammography. Rigorous evaluations demonstrate MedImageInsight's ability to achieve state-of-the-art (SOTA) or human expert level performance across classification, image-image search, and fine-tuning tasks. Specifically, on public datasets, MedImageInsight achieves SOTA in CT 3D medical image retrieval, as well as SOTA in disease classification and search for chest X-ray, dermatology, and OCT imaging. Furthermore, MedImageInsight achieves human expert performance in bone age estimation (on both public and partner data), as well as AUC above 0.9 in most other domains. When paired with a text decoder, MedImageInsight achieves near SOTA level single image report findings generation with less than 10\% the parameters of other models. Compared to fine-tuning GPT-4o with only MIMIC-CXR data for the same task, MedImageInsight outperforms in clinical metrics, but underperforms on lexical metrics where GPT-4o sets a new SOTA. Importantly for regulatory purposes, MedImageInsight can generate ROC curves, adjust sensitivity and specificity based on clinical need, and provide evidence-based decision support through image-image search (which can also enable retrieval augmented generation). In an independent clinical evaluation of image-image search in chest X-ray, MedImageInsight outperformed every other publicly available foundation model evaluated by large margins (over 6 points AUC), and significantly outperformed other models in terms of AI fairness (across age and gender). We hope releasing MedImageInsight will help enhance collective progress in medical imaging AI research and development.

When Does Perceptual Alignment Benefit Vision Representations?

Humans judge perceptual similarity according to diverse visual attributes, including scene layout, subject location, and camera pose. Existing vision models understand a wide range of semantic abstractions but improperly weigh these attributes and thus make inferences misaligned with human perception. While vision representations have previously benefited from alignment in contexts like image generation, the utility of perceptually aligned representations in more general-purpose settings remains unclear. Here, we investigate how aligning vision model representations to human perceptual judgments impacts their usability across diverse computer vision tasks. We finetune state-of-the-art models on human similarity judgments for image triplets and evaluate them across standard vision benchmarks. We find that aligning models to perceptual judgments yields representations that improve upon the original backbones across many downstream tasks, including counting, segmentation, depth estimation, instance retrieval, and retrieval-augmented generation. In addition, we find that performance is widely preserved on other tasks, including specialized out-of-distribution domains such as in medical imaging and 3D environment frames. Our results suggest that injecting an inductive bias about human perceptual knowledge into vision models can contribute to better representations.

OAH-Net: A Deep Neural Network for Hologram Reconstruction of Off-axis Digital Holographic Microscope

Off-axis digital holographic microscopy is a high-throughput, label-free imaging technology that provides three-dimensional, high-resolution information about samples, particularly useful in large-scale cellular imaging. However, the hologram reconstruction process poses a significant bottleneck for timely data analysis. To address this challenge, we propose a novel reconstruction approach that integrates deep learning with the physical principles of off-axis holography. We initialized part of the network weights based on the physical principle and then fine-tuned them via weakly supersized learning. Our off-axis hologram network (OAH-Net) retrieves phase and amplitude images with errors that fall within the measurement error range attributable to hardware, and its reconstruction speed significantly surpasses the microscope's acquisition rate. Crucially, OAH-Net demonstrates remarkable external generalization capabilities on unseen samples with distinct patterns and can be seamlessly integrated with other models for downstream tasks to achieve end-to-end real-time hologram analysis. This capability further expands off-axis holography's applications in both biological and medical studies.

Retrieval Instead of Fine-tuning: A Retrieval-based Parameter Ensemble for Zero-shot Learning

Foundation models have become a cornerstone in deep learning, with techniques like Low-Rank Adaptation (LoRA) offering efficient fine-tuning of large models. Similarly, methods such as Retrieval-Augmented Generation (RAG), which leverage vectorized databases, have further improved model performance by grounding outputs in external information. While these approaches have demonstrated notable success, they often require extensive training or labeled data, which can limit their adaptability in resource-constrained environments. To address these challenges, we introduce Retrieval-based Parameter Ensemble (RPE), a new method that creates a vectorized database of LoRAs, enabling efficient retrieval and application of model adaptations to new tasks. RPE minimizes the need for extensive training and eliminates the requirement for labeled data, making it particularly effective for zero-shot learning. Additionally, RPE is well-suited for privacy-sensitive domains like healthcare, as it modifies model parameters without accessing raw data. When applied to tasks such as medical report generation and image segmentation, RPE not only proved effective but also surpassed supervised fine-tuning methods in certain cases, highlighting its potential to enhance both computational efficiency and privacy in deep learning applications.

Fine-Tuning In-House Large Language Models to Infer Differential Diagnosis from Radiology Reports

Radiology reports summarize key findings and differential diagnoses derived from medical imaging examinations. The extraction of differential diagnoses is crucial for downstream tasks, including patient management and treatment planning. However, the unstructured nature of these reports, characterized by diverse linguistic styles and inconsistent formatting, presents significant challenges. Although proprietary large language models (LLMs) such as GPT-4 can effectively retrieve clinical information, their use is limited in practice by high costs and concerns over the privacy of protected health information (PHI). This study introduces a pipeline for developing in-house LLMs tailored to identify differential diagnoses from radiology reports. We first utilize GPT-4 to create 31,056 labeled reports, then fine-tune open source LLM using this dataset. Evaluated on a set of 1,067 reports annotated by clinicians, the proposed model achieves an average F1 score of 92.1\%, which is on par with GPT-4 (90.8\%). Through this study, we provide a methodology for constructing in-house LLMs that: match the performance of GPT, reduce dependence on expensive proprietary models, and enhance the privacy and security of PHI.