Temporal Inversion for Learning Interval Change in Chest X-Rays

Recent advances in vision--language pretraining have enabled strong medical foundation models, yet most analyze radiographs in isolation, overlooking the key clinical task of comparing prior and current images to assess interval change. For chest radiographs (CXRs), capturing interval change is essential, as radiologists must evaluate not only the static appearance of findings but also how they evolve over time. We introduce TILA (Temporal Inversion-aware Learning and Alignment), a simple yet effective framework that uses temporal inversion, reversing image pairs, as a supervisory signal to enhance the sensitivity of existing temporal vision-language models to directional change. TILA integrates inversion-aware objectives across pretraining, fine-tuning, and inference, complementing conventional appearance modeling with explicit learning of temporal order. We also propose a unified evaluation protocol to assess order sensitivity and consistency under temporal inversion, and introduce MS-CXR-Tretrieval, a retrieval evaluation set constructed through a general protocol that can be applied to any temporal CXR dataset. Experiments on public datasets and real-world hospital cohorts demonstrate that TILA consistently improves progression classification and temporal embedding alignment when applied to multiple existing architectures.

RAP: Retrieve, Adapt, and Prompt-Fit for Training-Free Few-Shot Medical Image Segmentation

Few-shot medical image segmentation (FSMIS) has achieved notable progress, yet most existing methods mainly rely on semantic correspondences from scarce annotations while under-utilizing a key property of medical imagery: anatomical targets exhibit repeatable high-frequency morphology (e.g., boundary geometry and spatial layout) across patients and acquisitions. We propose RAP, a training-free framework that retrieves, adapts, and prompts Segment Anything Model 2 (SAM2) for FSMIS. First, RAP retrieves morphologically compatible supports from an archive using DINOv3 features to reduce brittleness in single-support choice. Second, it adapts the retrieved support mask to the query by fitting boundary-aware structural cues, yielding an anatomy-consistent pre-mask under domain shifts. Third, RAP converts the pre-mask into prompts by sampling positive points via Voronoi partitioning and negative points via sector-based sampling, and feeds them into SAM2 for final refinement without any fine-tuning. Extensive experiments on multiple medical segmentation benchmarks show that RAP consistently surpasses prior FSMIS baselines and achieves state-of-the-art performance. Overall, RAP demonstrates that explicit structural fitting combined with retrieval-augmented prompting offers a simple and effective route to robust training-free few-shot medical segmentation.

Sparse Autoencoders for Interpretable Medical Image Representation Learning

Vision foundation models (FMs) achieve state-of-the-art performance in medical imaging. However, they encode information in abstract latent representations that clinicians cannot interrogate or verify. The goal of this study is to investigate Sparse Autoencoders (SAEs) for replacing opaque FM image representations with human-interpretable, sparse features. We train SAEs on embeddings from BiomedParse (biomedical) and DINOv3 (general-purpose) using 909,873 CT and MRI 2D image slices from the TotalSegmentator dataset. We find that learned sparse features: (a) reconstruct original embeddings with high fidelity (R2 up to 0.941) and recover up to 87.8% of downstream performance using only 10 features (99.4% dimensionality reduction), (b) preserve semantic fidelity in image retrieval tasks, (c) correspond to specific concepts that can be expressed in language using large language model (LLM)-based auto-interpretation. (d) bridge clinical language and abstract latent representations in zero-shot language-driven image retrieval. Our work indicates SAEs are a promising pathway towards interpretable, concept-driven medical vision systems. Code repository: https://github.com/pwesp/sail.

HMAR: Hierarchical Modality-Aware Expert and Dynamic Routing Medical Image Retrieval Architecture

Medical image retrieval (MIR) is a critical component of computer-aided diagnosis, yet existing systems suffer from three persistent limitations: uniform feature encoding that fails to account for the varying clinical importance of anatomical structures, ambiguous similarity metrics based on coarse classification labels, and an exclusive focus on global image similarity that cannot meet the clinical demand for fine-grained region-specific retrieval. We propose HMAR (Hierarchical Modality-Aware Expert and Dynamic Routing), an adaptive retrieval framework built on a Mixture-of-Experts (MoE) architecture. HMAR employs a dual-expert mechanism: Expert0 extracts global features for holistic similarity matching, while Expert1 learns position-invariant local representations for precise lesion-region retrieval. A two-stage contrastive learning strategy eliminates the need for expensive bounding-box annotations, and a sliding-window matching algorithm enables dense local comparison at inference time. Hash codes are generated via Kolmogorov-Arnold Network (KAN) layers for efficient Hamming-distance search. Experiments on the RadioImageNet-CT dataset (16 clinical patterns, 29,903 images) show that HMAR achieves mean Average Precision (mAP) of 0.711 and 0.724 for 64-bit and 128-bit hash codes, improving over the state-of-the-art ACIR method by 0.7% and 1.1%, respectively.

Seeing Like Radiologists: Context- and Gaze-Guided Vision-Language Pretraining for Chest X-rays

Despite recent advances in medical vision-language pretraining, existing models still struggle to capture the diagnostic workflow: radiographs are typically treated as context-agnostic images, while radiologists' gaze -- a crucial cue for visual reasoning -- remains largely underexplored by existing methods. These limitations hinder the modeling of disease-specific patterns and weaken cross-modal alignment. To bridge this gap, we introduce CoGaze, a Context- and Gaze-guided vision-language pretraining framework for chest X-rays. We first propose a context-infused vision encoder that models how radiologists integrate clinical context -- including patient history, symptoms, and diagnostic intent -- to guide diagnostic reasoning. We then present a multi-level supervision paradigm that (1) enforces intra- and inter-modal semantic alignment through hybrid-positive contrastive learning, (2) injects diagnostic priors via disease-aware cross-modal representation learning, and (3) leverages radiologists' gaze as probabilistic priors to guide attention toward diagnostically salient regions. Extensive experiments demonstrate that CoGaze consistently outperforms state-of-the-art methods across diverse tasks, achieving up to +2.0% CheXbertF1 and +1.2% BLEU2 for free-text and structured report generation, +23.2% AUROC for zero-shot classification, and +12.2% Precision@1 for image-text retrieval. Code is available at https://github.com/mk-runner/CoGaze.

OmniFM: Toward Modality-Robust and Task-Agnostic Federated Learning for Heterogeneous Medical Imaging

Federated learning (FL) has become a promising paradigm for collaborative medical image analysis, yet existing frameworks remain tightly coupled to task-specific backbones and are fragile under heterogeneous imaging modalities. Such constraints hinder real-world deployment, where institutions vary widely in modality distributions and must support diverse downstream tasks. To address this limitation, we propose OmniFM, a modality- and task-agnostic FL framework that unifies training across classification, segmentation, super-resolution, visual question answering, and multimodal fusion without re-engineering the optimization pipeline. OmniFM builds on a key frequency-domain insight: low-frequency spectral components exhibit strong cross-modality consistency and encode modality-invariant anatomical structures. Accordingly, OmniFM integrates (i) Global Spectral Knowledge Retrieval to inject global frequency priors, (ii) Embedding-wise Cross-Attention Fusion to align representations, and (iii) Prefix-Suffix Spectral Prompting to jointly condition global and personalized cues, together regularized by a Spectral-Proximal Alignment objective that stabilizes aggregation. Experiments on real-world datasets show that OmniFM consistently surpasses state-of-the-art FL baselines across intra- and cross-modality heterogeneity, achieving superior results under both fine-tuning and training-from-scratch setups.

MedQ-Engine: A Closed-Loop Data Engine for Evolving MLLMs in Medical Image Quality Assessment

Medical image quality assessment (Med-IQA) is a prerequisite for clinical AI deployment, yet multimodal large language models (MLLMs) still fall substantially short of human experts, particularly when required to provide descriptive assessments with clinical reasoning beyond simple quality scores. However, improving them is hindered by the high cost of acquiring descriptive annotations and by the inability of one-time data collection to adapt to the model's evolving weaknesses. To address these challenges, we propose MedQ-Engine, a closed-loop data engine that iteratively evaluates the model to discover failure prototypes via data-driven clustering, explores a million-scale image pool using these prototypes as retrieval anchors with progressive human-in-the-loop annotation, and evolves through quality-assured fine-tuning, forming a self-improving cycle. Models are evaluated on complementary perception and description tasks. An entropy-guided routing mechanism triages annotations to minimize labeling cost. Experiments across five medical imaging modalities show that MedQ-Engine elevates an 8B-parameter model to surpass GPT-4o by over 13% and narrow the gap with human experts to only 4.34%, using only 10K annotations with more than 4x sample efficiency over random sampling.

Concept-to-Pixel: Prompt-Free Universal Medical Image Segmentation

Universal medical image segmentation seeks to use a single foundational model to handle diverse tasks across multiple imaging modalities. However, existing approaches often rely heavily on manual visual prompts or retrieved reference images, which limits their automation and robustness. In addition, naive joint training across modalities often fails to address large domain shifts. To address these limitations, we propose Concept-to-Pixel (C2P), a novel prompt-free universal segmentation framework. C2P explicitly separates anatomical knowledge into two components: Geometric and Semantic representations. It leverages Multimodal Large Language Models (MLLMs) to distill abstract, high-level medical concepts into learnable Semantic Tokens and introduces explicitly supervised Geometric Tokens to enforce universal physical and structural constraints. These disentangled tokens interact deeply with image features to generate input-specific dynamic kernels for precise mask prediction. Furthermore, we introduce a Geometry-Aware Inference Consensus mechanism, which utilizes the model's predicted geometric constraints to assess prediction reliability and suppress outliers. Extensive experiments and analysis on a unified benchmark comprising eight diverse datasets across seven modalities demonstrate the significant superiority of our jointly trained approach, compared to universe- or single-model approaches. Remarkably, our unified model demonstrates strong generalization, achieving impressive results not only on zero-shot tasks involving unseen cases but also in cross-modal transfers across similar tasks. Code is available at: https://github.com/Yundi218/Concept-to-Pixel

Composed Vision-Language Retrieval for Skin Cancer Case Search via Joint Alignment of Global and Local Representations

Medical image retrieval aims to identify clinically relevant lesion cases to support diagnostic decision making, education, and quality control. In practice, retrieval queries often combine a reference lesion image with textual descriptors such as dermoscopic features. We study composed vision-language retrieval for skin cancer, where each query consists of an image to text pair and the database contains biopsy-confirmed, multi-class disease cases. We propose a transformer based framework that learns hierarchical composed query representations and performs joint global-local alignment between queries and candidate images. Local alignment aggregates discriminative regions via multiple spatial attention masks, while global alignment provides holistic semantic supervision. The final similarity is computed through a convex, domain-informed weighting that emphasizes clinically salient local evidence while preserving global consistency. Experiments on the public Derm7pt dataset demonstrate consistent improvements over state-of-the-art methods. The proposed framework enables efficient access to relevant medical records and supports practical clinical deployment.

Gastric-X: A Multimodal Multi-Phase Benchmark Dataset for Advancing Vision-Language Models in Gastric Cancer Analysis

Recent vision-language models (VLMs) have shown strong generalization and multimodal reasoning abilities in natural domains. However, their application to medical diagnosis remains limited by the lack of comprehensive and structured datasets that capture real clinical workflows. To advance the development of VLMs for clinical applications, particularly in gastric cancer, we introduce Gastric-X, a large-scale multimodal benchmark for gastric cancer analysis providing 1.7K cases. Each case in Gastric-X includes paired resting and dynamic CT scans, endoscopic image, a set of structured biochemical indicators, expert-authored diagnostic notes, and bounding box annotations of tumor regions, reflecting realistic clinical conditions. We systematically examine the capability of recent VLMs on five core tasks: Visual Question Answering (VQA), report generation, cross-modal retrieval, disease classification, and lesion localization. These tasks simulate critical stages of clinical workflow, from visual understanding and reasoning to multimodal decision support. Through this evaluation, we aim not only to assess model performance but also to probe the nature of VLM understanding: Can current VLMs meaningfully correlate biochemical signals with spatial tumor features and textual reports? We envision Gastric-X as a step toward aligning machine intelligence with the cognitive and evidential reasoning processes of physicians, and as a resource to inspire the development of next-generation medical VLMs.