Extrapolating Prospective Glaucoma Fundus Images through Diffusion Model in Irregular Longitudinal Sequences

The utilization of longitudinal datasets for glaucoma progression prediction offers a compelling approach to support early therapeutic interventions. Predominant methodologies in this domain have primarily focused on the direct prediction of glaucoma stage labels from longitudinal datasets. However, such methods may not adequately encapsulate the nuanced developmental trajectory of the disease. To enhance the diagnostic acumen of medical practitioners, we propose a novel diffusion-based model to predict prospective images by extrapolating from existing longitudinal fundus images of patients. The methodology delineated in this study distinctively leverages sequences of images as inputs. Subsequently, a time-aligned mask is employed to select a specific year for image generation. During the training phase, the time-aligned mask resolves the issue of irregular temporal intervals in longitudinal image sequence sampling. Additionally, we utilize a strategy of randomly masking a frame in the sequence to establish the ground truth. This methodology aids the network in continuously acquiring knowledge regarding the internal relationships among the sequences throughout the learning phase. Moreover, the introduction of textual labels is instrumental in categorizing images generated within the sequence. The empirical findings from the conducted experiments indicate that our proposed model not only effectively generates longitudinal data but also significantly improves the precision of downstream classification tasks.

KaLDeX: Kalman Filter based Linear Deformable Cross Attention for Retina Vessel Segmentation

Background and Objective: In the realm of ophthalmic imaging, accurate vascular segmentation is paramount for diagnosing and managing various eye diseases. Contemporary deep learning-based vascular segmentation models rival human accuracy but still face substantial challenges in accurately segmenting minuscule blood vessels in neural network applications. Due to the necessity of multiple downsampling operations in the CNN models, fine details from high-resolution images are inevitably lost. The objective of this study is to design a structure to capture the delicate and small blood vessels. Methods: To address these issues, we propose a novel network (KaLDeX) for vascular segmentation leveraging a Kalman filter based linear deformable cross attention (LDCA) module, integrated within a UNet++ framework. Our approach is based on two key components: Kalman filter (KF) based linear deformable convolution (LD) and cross-attention (CA) modules. The LD module is designed to adaptively adjust the focus on thin vessels that might be overlooked in standard convolution. The CA module improves the global understanding of vascular structures by aggregating the detailed features from the LD module with the high level features from the UNet++ architecture. Finally, we adopt a topological loss function based on persistent homology to constrain the topological continuity of the segmentation. Results: The proposed method is evaluated on retinal fundus image datasets (DRIVE, CHASE_BD1, and STARE) as well as the 3mm and 6mm of the OCTA-500 dataset, achieving an average accuracy (ACC) of 97.25%, 97.77%, 97.85%, 98.89%, and 98.21%, respectively. Conclusions: Empirical evidence shows that our method outperforms the current best models on different vessel segmentation datasets. Our source code is available at: https://github.com/AIEyeSystem/KalDeX.

AI-Based Fully Automatic Analysis of Retinal Vascular Morphology in Pediatric High Myopia

Purpose: To investigate the changes in retinal vascular structures associated various stages of myopia by designing automated software based on an artif intelligencemodel. Methods: The study involved 1324 pediatric participants from the National Childr Medical Center in China, and 2366 high-quality retinal images and correspon refractive parameters were obtained and analyzed. Spherical equivalent refrac(SER) degree was calculated. We proposed a data analysis model based c combination of the Convolutional Neural Networks (CNN) model and the atter module to classify images, segment vascular structures, and measure vasc parameters, such as main angle (MA), branching angle (BA), bifurcation edge al(BEA) and bifurcation edge coefficient (BEC). One-way ANOVA compared param measurements betweenthenormalfundus,lowmyopia,moderate myopia,and high myopia group. Results: There were 279 (12.38%) images in normal group and 384 (16.23%) images in the high myopia group. Compared normal fundus, the MA of fundus vessels in different myopic refractive groups significantly reduced (P = 0.006, P = 0.004, P = 0.019, respectively), and performance of the venous system was particularly obvious (P<0.001). At the sa time, the BEC decreased disproportionately (P<0.001). Further analysis of fundus vascular parameters at different degrees of myopia showed that there were also significant differences in BA and branching coefficient (BC). The arterial BA value of the fundus vessel in the high myopia group was lower than that of other groups (P : 0.032, 95% confidence interval [Ci], 0.22-4.86), while the venous BA values increased(P = 0.026). The BEC values of high myopia were higher than those of low and moderate myopia groups. When the loss function of our data classification model converged to 0.09,the model accuracy reached 94.19%