STProtein: predicting spatial protein expression from multi-omics data

The integration of spatial multi-omics data from single tissues is crucial for advancing biological research. However, a significant data imbalance impedes progress: while spatial transcriptomics data is relatively abundant, spatial proteomics data remains scarce due to technical limitations and high costs. To overcome this challenge we propose STProtein, a novel framework leveraging graph neural networks with multi-task learning strategy. STProtein is designed to accurately predict unknown spatial protein expression using more accessible spatial multi-omics data, such as spatial transcriptomics. We believe that STProtein can effectively addresses the scarcity of spatial proteomics, accelerating the integration of spatial multi-omics and potentially catalyzing transformative breakthroughs in life sciences. This tool enables scientists to accelerate discovery by identifying complex and previously hidden spatial patterns of proteins within tissues, uncovering novel relationships between different marker genes, and exploring the biological "Dark Matter".

Convergence Properties of Good Quantum Codes for Classical Communication

An important part of the information theory folklore had been about the output statistics of codes that achieve the capacity and how the empirical distributions compare to the output distributions induced by the optimal input in the channel capacity problem. Results for a variety of such empirical output distributions of good codes have been known in the literature, such as the comparison of the output distribution of the code to the optimal output distribution in vanishing and non-vanishing error probability cases. Motivated by these, we aim to achieve similar results for the quantum codes that are used for classical communication, that is the setting in which the classical messages are communicated through quantum codewords that pass through a noisy quantum channel. We first show the uniqueness of the optimal output distribution, to be able to talk more concretely about the optimal output distribution. Then, we extend the vanishing error probability results to the quantum case, by using techniques that are close in spirit to the classical case. We also extend non-vanishing error probability results to the quantum case on block codes, by using the second-order converses for such codes based on hypercontractivity results for the quantum generalized depolarizing semi-groups.

Breaking the Storage-Bandwidth Tradeoff in Distributed Storage with Quantum Entanglement

This work investigates the use of quantum resources in distributed storage systems. Consider an $(n,k,d)$ distributed storage system in which a file is stored across $n$ nodes such that any $k$ nodes suffice to reconstruct the file. When a node fails, any $d$ helper nodes transmit information to a newcomer to rebuild the system. In contrast to the classical repair, where helper nodes transmit classical bits, we allow them to send classical information over quantum channels to the newcomer. The newcomer then generates its storage by performing appropriate measurements on the received quantum states. In this setting, we fully characterize the fundamental tradeoff between storage and repair bandwidth (total communication cost). Compared to classical systems, the optimal storage--bandwidth tradeoff can be significantly improved with the enhancement of quantum entanglement shared only among the surviving nodes, particularly at the minimum-storage regenerating point. Remarkably, we show that when $d \geq 2k-2$, there exists an operating point at which \textit{both storage and repair bandwidth are simultaneously minimized}. This phenomenon breaks the tradeoff in the classical setting and reveals a fundamentally new regime enabled by quantum communication.

On the Capacity Region of Individual Key Rates in Vector Linear Secure Aggregation

We provide new insights into an open problem recently posed by Yuan-Sun [ISIT 2025], concerning the minimum individual key rate required in the vector linear secure aggregation problem. Consider a distributed system with $K$ users, where each user $k\in [K]$ holds a data stream $W_k$ and an individual key $Z_k$. A server aims to compute a linear function $\mathbf{F}[W_1;\ldots;W_K]$ without learning any information about another linear function $\mathbf{G}[W_1;\ldots;W_K]$, where $[W_1;\ldots;W_K]$ denotes the row stack of $W_1,\ldots,W_K$. The open problem is to determine the minimum required length of $Z_k$, denoted as $R_k$, $k\in [K]$. In this paper, we characterize a new achievable region for the rate tuple $(R_1,\ldots,R_K)$. The region is polyhedral, with vertices characterized by a binary rate assignment $(R_1,\ldots,R_K) = (\mathbf{1}(1 \in \mathcal{I}),\ldots,\mathbf{1}(K\in \mathcal{I}))$, where $\mathcal{I}\subseteq [K]$ satisfies the \textit{rank-increment condition}: $\mathrm{rank}\left(\bigl[\mathbf{F}_{\mathcal{I}};\mathbf{G}_{\mathcal{I}}\bigr]\right) =\mathrm{rank}\bigl(\mathbf{F}_{\mathcal{I}}\bigr)+N$. Here, $\mathbf{F}_\mathcal{I}$ and $\mathbf{G}_\mathcal{I}$ are the submatrices formed by the columns indexed by $\mathcal{I}$. Our results uncover the novel fact that it is not necessary for every user to hold a key, thereby strictly enlarging the best-known achievable region in the literature. Furthermore, we provide a converse analysis to demonstrate its optimality when minimizing the number of users that hold keys.

ReplayCAD: Generative Diffusion Replay for Continual Anomaly Detection

Continual Anomaly Detection (CAD) enables anomaly detection models in learning new classes while preserving knowledge of historical classes. CAD faces two key challenges: catastrophic forgetting and segmentation of small anomalous regions. Existing CAD methods store image distributions or patch features to mitigate catastrophic forgetting, but they fail to preserve pixel-level detailed features for accurate segmentation. To overcome this limitation, we propose ReplayCAD, a novel diffusion-driven generative replay framework that replay high-quality historical data, thus effectively preserving pixel-level detailed features. Specifically, we compress historical data by searching for a class semantic embedding in the conditional space of the pre-trained diffusion model, which can guide the model to replay data with fine-grained pixel details, thus improving the segmentation performance. However, relying solely on semantic features results in limited spatial diversity. Hence, we further use spatial features to guide data compression, achieving precise control of sample space, thereby generating more diverse data. Our method achieves state-of-the-art performance in both classification and segmentation, with notable improvements in segmentation: 11.5% on VisA and 8.1% on MVTec. Our source code is available at https://github.com/HULEI7/ReplayCAD.

Structure-Accurate Medical Image Translation based on Dynamic Frequency Balance and Knowledge Guidance

Multimodal medical images play a crucial role in the precise and comprehensive clinical diagnosis. Diffusion model is a powerful strategy to synthesize the required medical images. However, existing approaches still suffer from the problem of anatomical structure distortion due to the overfitting of high-frequency information and the weakening of low-frequency information. Thus, we propose a novel method based on dynamic frequency balance and knowledge guidance. Specifically, we first extract the low-frequency and high-frequency components by decomposing the critical features of the model using wavelet transform. Then, a dynamic frequency balance module is designed to adaptively adjust frequency for enhancing global low-frequency features and effective high-frequency details as well as suppressing high-frequency noise. To further overcome the challenges posed by the large differences between different medical modalities, we construct a knowledge-guided mechanism that fuses the prior clinical knowledge from a visual language model with visual features, to facilitate the generation of accurate anatomical structures. Experimental evaluations on multiple datasets show the proposed method achieves significant improvements in qualitative and quantitative assessments, verifying its effectiveness and superiority.

Learning Transformation-Isomorphic Latent Space for Accurate Hand Pose Estimation

Vision-based regression tasks, such as hand pose estimation, have achieved higher accuracy and faster convergence through representation learning. However, existing representation learning methods often encounter the following issues: the high semantic level of features extracted from images is inadequate for regressing low-level information, and the extracted features include task-irrelevant information, reducing their compactness and interfering with regression tasks. To address these challenges, we propose TI-Net, a highly versatile visual Network backbone designed to construct a Transformation Isomorphic latent space. Specifically, we employ linear transformations to model geometric transformations in the latent space and ensure that {\rm TI-Net} aligns them with those in the image space. This ensures that the latent features capture compact, low-level information beneficial for pose estimation tasks. We evaluated TI-Net on the hand pose estimation task to demonstrate the network's superiority. On the DexYCB dataset, TI-Net achieved a 10% improvement in the PA-MPJPE metric compared to specialized state-of-the-art (SOTA) hand pose estimation methods. Our code will be released in the future.

Entanglement-Assisted Coding for Arbitrary Linear Computations Over a Quantum MAC

We study a linear computation problem over a quantum multiple access channel (LC-QMAC), where $S$ servers share an entangled state and separately store classical data streams $W_1,\cdots, W_S$ over a finite field $\mathbb{F}_d$. A user aims to compute $K$ linear combinations of these data streams, represented as $Y = \mathbf{V}_1 W_1 + \mathbf{V}_2 W_2 + \cdots + \mathbf{V}_S W_S \in \mathbb{F}_d^{K \times 1}$. To this end, each server encodes its classical information into its local quantum subsystem and transmits it to the user, who retrieves the desired computations via quantum measurements. In this work, we propose an achievable scheme for LC-QMAC based on the stabilizer formalism and the ideas from entanglement-assisted quantum error-correcting codes (EAQECC). Specifically, given any linear computation matrix, we construct a self-orthogonal matrix that can be implemented using the stabilizer formalism. Also, we apply precoding matrices to minimize the number of auxiliary qudits required. Our scheme achieves more computations per qudit, i.e., a higher computation rate, compared to the best-known methods in the literature, and attains the capacity in certain cases.

Motion Artifact Removal in Pixel-Frequency Domain via Alternate Masks and Diffusion Model

Motion artifacts present in magnetic resonance imaging (MRI) can seriously interfere with clinical diagnosis. Removing motion artifacts is a straightforward solution and has been extensively studied. However, paired data are still heavily relied on in recent works and the perturbations in \textit{k}-space (frequency domain) are not well considered, which limits their applications in the clinical field. To address these issues, we propose a novel unsupervised purification method which leverages pixel-frequency information of noisy MRI images to guide a pre-trained diffusion model to recover clean MRI images. Specifically, considering that motion artifacts are mainly concentrated in high-frequency components in \textit{k}-space, we utilize the low-frequency components as the guide to ensure correct tissue textures. Additionally, given that high-frequency and pixel information are helpful for recovering shape and detail textures, we design alternate complementary masks to simultaneously destroy the artifact structure and exploit useful information. Quantitative experiments are performed on datasets from different tissues and show that our method achieves superior performance on several metrics. Qualitative evaluations with radiologists also show that our method provides better clinical feedback. Our code is available at https://github.com/medcx/PFAD.

Advancing Large Language Models for Spatiotemporal and Semantic Association Mining of Similar Environmental Events

Retrieval and recommendation are two essential tasks in modern search tools. This paper introduces a novel retrieval-reranking framework leveraging Large Language Models (LLMs) to enhance the spatiotemporal and semantic associated mining and recommendation of relevant unusual climate and environmental events described in news articles and web posts. This framework uses advanced natural language processing techniques to address the limitations of traditional manual curation methods in terms of high labor cost and lack of scalability. Specifically, we explore an optimized solution to employ cutting-edge embedding models for semantically analyzing spatiotemporal events (news) and propose a Geo-Time Re-ranking (GT-R) strategy that integrates multi-faceted criteria including spatial proximity, temporal association, semantic similarity, and category-instructed similarity to rank and identify similar spatiotemporal events. We apply the proposed framework to a dataset of four thousand Local Environmental Observer (LEO) Network events, achieving top performance in recommending similar events among multiple cutting-edge dense retrieval models. The search and recommendation pipeline can be applied to a wide range of similar data search tasks dealing with geospatial and temporal data. We hope that by linking relevant events, we can better aid the general public to gain an enhanced understanding of climate change and its impact on different communities.