Extrapolating Prospective Glaucoma Fundus Images through Diffusion Model in Irregular Longitudinal Sequences

The utilization of longitudinal datasets for glaucoma progression prediction offers a compelling approach to support early therapeutic interventions. Predominant methodologies in this domain have primarily focused on the direct prediction of glaucoma stage labels from longitudinal datasets. However, such methods may not adequately encapsulate the nuanced developmental trajectory of the disease. To enhance the diagnostic acumen of medical practitioners, we propose a novel diffusion-based model to predict prospective images by extrapolating from existing longitudinal fundus images of patients. The methodology delineated in this study distinctively leverages sequences of images as inputs. Subsequently, a time-aligned mask is employed to select a specific year for image generation. During the training phase, the time-aligned mask resolves the issue of irregular temporal intervals in longitudinal image sequence sampling. Additionally, we utilize a strategy of randomly masking a frame in the sequence to establish the ground truth. This methodology aids the network in continuously acquiring knowledge regarding the internal relationships among the sequences throughout the learning phase. Moreover, the introduction of textual labels is instrumental in categorizing images generated within the sequence. The empirical findings from the conducted experiments indicate that our proposed model not only effectively generates longitudinal data but also significantly improves the precision of downstream classification tasks.

KaLDeX: Kalman Filter based Linear Deformable Cross Attention for Retina Vessel Segmentation

Background and Objective: In the realm of ophthalmic imaging, accurate vascular segmentation is paramount for diagnosing and managing various eye diseases. Contemporary deep learning-based vascular segmentation models rival human accuracy but still face substantial challenges in accurately segmenting minuscule blood vessels in neural network applications. Due to the necessity of multiple downsampling operations in the CNN models, fine details from high-resolution images are inevitably lost. The objective of this study is to design a structure to capture the delicate and small blood vessels. Methods: To address these issues, we propose a novel network (KaLDeX) for vascular segmentation leveraging a Kalman filter based linear deformable cross attention (LDCA) module, integrated within a UNet++ framework. Our approach is based on two key components: Kalman filter (KF) based linear deformable convolution (LD) and cross-attention (CA) modules. The LD module is designed to adaptively adjust the focus on thin vessels that might be overlooked in standard convolution. The CA module improves the global understanding of vascular structures by aggregating the detailed features from the LD module with the high level features from the UNet++ architecture. Finally, we adopt a topological loss function based on persistent homology to constrain the topological continuity of the segmentation. Results: The proposed method is evaluated on retinal fundus image datasets (DRIVE, CHASE_BD1, and STARE) as well as the 3mm and 6mm of the OCTA-500 dataset, achieving an average accuracy (ACC) of 97.25%, 97.77%, 97.85%, 98.89%, and 98.21%, respectively. Conclusions: Empirical evidence shows that our method outperforms the current best models on different vessel segmentation datasets. Our source code is available at: https://github.com/AIEyeSystem/KalDeX.

AI-Based Fully Automatic Analysis of Retinal Vascular Morphology in Pediatric High Myopia

Purpose: To investigate the changes in retinal vascular structures associated various stages of myopia by designing automated software based on an artif intelligencemodel. Methods: The study involved 1324 pediatric participants from the National Childr Medical Center in China, and 2366 high-quality retinal images and correspon refractive parameters were obtained and analyzed. Spherical equivalent refrac(SER) degree was calculated. We proposed a data analysis model based c combination of the Convolutional Neural Networks (CNN) model and the atter module to classify images, segment vascular structures, and measure vasc parameters, such as main angle (MA), branching angle (BA), bifurcation edge al(BEA) and bifurcation edge coefficient (BEC). One-way ANOVA compared param measurements betweenthenormalfundus,lowmyopia,moderate myopia,and high myopia group. Results: There were 279 (12.38%) images in normal group and 384 (16.23%) images in the high myopia group. Compared normal fundus, the MA of fundus vessels in different myopic refractive groups significantly reduced (P = 0.006, P = 0.004, P = 0.019, respectively), and performance of the venous system was particularly obvious (P<0.001). At the sa time, the BEC decreased disproportionately (P<0.001). Further analysis of fundus vascular parameters at different degrees of myopia showed that there were also significant differences in BA and branching coefficient (BC). The arterial BA value of the fundus vessel in the high myopia group was lower than that of other groups (P : 0.032, 95% confidence interval [Ci], 0.22-4.86), while the venous BA values increased(P = 0.026). The BEC values of high myopia were higher than those of low and moderate myopia groups. When the loss function of our data classification model converged to 0.09,the model accuracy reached 94.19%

EyeLS: Shadow-Guided Instrument Landing System for Intraocular Target Approaching in Robotic Eye Surgery

Robotic ophthalmic surgery is an emerging technology to facilitate high-precision interventions such as retina penetration in subretinal injection and removal of floating tissues in retinal detachment depending on the input imaging modalities such as microscopy and intraoperative OCT (iOCT). Although iOCT is explored to locate the needle tip within its range-limited ROI, it is still difficult to coordinate iOCT's motion with the needle, especially at the initial target-approaching stage. Meanwhile, due to 2D perspective projection and thus the loss of depth information, current image-based methods cannot effectively estimate the needle tip's trajectory towards both retinal and floating targets. To address this limitation, we propose to use the shadow positions of the target and the instrument tip to estimate their relative depth position and accordingly optimize the instrument tip's insertion trajectory until the tip approaches targets within iOCT's scanning area. Our method succeeds target approaching on a retina model, and achieves an average depth error of 0.0127 mm and 0.3473 mm for floating and retinal targets respectively in the surgical simulator without damaging the retina.

Deep Autoencoder Model Construction Based on Pytorch

This paper proposes a deep autoencoder model based on Pytorch. This algorithm introduces the idea of Pytorch into the auto-encoder, and randomly clears the input weights connected to the hidden layer neurons with a certain probability, so as to achieve the effect of sparse network, which is similar to the starting point of the sparse auto-encoder. The new algorithm effectively solves the problem of possible overfitting of the model and improves the accuracy of image classification. Finally, the experiment is carried out, and the experimental results are compared with ELM, RELM, AE, SAE, DAE.

Research on restaurant recommendation using machine learning

A recommender system is a system that helps users filter irrelevant information and create user interest models based on their historical records. With the continuous development of Internet information, recommendation systems have received widespread attention in the industry. In this era of ubiquitous data and information, how to obtain and analyze these data has become the research topic of many people. In view of this situation, this paper makes some brief overviews of machine learning-related recommendation systems. By analyzing some technologies and ideas used by machine learning in recommender systems, let more people understand what is Big data and what is machine learning. The most important point is to let everyone understand the profound impact of machine learning on our daily life.

Capsule networks with non-iterative cluster routing

Capsule networks use routing algorithms to flow information between consecutive layers. In the existing routing procedures, capsules produce predictions (termed votes) for capsules of the next layer. In a nutshell, the next-layer capsule's input is a weighted sum over all the votes it receives. In this paper, we propose non-iterative cluster routing for capsule networks. In the proposed cluster routing, capsules produce vote clusters instead of individual votes for next-layer capsules, and each vote cluster sends its centroid to a next-layer capsule. Generally speaking, the next-layer capsule's input is a weighted sum over the centroid of each vote cluster it receives. The centroid that comes from a cluster with a smaller variance is assigned a larger weight in the weighted sum process. Compared with the state-of-the-art capsule networks, the proposed capsule networks achieve the best accuracy on the Fashion-MNIST and SVHN datasets with fewer parameters, and achieve the best accuracy on the smallNORB and CIFAR-10 datasets with a moderate number of parameters. The proposed capsule networks also produce capsules with disentangled representation and generalize well to images captured at novel viewpoints. The proposed capsule networks also preserve 2D spatial information of an input image in the capsule channels: if the capsule channels are rotated, the object reconstructed from these channels will be rotated by the same transformation. Codes are available at https://github.com/ZHAOZHIHAO/ClusterRouting.

A Knowledge-Enhanced Pretraining Model for Commonsense Story Generation

Story generation, namely generating a reasonable story from a leading context, is an important but challenging task. In spite of the success in modeling fluency and local coherence, existing neural language generation models (e.g., GPT-2) still suffer from repetition, logic conflicts, and lack of long-range coherence in generated stories. We conjecture that this is because of the difficulty of associating relevant commonsense knowledge, understanding the causal relationships, and planning entities and events with proper temporal order. In this paper, we devise a knowledge-enhanced pretraining model for commonsense story generation. We propose to utilize commonsense knowledge from external knowledge bases to generate reasonable stories. To further capture the causal and temporal dependencies between the sentences in a reasonable story, we employ multi-task learning which combines a discriminative objective to distinguish true and fake stories during fine-tuning. Automatic and manual evaluation shows that our model can generate more reasonable stories than state-of-the-art baselines, particularly in terms of logic and global coherence.

Computer-Aided Clinical Skin Disease Diagnosis Using CNN and Object Detection Models

Skin disease is one of the most common types of human diseases, which may happen to everyone regardless of age, gender or race. Due to the high visual diversity, human diagnosis highly relies on personal experience; and there is a serious shortage of experienced dermatologists in many countries. To alleviate this problem, computer-aided diagnosis with state-of-the-art (SOTA) machine learning techniques would be a promising solution. In this paper, we aim at understanding the performance of convolutional neural network (CNN) based approaches. We first build two versions of skin disease datasets from Internet images: (a) Skin-10, which contains 10 common classes of skin disease with a total of 10,218 images; (b) Skin-100, which is a larger dataset that consists of 19,807 images of 100 skin disease classes. Based on these datasets, we benchmark several SOTA CNN models and show that the accuracy of skin-100 is much lower than the accuracy of skin-10. We then implement an ensemble method based on several CNN models and achieve the best accuracy of 79.01\% for Skin-10 and 53.54\% for Skin-100. We also present an object detection based approach by introducing bounding boxes into the Skin-10 dataset. Our results show that object detection can help improve the accuracy of some skin disease classes.