FFA Sora, video generation as fundus fluorescein angiography simulator

Fundus fluorescein angiography (FFA) is critical for diagnosing retinal vascular diseases, but beginners often struggle with image interpretation. This study develops FFA Sora, a text-to-video model that converts FFA reports into dynamic videos via a Wavelet-Flow Variational Autoencoder (WF-VAE) and a diffusion transformer (DiT). Trained on an anonymized dataset, FFA Sora accurately simulates disease features from the input text, as confirmed by objective metrics: Frechet Video Distance (FVD) = 329.78, Learned Perceptual Image Patch Similarity (LPIPS) = 0.48, and Visual-question-answering Score (VQAScore) = 0.61. Specific evaluations showed acceptable alignment between the generated videos and textual prompts, with BERTScore of 0.35. Additionally, the model demonstrated strong privacy-preserving performance in retrieval evaluations, achieving an average Recall@K of 0.073. Human assessments indicated satisfactory visual quality, with an average score of 1.570(scale: 1 = best, 5 = worst). This model addresses privacy concerns associated with sharing large-scale FFA data and enhances medical education.

The Role of Recurrency in Image Segmentation for Noisy and Limited Sample Settings

The biological brain has inspired multiple advances in machine learning. However, most state-of-the-art models in computer vision do not operate like the human brain, simply because they are not capable of changing or improving their decisions/outputs based on a deeper analysis. The brain is recurrent, while these models are not. It is therefore relevant to explore what would be the impact of adding recurrent mechanisms to existing state-of-the-art architectures and to answer the question of whether recurrency can improve existing architectures. To this end, we build on a feed-forward segmentation model and explore multiple types of recurrency for image segmentation. We explore self-organizing, relational, and memory retrieval types of recurrency that minimize a specific energy function. In our experiments, we tested these models on artificial and medical imaging data, while analyzing the impact of high levels of noise and few-shot learning settings. Our results do not validate our initial hypothesis that recurrent models should perform better in these settings, suggesting that these recurrent architectures, by themselves, are not sufficient to surpass state-of-the-art feed-forward versions and that additional work needs to be done on the topic.

Towards Interpretable Radiology Report Generation via Concept Bottlenecks using a Multi-Agentic RAG

Deep learning has advanced medical image classification, but interpretability challenges hinder its clinical adoption. This study enhances interpretability in Chest X-ray (CXR) classification by using concept bottleneck models (CBMs) and a multi-agent Retrieval-Augmented Generation (RAG) system for report generation. By modeling relationships between visual features and clinical concepts, we create interpretable concept vectors that guide a multi-agent RAG system to generate radiology reports, enhancing clinical relevance, explainability, and transparency. Evaluation of the generated reports using an LLM-as-a-judge confirmed the interpretability and clinical utility of our model's outputs. On the COVID-QU dataset, our model achieved 81% classification accuracy and demonstrated robust report generation performance, with five key metrics ranging between 84% and 90%. This interpretable multi-agent framework bridges the gap between high-performance AI and the explainability required for reliable AI-driven CXR analysis in clinical settings.

Transversal PACS Browser API: Addressing Interoperability Challenges in Medical Imaging Systems

Advances in imaging technologies have revolutionised the medical imaging and healthcare sectors, leading to the widespread adoption of PACS for the storage, retrieval, and communication of medical images. Although these systems have improved operational efficiency, significant challenges remain in effectively retrieving DICOM images, which are essential for diagnosis and overall patient care. Moreover, issues such as fragmented systems, interoperability barriers, and complex user interfaces can often prevent healthcare professionals from efficiently accessing medical images. Addressing these challenges, the Transversal PACS Browser API is a robust and user-friendly solution designed to enhance the process of querying and retrieving DICOM images. It offers advanced filtering capabilities through a variety of filter options as well as a custom field search, that allows users to easily navigate through large medical image collections with ease. Additionally, the application provides a unified interface for querying and retrieving from multiple PACS stations, addressing the challenges of fragmentation and complexity associated with accessing medical images. Other key features include the ability to pre-view images directly within the application. All of this contributes to the transversal nature of the API, serving not only healthcare providers, but anyone who relies on efficient access to these resources. To validate the performance and usability of the application, comprehensive testing was carried out with stakeholders of the field, the results of which showed general satisfaction, highlighting the API's clean design, ease of use, and effective search capabilities of the API, as well as the usefulness of previewing images within the application.

Integrating MedCLIP and Cross-Modal Fusion for Automatic Radiology Report Generation

Automating radiology report generation can significantly reduce the workload of radiologists and enhance the accuracy, consistency, and efficiency of clinical documentation.We propose a novel cross-modal framework that uses MedCLIP as both a vision extractor and a retrieval mechanism to improve the process of medical report generation.By extracting retrieved report features and image features through an attention-based extract module, and integrating them with a fusion module, our method improves the coherence and clinical relevance of generated reports.Experimental results on the widely used IU-Xray dataset demonstrate the effectiveness of our approach, showing improvements over commonly used methods in both report quality and relevance.Additionally, ablation studies provide further validation of the framework, highlighting the importance of accurate report retrieval and feature integration in generating comprehensive medical reports.

DAug: Diffusion-based Channel Augmentation for Radiology Image Retrieval and Classification

Medical image understanding requires meticulous examination of fine visual details, with particular regions requiring additional attention. While radiologists build such expertise over years of experience, it is challenging for AI models to learn where to look with limited amounts of training data. This limitation results in unsatisfying robustness in medical image understanding. To address this issue, we propose Diffusion-based Feature Augmentation (DAug), a portable method that improves a perception model's performance with a generative model's output. Specifically, we extend a radiology image to multiple channels, with the additional channels being the heatmaps of regions where diseases tend to develop. A diffusion-based image-to-image translation model was used to generate such heatmaps conditioned on selected disease classes. Our method is motivated by the fact that generative models learn the distribution of normal and abnormal images, and such knowledge is complementary to image understanding tasks. In addition, we propose the Image-Text-Class Hybrid Contrastive learning to utilize both text and class labels. With two novel approaches combined, our method surpasses baseline models without changing the model architecture, and achieves state-of-the-art performance on both medical image retrieval and classification tasks.

FedMetaMed: Federated Meta-Learning for Personalized Medication in Distributed Healthcare Systems

Personalized medication aims to tailor healthcare to individual patient characteristics. However, the heterogeneity of patient data across healthcare systems presents significant challenges to achieving accurate and effective personalized treatments. Ethical concerns further complicate the aggregation of large volumes of data from diverse institutions. Federated Learning (FL) offers a promising decentralized solution by enabling collaborative model training through the exchange of client models rather than raw data, thus preserving privacy. However, existing FL methods often suffer from retrogression during server aggregation, leading to a decline in model performance in real-world medical FL settings. To address data variability in distributed healthcare systems, we introduce Federated Meta-Learning for Personalized Medication (FedMetaMed), which combines federated learning and meta-learning to create models that adapt to diverse patient data across healthcare systems. The FedMetaMed framework aims to produce superior personalized models for individual clients by addressing these limitations. Specifically, we introduce Cumulative Fourier Aggregation (CFA) at the server to improve stability and effectiveness in global knowledge aggregation. CFA achieves this by gradually integrating client models from low to high frequencies. At the client level, we implement a Collaborative Transfer Optimization (CTO) strategy with a three-step process - Retrieve, Reciprocate, and Refine - to enhance the personalized local model through seamless global knowledge transfer. Experiments on real-world medical imaging datasets demonstrate that FedMetaMed outperforms state-of-the-art FL methods, showing superior generalization even on out-of-distribution cohorts.

2-Factor Retrieval for Improved Human-AI Decision Making in Radiology

Human-machine teaming in medical AI requires us to understand to what degree a trained clinician should weigh AI predictions. While previous work has shown the potential of AI assistance at improving clinical predictions, existing clinical decision support systems either provide no explainability of their predictions or use techniques like saliency and Shapley values, which do not allow for physician-based verification. To address this gap, this study compares previously used explainable AI techniques with a newly proposed technique termed '2-factor retrieval (2FR)', which is a combination of interface design and search retrieval that returns similarly labeled data without processing this data. This results in a 2-factor security blanket where: (a) correct images need to be retrieved by the AI; and (b) humans should associate the retrieved images with the current pathology under test. We find that when tested on chest X-ray diagnoses, 2FR leads to increases in clinician accuracy, with particular improvements when clinicians are radiologists and have low confidence in their decision. Our results highlight the importance of understanding how different modes of human-AI decision making may impact clinician accuracy in clinical decision support systems.

A Survey of Medical Vision-and-Language Applications and Their Techniques

Medical vision-and-language models (MVLMs) have attracted substantial interest due to their capability to offer a natural language interface for interpreting complex medical data. Their applications are versatile and have the potential to improve diagnostic accuracy and decision-making for individual patients while also contributing to enhanced public health monitoring, disease surveillance, and policy-making through more efficient analysis of large data sets. MVLMS integrate natural language processing with medical images to enable a more comprehensive and contextual understanding of medical images alongside their corresponding textual information. Unlike general vision-and-language models trained on diverse, non-specialized datasets, MVLMs are purpose-built for the medical domain, automatically extracting and interpreting critical information from medical images and textual reports to support clinical decision-making. Popular clinical applications of MVLMs include automated medical report generation, medical visual question answering, medical multimodal segmentation, diagnosis and prognosis and medical image-text retrieval. Here, we provide a comprehensive overview of MVLMs and the various medical tasks to which they have been applied. We conduct a detailed analysis of various vision-and-language model architectures, focusing on their distinct strategies for cross-modal integration/exploitation of medical visual and textual features. We also examine the datasets used for these tasks and compare the performance of different models based on standardized evaluation metrics. Furthermore, we highlight potential challenges and summarize future research trends and directions. The full collection of papers and codes is available at: https://github.com/YtongXie/Medical-Vision-and-Language-Tasks-and-Methodologies-A-Survey.

Uni-Mlip: Unified Self-supervision for Medical Vision Language Pre-training

Recent advancements in vision-language pre-training via contrastive learning have significantly improved performance across computer vision tasks. However, in the medical domain, obtaining multimodal data is often costly and challenging due to privacy, sensitivity, and annotation complexity. To mitigate data scarcity while boosting model performance, we introduce \textbf{Uni-Mlip}, a unified self-supervision framework specifically designed to enhance medical vision-language pre-training. Uni-Mlip seamlessly integrates cross-modality, uni-modality, and fused-modality self-supervision techniques at the data-level and the feature-level. Additionally, Uni-Mlip tailors uni-modal image self-supervision to accommodate the unique characteristics of medical images. Our experiments across datasets of varying scales demonstrate that Uni-Mlip significantly surpasses current state-of-the-art methods in three key downstream tasks: image-text retrieval, image classification, and visual question answering (VQA).