Deep Learning-Based Longitudinal Prediction of Childhood Myopia Progression Using Fundus Image Sequences and Baseline Refraction Data

Childhood myopia constitutes a significant global health concern. It exhibits an escalating prevalence and has the potential to evolve into severe, irreversible conditions that detrimentally impact familial well-being and create substantial economic costs. Contemporary research underscores the importance of precisely predicting myopia progression to enable timely and effective interventions, thereby averting severe visual impairment in children. Such predictions predominantly rely on subjective clinical assessments, which are inherently biased and resource-intensive, thus hindering their widespread application. In this study, we introduce a novel, high-accuracy method for quantitatively predicting the myopic trajectory and myopia risk in children using only fundus images and baseline refraction data. This approach was validated through a six-year longitudinal study of 3,408 children in Henan, utilizing 16,211 fundus images and corresponding refractive data. Our method based on deep learning demonstrated predictive accuracy with an error margin of 0.311D per year and AUC scores of 0.944 and 0.995 for forecasting the risks of developing myopia and high myopia, respectively. These findings confirm the utility of our model in supporting early intervention strategies and in significantly reducing healthcare costs, particularly by obviating the need for additional metadata and repeated consultations. Furthermore, our method was designed to rely only on fundus images and refractive error data, without the need for meta data or multiple inquiries from doctors, strongly reducing the associated medical costs and facilitating large-scale screening. Our model can even provide good predictions based on only a single time measurement. Consequently, the proposed method is an important means to reduce medical inequities caused by economic disparities.

Interference Mitigation in LEO Constellations with Limited Radio Environment Information

This research paper delves into interference mitigation within Low Earth Orbit (LEO) satellite constellations, particularly when operating under constraints of limited radio environment information. Leveraging cognitive capabilities facilitated by the Radio Environment Map (REM), we explore strategies to mitigate the impact of both intentional and unintentional interference using planar antenna array (PAA) beamforming techniques. We address the complexities encountered in the design of beamforming weights, a challenge exacerbated by the array size and the increasing number of directions of interest and avoidance. Furthermore, we conduct an extensive analysis of beamforming performance from various perspectives associated with limited REM information: static versus dynamic, partial versus full, and perfect versus imperfect. To substantiate our findings, we provide simulation results and offer conclusions based on the outcomes of our investigation.

An Index Policy Based on Sarsa and Q-learning for Heterogeneous Smart Target Tracking

In solving the non-myopic radar scheduling for multiple smart target tracking within an active and passive radar network, we need to consider both short-term enhanced tracking performance and a higher probability of target maneuvering in the future with active tracking. Acquiring the long-term tracking performance while scheduling the beam resources of active and passive radars poses a challenge. To address this challenge, we model this problem as a Markov decision process consisting of parallel restless bandit processes. Each bandit process is associated with a smart target, of which the estimation state evolves according to different discrete dynamic models for different actions - whether or not the target is being tracked. The discrete state is defined by the dynamic mode. The problem exhibits the curse of dimensionality, where optimal solutions are in general intractable. We resort to heuristics through the famous restless multi-armed bandit techniques. It follows with efficient scheduling policies based on the indices that are real numbers representing the marginal rewards of taking different actions. For the inevitable practical case with unknown transition matrices, we propose a new method that utilizes the forward Sarsa and backward Q-learning to approximate the indices through adapting the state-action value functions, or equivalently the Q-functions, and propose a new policy, namely ISQ, aiming to maximize the long-term tracking rewards. Numerical results demonstrate that the proposed ISQ policy outperforms conventional Q-learning-based methods and rapidly converges to the well-known Whittle index policy with revealed state transition models, which is considered the benchmark.

Joint State Estimation and Noise Identification Based on Variational Optimization

In this article, the state estimation problems with unknown process noise and measurement noise covariances for both linear and nonlinear systems are considered. By formulating the joint estimation of system state and noise parameters into an optimization problem, a novel adaptive Kalman filter method based on conjugate-computation variational inference, referred to as CVIAKF, is proposed to approximate the joint posterior probability density function of the latent variables. Unlike the existing adaptive Kalman filter methods utilizing variational inference in natural-parameter space, CVIAKF performs optimization in expectation-parameter space, resulting in a faster and simpler solution. Meanwhile, CVIAKF divides optimization objectives into conjugate and non-conjugate parts of nonlinear dynamical models, whereas conjugate computations and stochastic mirror-descent are applied, respectively. Remarkably, the reparameterization trick is used to reduce the variance of stochastic gradients of the non-conjugate parts. The effectiveness of CVIAKF is validated through synthetic and real-world datasets of maneuvering target tracking.

Experts' cognition-driven ensemble deep learning for external validation of predicting pathological complete response to neoadjuvant chemotherapy from histological images in breast cancer

In breast cancer imaging, there has been a trend to directly predict pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) from histological images based on deep learning (DL). However, it has been a commonly known problem that the constructed DL-based models numerically have better performances in internal validation than in external validation. The primary reason for this situation lies in that the distribution of the external data for validation is different from the distribution of the training data for the construction of the predictive model. In this paper, we aim to alleviate this situation with a more intrinsic approach. We propose an experts' cognition-driven ensemble deep learning (ECDEDL) approach for external validation of predicting pCR to NAC from histological images in breast cancer. The proposed ECDEDL, which takes the cognition of both pathology and artificial intelligence experts into consideration to improve the generalization of the predictive model to the external validation, more intrinsically approximates the working paradigm of a human being which will refer to his various working experiences to make decisions. The proposed ECDEDL approach was validated with 695 WSIs collected from the same center as the primary dataset to develop the predictive model and perform the internal validation, and 340 WSIs collected from other three centers as the external dataset to perform the external validation. In external validation, the proposed ECDEDL approach improves the AUCs of pCR prediction from 61.52(59.80-63.26) to 67.75(66.74-68.80) and the Accuracies of pCR prediction from 56.09(49.39-62.79) to 71.01(69.44-72.58). The proposed ECDEDL was quite effective for external validation, numerically more approximating the internal validation.