Multi-Class Segmentation of Aortic Branches and Zones in Computed Tomography Angiography: The AortaSeg24 Challenge

Multi-class segmentation of the aorta in computed tomography angiography (CTA) scans is essential for diagnosing and planning complex endovascular treatments for patients with aortic dissections. However, existing methods reduce aortic segmentation to a binary problem, limiting their ability to measure diameters across different branches and zones. Furthermore, no open-source dataset is currently available to support the development of multi-class aortic segmentation methods. To address this gap, we organized the AortaSeg24 MICCAI Challenge, introducing the first dataset of 100 CTA volumes annotated for 23 clinically relevant aortic branches and zones. This dataset was designed to facilitate both model development and validation. The challenge attracted 121 teams worldwide, with participants leveraging state-of-the-art frameworks such as nnU-Net and exploring novel techniques, including cascaded models, data augmentation strategies, and custom loss functions. We evaluated the submitted algorithms using the Dice Similarity Coefficient (DSC) and Normalized Surface Distance (NSD), highlighting the approaches adopted by the top five performing teams. This paper presents the challenge design, dataset details, evaluation metrics, and an in-depth analysis of the top-performing algorithms. The annotated dataset, evaluation code, and implementations of the leading methods are publicly available to support further research. All resources can be accessed at https://aortaseg24.grand-challenge.org.

Outlier Synthesis via Hamiltonian Monte Carlo for Out-of-Distribution Detection

Out-of-distribution (OOD) detection is crucial for developing trustworthy and reliable machine learning systems. Recent advances in training with auxiliary OOD data demonstrate efficacy in enhancing detection capabilities. Nonetheless, these methods heavily rely on acquiring a large pool of high-quality natural outliers. Some prior methods try to alleviate this problem by synthesizing virtual outliers but suffer from either poor quality or high cost due to the monotonous sampling strategy and the heavy-parameterized generative models. In this paper, we overcome all these problems by proposing the Hamiltonian Monte Carlo Outlier Synthesis (HamOS) framework, which views the synthesis process as sampling from Markov chains. Based solely on the in-distribution data, the Markov chains can extensively traverse the feature space and generate diverse and representative outliers, hence exposing the model to miscellaneous potential OOD scenarios. The Hamiltonian Monte Carlo with sampling acceptance rate almost close to 1 also makes our framework enjoy great efficiency. By empirically competing with SOTA baselines on both standard and large-scale benchmarks, we verify the efficacy and efficiency of our proposed HamOS.

Hyperbolic Hypergraph Neural Networks for Multi-Relational Knowledge Hypergraph Representation

Knowledge hypergraphs generalize knowledge graphs using hyperedges to connect multiple entities and depict complicated relations. Existing methods either transform hyperedges into an easier-to-handle set of binary relations or view hyperedges as isolated and ignore their adjacencies. Both approaches have information loss and may potentially lead to the creation of sub-optimal models. To fix these issues, we propose the Hyperbolic Hypergraph Neural Network (H2GNN), whose essential component is the hyper-star message passing, a novel scheme motivated by a lossless expansion of hyperedges into hierarchies. It implements a direct embedding that consciously incorporates adjacent entities, hyper-relations, and entity position-aware information. As the name suggests, H2GNN operates in the hyperbolic space, which is more adept at capturing the tree-like hierarchy. We compare H2GNN with 15 baselines on knowledge hypergraphs, and it outperforms state-of-the-art approaches in both node classification and link prediction tasks.

Preliminary Investigation into Data Scaling Laws for Imitation Learning-Based End-to-End Autonomous Driving

The end-to-end autonomous driving paradigm has recently attracted lots of attention due to its scalability. However, existing methods are constrained by the limited scale of real-world data, which hinders a comprehensive exploration of the scaling laws associated with end-to-end autonomous driving. To address this issue, we collected substantial data from various driving scenarios and behaviors and conducted an extensive study on the scaling laws of existing imitation learning-based end-to-end autonomous driving paradigms. Specifically, approximately 4 million demonstrations from 23 different scenario types were gathered, amounting to over 30,000 hours of driving demonstrations. We performed open-loop evaluations and closed-loop simulation evaluations in 1,400 diverse driving demonstrations (1,300 for open-loop and 100 for closed-loop) under stringent assessment conditions. Through experimental analysis, we discovered that (1) the performance of the driving model exhibits a power-law relationship with the amount of training data; (2) a small increase in the quantity of long-tailed data can significantly improve the performance for the corresponding scenarios; (3) appropriate scaling of data enables the model to achieve combinatorial generalization in novel scenes and actions. Our results highlight the critical role of data scaling in improving the generalizability of models across diverse autonomous driving scenarios, assuring safe deployment in the real world. Project repository: https://github.com/ucaszyp/Driving-Scaling-Law

Harnessing Knowledge Retrieval with Large Language Models for Clinical Report Error Correction

This study proposes an approach for error correction in clinical radiology reports, leveraging large language models (LLMs) and retrieval-augmented generation (RAG) techniques. The proposed framework employs internal and external retrieval mechanisms to extract relevant medical entities and relations from the report and external knowledge sources. A three-stage inference process is introduced, decomposing the task into error detection, localization, and correction subtasks, which enhances the explainability and performance of the system. The effectiveness of the approach is evaluated using a benchmark dataset created by corrupting real-world radiology reports with realistic errors, guided by domain experts. Experimental results demonstrate the benefits of the proposed methods, with the combination of internal and external retrieval significantly improving the accuracy of error detection, localization, and correction across various state-of-the-art LLMs. The findings contribute to the development of more robust and reliable error correction systems for clinical documentation.

Chain-of-Though (CoT) prompting strategies for medical error detection and correction

This paper describes our submission to the MEDIQA-CORR 2024 shared task for automatically detecting and correcting medical errors in clinical notes. We report results for three methods of few-shot In-Context Learning (ICL) augmented with Chain-of-Thought (CoT) and reason prompts using a large language model (LLM). In the first method, we manually analyse a subset of train and validation dataset to infer three CoT prompts by examining error types in the clinical notes. In the second method, we utilise the training dataset to prompt the LLM to deduce reasons about their correctness or incorrectness. The constructed CoTs and reasons are then augmented with ICL examples to solve the tasks of error detection, span identification, and error correction. Finally, we combine the two methods using a rule-based ensemble method. Across the three sub-tasks, our ensemble method achieves a ranking of 3rd for both sub-task 1 and 2, while securing 7th place in sub-task 3 among all submissions.

Fast-DDPM: Fast Denoising Diffusion Probabilistic Models for Medical Image-to-Image Generation

Denoising diffusion probabilistic models (DDPMs) have achieved unprecedented success in computer vision. However, they remain underutilized in medical imaging, a field crucial for disease diagnosis and treatment planning. This is primarily due to the high computational cost associated with (1) the use of large number of time steps (e.g., 1,000) in diffusion processes and (2) the increased dimensionality of medical images, which are often 3D or 4D. Training a diffusion model on medical images typically takes days to weeks, while sampling each image volume takes minutes to hours. To address this challenge, we introduce Fast-DDPM, a simple yet effective approach capable of improving training speed, sampling speed, and generation quality simultaneously. Unlike DDPM, which trains the image denoiser across 1,000 time steps, Fast-DDPM trains and samples using only 10 time steps. The key to our method lies in aligning the training and sampling procedures to optimize time-step utilization. Specifically, we introduced two efficient noise schedulers with 10 time steps: one with uniform time step sampling and another with non-uniform sampling. We evaluated Fast-DDPM across three medical image-to-image generation tasks: multi-image super-resolution, image denoising, and image-to-image translation. Fast-DDPM outperformed DDPM and current state-of-the-art methods based on convolutional networks and generative adversarial networks in all tasks. Additionally, Fast-DDPM reduced the training time to 0.2x and the sampling time to 0.01x compared to DDPM. Our code is publicly available at: https://github.com/mirthAI/Fast-DDPM.

Fast Denoising Diffusion Probabilistic Models for Medical Image-to-Image Generation

Denoising diffusion probabilistic models (DDPMs) have achieved unprecedented success in computer vision. However, they remain underutilized in medical imaging, a field crucial for disease diagnosis and treatment planning. This is primarily due to the high computational cost associated with (1) the use of large number of time steps (e.g., 1,000) in diffusion processes and (2) the increased dimensionality of medical images, which are often 3D or 4D. Training a diffusion model on medical images typically takes days to weeks, while sampling each image volume takes minutes to hours. To address this challenge, we introduce Fast-DDPM, a simple yet effective approach capable of improving training speed, sampling speed, and generation quality simultaneously. Unlike DDPM, which trains the image denoiser across 1,000 time steps, Fast-DDPM trains and samples using only 10 time steps. The key to our method lies in aligning the training and sampling procedures. We introduced two efficient noise schedulers with 10 time steps: one with uniform time step sampling and another with non-uniform sampling. We evaluated Fast-DDPM across three medical image-to-image generation tasks: multi-image super-resolution, image denoising, and image-to-image translation. Fast-DDPM outperformed DDPM and current state-of-the-art methods based on convolutional networks and generative adversarial networks in all tasks. Additionally, Fast-DDPM reduced training time by a factor of 5 and sampling time by a factor of 100 compared to DDPM. Our code is publicly available at: https://github.com/mirthAI/Fast-DDPM.

Weakly supervised alignment and registration of MR-CT for cervical cancer radiotherapy

Cervical cancer is one of the leading causes of death in women, and brachytherapy is currently the primary treatment method. However, it is important to precisely define the extent of paracervical tissue invasion to improve cancer diagnosis and treatment options. The fusion of the information characteristics of both computed tomography (CT) and magnetic resonance imaging(MRI) modalities may be useful in achieving a precise outline of the extent of paracervical tissue invasion. Registration is the initial step in information fusion. However, when aligning multimodal images with varying depths, manual alignment is prone to large errors and is time-consuming. Furthermore, the variations in the size of the Region of Interest (ROI) and the shape of multimodal images pose a significant challenge for achieving accurate registration.In this paper, we propose a preliminary spatial alignment algorithm and a weakly supervised multimodal registration network. The spatial position alignment algorithm efficiently utilizes the limited annotation information in the two modal images provided by the doctor to automatically align multimodal images with varying depths. By utilizing aligned multimodal images for weakly supervised registration and incorporating pyramidal features and cost volume to estimate the optical flow, the results indicate that the proposed method outperforms traditional volume rendering alignment methods and registration networks in various evaluation metrics. This demonstrates the effectiveness of our model in multimodal image registration.

A Subspace-Constrained Tyler's Estimator and its Applications to Structure from Motion

We present the subspace-constrained Tyler's estimator (STE) designed for recovering a low-dimensional subspace within a dataset that may be highly corrupted with outliers. STE is a fusion of the Tyler's M-estimator (TME) and a variant of the fast median subspace. Our theoretical analysis suggests that, under a common inlier-outlier model, STE can effectively recover the underlying subspace, even when it contains a smaller fraction of inliers relative to other methods in the field of robust subspace recovery. We apply STE in the context of Structure from Motion (SfM) in two ways: for robust estimation of the fundamental matrix and for the removal of outlying cameras, enhancing the robustness of the SfM pipeline. Numerical experiments confirm the state-of-the-art performance of our method in these applications. This research makes significant contributions to the field of robust subspace recovery, particularly in the context of computer vision and 3D reconstruction.