SGUQ: Staged Graph Convolution Neural Network for Alzheimer's Disease Diagnosis using Multi-Omics Data

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the leading cause of dementia, significantly impacting cost, mortality, and burden worldwide. The advent of high-throughput omics technologies, such as genomics, transcriptomics, proteomics, and epigenomics, has revolutionized the molecular understanding of AD. Conventional AI approaches typically require the completion of all omics data at the outset to achieve optimal AD diagnosis, which are inefficient and may be unnecessary. To reduce the clinical cost and improve the accuracy of AD diagnosis using multi-omics data, we propose a novel staged graph convolutional network with uncertainty quantification (SGUQ). SGUQ begins with mRNA and progressively incorporates DNA methylation and miRNA data only when necessary, reducing overall costs and exposure to harmful tests. Experimental results indicate that 46.23% of the samples can be reliably predicted using only single-modal omics data (mRNA), while an additional 16.04% of the samples can achieve reliable predictions when combining two omics data types (mRNA + DNA methylation). In addition, the proposed staged SGUQ achieved an accuracy of 0.858 on ROSMAP dataset, which outperformed existing methods significantly. The proposed SGUQ can not only be applied to AD diagnosis using multi-omics data but also has the potential for clinical decision-making using multi-viewed data. Our implementation is publicly available at https://github.com/chenzhao2023/multiomicsuncertainty.

DG-Labeler and DGL-MOTS Dataset: Boost the Autonomous Driving Perception

Multi-object tracking and segmentation (MOTS) is a critical task for autonomous driving applications. The existing MOTS studies face two critical challenges: 1) the published datasets inadequately capture the real-world complexity for network training to address various driving settings; 2) the working pipeline annotation tool is under-studied in the literature to improve the quality of MOTS learning examples. In this work, we introduce the DG-Labeler and DGL-MOTS dataset to facilitate the training data annotation for the MOTS task and accordingly improve network training accuracy and efficiency. DG-Labeler uses the novel Depth-Granularity Module to depict the instance spatial relations and produce fine-grained instance masks. Annotated by DG-Labeler, our DGL-MOTS dataset exceeds the prior effort (i.e., KITTI MOTS and BDD100K) in data diversity, annotation quality, and temporal representations. Results on extensive cross-dataset evaluations indicate significant performance improvements for several state-of-the-art methods trained on our DGL-MOTS dataset. We believe our DGL-MOTS Dataset and DG-Labeler hold the valuable potential to boost the visual perception of future transportation.