Adaptive Wavelet Filters as Practical Texture Feature Amplifiers for Parkinson's Disease Screening in OCT

Parkinson's disease (PD) is a prevalent neurodegenerative disorder globally. The eye's retina is an extension of the brain and has great potential in PD screening. Recent studies have suggested that texture features extracted from retinal layers can be adopted as biomarkers for PD diagnosis under optical coherence tomography (OCT) images. Frequency domain learning techniques can enhance the feature representations of deep neural networks (DNNs) by decomposing frequency components involving rich texture features. Additionally, previous works have not exploited texture features for automated PD screening in OCT. Motivated by the above analysis, we propose a novel Adaptive Wavelet Filter (AWF) that serves as the Practical Texture Feature Amplifier to fully leverage the merits of texture features to boost the PD screening performance of DNNs with the aid of frequency domain learning. Specifically, AWF first enhances texture feature representation diversities via channel mixer, then emphasizes informative texture feature representations with the well-designed adaptive wavelet filtering token mixer. By combining the AWFs with the DNN stem, AWFNet is constructed for automated PD screening. Additionally, we introduce a novel Balanced Confidence (BC) Loss by mining the potential of sample-wise predicted probabilities of all classes and class frequency prior, to further boost the PD screening performance and trustworthiness of AWFNet. The extensive experiments manifest the superiority of our AWFNet and BC over state-of-the-art methods in terms of PD screening performance and trustworthiness.

Primal-Dual Spectral Representation for Off-policy Evaluation

Off-policy evaluation (OPE) is one of the most fundamental problems in reinforcement learning (RL) to estimate the expected long-term payoff of a given target policy with only experiences from another behavior policy that is potentially unknown. The distribution correction estimation (DICE) family of estimators have advanced the state of the art in OPE by breaking the curse of horizon. However, the major bottleneck of applying DICE estimators lies in the difficulty of solving the saddle-point optimization involved, especially with neural network implementations. In this paper, we tackle this challenge by establishing a linear representation of value function and stationary distribution correction ratio, i.e., primal and dual variables in the DICE framework, using the spectral decomposition of the transition operator. Such primal-dual representation not only bypasses the non-convex non-concave optimization in vanilla DICE, therefore enabling an computational efficient algorithm, but also paves the way for more efficient utilization of historical data. We highlight that our algorithm, SpectralDICE, is the first to leverage the linear representation of primal-dual variables that is both computation and sample efficient, the performance of which is supported by a rigorous theoretical sample complexity guarantee and a thorough empirical evaluation on various benchmarks.

Scalable spectral representations for network multiagent control

Network Markov Decision Processes (MDPs), a popular model for multi-agent control, pose a significant challenge to efficient learning due to the exponential growth of the global state-action space with the number of agents. In this work, utilizing the exponential decay property of network dynamics, we first derive scalable spectral local representations for network MDPs, which induces a network linear subspace for the local $Q$-function of each agent. Building on these local spectral representations, we design a scalable algorithmic framework for continuous state-action network MDPs, and provide end-to-end guarantees for the convergence of our algorithm. Empirically, we validate the effectiveness of our scalable representation-based approach on two benchmark problems, and demonstrate the advantages of our approach over generic function approximation approaches to representing the local $Q$-functions.

Distributed Thompson sampling under constrained communication

In Bayesian optimization, a black-box function is maximized via the use of a surrogate model. We apply distributed Thompson sampling, using a Gaussian process as a surrogate model, to approach the multi-agent Bayesian optimization problem. In our distributed Thompson sampling implementation, each agent receives sampled points from neighbors, where the communication network is encoded in a graph; each agent utilizes a Gaussian process to model the objective function. We demonstrate a theoretical bound on Bayesian Simple Regret, where the bound depends on the size of the largest complete subgraph of the communication graph. Unlike in batch Bayesian optimization, this bound is applicable in cases where the communication graph amongst agents is constrained. When compared to sequential Thompson sampling, our bound guarantees faster convergence with respect to time as long as there is a fully connected subgraph of at least two agents. We confirm the efficacy of our algorithm with numerical simulations on traditional optimization test functions, illustrating the significance of graph connectivity on improving regret convergence.

Drift to Remember

Lifelong learning in artificial intelligence (AI) aims to mimic the biological brain's ability to continuously learn and retain knowledge, yet it faces challenges such as catastrophic forgetting. Recent neuroscience research suggests that neural activity in biological systems undergoes representational drift, where neural responses evolve over time, even with consistent inputs and tasks. We hypothesize that representational drift can alleviate catastrophic forgetting in AI during new task acquisition. To test this, we introduce DriftNet, a network designed to constantly explore various local minima in the loss landscape while dynamically retrieving relevant tasks. This approach ensures efficient integration of new information and preserves existing knowledge. Experimental studies in image classification and natural language processing demonstrate that DriftNet outperforms existing models in lifelong learning. Importantly, DriftNet is scalable in handling a sequence of tasks such as sentiment analysis and question answering using large language models (LLMs) with billions of parameters on a single Nvidia A100 GPU. DriftNet efficiently updates LLMs using only new data, avoiding the need for full dataset retraining. Tested on GPT-2 and RoBERTa, DriftNet is a robust, cost-effective solution for lifelong learning in LLMs. This study not only advances AI systems to emulate biological learning, but also provides insights into the adaptive mechanisms of biological neural systems, deepening our understanding of lifelong learning in nature.

Model-in-the-Loop (MILO): Accelerating Multimodal AI Data Annotation with LLMs

The growing demand for AI training data has transformed data annotation into a global industry, but traditional approaches relying on human annotators are often time-consuming, labor-intensive, and prone to inconsistent quality. We propose the Model-in-the-Loop (MILO) framework, which integrates AI/ML models into the annotation process. Our research introduces a collaborative paradigm that leverages the strengths of both professional human annotators and large language models (LLMs). By employing LLMs as pre-annotation and real-time assistants, and judges on annotator responses, MILO enables effective interaction patterns between human annotators and LLMs. Three empirical studies on multimodal data annotation demonstrate MILO's efficacy in reducing handling time, improving data quality, and enhancing annotator experiences. We also introduce quality rubrics for flexible evaluation and fine-grained feedback on open-ended annotations. The MILO framework has implications for accelerating AI/ML development, reducing reliance on human annotation alone, and promoting better alignment between human and machine values.

Enhancing Preference-based Linear Bandits via Human Response Time

Binary human choice feedback is widely used in interactive preference learning for its simplicity, but it provides limited information about preference strength. To overcome this limitation, we leverage human response times, which inversely correlate with preference strength, as complementary information. Our work integrates the EZ-diffusion model, which jointly models human choices and response times, into preference-based linear bandits. We introduce a computationally efficient utility estimator that reformulates the utility estimation problem using both choices and response times as a linear regression problem. Theoretical and empirical comparisons with traditional choice-only estimators reveal that for queries with strong preferences ("easy" queries), choices alone provide limited information, while response times offer valuable complementary information about preference strength. As a result, incorporating response times makes easy queries more useful. We demonstrate this advantage in the fixed-budget best-arm identification problem, with simulations based on three real-world datasets, consistently showing accelerated learning when response times are incorporated.

Towards Evaluating and Building Versatile Large Language Models for Medicine

In this study, we present MedS-Bench, a comprehensive benchmark designed to evaluate the performance of large language models (LLMs) in clinical contexts. Unlike existing benchmarks that focus on multiple-choice question answering, MedS-Bench spans 11 high-level clinical tasks, including clinical report summarization, treatment recommendations, diagnosis, named entity recognition, and medical concept explanation, among others. We evaluated six leading LLMs, e.g., MEDITRON, Mistral, InternLM 2, Llama 3, GPT-4, and Claude-3.5 using few-shot prompting, and found that even the most sophisticated models struggle with these complex tasks. To address these limitations, we developed MedS-Ins, a large-scale instruction tuning dataset for medicine. MedS-Ins comprises 58 medically oriented language corpora, totaling 13.5 million samples across 122 tasks. To demonstrate the dataset's utility, we conducted a proof-of-concept experiment by performing instruction tuning on a lightweight, open-source medical language model. The resulting model, MMedIns-Llama 3, significantly outperformed existing models across nearly all clinical tasks. To promote further advancements in the application of LLMs to clinical challenges, we have made the MedS-Ins dataset fully accessible and invite the research community to contribute to its expansion.Additionally, we have launched a dynamic leaderboard for MedS-Bench, which we plan to regularly update the test set to track progress and enhance the adaptation of general LLMs to the medical domain. Leaderboard: https://henrychur.github.io/MedS-Bench/. Github: https://github.com/MAGIC-AI4Med/MedS-Ins.

LDM-SVC: Latent Diffusion Model Based Zero-Shot Any-to-Any Singing Voice Conversion with Singer Guidance

Any-to-any singing voice conversion (SVC) is an interesting audio editing technique, aiming to convert the singing voice of one singer into that of another, given only a few seconds of singing data. However, during the conversion process, the issue of timbre leakage is inevitable: the converted singing voice still sounds like the original singer's voice. To tackle this, we propose a latent diffusion model for SVC (LDM-SVC) in this work, which attempts to perform SVC in the latent space using an LDM. We pretrain a variational autoencoder structure using the noted open-source So-VITS-SVC project based on the VITS framework, which is then used for the LDM training. Besides, we propose a singer guidance training method based on classifier-free guidance to further suppress the timbre of the original singer. Experimental results show the superiority of the proposed method over previous works in both subjective and objective evaluations of timbre similarity.

Support-Query Prototype Fusion Network for Few-shot Medical Image Segmentation

In recent years, deep learning based on Convolutional Neural Networks (CNNs) has achieved remarkable success in many applications. However, their heavy reliance on extensive labeled data and limited generalization ability to unseen classes pose challenges to their suitability for medical image processing tasks. Few-shot learning, which utilizes a small amount of labeled data to generalize to unseen classes, has emerged as a critical research area, attracting substantial attention. Currently, most studies employ a prototype-based approach, in which prototypical networks are used to construct prototypes from the support set, guiding the processing of the query set to obtain the final results. While effective, this approach heavily relies on the support set while neglecting the query set, resulting in notable disparities within the model classes. To mitigate this drawback, we propose a novel Support-Query Prototype Fusion Network (SQPFNet). SQPFNet initially generates several support prototypes for the foreground areas of the support images, thus producing a coarse segmentation mask. Subsequently, a query prototype is constructed based on the coarse segmentation mask, additionally exploiting pattern information in the query set. Thus, SQPFNet constructs high-quality support-query fused prototypes, upon which the query image is segmented to obtain the final refined query mask. Evaluation results on two public datasets, SABS and CMR, show that SQPFNet achieves state-of-the-art performance.