CovidLLM: A Robust Large Language Model with Missing Value Adaptation and Multi-Objective Learning Strategy for Predicting Disease Severity and Clinical Outcomes in COVID-19 Patients

Coronavirus Disease 2019 (COVID-19), which emerged in 2019, has caused millions of deaths worldwide. Although effective vaccines have been developed to mitigate severe symptoms, certain populations, particularly the elderly and those with comorbidities, remain at high risk for severe outcomes and increased mortality. Consequently, early identification of the severity and clinical outcomes of the disease in these patients is vital to prevent adverse prognoses. Although traditional machine learning and deep learning models have been widely employed in this area, the potential of large language models (LLMs) remains largely unexplored. Our research focuses primarily on constructing specialized prompts and adopting multi-objective learning strategies. We started by selecting serological indicators that significantly correlate with clinical outcomes and disease severity to serve as input data for the model. Blood test samples often contain numerous missing values, and traditional models generally rely on imputation to handle these gaps in the data. In contrast, LLMs offer the advantage of robust semantic understanding. By setting prompts, we can explicitly inform the model when a feature's value is missing, without the need for imputation. For the multi-objective learning strategy, the model is designed to first predict disease severity and then predict clinical outcomes. Given that LLMs utilize both the input text and the generated tokens as input for generating the next token, the predicted severity is used as a basis for generating the clinical outcome. During the fine-tuning of the LLM, the two objectives influence and improve each other. Our experiments were implemented based on the ChatGLM model. The results demonstrate the effectiveness of LLMs in this task, suggesting promising potential for further development.

SMILE-UHURA Challenge -- Small Vessel Segmentation at Mesoscopic Scale from Ultra-High Resolution 7T Magnetic Resonance Angiograms

The human brain receives nutrients and oxygen through an intricate network of blood vessels. Pathology affecting small vessels, at the mesoscopic scale, represents a critical vulnerability within the cerebral blood supply and can lead to severe conditions, such as Cerebral Small Vessel Diseases. The advent of 7 Tesla MRI systems has enabled the acquisition of higher spatial resolution images, making it possible to visualise such vessels in the brain. However, the lack of publicly available annotated datasets has impeded the development of robust, machine learning-driven segmentation algorithms. To address this, the SMILE-UHURA challenge was organised. This challenge, held in conjunction with the ISBI 2023, in Cartagena de Indias, Colombia, aimed to provide a platform for researchers working on related topics. The SMILE-UHURA challenge addresses the gap in publicly available annotated datasets by providing an annotated dataset of Time-of-Flight angiography acquired with 7T MRI. This dataset was created through a combination of automated pre-segmentation and extensive manual refinement. In this manuscript, sixteen submitted methods and two baseline methods are compared both quantitatively and qualitatively on two different datasets: held-out test MRAs from the same dataset as the training data (with labels kept secret) and a separate 7T ToF MRA dataset where both input volumes and labels are kept secret. The results demonstrate that most of the submitted deep learning methods, trained on the provided training dataset, achieved reliable segmentation performance. Dice scores reached up to 0.838 $\pm$ 0.066 and 0.716 $\pm$ 0.125 on the respective datasets, with an average performance of up to 0.804 $\pm$ 0.15.

IterSelectTune: An Iterative Training Framework for Efficient Instruction-Tuning Data Selection

As large language models (LLMs) continue to advance, instruction tuning has become critical for improving their ability to generate accurate and contextually appropriate responses. Although numerous instruction-tuning datasets have been developed to enhance LLM performance, selecting high-quality instruction data from large source datasets typically demands significant human effort. In this work, we introduce $\textbf{IterSelectTune}$, an efficient, cost-effective iterative training policy for selecting high-quality instruction data with no human involvement and limited reliance on GPT-4. By fine-tuning on approximately 20\% of the source data, our method consistently outperforms models fine-tuned on the full dataset across multiple benchmarks and public test datasets. These results highlight the effectiveness of our approach in enhancing LLM performance while reducing the computational resources required for instruction tuning.

A comprehensive survey on deep active learning and its applications in medical image analysis

Deep learning has achieved widespread success in medical image analysis, leading to an increasing demand for large-scale expert-annotated medical image datasets. Yet, the high cost of annotating medical images severely hampers the development of deep learning in this field. To reduce annotation costs, active learning aims to select the most informative samples for annotation and train high-performance models with as few labeled samples as possible. In this survey, we review the core methods of active learning, including the evaluation of informativeness and sampling strategy. For the first time, we provide a detailed summary of the integration of active learning with other label-efficient techniques, such as semi-supervised, self-supervised learning, and so on. Additionally, we also highlight active learning works that are specifically tailored to medical image analysis. In the end, we offer our perspectives on the future trends and challenges of active learning and its applications in medical image analysis.

TriFormer: A Multi-modal Transformer Framework For Mild Cognitive Impairment Conversion Prediction

The prediction of mild cognitive impairment (MCI) conversion to Alzheimer's disease (AD) is important for early treatment to prevent or slow the progression of AD. To accurately predict the MCI conversion to stable MCI or progressive MCI, we propose Triformer, a novel transformer-based framework with three specialized transformers to incorporate multi-model data. Triformer uses I) an image transformer to extract multi-view image features from medical scans, II) a clinical transformer to embed and correlate multi-modal clinical data, and III) a modality fusion transformer that produces an accurate prediction based on fusing the outputs from the image and clinical transformers. Triformer is evaluated on the Alzheimer's Disease Neuroimaging Initiative (ANDI)1 and ADNI2 datasets and outperforms previous state-of-the-art single and multi-modal methods.

Explainable Semantic Medical Image Segmentation with Style

Semantic medical image segmentation using deep learning has recently achieved high accuracy, making it appealing to clinical problems such as radiation therapy. However, the lack of high-quality semantically labelled data remains a challenge leading to model brittleness to small shifts to input data. Most works require extra data for semi-supervised learning and lack the interpretability of the boundaries of the training data distribution during training, which is essential for model deployment in clinical practice. We propose a fully supervised generative framework that can achieve generalisable segmentation with only limited labelled data by simultaneously constructing an explorable manifold during training. The proposed approach creates medical image style paired with a segmentation task driven discriminator incorporating end-to-end adversarial training. The discriminator is generalised to small domain shifts as much as permissible by the training data, and the generator automatically diversifies the training samples using a manifold of input features learnt during segmentation. All the while, the discriminator guides the manifold learning by supervising the semantic content and fine-grained features separately during the image diversification. After training, visualisation of the learnt manifold from the generator is available to interpret the model limits. Experiments on a fully semantic, publicly available pelvis dataset demonstrated that our method is more generalisable to shifts than other state-of-the-art methods while being more explainable using an explorable manifold.

Cascaded Multi-Modal Mixing Transformers for Alzheimer's Disease Classification with Incomplete Data

Accurate medical classification requires a large number of multi-modal data, and in many cases, in different formats. Previous studies have shown promising results when using multi-modal data, outperforming single-modality models on when classifying disease such as AD. However, those models are usually not flexible enough to handle missing modalities. Currently, the most common workaround is excluding samples with missing modalities which leads to considerable data under-utilisation. Adding to the fact that labelled medical images are already scarce, the performance of data-driven methods like deep learning is severely hampered. Therefore, a multi-modal method that can gracefully handle missing data in various clinical settings is highly desirable. In this paper, we present the Multi-Modal Mixing Transformer (3MT), a novel Transformer for disease classification based on multi-modal data. In this work, we test it for \ac{AD} or \ac{CN} classification using neuroimaging data, gender, age and MMSE scores. The model uses a novel Cascaded Modality Transformers architecture with cross-attention to incorporate multi-modal information for more informed predictions. Auxiliary outputs and a novel modality dropout mechanism were incorporated to ensure an unprecedented level of modality independence and robustness. The result is a versatile network that enables the mixing of an unlimited number of modalities with different formats and full data utilization. 3MT was first tested on the ADNI dataset and achieved state-of-the-art test accuracy of $0.987\pm0.0006$. To test its generalisability, 3MT was directly applied to the AIBL after training on the ADNI dataset, and achieved a test accuracy of $0.925\pm0.0004$ without fine-tuning. Finally, we show that Grad-CAM visualizations are also possible with our model for explainable results.

Structure Guided Manifolds for Discovery of Disease Characteristics

In medical image analysis, the subtle visual characteristics of many diseases are challenging to discern, particularly due to the lack of paired data. For example, in mild Alzheimer's Disease (AD), brain tissue atrophy can be difficult to observe from pure imaging data, especially without paired AD and Cognitively Normal ( CN ) data for comparison. This work presents Disease Discovery GAN ( DiDiGAN), a weakly-supervised style-based framework for discovering and visualising subtle disease features. DiDiGAN learns a disease manifold of AD and CN visual characteristics, and the style codes sampled from this manifold are imposed onto an anatomical structural "blueprint" to synthesise paired AD and CN magnetic resonance images (MRIs). To suppress non-disease-related variations between the generated AD and CN pairs, DiDiGAN leverages a structural constraint with cycle consistency and anti-aliasing to enforce anatomical correspondence. When tested on the Alzheimer's Disease Neuroimaging Initiative ( ADNI) dataset, DiDiGAN showed key AD characteristics (reduced hippocampal volume, ventricular enlargement, and atrophy of cortical structures) through synthesising paired AD and CN scans. The qualitative results were backed up by automated brain volume analysis, where systematic pair-wise reductions in brain tissue structures were also measured

Towards Label-efficient Automatic Diagnosis and Analysis: A Comprehensive Survey of Advanced Deep Learning-based Weakly-supervised, Semi-supervised and Self-supervised Techniques in Histopathological Image Analysis

Histopathological images contain abundant phenotypic information and pathological patterns, which are the gold standards for disease diagnosis and essential for the prediction of patient prognosis and treatment outcome. In recent years, computer-automated analysis techniques for histopathological images have been urgently required in clinical practice, and deep learning methods represented by convolutional neural networks have gradually become the mainstream in the field of digital pathology. However, obtaining large numbers of fine-grained annotated data in this field is a very expensive and difficult task, which hinders the further development of traditional supervised algorithms based on large numbers of annotated data. More recent studies have started to liberate from the traditional supervised paradigm, and the most representative ones are the studies on weakly supervised learning paradigm based on weak annotation, semi-supervised learning paradigm based on limited annotation, and self-supervised learning paradigm based on pathological image representation learning. These new methods have led a new wave of automatic pathological image diagnosis and analysis targeted at annotation efficiency. With a survey of over 130 papers, we present a comprehensive and systematic review of the latest studies on weakly supervised learning, semi-supervised learning, and self-supervised learning in the field of computational pathology from both technical and methodological perspectives. Finally, we present the key challenges and future trends for these techniques.

Explainable AI for Suicide Risk Assessment Using Eye Activities and Head Gestures

The prevalence of suicide has been on the rise since the 20th century, causing severe emotional damage to individuals, families, and communities alike. Despite the severity of this suicide epidemic, there is so far no reliable and systematic way to assess suicide intent of a given individual. Through efforts to automate and systematize diagnosis of mental illnesses over the past few years, verbal and acoustic behaviors have received increasing attention as biomarkers, but little has been done to study eyelids, gaze, and head pose in evaluating suicide risk. This study explores statistical analysis, feature selection, and machine learning classification as means of suicide risk evaluation and nonverbal behavioral interpretation. Applying these methods to the eye and head signals extracted from our unique dataset, this study finds that high-risk suicidal individuals experience psycho-motor retardation and symptoms of anxiety and depression, characterized by eye contact avoidance, slower blinks and a downward eye gaze. By comparing results from different methods of classification, we determined that these features are highly capable of automatically classifying different levels of suicide risk consistently and with high accuracy, above 98%. Our conclusion corroborates psychological studies, and shows great potential of a systematic approach in suicide risk evaluation that is adoptable by both healthcare providers and naive observers.