HC$^3$L-Diff: Hybrid conditional latent diffusion with high frequency enhancement for CBCT-to-CT synthesis

Background: Cone-beam computed tomography (CBCT) plays a crucial role in image-guided radiotherapy, but artifacts and noise make them unsuitable for accurate dose calculation. Artificial intelligence methods have shown promise in enhancing CBCT quality to produce synthetic CT (sCT) images. However, existing methods either produce images of suboptimal quality or incur excessive time costs, failing to satisfy clinical practice standards. Methods and materials: We propose a novel hybrid conditional latent diffusion model for efficient and accurate CBCT-to-CT synthesis, named HC$^3$L-Diff. We employ the Unified Feature Encoder (UFE) to compress images into a low-dimensional latent space, thereby optimizing computational efficiency. Beyond the use of CBCT images, we propose integrating its high-frequency knowledge as a hybrid condition to guide the diffusion model in generating sCT images with preserved structural details. This high-frequency information is captured using our designed High-Frequency Extractor (HFE). During inference, we utilize denoising diffusion implicit model to facilitate rapid sampling. We construct a new in-house prostate dataset with paired CBCT and CT to validate the effectiveness of our method. Result: Extensive experimental results demonstrate that our approach outperforms state-of-the-art methods in terms of sCT quality and generation efficiency. Moreover, our medical physicist conducts the dosimetric evaluations to validate the benefit of our method in practical dose calculation, achieving a remarkable 93.8% gamma passing rate with a 2%/2mm criterion, superior to other methods. Conclusion: The proposed HC$^3$L-Diff can efficiently achieve high-quality CBCT-to-CT synthesis in only over 2 mins per patient. Its promising performance in dose calculation shows great potential for enhancing real-world adaptive radiotherapy.

Performance Analysis of Pair-wise Symbol Detection in Uplink NOMA-ISaC Systems

This paper investigates the bit error rate (BER) and outage probability performance of integrated sensing and communication (ISaC) in uplink non-orthogonal multiple access (NOMA) based Internet of Things (IoT) systems. Specifically, we consider an ISaC system where the radar signal is designed to be orthogonal to the communication signal over two symbol periods so that its interference on the communication signal is completely eliminated when detecting the data in pairs of consecutive symbols. This is akin to multi-symbol rate NOMA systems except in this case as the radar bears no data, its waveform is manipulated to be orthogonal to the transmitted communication signal. To eliminate potential decision ambiguity during the pair-wise data detection, a constant phase-offset between adjacent communication symbols is applied at the transmitter. The performance of such a system is analyzed through deriving analytical expressions for the exact BER of zero-forcing (ZF) based receivers. In addition, close-form expressions for the upper BER bound and the outage probability for both ZF and the joint maximum likelihood (JML) receivers are presented. The results show that the derived expressions are perfectly matched with the simulation results. The obtained expressions provide an insight into the performance of this novel ISaC system including demonstrating the impact of various parameters and showing how the ZF receiver provides a useful trade-off between performance and complexity relative to the JML receiver.

Surgical SAM 2: Real-time Segment Anything in Surgical Video by Efficient Frame Pruning

Surgical video segmentation is a critical task in computer-assisted surgery and is vital for enhancing surgical quality and patient outcomes. Recently, the Segment Anything Model 2 (SAM2) framework has shown superior advancements in image and video segmentation. However, SAM2 struggles with efficiency due to the high computational demands of processing high-resolution images and complex and long-range temporal dynamics in surgical videos. To address these challenges, we introduce Surgical SAM 2 (SurgSAM-2), an advanced model to utilize SAM2 with an Efficient Frame Pruning (EFP) mechanism, to facilitate real-time surgical video segmentation. The EFP mechanism dynamically manages the memory bank by selectively retaining only the most informative frames, reducing memory usage and computational cost while maintaining high segmentation accuracy. Our extensive experiments demonstrate that SurgSAM-2 significantly improves both efficiency and segmentation accuracy compared to the vanilla SAM2. Remarkably, SurgSAM-2 achieves a 3$\times$ FPS compared with SAM2, while also delivering state-of-the-art performance after fine-tuning with lower-resolution data. These advancements establish SurgSAM-2 as a leading model for surgical video analysis, making real-time surgical video segmentation in resource-constrained environments a feasible reality.

Drag Your Noise: Interactive Point-based Editing via Diffusion Semantic Propagation

Point-based interactive editing serves as an essential tool to complement the controllability of existing generative models. A concurrent work, DragDiffusion, updates the diffusion latent map in response to user inputs, causing global latent map alterations. This results in imprecise preservation of the original content and unsuccessful editing due to gradient vanishing. In contrast, we present DragNoise, offering robust and accelerated editing without retracing the latent map. The core rationale of DragNoise lies in utilizing the predicted noise output of each U-Net as a semantic editor. This approach is grounded in two critical observations: firstly, the bottleneck features of U-Net inherently possess semantically rich features ideal for interactive editing; secondly, high-level semantics, established early in the denoising process, show minimal variation in subsequent stages. Leveraging these insights, DragNoise edits diffusion semantics in a single denoising step and efficiently propagates these changes, ensuring stability and efficiency in diffusion editing. Comparative experiments reveal that DragNoise achieves superior control and semantic retention, reducing the optimization time by over 50% compared to DragDiffusion. Our codes are available at https://github.com/haofengl/DragNoise.

A Generic Fundus Image Enhancement Network Boosted by Frequency Self-supervised Representation Learning

Fundus photography is prone to suffer from image quality degradation that impacts clinical examination performed by ophthalmologists or intelligent systems. Though enhancement algorithms have been developed to promote fundus observation on degraded images, high data demands and limited applicability hinder their clinical deployment. To circumvent this bottleneck, a generic fundus image enhancement network (GFE-Net) is developed in this study to robustly correct unknown fundus images without supervised or extra data. Levering image frequency information, self-supervised representation learning is conducted to learn robust structure-aware representations from degraded images. Then with a seamless architecture that couples representation learning and image enhancement, GFE-Net can accurately correct fundus images and meanwhile preserve retinal structures. Comprehensive experiments are implemented to demonstrate the effectiveness and advantages of GFE-Net. Compared with state-of-the-art algorithms, GFE-Net achieves superior performance in data dependency, enhancement performance, deployment efficiency, and scale generalizability. Follow-up fundus image analysis is also facilitated by GFE-Net, whose modules are respectively verified to be effective for image enhancement.

Degradation-invariant Enhancement of Fundus Images via Pyramid Constraint Network

As an economical and efficient fundus imaging modality, retinal fundus images have been widely adopted in clinical fundus examination. Unfortunately, fundus images often suffer from quality degradation caused by imaging interferences, leading to misdiagnosis. Despite impressive enhancement performances that state-of-the-art methods have achieved, challenges remain in clinical scenarios. For boosting the clinical deployment of fundus image enhancement, this paper proposes the pyramid constraint to develop a degradation-invariant enhancement network (PCE-Net), which mitigates the demand for clinical data and stably enhances unknown data. Firstly, high-quality images are randomly degraded to form sequences of low-quality ones sharing the same content (SeqLCs). Then individual low-quality images are decomposed to Laplacian pyramid features (LPF) as the multi-level input for the enhancement. Subsequently, a feature pyramid constraint (FPC) for the sequence is introduced to enforce the PCE-Net to learn a degradation-invariant model. Extensive experiments have been conducted under the evaluation metrics of enhancement and segmentation. The effectiveness of the PCE-Net was demonstrated in comparison with state-of-the-art methods and the ablation study. The source code of this study is publicly available at https://github.com/HeverLaw/PCENet-Image-Enhancement.

Structure-consistent Restoration Network for Cataract Fundus Image Enhancement

Fundus photography is a routine examination in clinics to diagnose and monitor ocular diseases. However, for cataract patients, the fundus image always suffers quality degradation caused by the clouding lens. The degradation prevents reliable diagnosis by ophthalmologists or computer-aided systems. To improve the certainty in clinical diagnosis, restoration algorithms have been proposed to enhance the quality of fundus images. Unfortunately, challenges remain in the deployment of these algorithms, such as collecting sufficient training data and preserving retinal structures. In this paper, to circumvent the strict deployment requirement, a structure-consistent restoration network (SCR-Net) for cataract fundus images is developed from synthesized data that shares an identical structure. A cataract simulation model is firstly designed to collect synthesized cataract sets (SCS) formed by cataract fundus images sharing identical structures. Then high-frequency components (HFCs) are extracted from the SCS to constrain structure consistency such that the structure preservation in SCR-Net is enforced. The experiments demonstrate the effectiveness of SCR-Net in the comparison with state-of-the-art methods and the follow-up clinical applications. The code is available at https://github.com/liamheng/ArcNet-Medical-Image-Enhancement.

An Annotation-free Restoration Network for Cataractous Fundus Images

Cataracts are the leading cause of vision loss worldwide. Restoration algorithms are developed to improve the readability of cataract fundus images in order to increase the certainty in diagnosis and treatment for cataract patients. Unfortunately, the requirement of annotation limits the application of these algorithms in clinics. This paper proposes a network to annotation-freely restore cataractous fundus images (ArcNet) so as to boost the clinical practicability of restoration. Annotations are unnecessary in ArcNet, where the high-frequency component is extracted from fundus images to replace segmentation in the preservation of retinal structures. The restoration model is learned from the synthesized images and adapted to real cataract images. Extensive experiments are implemented to verify the performance and effectiveness of ArcNet. Favorable performance is achieved using ArcNet against state-of-the-art algorithms, and the diagnosis of ocular fundus diseases in cataract patients is promoted by ArcNet. The capability of properly restoring cataractous images in the absence of annotated data promises the proposed algorithm outstanding clinical practicability.

FIRL: Fast Imitation and Policy Reuse Learning

Intelligent robotics policies have been widely researched for challenging applications such as opening doors, washing dishes, and table organization. We refer to a "Policy Pool", containing skills that be easily accessed and reused. There are researches to leverage the pool, such as policy reuse, modular learning, assembly learning, transfer learning, hierarchical reinforcement learning (HRL), etc. However, most methods generally do not perform well in learning efficiency and require large datasets for training. This work focuses on enabling fast learning based on the policy pool. It should learn fast enough in one-shot or few-shot by avoiding learning from scratch. We also allow it to interact and learn from humans, but the training period should be within minutes. We propose FIRL, Fast (one-shot) Imitation, and Policy Reuse Learning. Instead of learning a new skill from scratch, it performs the one-shot imitation learning on the higher layer under a 2-layer hierarchical mechanism. Our method reduces a complex task learning to a simple regression problem that it could solve in a few offline iterations. The agent could have a good command of a new task given a one-shot demonstration. We demonstrate this method on the OpenDoors mini-grid environment, and the code is available on http://www.github.com/yiwc/firl.

Improving Learning from Demonstrations by Learning from Experience

How to make imitation learning more general when demonstrations are relatively limited has been a persistent problem in reinforcement learning (RL). Poor demonstrations lead to narrow and biased date distribution, non-Markovian human expert demonstration makes it difficult for the agent to learn, and over-reliance on sub-optimal trajectories can make it hard for the agent to improve its performance. To solve these problems we propose a new algorithm named TD3fG that can smoothly transition from learning from experts to learning from experience. Our algorithm achieves good performance in the MUJOCO environment with limited and sub-optimal demonstrations. We use behavior cloning to train the network as a reference action generator and utilize it in terms of both loss function and exploration noise. This innovation can help agents extract a priori knowledge from demonstrations while reducing the detrimental effects of the poor Markovian properties of the demonstrations. It has a better performance compared to the BC+ fine-tuning and DDPGfD approach, especially when the demonstrations are relatively limited. We call our method TD3fG meaning TD3 from a generator.