Poisson Ordinal Network for Gleason Group Estimation Using Bi-Parametric MRI

The Gleason groups serve as the primary histological grading system for prostate cancer, providing crucial insights into the cancer's potential for growth and metastasis. In clinical practice, pathologists determine the Gleason groups based on specimens obtained from ultrasound-guided biopsies. In this study, we investigate the feasibility of directly estimating the Gleason groups from MRI scans to reduce otherwise required biopsies. We identify two characteristics of this task, ordinality and the resulting dependent yet unknown variances between Gleason groups. In addition to the inter- / intra- observer variability in a multi-step Gleason scoring process based on the interpretation of Gleason patterns, our MR-based prediction is also subject to specimen sampling variance and, to a lesser degree, varying MR imaging protocols. To address this challenge, we propose a novel Poisson ordinal network (PON). PONs model the prediction using a Poisson distribution and leverages Poisson encoding and Poisson focal loss to capture a learnable dependency between ordinal classes (here, Gleason groups), rather than relying solely on the numerical ground-truth (e.g. Gleason Groups 1-5 or Gleason Scores 6-10). To improve this modelling efficacy, PONs also employ contrastive learning with a memory bank to regularise intra-class variance, decoupling the memory requirement of contrast learning from the batch size. Experimental results based on the images labelled by saturation biopsies from 265 prior-biopsy-blind patients, across two tasks demonstrate the superiority and effectiveness of our proposed method.

Camera-Invariant Meta-Learning Network for Single-Camera-Training Person Re-identification

Single-camera-training person re-identification (SCT re-ID) aims to train a re-ID model using SCT datasets where each person appears in only one camera. The main challenge of SCT re-ID is to learn camera-invariant feature representations without cross-camera same-person (CCSP) data as supervision. Previous methods address it by assuming that the most similar person should be found in another camera. However, this assumption is not guaranteed to be correct. In this paper, we propose a Camera-Invariant Meta-Learning Network (CIMN) for SCT re-ID. CIMN assumes that the camera-invariant feature representations should be robust to camera changes. To this end, we split the training data into meta-train set and meta-test set based on camera IDs and perform a cross-camera simulation via meta-learning strategy, aiming to enforce the representations learned from the meta-train set to be robust to the meta-test set. With the cross-camera simulation, CIMN can learn camera-invariant and identity-discriminative representations even there are no CCSP data. However, this simulation also causes the separation of the meta-train set and the meta-test set, which ignores some beneficial relations between them. Thus, we introduce three losses: meta triplet loss, meta classification loss, and meta camera alignment loss, to leverage the ignored relations. The experiment results demonstrate that our method achieves comparable performance with and without CCSP data, and outperforms the state-of-the-art methods on SCT re-ID benchmarks. In addition, it is also effective in improving the domain generalization ability of the model.

PracticalDG: Perturbation Distillation on Vision-Language Models for Hybrid Domain Generalization

Domain Generalization (DG) aims to resolve distribution shifts between source and target domains, and current DG methods are default to the setting that data from source and target domains share identical categories. Nevertheless, there exists unseen classes from target domains in practical scenarios. To address this issue, Open Set Domain Generalization (OSDG) has emerged and several methods have been exclusively proposed. However, most existing methods adopt complex architectures with slight improvement compared with DG methods. Recently, vision-language models (VLMs) have been introduced in DG following the fine-tuning paradigm, but consume huge training overhead with large vision models. Therefore, in this paper, we innovate to transfer knowledge from VLMs to lightweight vision models and improve the robustness by introducing Perturbation Distillation (PD) from three perspectives, including Score, Class and Instance (SCI), named SCI-PD. Moreover, previous methods are oriented by the benchmarks with identical and fixed splits, ignoring the divergence between source domains. These methods are revealed to suffer from sharp performance decay with our proposed new benchmark Hybrid Domain Generalization (HDG) and a novel metric $H^{2}$-CV, which construct various splits to comprehensively assess the robustness of algorithms. Extensive experiments demonstrate that our method outperforms state-of-the-art algorithms on multiple datasets, especially improving the robustness when confronting data scarcity.

EviPrompt: A Training-Free Evidential Prompt Generation Method for Segment Anything Model in Medical Images

Medical image segmentation has immense clinical applicability but remains a challenge despite advancements in deep learning. The Segment Anything Model (SAM) exhibits potential in this field, yet the requirement for expertise intervention and the domain gap between natural and medical images poses significant obstacles. This paper introduces a novel training-free evidential prompt generation method named EviPrompt to overcome these issues. The proposed method, built on the inherent similarities within medical images, requires only a single reference image-annotation pair, making it a training-free solution that significantly reduces the need for extensive labeling and computational resources. First, to automatically generate prompts for SAM in medical images, we introduce an evidential method based on uncertainty estimation without the interaction of clinical experts. Then, we incorporate the human prior into the prompts, which is vital for alleviating the domain gap between natural and medical images and enhancing the applicability and usefulness of SAM in medical scenarios. EviPrompt represents an efficient and robust approach to medical image segmentation, with evaluations across a broad range of tasks and modalities confirming its efficacy.

Incorporating Pre-training Data Matters in Unsupervised Domain Adaptation

Unsupervised domain adaptation(UDA) and Source-free UDA(SFUDA) methods formulate the problem involving two domains: source and target. They typically employ a standard training approach that begins with models pre-trained on large-scale datasets e.g., ImageNet, while rarely discussing its effect. Recognizing this gap, we investigate the following research questions: (1) What is the correlation among ImageNet, the source, and the target domain? (2) How does pre-training on ImageNet influence the target risk? To answer the first question, we empirically observed an interesting Spontaneous Pulling (SP) Effect in fine-tuning where the discrepancies between any two of the three domains (ImageNet, Source, Target) decrease but at the cost of the impaired semantic structure of the pre-train domain. For the second question, we put forward a theory to explain SP and quantify that the target risk is bound by gradient disparities among the three domains. Our observations reveal a key limitation of existing methods: it hinders the adaptation performance if the semantic cluster structure of the pre-train dataset (i.e.ImageNet) is impaired. To address it, we incorporate ImageNet as the third domain and redefine the UDA/SFUDA as a three-player game. Specifically, inspired by the theory and empirical findings, we present a novel framework termed TriDA which additionally preserves the semantic structure of the pre-train dataset during fine-tuning. Experimental results demonstrate that it achieves state-of-the-art performance across various UDA and SFUDA benchmarks.

Causality-based Dual-Contrastive Learning Framework for Domain Generalization

Domain Generalization (DG) is essentially a sub-branch of out-of-distribution generalization, which trains models from multiple source domains and generalizes to unseen target domains. Recently, some domain generalization algorithms have emerged, but most of them were designed with non-transferable complex architecture. Additionally, contrastive learning has become a promising solution for simplicity and efficiency in DG. However, existing contrastive learning neglected domain shifts that caused severe model confusions. In this paper, we propose a Dual-Contrastive Learning (DCL) module on feature and prototype contrast. Moreover, we design a novel Causal Fusion Attention (CFA) module to fuse diverse views of a single image to attain prototype. Furthermore, we introduce a Similarity-based Hard-pair Mining (SHM) strategy to leverage information on diversity shift. Extensive experiments show that our method outperforms state-of-the-art algorithms on three DG datasets. The proposed algorithm can also serve as a plug-and-play module without usage of domain labels.

Uncertainty-Induced Transferability Representation for Source-Free Unsupervised Domain Adaptation

Source-free unsupervised domain adaptation (SFUDA) aims to learn a target domain model using unlabeled target data and the knowledge of a well-trained source domain model. Most previous SFUDA works focus on inferring semantics of target data based on the source knowledge. Without measuring the transferability of the source knowledge, these methods insufficiently exploit the source knowledge, and fail to identify the reliability of the inferred target semantics. However, existing transferability measurements require either source data or target labels, which are infeasible in SFUDA. To this end, firstly, we propose a novel Uncertainty-induced Transferability Representation (UTR), which leverages uncertainty as the tool to analyse the channel-wise transferability of the source encoder in the absence of the source data and target labels. The domain-level UTR unravels how transferable the encoder channels are to the target domain and the instance-level UTR characterizes the reliability of the inferred target semantics. Secondly, based on the UTR, we propose a novel Calibrated Adaption Framework (CAF) for SFUDA, including i)the source knowledge calibration module that guides the target model to learn the transferable source knowledge and discard the non-transferable one, and ii)the target semantics calibration module that calibrates the unreliable semantics. With the help of the calibrated source knowledge and the target semantics, the model adapts to the target domain safely and ultimately better. We verified the effectiveness of our method using experimental results and demonstrated that the proposed method achieves state-of-the-art performances on the three SFUDA benchmarks. Code is available at https://github.com/SPIresearch/UTR.

Delving into the Continuous Domain Adaptation

Existing domain adaptation methods assume that domain discrepancies are caused by a few discrete attributes and variations, e.g., art, real, painting, quickdraw, etc. We argue that this is not realistic as it is implausible to define the real-world datasets using a few discrete attributes. Therefore, we propose to investigate a new problem namely the Continuous Domain Adaptation (CDA) through the lens where infinite domains are formed by continuously varying attributes. Leveraging knowledge of two labeled source domains and several observed unlabeled target domains data, the objective of CDA is to learn a generalized model for whole data distribution with the continuous attribute. Besides the contributions of formulating a new problem, we also propose a novel approach as a strong CDA baseline. To be specific, firstly we propose a novel alternating training strategy to reduce discrepancies among multiple domains meanwhile generalize to unseen target domains. Secondly, we propose a continuity constraint when estimating the cross-domain divergence measurement. Finally, to decouple the discrepancy from the mini-batch size, we design a domain-specific queue to maintain the global view of the source domain that further boosts the adaptation performances. Our method is proven to achieve the state-of-the-art in CDA problem using extensive experiments. The code is available at https://github.com/SPIresearch/CDA.

Bag of Tricks for Out-of-Distribution Generalization

Recently, out-of-distribution (OOD) generalization has attracted attention to the robustness and generalization ability of deep learning based models, and accordingly, many strategies have been made to address different aspects related to this issue. However, most existing algorithms for OOD generalization are complicated and specifically designed for certain dataset. To alleviate this problem, nicochallenge-2022 provides NICO++, a large-scale dataset with diverse context information. In this paper, based on systematic analysis of different schemes on NICO++ dataset, we propose a simple but effective learning framework via coupling bag of tricks, including multi-objective framework design, data augmentations, training and inference strategies. Our algorithm is memory-efficient and easily-equipped, without complicated modules and does not require for large pre-trained models. It achieves an excellent performance with Top-1 accuracy of 88.16% on public test set and 75.65% on private test set, and ranks 1st in domain generalization task of nicochallenge-2022.

Seeing your sleep stage: cross-modal distillation from EEG to infrared video

It is inevitably crucial to classify sleep stage for the diagnosis of various diseases. However, existing automated diagnosis methods mostly adopt the "gold-standard" lectroencephalogram (EEG) or other uni-modal sensing signal of the PolySomnoGraphy (PSG) machine in hospital, that are expensive, importable and therefore unsuitable for point-of-care monitoring at home. To enable the sleep stage monitoring at home, in this paper, we analyze the relationship between infrared videos and the EEG signal and propose a new task: to classify the sleep stage using infrared videos by distilling useful knowledge from EEG signals to the visual ones. To establish a solid cross-modal benchmark for this application, we develop a new dataset termed as Seeing your Sleep Stage via Infrared Video and EEG ($S^3VE$). $S^3VE$ is a large-scale dataset including synchronized infrared video and EEG signal for sleep stage classification, including 105 subjects and 154,573 video clips that is more than 1100 hours long. Our contributions are not limited to datasets but also about a novel cross-modal distillation baseline model namely the structure-aware contrastive distillation (SACD) to distill the EEG knowledge to infrared video features. The SACD achieved the state-of-the-art performances on both our $S^3VE$ and the existing cross-modal distillation benchmark. Both the benchmark and the baseline methods will be released to the community. We expect to raise more attentions and promote more developments in the sleep stage classification and more importantly the cross-modal distillation from clinical signal/media to the conventional media.