High-Fidelity Document Stain Removal via A Large-Scale Real-World Dataset and A Memory-Augmented Transformer

Document images are often degraded by various stains, significantly impacting their readability and hindering downstream applications such as document digitization and analysis. The absence of a comprehensive stained document dataset has limited the effectiveness of existing document enhancement methods in removing stains while preserving fine-grained details. To address this challenge, we construct StainDoc, the first large-scale, high-resolution ($2145\times2245$) dataset specifically designed for document stain removal. StainDoc comprises over 5,000 pairs of stained and clean document images across multiple scenes. This dataset encompasses a diverse range of stain types, severities, and document backgrounds, facilitating robust training and evaluation of document stain removal algorithms. Furthermore, we propose StainRestorer, a Transformer-based document stain removal approach. StainRestorer employs a memory-augmented Transformer architecture that captures hierarchical stain representations at part, instance, and semantic levels via the DocMemory module. The Stain Removal Transformer (SRTransformer) leverages these feature representations through a dual attention mechanism: an enhanced spatial attention with an expanded receptive field, and a channel attention captures channel-wise feature importance. This combination enables precise stain removal while preserving document content integrity. Extensive experiments demonstrate StainRestorer's superior performance over state-of-the-art methods on the StainDoc dataset and its variants StainDoc\_Mark and StainDoc\_Seal, establishing a new benchmark for document stain removal. Our work highlights the potential of memory-augmented Transformers for this task and contributes a valuable dataset to advance future research.

Test-Time Intensity Consistency Adaptation for Shadow Detection

Shadow detection is crucial for accurate scene understanding in computer vision, yet it is challenged by the diverse appearances of shadows caused by variations in illumination, object geometry, and scene context. Deep learning models often struggle to generalize to real-world images due to the limited size and diversity of training datasets. To address this, we introduce TICA, a novel framework that leverages light-intensity information during test-time adaptation to enhance shadow detection accuracy. TICA exploits the inherent inconsistencies in light intensity across shadow regions to guide the model toward a more consistent prediction. A basic encoder-decoder model is initially trained on a labeled dataset for shadow detection. Then, during the testing phase, the network is adjusted for each test sample by enforcing consistent intensity predictions between two augmented input image versions. This consistency training specifically targets both foreground and background intersection regions to identify shadow regions within images accurately for robust adaptation. Extensive evaluations on the ISTD and SBU shadow detection datasets reveal that TICA significantly demonstrates that TICA outperforms existing state-of-the-art methods, achieving superior results in balanced error rate (BER).

Enhanced Self-supervised Learning for Multi-modality MRI Segmentation and Classification: A Novel Approach Avoiding Model Collapse

Multi-modality magnetic resonance imaging (MRI) can provide complementary information for computer-aided diagnosis. Traditional deep learning algorithms are suitable for identifying specific anatomical structures segmenting lesions and classifying diseases with magnetic resonance images. However, manual labels are limited due to high expense, which hinders further improvement of model accuracy. Self-supervised learning (SSL) can effectively learn feature representations from unlabeled data by pre-training and is demonstrated to be effective in natural image analysis. Most SSL methods ignore the similarity of multi-modality MRI, leading to model collapse. This limits the efficiency of pre-training, causing low accuracy in downstream segmentation and classification tasks. To solve this challenge, we establish and validate a multi-modality MRI masked autoencoder consisting of hybrid mask pattern (HMP) and pyramid barlow twin (PBT) module for SSL on multi-modality MRI analysis. The HMP concatenates three masking steps forcing the SSL to learn the semantic connections of multi-modality images by reconstructing the masking patches. We have proved that the proposed HMP can avoid model collapse. The PBT module exploits the pyramidal hierarchy of the network to construct barlow twin loss between masked and original views, aligning the semantic representations of image patches at different vision scales in latent space. Experiments on BraTS2023, PI-CAI, and lung gas MRI datasets further demonstrate the superiority of our framework over the state-of-the-art. The performance of the segmentation and classification is substantially enhanced, supporting the accurate detection of small lesion areas. The code is available at https://github.com/LinxuanHan/M2-MAE.

Full Bayesian Significance Testing for Neural Networks

Significance testing aims to determine whether a proposition about the population distribution is the truth or not given observations. However, traditional significance testing often needs to derive the distribution of the testing statistic, failing to deal with complex nonlinear relationships. In this paper, we propose to conduct Full Bayesian Significance Testing for neural networks, called \textit{n}FBST, to overcome the limitation in relationship characterization of traditional approaches. A Bayesian neural network is utilized to fit the nonlinear and multi-dimensional relationships with small errors and avoid hard theoretical derivation by computing the evidence value. Besides, \textit{n}FBST can test not only global significance but also local and instance-wise significance, which previous testing methods don't focus on. Moreover, \textit{n}FBST is a general framework that can be extended based on the measures selected, such as Grad-\textit{n}FBST, LRP-\textit{n}FBST, DeepLIFT-\textit{n}FBST, LIME-\textit{n}FBST. A range of experiments on both simulated and real data are conducted to show the advantages of our method.

Encoding Enhanced Complex CNN for Accurate and Highly Accelerated MRI

Magnetic resonance imaging (MRI) using hyperpolarized noble gases provides a way to visualize the structure and function of human lung, but the long imaging time limits its broad research and clinical applications. Deep learning has demonstrated great potential for accelerating MRI by reconstructing images from undersampled data. However, most existing deep conventional neural networks (CNN) directly apply square convolution to k-space data without considering the inherent properties of k-space sampling, limiting k-space learning efficiency and image reconstruction quality. In this work, we propose an encoding enhanced (EN2) complex CNN for highly undersampled pulmonary MRI reconstruction. EN2 employs convolution along either the frequency or phase-encoding direction, resembling the mechanisms of k-space sampling, to maximize the utilization of the encoding correlation and integrity within a row or column of k-space. We also employ complex convolution to learn rich representations from the complex k-space data. In addition, we develop a feature-strengthened modularized unit to further boost the reconstruction performance. Experiments demonstrate that our approach can accurately reconstruct hyperpolarized 129Xe and 1H lung MRI from 6-fold undersampled k-space data and provide lung function measurements with minimal biases compared with fully-sampled image. These results demonstrate the effectiveness of the proposed algorithmic components and indicate that the proposed approach could be used for accelerated pulmonary MRI in research and clinical lung disease patient care.

Multi-View Substructure Learning for Drug-Drug Interaction Prediction

Drug-drug interaction (DDI) prediction provides a drug combination strategy for systemically effective treatment. Previous studies usually model drug information constrained on a single view such as the drug itself, leading to incomplete and noisy information, which limits the accuracy of DDI prediction. In this work, we propose a novel multi- view drug substructure network for DDI prediction (MSN-DDI), which learns chemical substructures from both the representations of the single drug (intra-view) and the drug pair (inter-view) simultaneously and utilizes the substructures to update the drug representation iteratively. Comprehensive evaluations demonstrate that MSN-DDI has almost solved DDI prediction for existing drugs by achieving a relatively improved accuracy of 19.32% and an over 99% accuracy under the transductive setting. More importantly, MSN-DDI exhibits better generalization ability to unseen drugs with a relatively improved accuracy of 7.07% under more challenging inductive scenarios. Finally, MSN-DDI improves prediction performance for real-world DDI applications to new drugs.