Touchstone Benchmark: Are We on the Right Way for Evaluating AI Algorithms for Medical Segmentation?

How can we test AI performance? This question seems trivial, but it isn't. Standard benchmarks often have problems such as in-distribution and small-size test sets, oversimplified metrics, unfair comparisons, and short-term outcome pressure. As a consequence, good performance on standard benchmarks does not guarantee success in real-world scenarios. To address these problems, we present Touchstone, a large-scale collaborative segmentation benchmark of 9 types of abdominal organs. This benchmark is based on 5,195 training CT scans from 76 hospitals around the world and 5,903 testing CT scans from 11 additional hospitals. This diverse test set enhances the statistical significance of benchmark results and rigorously evaluates AI algorithms across various out-of-distribution scenarios. We invited 14 inventors of 19 AI algorithms to train their algorithms, while our team, as a third party, independently evaluated these algorithms on three test sets. In addition, we also evaluated pre-existing AI frameworks--which, differing from algorithms, are more flexible and can support different algorithms--including MONAI from NVIDIA, nnU-Net from DKFZ, and numerous other open-source frameworks. We are committed to expanding this benchmark to encourage more innovation of AI algorithms for the medical domain.

Can LLMs Learn by Teaching? A Preliminary Study

Teaching to improve student models (e.g., knowledge distillation) is an extensively studied methodology in LLMs. However, for humans, teaching not only improves students but also improves teachers. We ask: Can LLMs also learn by teaching (LbT)? If yes, we can potentially unlock the possibility of continuously advancing the models without solely relying on human-produced data or stronger models. In this paper, we provide a preliminary exploration of this ambitious agenda. We show that LbT ideas can be incorporated into existing LLM training/prompting pipelines and provide noticeable improvements. Specifically, we design three methods, each mimicking one of the three levels of LbT in humans: observing students' feedback, learning from the feedback, and learning iteratively, with the goals of improving answer accuracy without training and improving models' inherent capability with fine-tuning. The findings are encouraging. For example, similar to LbT in human, we see that: (1) LbT can induce weak-to-strong generalization: strong models can improve themselves by teaching other weak models; (2) Diversity in students might help: teaching multiple students could be better than teaching one student or the teacher itself. We hope that this early promise can inspire future research on LbT and more broadly adopting the advanced techniques in education to improve LLMs. The code is available at https://github.com/imagination-research/lbt.

Revisiting Evaluation Metrics for Semantic Segmentation: Optimization and Evaluation of Fine-grained Intersection over Union

Semantic segmentation datasets often exhibit two types of imbalance: \textit{class imbalance}, where some classes appear more frequently than others and \textit{size imbalance}, where some objects occupy more pixels than others. This causes traditional evaluation metrics to be biased towards \textit{majority classes} (e.g. overall pixel-wise accuracy) and \textit{large objects} (e.g. mean pixel-wise accuracy and per-dataset mean intersection over union). To address these shortcomings, we propose the use of fine-grained mIoUs along with corresponding worst-case metrics, thereby offering a more holistic evaluation of segmentation techniques. These fine-grained metrics offer less bias towards large objects, richer statistical information, and valuable insights into model and dataset auditing. Furthermore, we undertake an extensive benchmark study, where we train and evaluate 15 modern neural networks with the proposed metrics on 12 diverse natural and aerial segmentation datasets. Our benchmark study highlights the necessity of not basing evaluations on a single metric and confirms that fine-grained mIoUs reduce the bias towards large objects. Moreover, we identify the crucial role played by architecture designs and loss functions, which lead to best practices in optimizing fine-grained metrics. The code is available at \href{https://github.com/zifuwanggg/JDTLosses}{https://github.com/zifuwanggg/JDTLosses}.

Dice Semimetric Losses: Optimizing the Dice Score with Soft Labels

The soft Dice loss (SDL) has taken a pivotal role in many automated segmentation pipelines in the medical imaging community. Over the last years, some reasons behind its superior functioning have been uncovered and further optimizations have been explored. However, there is currently no implementation that supports its direct use in settings with soft labels. Hence, a synergy between the use of SDL and research leveraging the use of soft labels, also in the context of model calibration, is still missing. In this work, we introduce Dice semimetric losses (DMLs), which (i) are by design identical to SDL in a standard setting with hard labels, but (ii) can be used in settings with soft labels. Our experiments on the public QUBIQ, LiTS and KiTS benchmarks confirm the potential synergy of DMLs with soft labels (e.g. averaging, label smoothing, and knowledge distillation) over hard labels (e.g. majority voting and random selection). As a result, we obtain superior Dice scores and model calibration, which supports the wider adoption of DMLs in practice. Code is available at \href{https://github.com/zifuwanggg/JDTLosses}{https://github.com/zifuwanggg/JDTLosses}.

Jaccard Metric Losses: Optimizing the Jaccard Index with Soft Labels

IoU losses are surrogates that directly optimize the Jaccard index. In semantic segmentation, IoU losses are shown to perform better with respect to the Jaccard index measure than pixel-wise losses such as the cross-entropy loss. The most notable IoU losses are the soft Jaccard loss and the Lovasz-Softmax loss. However, these losses are incompatible with soft labels which are ubiquitous in machine learning. In this paper, we propose Jaccard metric losses (JMLs), which are variants of the soft Jaccard loss, and are compatible with soft labels. With JMLs, we study two of the most popular use cases of soft labels: label smoothing and knowledge distillation. With a variety of architectures, our experiments show significant improvements over the cross-entropy loss on three semantic segmentation datasets (Cityscapes, PASCAL VOC and DeepGlobe Land), and our simple approach outperforms state-of-the-art knowledge distillation methods by a large margin. Our source code is available at: \href{https://github.com/zifuwanggg/JDML}{https://github.com/zifuwanggg/JDML}.

MRF-UNets: Searching UNet with Markov Random Fields

UNet [27] is widely used in semantic segmentation due to its simplicity and effectiveness. However, its manually-designed architecture is applied to a large number of problem settings, either with no architecture optimizations, or with manual tuning, which is time consuming and can be sub-optimal. In this work, firstly, we propose Markov Random Field Neural Architecture Search (MRF-NAS) that extends and improves the recent Adaptive and Optimal Network Width Search (AOWS) method [4] with (i) a more general MRF framework (ii) diverse M-best loopy inference (iii) differentiable parameter learning. This provides the necessary NAS framework to efficiently explore network architectures that induce loopy inference graphs, including loops that arise from skip connections. With UNet as the backbone, we find an architecture, MRF-UNet, that shows several interesting characteristics. Secondly, through the lens of these characteristics, we identify the sub-optimality of the original UNet architecture and further improve our results with MRF-UNetV2. Experiments show that our MRF-UNets significantly outperform several benchmarks on three aerial image datasets and two medical image datasets while maintaining low computational costs. The code is available at: https://github.com/zifuwanggg/MRF-UNets.