STimage-1K4M: A histopathology image-gene expression dataset for spatial transcriptomics

Recent advances in multi-modal algorithms have driven and been driven by the increasing availability of large image-text datasets, leading to significant strides in various fields, including computational pathology. However, in most existing medical image-text datasets, the text typically provides high-level summaries that may not sufficiently describe sub-tile regions within a large pathology image. For example, an image might cover an extensive tissue area containing cancerous and healthy regions, but the accompanying text might only specify that this image is a cancer slide, lacking the nuanced details needed for in-depth analysis. In this study, we introduce STimage-1K4M, a novel dataset designed to bridge this gap by providing genomic features for sub-tile images. STimage-1K4M contains 1,149 images derived from spatial transcriptomics data, which captures gene expression information at the level of individual spatial spots within a pathology image. Specifically, each image in the dataset is broken down into smaller sub-image tiles, with each tile paired with 15,000-30,000 dimensional gene expressions. With 4,293,195 pairs of sub-tile images and gene expressions, STimage-1K4M offers unprecedented granularity, paving the way for a wide range of advanced research in multi-modal data analysis an innovative applications in computational pathology, and beyond.

Benchmarking Generation and Evaluation Capabilities of Large Language Models for Instruction Controllable Summarization

While large language models (LLMs) already achieve strong performance on standard generic summarization benchmarks, their performance on more complex summarization task settings is less studied. Therefore, we benchmark LLMs on instruction controllable text summarization, where the model input consists of both a source article and a natural language requirement for the desired summary characteristics. To this end, we curate an evaluation-only dataset for this task setting and conduct human evaluation on 5 LLM-based summarization systems. We then benchmark LLM-based automatic evaluation for this task with 4 different evaluation protocols and 11 LLMs, resulting in 40 evaluation methods in total. Our study reveals that instruction controllable text summarization remains a challenging task for LLMs, since (1) all LLMs evaluated still make factual and other types of errors in their summaries; (2) all LLM-based evaluation methods cannot achieve a strong alignment with human annotators when judging the quality of candidate summaries; (3) different LLMs show large performance gaps in summary generation and evaluation. We make our collected benchmark, InstruSum, publicly available to facilitate future research in this direction.

On the Identifiability and Interpretability of Gaussian Process Models

In this paper, we critically examine the prevalent practice of using additive mixtures of Mat\'ern kernels in single-output Gaussian process (GP) models and explore the properties of multiplicative mixtures of Mat\'ern kernels for multi-output GP models. For the single-output case, we derive a series of theoretical results showing that the smoothness of a mixture of Mat\'ern kernels is determined by the least smooth component and that a GP with such a kernel is effectively equivalent to the least smooth kernel component. Furthermore, we demonstrate that none of the mixing weights or parameters within individual kernel components are identifiable. We then turn our attention to multi-output GP models and analyze the identifiability of the covariance matrix $A$ in the multiplicative kernel $K(x,y) = AK_0(x,y)$, where $K_0$ is a standard single output kernel such as Mat\'ern. We show that $A$ is identifiable up to a multiplicative constant, suggesting that multiplicative mixtures are well suited for multi-output tasks. Our findings are supported by extensive simulations and real applications for both single- and multi-output settings. This work provides insight into kernel selection and interpretation for GP models, emphasizing the importance of choosing appropriate kernel structures for different tasks.

Learning Lens Blur Fields

Optical blur is an inherent property of any lens system and is challenging to model in modern cameras because of their complex optical elements. To tackle this challenge, we introduce a high-dimensional neural representation of blur$-$$\textit{the lens blur field}$$-$and a practical method for acquiring it. The lens blur field is a multilayer perceptron (MLP) designed to (1) accurately capture variations of the lens 2D point spread function over image plane location, focus setting and, optionally, depth and (2) represent these variations parametrically as a single, sensor-specific function. The representation models the combined effects of defocus, diffraction, aberration, and accounts for sensor features such as pixel color filters and pixel-specific micro-lenses. To learn the real-world blur field of a given device, we formulate a generalized non-blind deconvolution problem that directly optimizes the MLP weights using a small set of focal stacks as the only input. We also provide a first-of-its-kind dataset of 5D blur fields$-$for smartphone cameras, camera bodies equipped with a variety of lenses, etc. Lastly, we show that acquired 5D blur fields are expressive and accurate enough to reveal, for the first time, differences in optical behavior of smartphone devices of the same make and model.

Advancements in 3D Lane Detection Using LiDAR Point Clouds: From Data Collection to Model Development

Advanced Driver-Assistance Systems (ADAS) have successfully integrated learning-based techniques into vehicle perception and decision-making. However, their application in 3D lane detection for effective driving environment perception is hindered by the lack of comprehensive LiDAR datasets. The sparse nature of LiDAR point cloud data prevents an efficient manual annotation process. To solve this problem, we present LiSV-3DLane, a large-scale 3D lane dataset that comprises 20k frames of surround-view LiDAR point clouds with enriched semantic annotation. Unlike existing datasets confined to a frontal perspective, LiSV-3DLane provides a full 360-degree spatial panorama around the ego vehicle, capturing complex lane patterns in both urban and highway environments. We leverage the geometric traits of lane lines and the intrinsic spatial attributes of LiDAR data to design a simple yet effective automatic annotation pipeline for generating finer lane labels. To propel future research, we propose a novel LiDAR-based 3D lane detection model, LiLaDet, incorporating the spatial geometry learning of the LiDAR point cloud into Bird's Eye View (BEV) based lane identification. Experimental results indicate that LiLaDet outperforms existing camera- and LiDAR-based approaches in the 3D lane detection task on the K-Lane dataset and our LiSV-3DLane.

MatSpectNet: Material Segmentation Network with Domain-Aware and Physically-Constrained Hyperspectral Reconstruction

Achieving accurate material segmentation for 3-channel RGB images is challenging due to the considerable variation in a material's appearance. Hyperspectral images, which are sets of spectral measurements sampled at multiple wavelengths, theoretically offer distinct information for material identification, as variations in intensity of electromagnetic radiation reflected by a surface depend on the material composition of a scene. However, existing hyperspectral datasets are impoverished regarding the number of images and material categories for the dense material segmentation task, and collecting and annotating hyperspectral images with a spectral camera is prohibitively expensive. To address this, we propose a new model, the MatSpectNet to segment materials with recovered hyperspectral images from RGB images. The network leverages the principles of colour perception in modern cameras to constrain the reconstructed hyperspectral images and employs the domain adaptation method to generalise the hyperspectral reconstruction capability from a spectral recovery dataset to material segmentation datasets. The reconstructed hyperspectral images are further filtered using learned response curves and enhanced with human perception. The performance of MatSpectNet is evaluated on the LMD dataset as well as the OpenSurfaces dataset. Our experiments demonstrate that MatSpectNet attains a 1.60% increase in average pixel accuracy and a 3.42% improvement in mean class accuracy compared with the most recent publication. The project code is attached to the supplementary material and will be published on GitHub.

Splatting-based Synthesis for Video Frame Interpolation

Frame interpolation is an essential video processing technique that adjusts the temporal resolution of an image sequence. An effective approach to perform frame interpolation is based on splatting, also known as forward warping. Specifically, splatting can be used to warp the input images to an arbitrary temporal location based on an optical flow estimate. A synthesis network, also sometimes referred to as refinement network, can then be used to generate the output frame from the warped images. In doing so, it is common to not only warp the images but also various feature representations which provide rich contextual cues to the synthesis network. However, while this approach has been shown to work well and enables arbitrary-time interpolation due to using splatting, the involved synthesis network is prohibitively slow. In contrast, we propose to solely rely on splatting to synthesize the output without any subsequent refinement. This splatting-based synthesis is much faster than similar approaches, especially for multi-frame interpolation, while enabling new state-of-the-art results at high resolutions.

The Implicit Values of A Good Hand Shake: Handheld Multi-Frame Neural Depth Refinement

Modern smartphones can continuously stream multi-megapixel RGB images at 60~Hz, synchronized with high-quality 3D pose information and low-resolution LiDAR-driven depth estimates. During a snapshot photograph, the natural unsteadiness of the photographer's hands offers millimeter-scale variation in camera pose, which we can capture along with RGB and depth in a circular buffer. In this work we explore how, from a bundle of these measurements acquired during viewfinding, we can combine dense micro-baseline parallax cues with kilopixel LiDAR depth to distill a high-fidelity depth map. We take a test-time optimization approach and train a coordinate MLP to output photometrically and geometrically consistent depth estimates at the continuous coordinates along the path traced by the photographer's natural hand shake. The proposed method brings high-resolution depth estimates to 'point-and-shoot' tabletop photography and requires no additional hardware, artificial hand motion, or user interaction beyond the press of a button.

Defocus Map Estimation and Deblurring from a Single Dual-Pixel Image

We present a method that takes as input a single dual-pixel image, and simultaneously estimates the image's defocus map -- the amount of defocus blur at each pixel -- and recovers an all-in-focus image. Our method is inspired from recent works that leverage the dual-pixel sensors available in many consumer cameras to assist with autofocus, and use them for recovery of defocus maps or all-in-focus images. These prior works have solved the two recovery problems independently of each other, and often require large labeled datasets for supervised training. By contrast, we show that it is beneficial to treat these two closely-connected problems simultaneously. To this end, we set up an optimization problem that, by carefully modeling the optics of dual-pixel images, jointly solves both problems. We use data captured with a consumer smartphone camera to demonstrate that, after a one-time calibration step, our approach improves upon prior works for both defocus map estimation and blur removal, despite being entirely unsupervised.

Single-Image Lens Flare Removal

Lens flare is a common artifact in photographs occurring when the camera is pointed at a strong light source. It is caused by either multiple reflections within the lens or scattering due to scratches or dust on the lens, and may appear in a wide variety of patterns: halos, streaks, color bleeding, haze, etc. The diversity in its appearance makes flare removal extremely challenging. Existing software methods make strong assumptions about the artifacts' geometry or brightness, and thus only handle a small subset of flares. We take a principled approach to explicitly model the optical causes of flare, which leads to a novel semi-synthetic pipeline for generating flare-corrupted images from both empirical and wave-optics-simulated lens flares. Using the semi-synthetic data generated by this pipeline, we build a neural network to remove lens flare. Experiments show that our model generalizes well to real lens flares captured by different devices, and outperforms start-of-the-art methods by 3dB in PSNR.