MMRAG: Multi-Mode Retrieval-Augmented Generation with Large Language Models for Biomedical In-Context Learning

Objective: To optimize in-context learning in biomedical natural language processing by improving example selection. Methods: We introduce a novel multi-mode retrieval-augmented generation (MMRAG) framework, which integrates four retrieval strategies: (1) Random Mode, selecting examples arbitrarily; (2) Top Mode, retrieving the most relevant examples based on similarity; (3) Diversity Mode, ensuring variation in selected examples; and (4) Class Mode, selecting category-representative examples. This study evaluates MMRAG on three core biomedical NLP tasks: Named Entity Recognition (NER), Relation Extraction (RE), and Text Classification (TC). The datasets used include BC2GM for gene and protein mention recognition (NER), DDI for drug-drug interaction extraction (RE), GIT for general biomedical information extraction (RE), and HealthAdvice for health-related text classification (TC). The framework is tested with two large language models (Llama2-7B, Llama3-8B) and three retrievers (Contriever, MedCPT, BGE-Large) to assess performance across different retrieval strategies. Results: The results from the Random mode indicate that providing more examples in the prompt improves the model's generation performance. Meanwhile, Top mode and Diversity mode significantly outperform Random mode on the RE (DDI) task, achieving an F1 score of 0.9669, a 26.4% improvement. Among the three retrievers tested, Contriever outperformed the other two in a greater number of experiments. Additionally, Llama 2 and Llama 3 demonstrated varying capabilities across different tasks, with Llama 3 showing a clear advantage in handling NER tasks. Conclusion: MMRAG effectively enhances biomedical in-context learning by refining example selection, mitigating data scarcity issues, and demonstrating superior adaptability for NLP-driven healthcare applications.

Bridging the User-side Knowledge Gap in Knowledge-aware Recommendations with Large Language Models

In recent years, knowledge graphs have been integrated into recommender systems as item-side auxiliary information, enhancing recommendation accuracy. However, constructing and integrating structural user-side knowledge remains a significant challenge due to the improper granularity and inherent scarcity of user-side features. Recent advancements in Large Language Models (LLMs) offer the potential to bridge this gap by leveraging their human behavior understanding and extensive real-world knowledge. Nevertheless, integrating LLM-generated information into recommender systems presents challenges, including the risk of noisy information and the need for additional knowledge transfer. In this paper, we propose an LLM-based user-side knowledge inference method alongside a carefully designed recommendation framework to address these challenges. Our approach employs LLMs to infer user interests based on historical behaviors, integrating this user-side information with item-side and collaborative data to construct a hybrid structure: the Collaborative Interest Knowledge Graph (CIKG). Furthermore, we propose a CIKG-based recommendation framework that includes a user interest reconstruction module and a cross-domain contrastive learning module to mitigate potential noise and facilitate knowledge transfer. We conduct extensive experiments on three real-world datasets to validate the effectiveness of our method. Our approach achieves state-of-the-art performance compared to competitive baselines, particularly for users with sparse interactions.

SSP: A Simple and Safe automatic Prompt engineering method towards realistic image synthesis on LVM

Recently, text-to-image (T2I) synthesis has undergone significant advancements, particularly with the emergence of Large Language Models (LLM) and their enhancement in Large Vision Models (LVM), greatly enhancing the instruction-following capabilities of traditional T2I models. Nevertheless, previous methods focus on improving generation quality but introduce unsafe factors into prompts. We explore that appending specific camera descriptions to prompts can enhance safety performance. Consequently, we propose a simple and safe prompt engineering method (SSP) to improve image generation quality by providing optimal camera descriptions. Specifically, we create a dataset from multi-datasets as original prompts. To select the optimal camera, we design an optimal camera matching approach and implement a classifier for original prompts capable of automatically matching. Appending camera descriptions to original prompts generates optimized prompts for further LVM image generation. Experiments demonstrate that SSP improves semantic consistency by an average of 16% compared to others and safety metrics by 48.9%.

COKE: A Cognitive Knowledge Graph for Machine Theory of Mind

Theory of mind (ToM) refers to humans' ability to understand and infer the desires, beliefs, and intentions of others. The acquisition of ToM plays a key role in humans' social cognition and interpersonal relations. Though indispensable for social intelligence, ToM is still lacking for modern AI and NLP systems since they cannot access the human mental state and cognitive process beneath the training corpus. To empower AI systems with the ToM ability and narrow the gap between them and humans, in this paper, we propose COKE: the first cognitive knowledge graph for machine theory of mind. Specifically, COKE formalizes ToM as a collection of 45k+ manually verified cognitive chains that characterize human mental activities and subsequent behavioral/affective responses when facing specific social circumstances. Beyond that, we further generalize COKE using pre-trained language models and build a powerful cognitive generation model COKE+. Experimental results in both automatic and human evaluation demonstrate the high quality of COKE and the superior ToM ability of COKE+.

Automated Paper Screening for Clinical Reviews Using Large Language Models

Objective: To assess the performance of the OpenAI GPT API in accurately and efficiently identifying relevant titles and abstracts from real-world clinical review datasets and compare its performance against ground truth labelling by two independent human reviewers. Methods: We introduce a novel workflow using the OpenAI GPT API for screening titles and abstracts in clinical reviews. A Python script was created to make calls to the GPT API with the screening criteria in natural language and a corpus of title and abstract datasets that have been filtered by a minimum of two human reviewers. We compared the performance of our model against human-reviewed papers across six review papers, screening over 24,000 titles and abstracts. Results: Our results show an accuracy of 0.91, a sensitivity of excluded papers of 0.91, and a sensitivity of included papers of 0.76. On a randomly selected subset of papers, the GPT API demonstrated the ability to provide reasoning for its decisions and corrected its initial decision upon being asked to explain its reasoning for a subset of incorrect classifications. Conclusion: The GPT API has the potential to streamline the clinical review process, save valuable time and effort for researchers, and contribute to the overall quality of clinical reviews. By prioritizing the workflow and acting as an aid rather than a replacement for researchers and reviewers, the GPT API can enhance efficiency and lead to more accurate and reliable conclusions in medical research.

Safety Assessment of Chinese Large Language Models

With the rapid popularity of large language models such as ChatGPT and GPT-4, a growing amount of attention is paid to their safety concerns. These models may generate insulting and discriminatory content, reflect incorrect social values, and may be used for malicious purposes such as fraud and dissemination of misleading information. Evaluating and enhancing their safety is particularly essential for the wide application of large language models (LLMs). To further promote the safe deployment of LLMs, we develop a Chinese LLM safety assessment benchmark. Our benchmark explores the comprehensive safety performance of LLMs from two perspectives: 8 kinds of typical safety scenarios and 6 types of more challenging instruction attacks. Our benchmark is based on a straightforward process in which it provides the test prompts and evaluates the safety of the generated responses from the evaluated model. In evaluation, we utilize the LLM's strong evaluation ability and develop it as a safety evaluator by prompting. On top of this benchmark, we conduct safety assessments and analyze 15 LLMs including the OpenAI GPT series and other well-known Chinese LLMs, where we observe some interesting findings. For example, we find that instruction attacks are more likely to expose safety issues of all LLMs. Moreover, to promote the development and deployment of safe, responsible, and ethical AI, we publicly release SafetyPrompts including 100k augmented prompts and responses by LLMs.

Recent Advances towards Safe, Responsible, and Moral Dialogue Systems: A Survey

With the development of artificial intelligence, dialogue systems have been endowed with amazing chit-chat capabilities, and there is widespread interest and discussion about whether the generated contents are socially beneficial. In this paper, we present a new perspective of research scope towards building a safe, responsible, and modal dialogue system, including 1) abusive and toxic contents, 2) unfairness and discrimination, 3) ethics and morality issues, and 4) risk of misleading and privacy information. Besides, we review the mainstream methods for evaluating the safety of large models from the perspectives of exposure and detection of safety issues. The recent advances in methodologies for the safety improvement of both end-to-end dialogue systems and pipeline-based models are further introduced. Finally, we discussed six existing challenges towards responsible AI: explainable safety monitoring, continuous learning of safety issues, robustness against malicious attacks, multimodal information processing, unified research framework, and multidisciplinary theory integration. We hope this survey will inspire further research toward safer dialogue systems.

Constructing Highly Inductive Contexts for Dialogue Safety through Controllable Reverse Generation

Large pretrained language models can easily produce toxic or biased content, which is prohibitive for practical use. In order to detect such toxic generations, existing methods rely on templates, real-world data extraction, crowdsourcing workers, or automatic generation to construct adversarial contexts that are likely to induce toxic generations. However, what type of context is more likely to induce unsafe responses is still under-explored. In this paper, we identify that context toxicity and context category (e.g., \textit{profanity}, \textit{insult}, \textit{drugs}, etc.) are two important factors to cause safety issues in response generation. Hence, we propose a method called \emph{reverse generation} to construct adversarial contexts conditioned on a given response, with the flexibility to control category, toxicity level, and inductivity of the generated contexts. Via reverse generation, we augment the existing BAD dataset and construct a new dataset BAD+ which contains more than 120K diverse and highly inductive contexts in 12 categories. We test three popular pretrained dialogue models (Blender, DialoGPT, and Plato2) and find that BAD+ can largely expose their safety problems. Furthermore, we show that BAD+ can greatly enhance the safety of generation and reveal the key factors of safety improvement. Our code and dataset is available at \url{https://github.com/thu-coai/Reverse_Generation}.

Perplexity from PLM Is Unreliable for Evaluating Text Quality

Recently, amounts of works utilize perplexity~(PPL) to evaluate the quality of the generated text. They suppose that if the value of PPL is smaller, the quality(i.e. fluency) of the text to be evaluated is better. However, we find that the PPL referee is unqualified and it cannot evaluate the generated text fairly for the following reasons: (i) The PPL of short text is larger than long text, which goes against common sense, (ii) The repeated text span could damage the performance of PPL, and (iii) The punctuation marks could affect the performance of PPL heavily. Experiments show that the PPL is unreliable for evaluating the quality of given text. Last, we discuss the key problems with evaluating text quality using language models.

A Roadmap for Big Model

With the rapid development of deep learning, training Big Models (BMs) for multiple downstream tasks becomes a popular paradigm. Researchers have achieved various outcomes in the construction of BMs and the BM application in many fields. At present, there is a lack of research work that sorts out the overall progress of BMs and guides the follow-up research. In this paper, we cover not only the BM technologies themselves but also the prerequisites for BM training and applications with BMs, dividing the BM review into four parts: Resource, Models, Key Technologies and Application. We introduce 16 specific BM-related topics in those four parts, they are Data, Knowledge, Computing System, Parallel Training System, Language Model, Vision Model, Multi-modal Model, Theory&Interpretability, Commonsense Reasoning, Reliability&Security, Governance, Evaluation, Machine Translation, Text Generation, Dialogue and Protein Research. In each topic, we summarize clearly the current studies and propose some future research directions. At the end of this paper, we conclude the further development of BMs in a more general view.