TransFair: Transferring Fairness from Ocular Disease Classification to Progression Prediction

The use of artificial intelligence (AI) in automated disease classification significantly reduces healthcare costs and improves the accessibility of services. However, this transformation has given rise to concerns about the fairness of AI, which disproportionately affects certain groups, particularly patients from underprivileged populations. Recently, a number of methods and large-scale datasets have been proposed to address group performance disparities. Although these methods have shown effectiveness in disease classification tasks, they may fall short in ensuring fair prediction of disease progression, mainly because of limited longitudinal data with diverse demographics available for training a robust and equitable prediction model. In this paper, we introduce TransFair to enhance demographic fairness in progression prediction for ocular diseases. TransFair aims to transfer a fairness-enhanced disease classification model to the task of progression prediction with fairness preserved. Specifically, we train a fair EfficientNet, termed FairEN, equipped with a fairness-aware attention mechanism using extensive data for ocular disease classification. Subsequently, this fair classification model is adapted to a fair progression prediction model through knowledge distillation, which aims to minimize the latent feature distances between the classification and progression prediction models. We evaluate FairEN and TransFair for fairness-enhanced ocular disease classification and progression prediction using both two-dimensional (2D) and 3D retinal images. Extensive experiments and comparisons with models with and without considering fairness learning show that TransFair effectively enhances demographic equity in predicting ocular disease progression.

Modeling News Interactions and Influence for Financial Market Prediction

The diffusion of financial news into market prices is a complex process, making it challenging to evaluate the connections between news events and market movements. This paper introduces FININ (Financial Interconnected News Influence Network), a novel market prediction model that captures not only the links between news and prices but also the interactions among news items themselves. FININ effectively integrates multi-modal information from both market data and news articles. We conduct extensive experiments on two datasets, encompassing the S&P 500 and NASDAQ 100 indices over a 15-year period and over 2.7 million news articles. The results demonstrate FININ's effectiveness, outperforming advanced market prediction models with an improvement of 0.429 and 0.341 in the daily Sharpe ratio for the two markets respectively. Moreover, our results reveal insights into the financial news, including the delayed market pricing of news, the long memory effect of news, and the limitations of financial sentiment analysis in fully extracting predictive power from news data.

MANA-Net: Mitigating Aggregated Sentiment Homogenization with News Weighting for Enhanced Market Prediction

It is widely acknowledged that extracting market sentiments from news data benefits market predictions. However, existing methods of using financial sentiments remain simplistic, relying on equal-weight and static aggregation to manage sentiments from multiple news items. This leads to a critical issue termed ``Aggregated Sentiment Homogenization'', which has been explored through our analysis of a large financial news dataset from industry practice. This phenomenon occurs when aggregating numerous sentiments, causing representations to converge towards the mean values of sentiment distributions and thereby smoothing out unique and important information. Consequently, the aggregated sentiment representations lose much predictive value of news data. To address this problem, we introduce the Market Attention-weighted News Aggregation Network (MANA-Net), a novel method that leverages a dynamic market-news attention mechanism to aggregate news sentiments for market prediction. MANA-Net learns the relevance of news sentiments to price changes and assigns varying weights to individual news items. By integrating the news aggregation step into the networks for market prediction, MANA-Net allows for trainable sentiment representations that are optimized directly for prediction. We evaluate MANA-Net using the S&P 500 and NASDAQ 100 indices, along with financial news spanning from 2003 to 2018. Experimental results demonstrate that MANA-Net outperforms various recent market prediction methods, enhancing Profit & Loss by 1.1% and the daily Sharpe ratio by 0.252.

FairDomain: Achieving Fairness in Cross-Domain Medical Image Segmentation and Classification

Addressing fairness in artificial intelligence (AI), particularly in medical AI, is crucial for ensuring equitable healthcare outcomes. Recent efforts to enhance fairness have introduced new methodologies and datasets in medical AI. However, the fairness issue under the setting of domain transfer is almost unexplored, while it is common that clinics rely on different imaging technologies (e.g., different retinal imaging modalities) for patient diagnosis. This paper presents FairDomain, a pioneering systemic study into algorithmic fairness under domain shifts, employing state-of-the-art domain adaptation (DA) and generalization (DG) algorithms for both medical segmentation and classification tasks to understand how biases are transferred between different domains. We also introduce a novel plug-and-play fair identity attention (FIA) module that adapts to various DA and DG algorithms to improve fairness by using self-attention to adjust feature importance based on demographic attributes. Additionally, we curate the first fairness-focused dataset with two paired imaging modalities for the same patient cohort on medical segmentation and classification tasks, to rigorously assess fairness in domain-shift scenarios. Excluding the confounding impact of demographic distribution variation between source and target domains will allow clearer quantification of the performance of domain transfer models. Our extensive evaluations reveal that the proposed FIA significantly enhances both model performance accounted for fairness across all domain shift settings (i.e., DA and DG) with respect to different demographics, which outperforms existing methods on both segmentation and classification. The code and data can be accessed at https://ophai.hms.harvard.edu/datasets/harvard-fairdomain20k.

FairDiff: Fair Segmentation with Point-Image Diffusion

Fairness is an important topic for medical image analysis, driven by the challenge of unbalanced training data among diverse target groups and the societal demand for equitable medical quality. In response to this issue, our research adopts a data-driven strategy-enhancing data balance by integrating synthetic images. However, in terms of generating synthetic images, previous works either lack paired labels or fail to precisely control the boundaries of synthetic images to be aligned with those labels. To address this, we formulate the problem in a joint optimization manner, in which three networks are optimized towards the goal of empirical risk minimization and fairness maximization. On the implementation side, our solution features an innovative Point-Image Diffusion architecture, which leverages 3D point clouds for improved control over mask boundaries through a point-mask-image synthesis pipeline. This method outperforms significantly existing techniques in synthesizing scanning laser ophthalmoscopy (SLO) fundus images. By combining synthetic data with real data during the training phase using a proposed Equal Scale approach, our model achieves superior fairness segmentation performance compared to the state-of-the-art fairness learning models. Code is available at https://github.com/wenyi-li/FairDiff.

FairCLIP: Harnessing Fairness in Vision-Language Learning

Fairness is a critical concern in deep learning, especially in healthcare, where these models influence diagnoses and treatment decisions. Although fairness has been investigated in the vision-only domain, the fairness of medical vision-language (VL) models remains unexplored due to the scarcity of medical VL datasets for studying fairness. To bridge this research gap, we introduce the first fair vision-language medical dataset Harvard-FairVLMed that provides detailed demographic attributes, ground-truth labels, and clinical notes to facilitate an in-depth examination of fairness within VL foundation models. Using Harvard-FairVLMed, we conduct a comprehensive fairness analysis of two widely-used VL models (CLIP and BLIP2), pre-trained on both natural and medical domains, across four different protected attributes. Our results highlight significant biases in all VL models, with Asian, Male, Non-Hispanic, and Spanish being the preferred subgroups across the protected attributes of race, gender, ethnicity, and language, respectively. In order to alleviate these biases, we propose FairCLIP, an optimal-transport-based approach that achieves a favorable trade-off between performance and fairness by reducing the Sinkhorn distance between the overall sample distribution and the distributions corresponding to each demographic group. As the first VL dataset of its kind, Harvard-FairVLMed holds the potential to catalyze advancements in the development of machine learning models that are both ethically aware and clinically effective. Our dataset and code are available at https://ophai.hms.harvard.edu/datasets/harvard-fairvlmed10k.

SegRefiner: Towards Model-Agnostic Segmentation Refinement with Discrete Diffusion Process

In this paper, we explore a principal way to enhance the quality of object masks produced by different segmentation models. We propose a model-agnostic solution called SegRefiner, which offers a novel perspective on this problem by interpreting segmentation refinement as a data generation process. As a result, the refinement process can be smoothly implemented through a series of denoising diffusion steps. Specifically, SegRefiner takes coarse masks as inputs and refines them using a discrete diffusion process. By predicting the label and corresponding states-transition probabilities for each pixel, SegRefiner progressively refines the noisy masks in a conditional denoising manner. To assess the effectiveness of SegRefiner, we conduct comprehensive experiments on various segmentation tasks, including semantic segmentation, instance segmentation, and dichotomous image segmentation. The results demonstrate the superiority of our SegRefiner from multiple aspects. Firstly, it consistently improves both the segmentation metrics and boundary metrics across different types of coarse masks. Secondly, it outperforms previous model-agnostic refinement methods by a significant margin. Lastly, it exhibits a strong capability to capture extremely fine details when refining high-resolution images. The source code and trained models are available at https://github.com/MengyuWang826/SegRefiner.

FairSeg: A Large-scale Medical Image Segmentation Dataset for Fairness Learning with Fair Error-Bound Scaling

Fairness in artificial intelligence models has gained significantly more attention in recent years, especially in the area of medicine, as fairness in medical models is critical to people's well-being and lives. High-quality medical fairness datasets are needed to promote fairness learning research. Existing medical fairness datasets are all for classification tasks, and no fairness datasets are available for medical segmentation, while medical segmentation is an equally important clinical task as classifications, which can provide detailed spatial information on organ abnormalities ready to be assessed by clinicians. In this paper, we propose the first fairness dataset for medical segmentation named FairSeg with 10,000 subject samples. In addition, we propose a fair error-bound scaling approach to reweight the loss function with the upper error-bound in each identity group. We anticipate that the segmentation performance equity can be improved by explicitly tackling the hard cases with high training errors in each identity group. To facilitate fair comparisons, we propose new equity-scaled segmentation performance metrics, such as the equity-scaled Dice coefficient, which is calculated as the overall Dice coefficient divided by one plus the standard deviation of group Dice coefficients. Through comprehensive experiments, we demonstrate that our fair error-bound scaling approach either has superior or comparable fairness performance to the state-of-the-art fairness learning models. The dataset and code are publicly accessible via \url{https://github.com/Harvard-Ophthalmology-AI-Lab/FairSeg}.

Harvard Eye Fairness: A Large-Scale 3D Imaging Dataset for Equitable Eye Diseases Screening and Fair Identity Scaling

Fairness or equity in machine learning is profoundly important for societal well-being, but limited public datasets hinder its progress, especially in the area of medicine. It is undeniable that fairness in medicine is one of the most important areas for fairness learning's applications. Currently, no large-scale public medical datasets with 3D imaging data for fairness learning are available, while 3D imaging data in modern clinics are standard tests for disease diagnosis. In addition, existing medical fairness datasets are actually repurposed datasets, and therefore they typically have limited demographic identity attributes with at most three identity attributes of age, gender, and race for fairness modeling. To address this gap, we introduce our Eye Fairness dataset with 30,000 subjects (Harvard-EF) covering three major eye diseases including age-related macular degeneration, diabetic retinopathy, and glaucoma affecting 380 million patients globally. Our Harvard-EF dataset includes both 2D fundus photos and 3D optical coherence tomography scans with six demographic identity attributes including age, gender, race, ethnicity, preferred language, and marital status. We also propose a fair identity scaling (FIS) approach combining group and individual scaling together to improve model fairness. Our FIS approach is compared with various state-of-the-art fairness learning methods with superior performance in the racial, gender, and ethnicity fairness tasks with 2D and 3D imaging data, which demonstrate the utilities of our Harvard-EF dataset for fairness learning. To facilitate fairness comparisons between different models, we propose performance-scaled disparity measures, which can be used to compare model fairness accounting for overall performance levels. The dataset and code are publicly accessible via https://ophai.hms.harvard.edu/datasets/harvard-ef30k.

Harvard Glaucoma Detection and Progression: A Multimodal Multitask Dataset and Generalization-Reinforced Semi-Supervised Learning

Glaucoma is the number one cause of irreversible blindness globally. A major challenge for accurate glaucoma detection and progression forecasting is the bottleneck of limited labeled patients with the state-of-the-art (SOTA) 3D retinal imaging data of optical coherence tomography (OCT). To address the data scarcity issue, this paper proposes two solutions. First, we develop a novel generalization-reinforced semi-supervised learning (SSL) model called pseudo supervisor to optimally utilize unlabeled data. Compared with SOTA models, the proposed pseudo supervisor optimizes the policy of predicting pseudo labels with unlabeled samples to improve empirical generalization. Our pseudo supervisor model is evaluated with two clinical tasks consisting of glaucoma detection and progression forecasting. The progression forecasting task is evaluated both unimodally and multimodally. Our pseudo supervisor model demonstrates superior performance than SOTA SSL comparison models. Moreover, our model also achieves the best results on the publicly available LAG fundus dataset. Second, we introduce the Harvard Glaucoma Detection and Progression (Harvard-GDP) Dataset, a multimodal multitask dataset that includes data from 1,000 patients with OCT imaging data, as well as labels for glaucoma detection and progression. This is the largest glaucoma detection dataset with 3D OCT imaging data and the first glaucoma progression forecasting dataset that is publicly available. Detailed sex and racial analysis are provided, which can be used by interested researchers for fairness learning studies. Our released dataset is benchmarked with several SOTA supervised CNN and transformer deep learning models. The dataset and code are made publicly available via \url{https://ophai.hms.harvard.edu/datasets/harvard-gdp1000}.