AI-Powered Automated Model Construction for Patient-Specific CFD Simulations of Aortic Flows

Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and time-consuming, limiting their clinical applications. This study introduces a deep-learning framework that automates the creation of simulation-ready vascular models from medical images. The framework integrates a segmentation module for accurate voxel-based vessel delineation with a surface deformation module that performs anatomically consistent and unsupervised surface refinements guided by medical image data. By unifying voxel segmentation and surface deformation into a single cohesive pipeline, the framework addresses key limitations of existing methods, enhancing geometric accuracy and computational efficiency. Evaluated on publicly available datasets, the proposed approach demonstrates state-of-the-art performance in segmentation and mesh quality while significantly reducing manual effort and processing time. This work advances the scalability and reliability of image-based computational modeling, facilitating broader applications in clinical and research settings.

Hierarchical LoG Bayesian Neural Network for Enhanced Aorta Segmentation

Accurate segmentation of the aorta and its associated arch branches is crucial for diagnosing aortic diseases. While deep learning techniques have significantly improved aorta segmentation, they remain challenging due to the intricate multiscale structure and the complexity of the surrounding tissues. This paper presents a novel approach for enhancing aorta segmentation using a Bayesian neural network-based hierarchical Laplacian of Gaussian (LoG) model. Our model consists of a 3D U-Net stream and a hierarchical LoG stream: the former provides an initial aorta segmentation, and the latter enhances blood vessel detection across varying scales by learning suitable LoG kernels, enabling self-adaptive handling of different parts of the aorta vessels with significant scale differences. We employ a Bayesian method to parameterize the LoG stream and provide confidence intervals for the segmentation results, ensuring robustness and reliability of the prediction for vascular medical image analysts. Experimental results show that our model can accurately segment main and supra-aortic vessels, yielding at least a 3% gain in the Dice coefficient over state-of-the-art methods across multiple volumes drawn from two aorta datasets, and can provide reliable confidence intervals for different parts of the aorta. The code is available at https://github.com/adlsn/LoGBNet.

Personalized Clustering via Targeted Representation Learning

Clustering traditionally aims to reveal a natural grouping structure model from unlabeled data. However, this model may not always align with users' preference. In this paper, we propose a personalized clustering method that explicitly performs targeted representation learning by interacting with users via modicum task information (e.g., $\textit{must-link}$ or $\textit{cannot-link}$ pairs) to guide the clustering direction. We query users with the most informative pairs, i.e., those pairs most hard to cluster and those most easy to miscluster, to facilitate the representation learning in terms of the clustering preference. Moreover, by exploiting attention mechanism, the targeted representation is learned and augmented. By leveraging the targeted representation and constrained constrastive loss as well, personalized clustering is obtained. Theoretically, we verify that the risk of personalized clustering is tightly bounded, guaranteeing that active queries to users do mitigate the clustering risk. Experimentally, extensive results show that our method performs well across different clustering tasks and datasets, even with a limited number of queries.

CoNFiLD-inlet: Synthetic Turbulence Inflow Using Generative Latent Diffusion Models with Neural Fields

Eddy-resolving turbulence simulations require stochastic inflow conditions that accurately replicate the complex, multi-scale structures of turbulence. Traditional recycling-based methods rely on computationally expensive precursor simulations, while existing synthetic inflow generators often fail to reproduce realistic coherent structures of turbulence. Recent advances in deep learning (DL) have opened new possibilities for inflow turbulence generation, yet many DL-based methods rely on deterministic, autoregressive frameworks prone to error accumulation, resulting in poor robustness for long-term predictions. In this work, we present CoNFiLD-inlet, a novel DL-based inflow turbulence generator that integrates diffusion models with a conditional neural field (CNF)-encoded latent space to produce realistic, stochastic inflow turbulence. By parameterizing inflow conditions using Reynolds numbers, CoNFiLD-inlet generalizes effectively across a wide range of Reynolds numbers ($Re_\tau$ between $10^3$ and $10^4$) without requiring retraining or parameter tuning. Comprehensive validation through a priori and a posteriori tests in Direct Numerical Simulation (DNS) and Wall-Modeled Large Eddy Simulation (WMLES) demonstrates its high fidelity, robustness, and scalability, positioning it as an efficient and versatile solution for inflow turbulence synthesis.

Semi-Supervised Learning via Weight-aware Distillation under Class Distribution Mismatch

Semi-Supervised Learning (SSL) under class distribution mismatch aims to tackle a challenging problem wherein unlabeled data contain lots of unknown categories unseen in the labeled ones. In such mismatch scenarios, traditional SSL suffers severe performance damage due to the harmful invasion of the instances with unknown categories into the target classifier. In this study, by strict mathematical reasoning, we reveal that the SSL error under class distribution mismatch is composed of pseudo-labeling error and invasion error, both of which jointly bound the SSL population risk. To alleviate the SSL error, we propose a robust SSL framework called Weight-Aware Distillation (WAD) that, by weights, selectively transfers knowledge beneficial to the target task from unsupervised contrastive representation to the target classifier. Specifically, WAD captures adaptive weights and high-quality pseudo labels to target instances by exploring point mutual information (PMI) in representation space to maximize the role of unlabeled data and filter unknown categories. Theoretically, we prove that WAD has a tight upper bound of population risk under class distribution mismatch. Experimentally, extensive results demonstrate that WAD outperforms five state-of-the-art SSL approaches and one standard baseline on two benchmark datasets, CIFAR10 and CIFAR100, and an artificial cross-dataset. The code is available at https://github.com/RUC-DWBI-ML/research/tree/main/WAD-master.

PReGAN: Answer Oriented Passage Ranking with Weakly Supervised GAN

Beyond topical relevance, passage ranking for open-domain factoid question answering also requires a passage to contain an answer (answerability). While a few recent studies have incorporated some reading capability into a ranker to account for answerability, the ranker is still hindered by the noisy nature of the training data typically available in this area, which considers any passage containing an answer entity as a positive sample. However, the answer entity in a passage is not necessarily mentioned in relation with the given question. To address the problem, we propose an approach called \ttt{PReGAN} for Passage Reranking based on Generative Adversarial Neural networks, which incorporates a discriminator on answerability, in addition to a discriminator on topical relevance. The goal is to force the generator to rank higher a passage that is topically relevant and contains an answer. Experiments on five public datasets show that \ttt{PReGAN} can better rank appropriate passages, which in turn, boosts the effectiveness of QA systems, and outperforms the existing approaches without using external data.

Deep learning-based surrogate model for 3-D patient-specific computational fluid dynamics

Optimization and uncertainty quantification have been playing an increasingly important role in computational hemodynamics. However, existing methods based on principled modeling and classic numerical techniques have faced significant challenges, particularly when it comes to complex 3D patient-specific shapes in the real world. First, it is notoriously challenging to parameterize the input space of arbitrarily complex 3-D geometries. Second, the process often involves massive forward simulations, which are extremely computationally demanding or even infeasible. We propose a novel deep learning surrogate modeling solution to address these challenges and enable rapid hemodynamic predictions. Specifically, a statistical generative model for 3-D patient-specific shapes is developed based on a small set of baseline patient-specific geometries. An unsupervised shape correspondence solution is used to enable geometric morphing and scalable shape synthesis statistically. Moreover, a simulation routine is developed for automatic data generation by automatic meshing, boundary setting, simulation, and post-processing. An efficient supervised learning solution is proposed to map the geometric inputs to the hemodynamics predictions in latent spaces. Numerical studies on aortic flows are conducted to demonstrate the effectiveness and merit of the proposed techniques.

FedGBF: An efficient vertical federated learning framework via gradient boosting and bagging

Federated learning, conducive to solving data privacy and security problems, has attracted increasing attention recently. However, the existing federated boosting model sequentially builds a decision tree model with the weak base learner, resulting in redundant boosting steps and high interactive communication costs. In contrast, the federated bagging model saves time by building multi-decision trees in parallel, but it suffers from performance loss. With the aim of obtaining an outstanding performance with less time cost, we propose a novel model in a vertically federated setting termed as Federated Gradient Boosting Forest (FedGBF). FedGBF simultaneously integrates the boosting and bagging's preponderance by building the decision trees in parallel as a base learner for boosting. Subsequent to FedGBF, the problem of hyperparameters tuning is rising. Then we propose the Dynamic FedGBF, which dynamically changes each forest's parameters and thus reduces the complexity. Finally, the experiments based on the benchmark datasets demonstrate the superiority of our method.

Contrastive Learning of User Behavior Sequence for Context-Aware Document Ranking

Context information in search sessions has proven to be useful for capturing user search intent. Existing studies explored user behavior sequences in sessions in different ways to enhance query suggestion or document ranking. However, a user behavior sequence has often been viewed as a definite and exact signal reflecting a user's behavior. In reality, it is highly variable: user's queries for the same intent can vary, and different documents can be clicked. To learn a more robust representation of the user behavior sequence, we propose a method based on contrastive learning, which takes into account the possible variations in user's behavior sequences. Specifically, we propose three data augmentation strategies to generate similar variants of user behavior sequences and contrast them with other sequences. In so doing, the model is forced to be more robust regarding the possible variations. The optimized sequence representation is incorporated into document ranking. Experiments on two real query log datasets show that our proposed model outperforms the state-of-the-art methods significantly, which demonstrates the effectiveness of our method for context-aware document ranking.

Proactive Retrieval-based Chatbots based on Relevant Knowledge and Goals

A proactive dialogue system has the ability to proactively lead the conversation. Different from the general chatbots which only react to the user, proactive dialogue systems can be used to achieve some goals, e.g., to recommend some items to the user. Background knowledge is essential to enable smooth and natural transitions in dialogue. In this paper, we propose a new multi-task learning framework for retrieval-based knowledge-grounded proactive dialogue. To determine the relevant knowledge to be used, we frame knowledge prediction as a complementary task and use explicit signals to supervise its learning. The final response is selected according to the predicted knowledge, the goal to achieve, and the context. Experimental results show that explicit modeling of knowledge prediction and goal selection can greatly improve the final response selection. Our code is available at https://github.com/DaoD/KPN/.