Towards Unified Molecule-Enhanced Pathology Image Representation Learning via Integrating Spatial Transcriptomics

Recent advancements in multimodal pre-training models have significantly advanced computational pathology. However, current approaches predominantly rely on visual-language models, which may impose limitations from a molecular perspective and lead to performance bottlenecks. Here, we introduce a Unified Molecule-enhanced Pathology Image REpresentationn Learning framework (UMPIRE). UMPIRE aims to leverage complementary information from gene expression profiles to guide the multimodal pre-training, enhancing the molecular awareness of pathology image representation learning. We demonstrate that this molecular perspective provides a robust, task-agnostic training signal for learning pathology image embeddings. Due to the scarcity of paired data, approximately 4 million entries of spatial transcriptomics gene expression were collected to train the gene encoder. By leveraging powerful pre-trained encoders, UMPIRE aligns the encoders across over 697K pathology image-gene expression pairs. The performance of UMPIRE is demonstrated across various molecular-related downstream tasks, including gene expression prediction, spot classification, and mutation state prediction in whole slide images. Our findings highlight the effectiveness of multimodal data integration and open new avenues for exploring computational pathology enhanced by molecular perspectives. The code and pre-trained weights are available at https://github.com/Hanminghao/UMPIRE.

Toward Robust Incomplete Multimodal Sentiment Analysis via Hierarchical Representation Learning

Multimodal Sentiment Analysis (MSA) is an important research area that aims to understand and recognize human sentiment through multiple modalities. The complementary information provided by multimodal fusion promotes better sentiment analysis compared to utilizing only a single modality. Nevertheless, in real-world applications, many unavoidable factors may lead to situations of uncertain modality missing, thus hindering the effectiveness of multimodal modeling and degrading the model's performance. To this end, we propose a Hierarchical Representation Learning Framework (HRLF) for the MSA task under uncertain missing modalities. Specifically, we propose a fine-grained representation factorization module that sufficiently extracts valuable sentiment information by factorizing modality into sentiment-relevant and modality-specific representations through crossmodal translation and sentiment semantic reconstruction. Moreover, a hierarchical mutual information maximization mechanism is introduced to incrementally maximize the mutual information between multi-scale representations to align and reconstruct the high-level semantics in the representations. Ultimately, we propose a hierarchical adversarial learning mechanism that further aligns and adapts the latent distribution of sentiment-relevant representations to produce robust joint multimodal representations. Comprehensive experiments on three datasets demonstrate that HRLF significantly improves MSA performance under uncertain modality missing cases.

MedAide: Towards an Omni Medical Aide via Specialized LLM-based Multi-Agent Collaboration

Large Language Model (LLM)-driven interactive systems currently show potential promise in healthcare domains. Despite their remarkable capabilities, LLMs typically lack personalized recommendations and diagnosis analysis in sophisticated medical applications, causing hallucinations and performance bottlenecks. To address these challenges, this paper proposes MedAide, an LLM-based omni medical multi-agent collaboration framework for specialized healthcare services. Specifically, MedAide first performs query rewriting through retrieval-augmented generation to accomplish accurate medical intent understanding. Immediately, we devise a contextual encoder to obtain intent prototype embeddings, which are used to recognize fine-grained intents by similarity matching. According to the intent relevance, the activated agents collaborate effectively to provide integrated decision analysis. Extensive experiments are conducted on four medical benchmarks with composite intents. Experimental results from automated metrics and expert doctor evaluations show that MedAide outperforms current LLMs and improves their medical proficiency and strategic reasoning.

Improving Factuality in Large Language Models via Decoding-Time Hallucinatory and Truthful Comparators

Despite their remarkable capabilities, Large Language Models (LLMs) are prone to generate responses that contradict verifiable facts, i.e., unfaithful hallucination content. Existing efforts generally focus on optimizing model parameters or editing semantic representations, which compromise the internal factual knowledge of target LLMs. In addition, hallucinations typically exhibit multifaceted patterns in downstream tasks, limiting the model's holistic performance across tasks. In this paper, we propose a Comparator-driven Decoding-Time (CDT) framework to alleviate the response hallucination. Firstly, we construct hallucinatory and truthful comparators with multi-task fine-tuning samples. In this case, we present an instruction prototype-guided mixture of experts strategy to enhance the ability of the corresponding comparators to capture different hallucination or truthfulness patterns in distinct task instructions. CDT constrains next-token predictions to factuality-robust distributions by contrasting the logit differences between the target LLMs and these comparators. Systematic experiments on multiple downstream tasks show that our framework can significantly improve the model performance and response factuality.

MSCPT: Few-shot Whole Slide Image Classification with Multi-scale and Context-focused Prompt Tuning

Multiple instance learning (MIL) has become a standard paradigm for weakly supervised classification of whole slide images (WSI). However, this paradigm relies on the use of a large number of labelled WSIs for training. The lack of training data and the presence of rare diseases present significant challenges for these methods. Prompt tuning combined with the pre-trained Vision-Language models (VLMs) is an effective solution to the Few-shot Weakly Supervised WSI classification (FSWC) tasks. Nevertheless, applying prompt tuning methods designed for natural images to WSIs presents three significant challenges: 1) These methods fail to fully leverage the prior knowledge from the VLM's text modality; 2) They overlook the essential multi-scale and contextual information in WSIs, leading to suboptimal results; and 3) They lack exploration of instance aggregation methods. To address these problems, we propose a Multi-Scale and Context-focused Prompt Tuning (MSCPT) method for FSWC tasks. Specifically, MSCPT employs the frozen large language model to generate pathological visual language prior knowledge at multi-scale, guiding hierarchical prompt tuning. Additionally, we design a graph prompt tuning module to learn essential contextual information within WSI, and finally, a non-parametric cross-guided instance aggregation module has been introduced to get the WSI-level features. Based on two VLMs, extensive experiments and visualizations on three datasets demonstrated the powerful performance of our MSCPT.

MaskBEV: Towards A Unified Framework for BEV Detection and Map Segmentation

Accurate and robust multimodal multi-task perception is crucial for modern autonomous driving systems. However, current multimodal perception research follows independent paradigms designed for specific perception tasks, leading to a lack of complementary learning among tasks and decreased performance in multi-task learning (MTL) due to joint training. In this paper, we propose MaskBEV, a masked attention-based MTL paradigm that unifies 3D object detection and bird's eye view (BEV) map segmentation. MaskBEV introduces a task-agnostic Transformer decoder to process these diverse tasks, enabling MTL to be completed in a unified decoder without requiring additional design of specific task heads. To fully exploit the complementary information between BEV map segmentation and 3D object detection tasks in BEV space, we propose spatial modulation and scene-level context aggregation strategies. These strategies consider the inherent dependencies between BEV segmentation and 3D detection, naturally boosting MTL performance. Extensive experiments on nuScenes dataset show that compared with previous state-of-the-art MTL methods, MaskBEV achieves 1.3 NDS improvement in 3D object detection and 2.7 mIoU improvement in BEV map segmentation, while also demonstrating slightly leading inference speed.

HybridOcc: NeRF Enhanced Transformer-based Multi-Camera 3D Occupancy Prediction

Vision-based 3D semantic scene completion (SSC) describes autonomous driving scenes through 3D volume representations. However, the occlusion of invisible voxels by scene surfaces poses challenges to current SSC methods in hallucinating refined 3D geometry. This paper proposes HybridOcc, a hybrid 3D volume query proposal method generated by Transformer framework and NeRF representation and refined in a coarse-to-fine SSC prediction framework. HybridOcc aggregates contextual features through the Transformer paradigm based on hybrid query proposals while combining it with NeRF representation to obtain depth supervision. The Transformer branch contains multiple scales and uses spatial cross-attention for 2D to 3D transformation. The newly designed NeRF branch implicitly infers scene occupancy through volume rendering, including visible and invisible voxels, and explicitly captures scene depth rather than generating RGB color. Furthermore, we present an innovative occupancy-aware ray sampling method to orient the SSC task instead of focusing on the scene surface, further improving the overall performance. Extensive experiments on nuScenes and SemanticKITTI datasets demonstrate the effectiveness of our HybridOcc on the SSC task.

Faster Diffusion Action Segmentation

Temporal Action Segmentation (TAS) is an essential task in video analysis, aiming to segment and classify continuous frames into distinct action segments. However, the ambiguous boundaries between actions pose a significant challenge for high-precision segmentation. Recent advances in diffusion models have demonstrated substantial success in TAS tasks due to their stable training process and high-quality generation capabilities. However, the heavy sampling steps required by diffusion models pose a substantial computational burden, limiting their practicality in real-time applications. Additionally, most related works utilize Transformer-based encoder architectures. Although these architectures excel at capturing long-range dependencies, they incur high computational costs and face feature-smoothing issues when processing long video sequences. To address these challenges, we propose EffiDiffAct, an efficient and high-performance TAS algorithm. Specifically, we develop a lightweight temporal feature encoder that reduces computational overhead and mitigates the rank collapse phenomenon associated with traditional self-attention mechanisms. Furthermore, we introduce an adaptive skip strategy that allows for dynamic adjustment of timestep lengths based on computed similarity metrics during inference, thereby further enhancing computational efficiency. Comprehensive experiments on the 50Salads, Breakfast, and GTEA datasets demonstrated the effectiveness of the proposed algorithm.

Large Vision-Language Models as Emotion Recognizers in Context Awareness

Context-aware emotion recognition (CAER) is a complex and significant task that requires perceiving emotions from various contextual cues. Previous approaches primarily focus on designing sophisticated architectures to extract emotional cues from images. However, their knowledge is confined to specific training datasets and may reflect the subjective emotional biases of the annotators. Furthermore, acquiring large amounts of labeled data is often challenging in real-world applications. In this paper, we systematically explore the potential of leveraging Large Vision-Language Models (LVLMs) to empower the CAER task from three paradigms: 1) We fine-tune LVLMs on two CAER datasets, which is the most common way to transfer large models to downstream tasks. 2) We design zero-shot and few-shot patterns to evaluate the performance of LVLMs in scenarios with limited data or even completely unseen. In this case, a training-free framework is proposed to fully exploit the In-Context Learning (ICL) capabilities of LVLMs. Specifically, we develop an image similarity-based ranking algorithm to retrieve examples; subsequently, the instructions, retrieved examples, and the test example are combined to feed LVLMs to obtain the corresponding sentiment judgment. 3) To leverage the rich knowledge base of LVLMs, we incorporate Chain-of-Thought (CoT) into our framework to enhance the model's reasoning ability and provide interpretable results. Extensive experiments and analyses demonstrate that LVLMs achieve competitive performance in the CAER task across different paradigms. Notably, the superior performance in few-shot settings indicates the feasibility of LVLMs for accomplishing specific tasks without extensive training.

Pathology-knowledge Enhanced Multi-instance Prompt Learning for Few-shot Whole Slide Image Classification

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical settings, restricted access to pathology slides is inevitable due to patient privacy concerns and the prevalence of rare or emerging diseases. The emergence of the Few-shot Weakly Supervised WSI Classification accommodates the significant challenge of the limited slide data and sparse slide-level labels for diagnosis. Prompt learning based on the pre-trained models (\eg, CLIP) appears to be a promising scheme for this setting; however, current research in this area is limited, and existing algorithms often focus solely on patch-level prompts or confine themselves to language prompts. This paper proposes a multi-instance prompt learning framework enhanced with pathology knowledge, \ie, integrating visual and textual prior knowledge into prompts at both patch and slide levels. The training process employs a combination of static and learnable prompts, effectively guiding the activation of pre-trained models and further facilitating the diagnosis of key pathology patterns. Lightweight Messenger (self-attention) and Summary (attention-pooling) layers are introduced to model relationships between patches and slides within the same patient data. Additionally, alignment-wise contrastive losses ensure the feature-level alignment between visual and textual learnable prompts for both patches and slides. Our method demonstrates superior performance in three challenging clinical tasks, significantly outperforming comparative few-shot methods.