Medical Heuristic Learning: An LLM-Driven Framework for Interpretable and Auditable Clinical Decision Rules

Predictive modeling for clinical tabular data is central to clinical decision support and therefore requires not only strong predictive performance but also transparent decision logic. Although deep learning and tree-based ensemble methods can achieve high accuracy, their black-box nature remains a major obstacle to clinical deployment. This challenge is further compounded by common characteristics of medical data, including limited sample sizes, severe class imbalance, and feature evolution arising from changes in diagnostic criteria and clinical documentation. To address these issues, we propose Medical Heuristic Learning (MHL), an instantiation of the learning-beyond-gradients paradigm for clinical tabular prediction. Instead of relying on neural network weight updates, MHL uses a large language model (LLM)-driven workflow that integrates statistical probes, medical knowledge probes, rule synthesis, and code-level iterative refinement to optimize a deterministic and executable decision system. The resulting model is expressed not as opaque parameters, but as versioned pure-Python decision rules that are explicitly interpretable, fully auditable, and clinically grounded. MHL also supports continual learning by starting from previously validated rules and iteratively revising them using updated feature information under data drift or feature evolution. Comprehensive experiments on medical datasets show that MHL achieves performance comparable to state-of-the-art methods while maintaining strong behavior in small-sample and highly imbalanced settings. The results further indicate that this explicit rule update mechanism can help alleviate catastrophic forgetting under feature evolution. Overall, these findings suggest that non-gradient-based heuristic systems offer a transparent and adaptable alternative for high-stakes clinical decision support.

Answer Presence Drives RAG Rewriting Gains

Retrieval-augmented QA pipelines often route retrieved passages through an LLM \emph{rewriter} before a smaller reader, lifting F1 by tens of points on multi-hop benchmarks; this gain is typically credited to improved evidence quality. We ask whether that lift is causally driven by the gold answer string appearing in the rewritten context rather than by curation per se, using a controlled intervention audit. For each rewritten context we re-run the reader after one of four controlled edits to the compile output: removing the gold answer span, replacing a length-matched random non-answer span (placebo), or injecting the gold into rewrites where it was absent (at the prefix or at a midpoint sentence boundary). Across twelve completed (cell, baseline) intervention runs spanning three reader families (Qwen2.5-7B, Qwen3.5-35B, GLM-4.7), two datasets (HotpotQA, 2WikiMultihopQA), and three compiler arrangements (MA-only, MB-only, MA$+$verify), removing the gold answer drops reader F1 by $28$ to $64$ points beyond the length-matched placebo on paired \texttt{answer-in-compile} strata, and prepending the gold into rewrites that lacked it raises F1 by $+0.7$ to $+9.7$ points in $10$ of $12$ (cell, baseline) combinations. A companion five-sentinel audit shows the conventional single-\texttt{[MASK]} probe is itself sentinel-fragile: on 2Wiki it reports a $+4.12$~F1 ``non-leakage residual'' that flips to $-3.33$ to $-7.81$~F1 under four alternative sentinels and fails an equivalence test for three of those four ($1/4$~pass). We do not propose a new rewriter or mitigation; we release the intervention runner and the sentinel panel so that other rewriter-gain claims can be tested against the same standard.

BiasGRPO: Stabilizing Bias Mitigation in High-Variance Reward Landscapes via Group-Relative Policy Optimization

Mitigating social bias in Large Language Models (LLMs) presents a distinct alignment challenge: unlike verifiable tasks, bias lacks a single ground truth, creating a high-variance, subjective reward landscape. Previous preference-based fine-tuning methods have major trade-offs: Direct Preference Optimization (DPO) is limited by the lack of exploration inherent in offline training, while Proximal Policy Optimization (PPO) can lead to training instability due to potentially unreliable critic estimates. In this paper, we propose BiasGRPO, a framework using Group Relative Policy Optimization (GRPO) to stabilize alignment by normalizing rewards across a group of sampled completions. By substituting the value function with a group-relative baseline, our approach reduces instability while maintaining the exploration benefits of online training. We find that BiasGRPO outperforms DPO and PPO across multiple benchmarks, indicating its effectiveness. To adapt GRPO, we synthetically extend a dataset spanning multiple domains and contexts. We also create and release a custom bias reward model that effectively guides generation while being highly compute-efficient and avoiding knowledge degradation, providing a valuable resource that can be seamlessly integrated into multi-objective RLHF pipelines.

When Retrieval Doesn't Help: A Large-Scale Study of Biomedical RAG

Medical question answering is a high-stakes setting where factual errors can have serious consequences. Retrieval-augmented generation (RAG) is widely viewed as a promising solution, and prior work has reported substantial gains for large medical QA models. We revisit this assumption across a broad range of open-weight instruction-tuned models spanning 7B to 72B parameters. Across five models, ten biomedical QA datasets, four retrieval methods, and four retrieval corpora, we find that retrieval yields only small and inconsistent improvements over a no-retrieval baseline, typically within 1-2 points. In contrast, the choice of backbone model has a much larger effect than the choice of retriever or corpus, and expert and layman retrieval sources perform similarly in most settings. These results suggest that the main bottleneck is not retrieval quality alone, but the model's limited ability to use retrieved evidence effectively.

The MiniMax-M2 Series: Mini Activations Unleashing Max Real-World Intelligence

We introduce the MiniMax-M2 series, a family of Mixture-of-Experts language models built around the principle that mini activations can unleash maximum real-world intelligence. The flagship M2 contains 229.9B total parameters with only 9.8B activated per token. Designed end-to-end for agentic deployment, the M2 series rests on three components: (i) agent-driven data pipelines producing large-scale, verifiable trajectories across agentic coding and agentic cowork, each grounded in an executable workspace and an artifact-aligned reward; (ii) Forge, a scalable agent-native RL system that adapts to long-horizon agent trajectories, paired with windowed-FIFO scheduling, prefix-tree merging, inference optimization, and a clean training-inference-agent decoupling that supports both white-box and black-box agents; (iii) the latest M2.7 checkpoint takes an early step toward self-evolution -- autonomously debugging training runs and modifying its own scaffold. Across M2 through M2.7, this combination translates a mini-activation footprint into frontier-tier performance on agentic coding, deep search, office-task, and reasoning benchmarks.

DART: Semantic Recoverability for Structured Tool Agents

When a structured tool agent fails mid-execution, the runtime faces a dilemma: replaying the entire task is safe but wasteful, while restoring from a local checkpoint is efficient but can leave committed downstream work tied to an upstream history that no longer exists. This tension is acute in commitment-sensitive settings, where rollback targets a single failed instance yet downstream consumers have already acted on its output. Existing recovery approaches provide mechanical rollback but no criterion for whether a local restore remains semantically valid after downstream commitment. We formalize this gap as semantic recoverability and address it in DART, a modular runtime that localizes the failed instance, certifies semantically recoverable boundaries of that instance, aligns checkpoints to those boundaries, and selects an admissible restore point that preserves committed downstream work under dependency and effect constraints-or blocks otherwise. Across three LLM-driven domains and external validation on a LangGraph-based substrate, DART correctly recovers all evaluated commitment-sensitive cases where baseline local recovery fails, and a five-domain safety audit finds no unsafe admitted rollbacks. These results show that controller legality does not imply semantic validity, and that sound local recovery requires an explicit admissibility check.

Code as Agent Harness

Recent large language models (LLMs) have demonstrated strong capabilities in understanding and generating code, from competitive programming to repository-level software engineering. In emerging agentic systems, code is no longer only a target output. It increasingly serves as an operational substrate for agent reasoning, acting, environment modeling, and execution-based verification. We frame this shift through the lens of agent harnesses and introduce code as agent harness: a unified view that centers code as the basis for agent infrastructure. To systematically study this perspective, we organize the survey around three connected layers. First, we study the harness interface, where code connects agents to reasoning, action, and environment modeling. Second, we examine harness mechanisms: planning, memory, and tool use for long-horizon execution, together with feedback-driven control and optimization that make harness reliable and adaptive. Third, we discuss scaling the harness from single-agent systems to multi-agent settings, where shared code artifacts support multi-agent coordination, review, and verification. Across these layers, we summarize representative methods and practical applications of code as agent harness, spanning coding assistants, GUI/OS automation, embodied agents, scientific discovery, personalization and recommendation, DevOps, and enterprise workflows. We further outline open challenges for harness engineering, including evaluation beyond final task success, verification under incomplete feedback, regression-free harness improvement, consistent shared state across multiple agents, human oversight for safety-critical actions, and extensions to multimodal environments. By centering code as the harness of agentic AI, this survey provides a unified roadmap toward executable, verifiable, and stateful AI agent systems.

Topology-Aware Skeleton Detection via Lighthouse-Guided Structured Inference

In natural images, object skeletons are used to represent geometric shapes. However, even slight variations in pose or movement can cause noticeable changes in skeleton structure, increasing the difficulty of detecting the skeleton and often resulting in discontinuous skeletons. Existing methods primarily focus on point-level skeleton point detection and overlook the importance of structural continuity in recovering complete skeletons. To address this issue, we propose Lighthouse-Skel, a topology-aware skeleton detection method via lighthouse-guided structured inference. Specifically, we introduce a dual-branch collaborative detection framework that jointly learns skeleton confidence field and structural anchors, including endpoints and junction points. The spatial distributions learned by the point branch guide the network to focus on topologically vulnerable regions, which improves the accuracy of skeleton detection. Based on the learned skeleton confidence field, we further propose a lighthouse-guided topology completion strategy, which uses detected junction points and breakpoints as lighthouses to reconnect discontinuous skeleton segments along low-cost paths, thereby improving skeleton continuity and structural integrity. Experimental results on four public datasets demonstrate that the proposed method achieves competitive detection accuracy while substantially improving skeleton connectivity and structural integrity.

Attention-guided Evidence Grounding for Spoken Question Answering

Spoken Question Answering (Spoken QA) presents a challenging cross-modal problem: effectively aligning acoustic queries with textual knowledge while avoiding the latency and error propagation inherent in cascaded ASR-based systems. In this paper, we introduce Attention-guided Evidence Grounding (AEG), a novel end-to-end framework that leverages the internal cross-modal attention of Speech Large Language Models (SpeechLLMs) to explicitly locate and ground key evidence in the model's latent space. To address the diffuse attention distribution in pre-trained models, we propose Learning to Focus on Evidence (LFE), a supervised fine-tuning paradigm that calibrates the model's attention mechanism to distinguish query-relevant segments from irrelevant context. Experiments on SQuAD, HotpotQA, and MuSiQue demonstrate that AEG reduces hallucinations and achieves strong efficiency gains, outperforming large-scale cascaded baselines (Whisper-Large-v3 + Reranker) while reducing inference latency by approximately 62%.

GUI-Libra: Training Native GUI Agents to Reason and Act with Action-aware Supervision and Partially Verifiable RL

Open-source native GUI agents still lag behind closed-source systems on long-horizon navigation tasks. This gap stems from two limitations: a shortage of high-quality, action-aligned reasoning data, and the direct adoption of generic post-training pipelines that overlook the unique challenges of GUI agents. We identify two fundamental issues in these pipelines: (i) standard SFT with CoT reasoning often hurts grounding, and (ii) step-wise RLVR-tyle training faces partial verifiability, where multiple actions can be correct but only a single demonstrated action is used for verification. This makes offline step-wise metrics weak predictors of online task success. In this work, we present GUI-Libra, a tailored training recipe that addresses these challenges. First, to mitigate the scarcity of action-aligned reasoning data, we introduce a data construction and filtering pipeline and release a curated 81K GUI reasoning dataset. Second, to reconcile reasoning with grounding, we propose action-aware SFT that mixes reasoning-then-action and direct-action data and reweights tokens to emphasize action and grounding. Third, to stabilize RL under partial verifiability, we identify the overlooked importance of KL regularization in RLVR and show that a KL trust region is critical for improving offline-to-online predictability; we further introduce success-adaptive scaling to downweight unreliable negative gradients. Across diverse web and mobile benchmarks, GUI-Libra consistently improves both step-wise accuracy and end-to-end task completion. Our results suggest that carefully designed post-training and data curation can unlock significantly stronger task-solving capabilities without costly online data collection. We release our dataset, code, and models to facilitate further research on data-efficient post-training for reasoning-capable GUI agents.