$χ$-sepnet: Deep neural network for magnetic susceptibility source separation

Magnetic susceptibility source separation ($\chi$-separation), an advanced quantitative susceptibility mapping (QSM) method, enables the separate estimation of para- and diamagnetic susceptibility source distributions in the brain. The method utilizes reversible transverse relaxation (R2'=R2*-R2) to complement frequency shift information for estimating susceptibility source concentrations, requiring time-consuming data acquisition for R2 in addition R2*. To address this challenge, we develop a new deep learning network, $\chi$-sepnet, and propose two deep learning-based susceptibility source separation pipelines, $\chi$-sepnet-R2' for inputs with multi-echo GRE and multi-echo spin-echo, and $\chi$-sepnet-R2* for input with multi-echo GRE only. $\chi$-sepnet is trained using multiple head orientation data that provide streaking artifact-free labels, generating high-quality $\chi$-separation maps. The evaluation of the pipelines encompasses both qualitative and quantitative assessments in healthy subjects, and visual inspection of lesion characteristics in multiple sclerosis patients. The susceptibility source-separated maps of the proposed pipelines delineate detailed brain structures with substantially reduced artifacts compared to those from conventional regularization-based reconstruction methods. In quantitative analysis, $\chi$-sepnet-R2' achieves the best outcomes followed by $\chi$-sepnet-R2*, outperforming the conventional methods. When the lesions of multiple sclerosis patients are assessed, both pipelines report identical lesion characteristics in most lesions ($\chi$para: 99.6% and $\chi$dia: 98.4% out of 250 lesions). The $\chi$-sepnet-R2* pipeline, which only requires multi-echo GRE data, has demonstrated its potential to offer broad clinical and scientific applications, although further evaluations for various diseases and pathological conditions are necessary.

Adaptive Selection of Sampling-Reconstruction in Fourier Compressed Sensing

Compressed sensing (CS) has emerged to overcome the inefficiency of Nyquist sampling. However, traditional optimization-based reconstruction is slow and can not yield an exact image in practice. Deep learning-based reconstruction has been a promising alternative to optimization-based reconstruction, outperforming it in accuracy and computation speed. Finding an efficient sampling method with deep learning-based reconstruction, especially for Fourier CS remains a challenge. Existing joint optimization of sampling-reconstruction works ($\mathcal{H}_1$) optimize the sampling mask but have low potential as it is not adaptive to each data point. Adaptive sampling ($\mathcal{H}_2$) has also disadvantages of difficult optimization and Pareto sub-optimality. Here, we propose a novel adaptive selection of sampling-reconstruction ($\mathcal{H}_{1.5}$) framework that selects the best sampling mask and reconstruction network for each input data. We provide theorems that our method has a higher potential than $\mathcal{H}_1$ and effectively solves the Pareto sub-optimality problem in sampling-reconstruction by using separate reconstruction networks for different sampling masks. To select the best sampling mask, we propose to quantify the high-frequency Bayesian uncertainty of the input, using a super-resolution space generation model. Our method outperforms joint optimization of sampling-reconstruction ($\mathcal{H}_1$) and adaptive sampling ($\mathcal{H}_2$) by achieving significant improvements on several Fourier CS problems.

MOST: MR reconstruction Optimization for multiple downStream Tasks via continual learning

Deep learning-based Magnetic Resonance (MR) reconstruction methods have focused on generating high-quality images but they often overlook the impact on downstream tasks (e.g., segmentation) that utilize the reconstructed images. Cascading separately trained reconstruction network and downstream task network has been shown to introduce performance degradation due to error propagation and domain gaps between training datasets. To mitigate this issue, downstream task-oriented reconstruction optimization has been proposed for a single downstream task. Expanding this optimization to multi-task scenarios is not straightforward. In this work, we extended this optimization to sequentially introduced multiple downstream tasks and demonstrated that a single MR reconstruction network can be optimized for multiple downstream tasks by deploying continual learning (MOST). MOST integrated techniques from replay-based continual learning and image-guided loss to overcome catastrophic forgetting. Comparative experiments demonstrated that MOST outperformed a reconstruction network without finetuning, a reconstruction network with na\"ive finetuning, and conventional continual learning methods. This advancement empowers the application of a single MR reconstruction network for multiple downstream tasks. The source code is available at: https://github.com/SNU-LIST/MOST

Volumetric B1+ field homogenization in 7 Tesla brain MRI using metasurface scattering

Ultrahigh field magnetic resonance imaging (UHF MRI) has become an indispensable tool for human brain imaging, offering excellent diagnostic accuracy while avoiding the risks associated with invasive modalities. When the radiofrequency magnetic field of the UHF MRI encounters the multifaceted complexity of the brain, characterized by wavelength-scale, dissipative, and random heterogeneous materials, detrimental mesoscopic challenges such as B1+ field inhomogeneity and local heating arise. Here we develop the metasurface design inspired by scattering theory to achieve the volumetric field homogeneity in the UHF MRI. The method focuses on finding the scattering ansatz systematically and incorporates a pruning technique to achieve the minimum number of participating modes, which guarantees stable practical implementation. Using full-wave analysis of realistic human brain models under a 7 Tesla MRI, we demonstrate more than a twofold improvement in field homogeneity and suppressed local heating, achieving better performance than even the commercial 3 Tesla MRI. The result shows a noninvasive generalization of constant intensity waves in optics, offering a universal methodology applicable to higher Tesla MRI.

RTP-LX: Can LLMs Evaluate Toxicity in Multilingual Scenarios?

Large language models (LLMs) and small language models (SLMs) are being adopted at remarkable speed, although their safety still remains a serious concern. With the advent of multilingual S/LLMs, the question now becomes a matter of scale: can we expand multilingual safety evaluations of these models with the same velocity at which they are deployed? To this end we introduce RTP-LX, a human-transcreated and human-annotated corpus of toxic prompts and outputs in 28 languages. RTP-LX follows participatory design practices, and a portion of the corpus is especially designed to detect culturally-specific toxic language. We evaluate seven S/LLMs on their ability to detect toxic content in a culturally-sensitive, multilingual scenario. We find that, although they typically score acceptably in terms of accuracy, they have low agreement with human judges when judging holistically the toxicity of a prompt, and have difficulty discerning harm in context-dependent scenarios, particularly with subtle-yet-harmful content (e.g. microagressions, bias). We release of this dataset to contribute to further reduce harmful uses of these models and improve their safe deployment.

A Note on LoRA

LoRA (Low-Rank Adaptation) has emerged as a preferred method for efficiently adapting Large Language Models (LLMs) with remarkable simplicity and efficacy. This note extends the original LoRA paper by offering new perspectives that were not initially discussed and presents a series of insights for deploying LoRA at scale. Without introducing new experiments, we aim to improve the understanding and application of LoRA.

QUICK: Quantization-aware Interleaving and Conflict-free Kernel for efficient LLM inference

We introduce QUICK, a group of novel optimized CUDA kernels for the efficient inference of quantized Large Language Models (LLMs). QUICK addresses the shared memory bank-conflict problem of state-of-the-art mixed precision matrix multiplication kernels. Our method interleaves the quantized weight matrices of LLMs offline to skip the shared memory write-back after the dequantization. We demonstrate up to 1.91x speedup over existing kernels of AutoAWQ on larger batches and up to 1.94x throughput gain on representative LLM models on various NVIDIA GPU devices.

So You Want to Image Myelin Using MRI: Advanced Magnetic Susceptibility Imaging for Myelin

In MRI, researchers have long endeavored to effectively visualize myelin distribution in the brain, a pursuit with significant implications for both scientific research and clinical applications. Over time, various methods such as myelin water imaging, magnetization transfer imaging, and relaxometric imaging have been developed, each carrying distinct advantages and limitations. Recently, an innovative technique named as magnetic susceptibility source separation has emerged, introducing a novel surrogate biomarker for myelin in the form of a diamagnetic susceptibility map. This paper comprehensively reviews this cutting-edge method, providing the fundamental concepts of magnetic susceptibility, susceptibility imaging, and the validation of the diamagnetic susceptibility map as a myelin biomarker. Additionally, the paper explores essential aspects of data acquisition and processing, offering practical insights for readers. A comparison with established myelin imaging methods is also presented, and both current and prospective clinical and scientific applications are discussed to provide a holistic understanding of the technique. This work aims to serve as a foundational resource for newcomers entering this dynamic and rapidly expanding field.

Fast and accurate sparse-view CBCT reconstruction using meta-learned neural attenuation field and hash-encoding regularization

Cone beam computed tomography (CBCT) is an emerging medical imaging technique to visualize the internal anatomical structures of patients. During a CBCT scan, several projection images of different angles or views are collectively utilized to reconstruct a tomographic image. However, reducing the number of projections in a CBCT scan while preserving the quality of a reconstructed image is challenging due to the nature of an ill-posed inverse problem. Recently, a neural attenuation field (NAF) method was proposed by adopting a neural radiance field algorithm as a new way for CBCT reconstruction, demonstrating fast and promising results using only 50 views. However, decreasing the number of projections is still preferable to reduce potential radiation exposure, and a faster reconstruction time is required considering a typical scan time. In this work, we propose a fast and accurate sparse-view CBCT reconstruction (FACT) method to provide better reconstruction quality and faster optimization speed in the minimal number of view acquisitions ($<$ 50 views). In the FACT method, we meta-trained a neural network and a hash-encoder using a few scans (= 15), and a new regularization technique is utilized to reconstruct the details of an anatomical structure. In conclusion, we have shown that the FACT method produced better, and faster reconstruction results over the other conventional algorithms based on CBCT scans of different body parts (chest, head, and abdomen) and CT vendors (Siemens, Phillips, and GE).

A human brain atlas of chi-separation for normative iron and myelin distributions

Iron and myelin are primary susceptibility sources in the human brain. These substances are essential for healthy brain, and their abnormalities are often related to various neurological disorders. Recently, an advanced susceptibility mapping technique, which is referred to as chi-separation, has been proposed successfully disentangling paramagnetic iron from diamagnetic myelin, opening a new potential for generating iron map and myelin map in the brain. Utilizing this technique, this study constructs a normative chi-separation atlas from 106 healthy human brains. The resulting atlas provides detailed anatomical structures associated with the distributions of iron and myelin, clearly delineating subcortical nuclei and white matter fiber bundles. Additionally, susceptibility values in a number of regions of interest are reported along with age-dependent changes. This atlas may have direct applications such as localization of subcortical structures for deep brain stimulation or high-intensity focused ultrasound and also serve as a valuable resource for future research.