Fundus2Globe: Generative AI-Driven 3D Digital Twins for Personalized Myopia Management

Myopia, projected to affect 50% population globally by 2050, is a leading cause of vision loss. Eyes with pathological myopia exhibit distinctive shape distributions, which are closely linked to the progression of vision-threatening complications. Recent understanding of eye-shape-based biomarkers requires magnetic resonance imaging (MRI), however, it is costly and unrealistic in routine ophthalmology clinics. We present Fundus2Globe, the first AI framework that synthesizes patient-specific 3D eye globes from ubiquitous 2D color fundus photographs (CFPs) and routine metadata (axial length, spherical equivalent), bypassing MRI dependency. By integrating a 3D morphable eye model (encoding biomechanical shape priors) with a latent diffusion model, our approach achieves submillimeter accuracy in reconstructing posterior ocular anatomy efficiently. Fundus2Globe uniquely quantifies how vision-threatening lesions (e.g., staphylomas) in CFPs correlate with MRI-validated 3D shape abnormalities, enabling clinicians to simulate posterior segment changes in response to refractive shifts. External validation demonstrates its robust generation performance, ensuring fairness across underrepresented groups. By transforming 2D fundus imaging into 3D digital replicas of ocular structures, Fundus2Globe is a gateway for precision ophthalmology, laying the foundation for AI-driven, personalized myopia management.

FFA Sora, video generation as fundus fluorescein angiography simulator

Fundus fluorescein angiography (FFA) is critical for diagnosing retinal vascular diseases, but beginners often struggle with image interpretation. This study develops FFA Sora, a text-to-video model that converts FFA reports into dynamic videos via a Wavelet-Flow Variational Autoencoder (WF-VAE) and a diffusion transformer (DiT). Trained on an anonymized dataset, FFA Sora accurately simulates disease features from the input text, as confirmed by objective metrics: Frechet Video Distance (FVD) = 329.78, Learned Perceptual Image Patch Similarity (LPIPS) = 0.48, and Visual-question-answering Score (VQAScore) = 0.61. Specific evaluations showed acceptable alignment between the generated videos and textual prompts, with BERTScore of 0.35. Additionally, the model demonstrated strong privacy-preserving performance in retrieval evaluations, achieving an average Recall@K of 0.073. Human assessments indicated satisfactory visual quality, with an average score of 1.570(scale: 1 = best, 5 = worst). This model addresses privacy concerns associated with sharing large-scale FFA data and enhances medical education.

EyeDiff: text-to-image diffusion model improves rare eye disease diagnosis

The rising prevalence of vision-threatening retinal diseases poses a significant burden on the global healthcare systems. Deep learning (DL) offers a promising solution for automatic disease screening but demands substantial data. Collecting and labeling large volumes of ophthalmic images across various modalities encounters several real-world challenges, especially for rare diseases. Here, we introduce EyeDiff, a text-to-image model designed to generate multimodal ophthalmic images from natural language prompts and evaluate its applicability in diagnosing common and rare diseases. EyeDiff is trained on eight large-scale datasets using the advanced latent diffusion model, covering 14 ophthalmic image modalities and over 80 ocular diseases, and is adapted to ten multi-country external datasets. The generated images accurately capture essential lesional characteristics, achieving high alignment with text prompts as evaluated by objective metrics and human experts. Furthermore, integrating generated images significantly enhances the accuracy of detecting minority classes and rare eye diseases, surpassing traditional oversampling methods in addressing data imbalance. EyeDiff effectively tackles the issue of data imbalance and insufficiency typically encountered in rare diseases and addresses the challenges of collecting large-scale annotated images, offering a transformative solution to enhance the development of expert-level diseases diagnosis models in ophthalmic field.

Subgraph Aggregation for Out-of-Distribution Generalization on Graphs

Out-of-distribution (OOD) generalization in Graph Neural Networks (GNNs) has gained significant attention due to its critical importance in graph-based predictions in real-world scenarios. Existing methods primarily focus on extracting a single causal subgraph from the input graph to achieve generalizable predictions. However, relying on a single subgraph can lead to susceptibility to spurious correlations and is insufficient for learning invariant patterns behind graph data. Moreover, in many real-world applications, such as molecular property prediction, multiple critical subgraphs may influence the target label property. To address these challenges, we propose a novel framework, SubGraph Aggregation (SuGAr), designed to learn a diverse set of subgraphs that are crucial for OOD generalization on graphs. Specifically, SuGAr employs a tailored subgraph sampler and diversity regularizer to extract a diverse set of invariant subgraphs. These invariant subgraphs are then aggregated by averaging their representations, which enriches the subgraph signals and enhances coverage of the underlying causal structures, thereby improving OOD generalization. Extensive experiments on both synthetic and real-world datasets demonstrate that \ours outperforms state-of-the-art methods, achieving up to a 24% improvement in OOD generalization on graphs. To the best of our knowledge, this is the first work to study graph OOD generalization by learning multiple invariant subgraphs.

CTA-Net: A CNN-Transformer Aggregation Network for Improving Multi-Scale Feature Extraction

Convolutional neural networks (CNNs) and vision transformers (ViTs) have become essential in computer vision for local and global feature extraction. However, aggregating these architectures in existing methods often results in inefficiencies. To address this, the CNN-Transformer Aggregation Network (CTA-Net) was developed. CTA-Net combines CNNs and ViTs, with transformers capturing long-range dependencies and CNNs extracting localized features. This integration enables efficient processing of detailed local and broader contextual information. CTA-Net introduces the Light Weight Multi-Scale Feature Fusion Multi-Head Self-Attention (LMF-MHSA) module for effective multi-scale feature integration with reduced parameters. Additionally, the Reverse Reconstruction CNN-Variants (RRCV) module enhances the embedding of CNNs within the transformer architecture. Extensive experiments on small-scale datasets with fewer than 100,000 samples show that CTA-Net achieves superior performance (TOP-1 Acc 86.76\%), fewer parameters (20.32M), and greater efficiency (FLOPs 2.83B), making it a highly efficient and lightweight solution for visual tasks on small-scale datasets (fewer than 100,000).

Edge Unlearning is Not "on Edge"! An Adaptive Exact Unlearning System on Resource-Constrained Devices

The right to be forgotten mandates that machine learning models enable the erasure of a data owner's data and information from a trained model. Removing data from the dataset alone is inadequate, as machine learning models can memorize information from the training data, increasing the potential privacy risk to users. To address this, multiple machine unlearning techniques have been developed and deployed. Among them, approximate unlearning is a popular solution, but recent studies report that its unlearning effectiveness is not fully guaranteed. Another approach, exact unlearning, tackles this issue by discarding the data and retraining the model from scratch, but at the cost of considerable computational and memory resources. However, not all devices have the capability to perform such retraining. In numerous machine learning applications, such as edge devices, Internet-of-Things (IoT), mobile devices, and satellites, resources are constrained, posing challenges for deploying existing exact unlearning methods. In this study, we propose a Constraint-aware Adaptive Exact Unlearning System at the network Edge (CAUSE), an approach to enabling exact unlearning on resource-constrained devices. Aiming to minimize the retrain overhead by storing sub-models on the resource-constrained device, CAUSE innovatively applies a Fibonacci-based replacement strategy and updates the number of shards adaptively in the user-based data partition process. To further improve the effectiveness of memory usage, CAUSE leverages the advantage of model pruning to save memory via compression with minimal accuracy sacrifice. The experimental results demonstrate that CAUSE significantly outperforms other representative systems in realizing exact unlearning on the resource-constrained device by 9.23%-80.86%, 66.21%-83.46%, and 5.26%-194.13% in terms of unlearning speed, energy consumption, and accuracy.

Fine-grained Classification of Port Wine Stains Using Optical Coherence Tomography Angiography

Accurate classification of port wine stains (PWS, vascular malformations present at birth), is critical for subsequent treatment planning. However, the current method of classifying PWS based on the external skin appearance rarely reflects the underlying angiopathological heterogeneity of PWS lesions, resulting in inconsistent outcomes with the common vascular-targeted photodynamic therapy (V-PDT) treatments. Conversely, optical coherence tomography angiography (OCTA) is an ideal tool for visualizing the vascular malformations of PWS. Previous studies have shown no significant correlation between OCTA quantitative metrics and the PWS subtypes determined by the current classification approach. This study proposes a new classification approach for PWS using both OCT and OCTA. By examining the hypodermic histopathology and vascular structure of PWS, we have devised a fine-grained classification method that subdivides PWS into five distinct types. To assess the angiopathological differences of various PWS subtypes, we have analyzed six metrics related to vascular morphology and depth information of PWS lesions. The five PWS types present significant differences across all metrics compared to the conventional subtypes. Our findings suggest that an angiopathology-based classification accurately reflects the heterogeneity in PWS lesions. This research marks the first attempt to classify PWS based on angiopathology, potentially guiding more effective subtyping and treatment strategies for PWS.

ADRS-CNet: An adaptive models of dimensionality reduction methods for DNA storage clustering algorithms

DNA storage technology, with its high density, long-term preservation capability, low maintenance requirements, and compact physical size, is emerging as a promising option for large-scale data storage. However, extracting features from DNA sequences of varying lengths can lead to the problem of dimensionality, which needs to be addressed. Techniques such as PCA, UMAP, and t-SNE are commonly used to project high-dimensional data into a lower-dimensional space, but their effectiveness varies across different datasets. To address this challenge, this paper proposes a model based on a multilayer perceptron (MLP) that classifies DNA sequence features and intelligently selects the optimal dimensionality reduction method, thereby enhancing subsequent clustering performance. Experimental results, tested on open-source datasets and compared with multiple benchmark methods, demonstrate that our model not only excels in classification performance but also significantly improves clustering accuracy, indicating that this approach effectively mitigates the challenges posed by high-dimensional features in clustering models.

YOLO-pdd: A Novel Multi-scale PCB Defect Detection Method Using Deep Representations with Sequential Images

With the rapid growth of the PCB manufacturing industry, there is an increasing demand for computer vision inspection to detect defects during production. Improving the accuracy and generalization of PCB defect detection models remains a significant challenge. This paper proposes a high-precision, robust, and real-time end-to-end method for PCB defect detection based on deep Convolutional Neural Networks (CNN). Traditional methods often suffer from low accuracy and limited applicability. We propose a novel approach combining YOLOv5 and multiscale modules for hierarchical residual-like connections. In PCB defect detection, noise can confuse the background and small targets. The YOLOv5 model provides a strong foundation with its real-time processing and accurate object detection capabilities. The multi-scale module extends traditional approaches by incorporating hierarchical residual-like connections within a single block, enabling multiscale feature extraction. This plug-and-play module significantly enhances performance by extracting features at multiple scales and levels, which are useful for identifying defects of varying sizes and complexities. Our multi-scale architecture integrates feature extraction, defect localization, and classification into a unified network. Experiments on a large-scale PCB dataset demonstrate significant improvements in precision, recall, and F1-score compared to existing methods. This work advances computer vision inspection for PCB defect detection, providing a reliable solution for high-precision, robust, real-time, and domain-adaptive defect detection in the PCB manufacturing industry.

Diffusion-Aided Joint Source Channel Coding For High Realism Wireless Image Transmission

Deep learning-based joint source-channel coding (deep JSCC) has been demonstrated as an effective approach for wireless image transmission. Nevertheless, current research has concentrated on minimizing a standard distortion metric such as Mean Squared Error (MSE), which does not necessarily improve the perceptual quality. To address this issue, we propose DiffJSCC, a novel framework that leverages pre-trained text-to-image diffusion models to enhance the realism of images transmitted over the channel. The proposed DiffJSCC utilizes prior deep JSCC frameworks to deliver an initial reconstructed image at the receiver. Then, the spatial and textual features are extracted from the initial reconstruction, which, together with the channel state information (e.g., signal-to-noise ratio, SNR), are passed to a control module to fine-tune the pre-trained Stable Diffusion model. Extensive experiments on the Kodak dataset reveal that our method significantly surpasses both conventional methods and prior deep JSCC approaches on perceptual metrics such as LPIPS and FID scores, especially with poor channel conditions and limited bandwidth. Notably, DiffJSCC can achieve highly realistic reconstructions for 768x512 pixel Kodak images with only 3072 symbols (<0.008 symbols per pixel) under 1dB SNR. Our code will be released in https://github.com/mingyuyng/DiffJSCC.