Vessel segmentation for X-separation

$\chi$-separation is an advanced quantitative susceptibility mapping (QSM) method that is designed to generate paramagnetic ($\chi_{para}$) and diamagnetic ($|\chi_{dia}|$) susceptibility maps, reflecting the distribution of iron and myelin in the brain. However, vessels have shown artifacts, interfering with the accurate quantification of iron and myelin in applications. To address this challenge, a new vessel segmentation method for $\chi$-separation is developed. The method comprises three steps: 1) Seed generation from $\textit{R}_2^*$ and the product of $\chi_{para}$ and $|\chi_{dia}|$ maps; 2) Region growing, guided by vessel geometry, creating a vessel mask; 3) Refinement of the vessel mask by excluding non-vessel structures. The performance of the method was compared to conventional vessel segmentation methods both qualitatively and quantitatively. To demonstrate the utility of the method, it was tested in two applications: quantitative evaluation of a neural network-based $\chi$-separation reconstruction method ($\chi$-sepnet-$\textit{R}_2^*$) and population-averaged region of interest (ROI) analysis. The proposed method demonstrates superior performance to the conventional vessel segmentation methods, effectively excluding the non-vessel structures, achieving the highest Dice score coefficient. For the applications, applying vessel masks report notable improvements for the quantitative evaluation of $\chi$-sepnet-$\textit{R}_2^*$ and statistically significant differences in population-averaged ROI analysis. These applications suggest excluding vessels when analyzing the $\chi$-separation maps provide more accurate evaluations. The proposed method has the potential to facilitate various applications, offering reliable analysis through the generation of a high-quality vessel mask.

DeepRF: Deep Reinforcement Learning Designed RadioFrequency Waveform in MRI

A carefully engineered radiofrequency (RF) pulse plays a key role in a number of systems such as mobile phone, radar, and magnetic resonance imaging (MRI). The design of an RF waveform, however, is often posed as an inverse problem that has no general solution. As a result, various design methods each with a specific purpose have been developed based on the intuition of human experts. In this work, we propose an artificial intelligence-powered RF pulse design framework, DeepRF, which utilizes the self-learning characteristics of deep reinforcement learning (DRL) to generate a novel RF beyond human intuition. Additionally, the method can design various types of RF pulses via customized reward functions. The algorithm of DeepRF consists of two modules: the RF generation module, which utilizes DRL to explore new RF pulses, and the RF refinement module, which optimizes the seed RF pulses from the generation module via gradient ascent. The effectiveness of DeepRF is demonstrated using four exemplary RF pulses, slice-selective excitation pulse, slice-selective inversion pulse, B1-insensitive volume inversion pulse, and B1-insensitive selective inversion pulse, that are commonly used in MRI. The results show that the DeepRF-designed pulses successfully satisfy the design criteria while improving specific absorption rates when compared to those of the conventional RF pulses. Further analyses suggest that the DeepRF-designed pulses utilize new mechanisms of magnetization manipulation that are difficult to be explained by conventional theory, suggesting the potentials of DeepRF in discovering unseen design dimensions beyond human intuition. This work may lay the foundation for an emerging field of AI-driven RF waveform design.