Deep Learning-based Unsupervised Domain Adaptation via a Unified Model for Prostate Lesion Detection Using Multisite Bi-parametric MRI Datasets

Our hypothesis is that UDA using diffusion-weighted images, generated with a unified model, offers a promising and reliable strategy for enhancing the performance of supervised learning models in multi-site prostate lesion detection, especially when various b-values are present. This retrospective study included data from 5,150 patients (14,191 samples) collected across nine different imaging centers. A novel UDA method using a unified generative model was developed for multi-site PCa detection. This method translates diffusion-weighted imaging (DWI) acquisitions, including apparent diffusion coefficient (ADC) and individual DW images acquired using various b-values, to align with the style of images acquired using b-values recommended by Prostate Imaging Reporting and Data System (PI-RADS) guidelines. The generated ADC and DW images replace the original images for PCa detection. An independent set of 1,692 test cases (2,393 samples) was used for evaluation. The area under the receiver operating characteristic curve (AUC) was used as the primary metric, and statistical analysis was performed via bootstrapping. For all test cases, the AUC values for baseline SL and UDA methods were 0.73 and 0.79 (p<.001), respectively, for PI-RADS>=3, and 0.77 and 0.80 (p<.001) for PI-RADS>=4 PCa lesions. In the 361 test cases under the most unfavorable image acquisition setting, the AUC values for baseline SL and UDA were 0.49 and 0.76 (p<.001) for PI-RADS>=3, and 0.50 and 0.77 (p<.001) for PI-RADS>=4 PCa lesions. The results indicate the proposed UDA with generated images improved the performance of SL methods in multi-site PCa lesion detection across datasets with various b values, especially for images acquired with significant deviations from the PI-RADS recommended DWI protocol (e.g. with an extremely high b-value).

Multi-Agent Reinforcement Learning Meets Leaf Sequencing in Radiotherapy

In contemporary radiotherapy planning (RTP), a key module leaf sequencing is predominantly addressed by optimization-based approaches. In this paper, we propose a novel deep reinforcement learning (DRL) model termed as Reinforced Leaf Sequencer (RLS) in a multi-agent framework for leaf sequencing. The RLS model offers improvements to time-consuming iterative optimization steps via large-scale training and can control movement patterns through the design of reward mechanisms. We have conducted experiments on four datasets with four metrics and compared our model with a leading optimization sequencer. Our findings reveal that the proposed RLS model can achieve reduced fluence reconstruction errors, and potential faster convergence when integrated in an optimization planner. Additionally, RLS has shown promising results in a full artificial intelligence RTP pipeline. We hope this pioneer multi-agent RL leaf sequencer can foster future research on machine learning for RTP.

A Wide-area, Low-latency, and Power-efficient 6-DoF Pose Tracking System for Rigid Objects

Position sensitive detectors (PSDs) offer possibility to track single active marker's two (or three) degrees of freedom (DoF) position with a high accuracy, while having a fast response time with high update frequency and low latency, all using a very simple signal processing circuit. However they are not particularly suitable for 6-DoF object pose tracking system due to lack of orientation measurement, limited tracking range, and sensitivity to environmental variation. We propose a novel 6-DoF pose tracking system for a rigid object tracking requiring a single active marker. The proposed system uses a stereo-based PSD pair and multiple Inertial Measurement Units (IMUs). This is done based on a practical approach to identify and control the power of Infrared-Light Emitting Diode (IR-LED) active markers, with an aim to increase the tracking work space and reduce the power consumption. Our proposed tracking system is validated with three different work space sizes and for static and dynamic positional accuracy using robotic arm manipulator with three different dynamic motion patterns. The results show that the static position root-mean-square (RMS) error is 0.6mm. The dynamic position RMS error is 0.7-0.9mm. The orientation RMS error is between 0.04 and 0.9 degree at varied dynamic motion. Overall, our proposed tracking system is capable of tracking a rigid object pose with sub-millimeter accuracy at the mid range of the work space and sub-degree accuracy for all work space under a lab setting.

Unsupervised Deformable Registration for Multi-Modal Images via Disentangled Representations

We propose a fully unsupervised multi-modal deformable image registration method (UMDIR), which does not require any ground truth deformation fields or any aligned multi-modal image pairs during training. Multi-modal registration is a key problem in many medical image analysis applications. It is very challenging due to complicated and unknown relationships between different modalities. In this paper, we propose an unsupervised learning approach to reduce the multi-modal registration problem to a mono-modal one through image disentangling. In particular, we decompose images of both modalities into a common latent shape space and separate latent appearance spaces via an unsupervised multi-modal image-to-image translation approach. The proposed registration approach is then built on the factorized latent shape code, with the assumption that the intrinsic shape deformation existing in original image domain is preserved in this latent space. Specifically, two metrics have been proposed for training the proposed network: a latent similarity metric defined in the common shape space and a learningbased image similarity metric based on an adversarial loss. We examined different variations of our proposed approach and compared them with conventional state-of-the-art multi-modal registration methods. Results show that our proposed methods achieve competitive performance against other methods at substantially reduced computation time.

Deep Adversarial Context-Aware Landmark Detection for Ultrasound Imaging

Real-time localization of prostate gland in trans-rectal ultrasound images is a key technology that is required to automate the ultrasound guided prostate biopsy procedures. In this paper, we propose a new deep learning based approach which is aimed at localizing several prostate landmarks efficiently and robustly. We propose a multitask learning approach primarily to make the overall algorithm more contextually aware. In this approach, we not only consider the explicit learning of landmark locations, but also build-in a mechanism to learn the contour of the prostate. This multitask learning is further coupled with an adversarial arm to promote the generation of feasible structures. We have trained this network using ~4000 labeled trans-rectal ultrasound images and tested on an independent set of images with ground truth landmark locations. We have achieved an overall Dice score of 92.6% for the adversarially trained multitask approach, which is significantly better than the Dice score of 88.3% obtained by only learning of landmark locations. The overall mean distance error using the adversarial multitask approach has also improved by 20% while reducing the standard deviation of the error compared to learning landmark locations only. In terms of computational complexity both approaches can process the images in real-time using standard computer with a standard CUDA enabled GPU.

An Artificial Agent for Robust Image Registration

3-D image registration, which involves aligning two or more images, is a critical step in a variety of medical applications from diagnosis to therapy. Image registration is commonly performed by optimizing an image matching metric as a cost function. However, this task is challenging due to the non-convex nature of the matching metric over the plausible registration parameter space and insufficient approaches for a robust optimization. As a result, current approaches are often customized to a specific problem and sensitive to image quality and artifacts. In this paper, we propose a completely different approach to image registration, inspired by how experts perform the task. We first cast the image registration problem as a "strategy learning" process, where the goal is to find the best sequence of motion actions (e.g. up, down, etc.) that yields image alignment. Within this approach, an artificial agent is learned, modeled using deep convolutional neural networks, with 3D raw image data as the input, and the next optimal action as the output. To cope with the dimensionality of the problem, we propose a greedy supervised approach for an end-to-end training, coupled with attention-driven hierarchical strategy. The resulting registration approach inherently encodes both a data-driven matching metric and an optimal registration strategy (policy). We demonstrate, on two 3-D/3-D medical image registration examples with drastically different nature of challenges, that the artificial agent outperforms several state-of-art registration methods by a large margin in terms of both accuracy and robustness.