Multi-Agent Reinforcement Learning Meets Leaf Sequencing in Radiotherapy

In contemporary radiotherapy planning (RTP), a key module leaf sequencing is predominantly addressed by optimization-based approaches. In this paper, we propose a novel deep reinforcement learning (DRL) model termed as Reinforced Leaf Sequencer (RLS) in a multi-agent framework for leaf sequencing. The RLS model offers improvements to time-consuming iterative optimization steps via large-scale training and can control movement patterns through the design of reward mechanisms. We have conducted experiments on four datasets with four metrics and compared our model with a leading optimization sequencer. Our findings reveal that the proposed RLS model can achieve reduced fluence reconstruction errors, and potential faster convergence when integrated in an optimization planner. Additionally, RLS has shown promising results in a full artificial intelligence RTP pipeline. We hope this pioneer multi-agent RL leaf sequencer can foster future research on machine learning for RTP.

Robust, scalable and fast bootstrap method for analyzing large scale data

In this paper we address the problem of performing statistical inference for large scale data sets i.e., Big Data. The volume and dimensionality of the data may be so high that it cannot be processed or stored in a single computing node. We propose a scalable, statistically robust and computationally efficient bootstrap method, compatible with distributed processing and storage systems. Bootstrap resamples are constructed with smaller number of distinct data points on multiple disjoint subsets of data, similarly to the bag of little bootstrap method (BLB) [1]. Then significant savings in computation is achieved by avoiding the re-computation of the estimator for each bootstrap sample. Instead, a computationally efficient fixed-point estimation equation is analytically solved via a smart approximation following the Fast and Robust Bootstrap method (FRB) [2]. Our proposed bootstrap method facilitates the use of highly robust statistical methods in analyzing large scale data sets. The favorable statistical properties of the method are established analytically. Numerical examples demonstrate scalability, low complexity and robust statistical performance of the method in analyzing large data sets.