LN-Gen: Rectal Lymph Nodes Generation via Anatomical Features

Accurate segmentation of rectal lymph nodes is crucial for the staging and treatment planning of rectal cancer. However, the complexity of the surrounding anatomical structures and the scarcity of annotated data pose significant challenges. This study introduces a novel lymph node synthesis technique aimed at generating diverse and realistic synthetic rectal lymph node samples to mitigate the reliance on manual annotation. Unlike direct diffusion methods, which often produce masks that are discontinuous and of suboptimal quality, our approach leverages an implicit SDF-based method for mask generation, ensuring the production of continuous, stable, and morphologically diverse masks. Experimental results demonstrate that our synthetic data significantly improves segmentation performance. Our work highlights the potential of diffusion model for accurately synthesizing structurally complex lesions, such as lymph nodes in rectal cancer, alleviating the challenge of limited annotated data in this field and aiding in advancements in rectal cancer diagnosis and treatment.

Optimizing and Testing Instruction-Following: Analyzing the Impact of Fine-Grained Instruction Variants on instruction-tuned LLMs

The effective alignment of Large Language Models (LLMs) with precise instructions is essential for their application in diverse real-world scenarios. Current methods focus on enhancing the diversity and complexity of training and evaluation samples, yet they fall short in accurately assessing LLMs' ability to follow similar instruction variants. We introduce an effective data augmentation technique that decomposes complex instructions into simpler sub-components, modifies these, and reconstructs them into new variants, thereby preserves the original instruction's context and complexity while introducing variability, which is critical for training and evaluating LLMs' instruction-following precision. We developed the DeMoRecon dataset using this method to both fine-tune and evaluate LLMs. Our findings show that LLMs fine-tuned with DeMoRecon will gain significant performance boost on both ours and commonly used instructions-following benchmarks.

Meply: A Large-scale Dataset and Baseline Evaluations for Metastatic Perirectal Lymph Node Detection and Segmentation

Accurate segmentation of metastatic lymph nodes in rectal cancer is crucial for the staging and treatment of rectal cancer. However, existing segmentation approaches face challenges due to the absence of pixel-level annotated datasets tailored for lymph nodes around the rectum. Additionally, metastatic lymph nodes are characterized by their relatively small size, irregular shapes, and lower contrast compared to the background, further complicating the segmentation task. To address these challenges, we present the first large-scale perirectal metastatic lymph node CT image dataset called Meply, which encompasses pixel-level annotations of 269 patients diagnosed with rectal cancer. Furthermore, we introduce a novel lymph-node segmentation model named CoSAM. The CoSAM utilizes sequence-based detection to guide the segmentation of metastatic lymph nodes in rectal cancer, contributing to improved localization performance for the segmentation model. It comprises three key components: sequence-based detection module, segmentation module, and collaborative convergence unit. To evaluate the effectiveness of CoSAM, we systematically compare its performance with several popular segmentation methods using the Meply dataset. Our code and dataset will be publicly available at: https://github.com/kanydao/CoSAM.

HRLAIF: Improvements in Helpfulness and Harmlessness in Open-domain Reinforcement Learning From AI Feedback

Reinforcement Learning from AI Feedback (RLAIF) has the advantages of shorter annotation cycles and lower costs over Reinforcement Learning from Human Feedback (RLHF), making it highly efficient during the rapid strategy iteration periods of large language model (LLM) training. Using ChatGPT as a labeler to provide feedback on open-domain prompts in RLAIF training, we observe an increase in human evaluators' preference win ratio for model responses, but a decrease in evaluators' satisfaction rate. Analysis suggests that the decrease in satisfaction rate is mainly due to some responses becoming less helpful, particularly in terms of correctness and truthfulness, highlighting practical limitations of basic RLAIF. In this paper, we propose Hybrid Reinforcement Learning from AI Feedback (HRLAIF). This method enhances the accuracy of AI annotations for responses, making the model's helpfulness more robust in training process. Additionally, it employs AI for Red Teaming, further improving the model's harmlessness. Human evaluation results show that HRLAIF inherits the ability of RLAIF to enhance human preference for outcomes at a low cost while also improving the satisfaction rate of responses. Compared to the policy model before Reinforcement Learning (RL), it achieves an increase of 2.08\% in satisfaction rate, effectively addressing the issue of a decrease of 4.58\% in satisfaction rate after basic RLAIF.

SIFiD: Reassess Summary Factual Inconsistency Detection with LLM

Ensuring factual consistency between the summary and the original document is paramount in summarization tasks. Consequently, considerable effort has been dedicated to detecting inconsistencies. With the advent of Large Language Models (LLMs), recent studies have begun to leverage their advanced language understanding capabilities for inconsistency detection. However, early attempts have shown that LLMs underperform traditional models due to their limited ability to follow instructions and the absence of an effective detection methodology. In this study, we reassess summary inconsistency detection with LLMs, comparing the performances of GPT-3.5 and GPT-4. To advance research in LLM-based inconsistency detection, we propose SIFiD (Summary Inconsistency Detection with Filtered Document) that identify key sentences within documents by either employing natural language inference or measuring semantic similarity between summaries and documents.

Generalizable Entity Grounding via Assistance of Large Language Model

In this work, we propose a novel approach to densely ground visual entities from a long caption. We leverage a large multimodal model (LMM) to extract semantic nouns, a class-agnostic segmentation model to generate entity-level segmentation, and the proposed multi-modal feature fusion module to associate each semantic noun with its corresponding segmentation mask. Additionally, we introduce a strategy of encoding entity segmentation masks into a colormap, enabling the preservation of fine-grained predictions from features of high-resolution masks. This approach allows us to extract visual features from low-resolution images using the CLIP vision encoder in the LMM, which is more computationally efficient than existing approaches that use an additional encoder for high-resolution images. Our comprehensive experiments demonstrate the superiority of our method, outperforming state-of-the-art techniques on three tasks, including panoptic narrative grounding, referring expression segmentation, and panoptic segmentation.

Instruction Fusion: Advancing Prompt Evolution through Hybridization

The fine-tuning of Large Language Models (LLMs) specialized in code generation has seen notable advancements through the use of open-domain coding queries. Despite the successes, existing methodologies like Evol-Instruct encounter performance limitations, impeding further enhancements in code generation tasks. This paper examines the constraints of existing prompt evolution techniques and introduces a novel approach, Instruction Fusion (IF). IF innovatively combines two distinct prompts through a hybridization process, thereby enhancing the evolution of training prompts for code LLMs. Our experimental results reveal that the proposed novel method effectively addresses the shortcomings of prior methods, significantly improving the performance of Code LLMs across five code generation benchmarks, namely HumanEval, HumanEval+, MBPP, MBPP+ and MultiPL-E, which underscore the effectiveness of Instruction Fusion in advancing the capabilities of LLMs in code generation.

UniGS: Unified Representation for Image Generation and Segmentation

This paper introduces a novel unified representation of diffusion models for image generation and segmentation. Specifically, we use a colormap to represent entity-level masks, addressing the challenge of varying entity numbers while aligning the representation closely with the image RGB domain. Two novel modules, including the location-aware color palette and progressive dichotomy module, are proposed to support our mask representation. On the one hand, a location-aware palette guarantees the colors' consistency to entities' locations. On the other hand, the progressive dichotomy module can efficiently decode the synthesized colormap to high-quality entity-level masks in a depth-first binary search without knowing the cluster numbers. To tackle the issue of lacking large-scale segmentation training data, we employ an inpainting pipeline and then improve the flexibility of diffusion models across various tasks, including inpainting, image synthesis, referring segmentation, and entity segmentation. Comprehensive experiments validate the efficiency of our approach, demonstrating comparable segmentation mask quality to state-of-the-art and adaptability to multiple tasks. The code will be released at \href{https://github.com/qqlu/Entity}{https://github.com/qqlu/Entity}.

CARE: A Large Scale CT Image Dataset and Clinical Applicable Benchmark Model for Rectal Cancer Segmentation

Rectal cancer segmentation of CT image plays a crucial role in timely clinical diagnosis, radiotherapy treatment, and follow-up. Although current segmentation methods have shown promise in delineating cancerous tissues, they still encounter challenges in achieving high segmentation precision. These obstacles arise from the intricate anatomical structures of the rectum and the difficulties in performing differential diagnosis of rectal cancer. Additionally, a major obstacle is the lack of a large-scale, finely annotated CT image dataset for rectal cancer segmentation. To address these issues, this work introduces a novel large scale rectal cancer CT image dataset CARE with pixel-level annotations for both normal and cancerous rectum, which serves as a valuable resource for algorithm research and clinical application development. Moreover, we propose a novel medical cancer lesion segmentation benchmark model named U-SAM. The model is specifically designed to tackle the challenges posed by the intricate anatomical structures of abdominal organs by incorporating prompt information. U-SAM contains three key components: promptable information (e.g., points) to aid in target area localization, a convolution module for capturing low-level lesion details, and skip-connections to preserve and recover spatial information during the encoding-decoding process. To evaluate the effectiveness of U-SAM, we systematically compare its performance with several popular segmentation methods on the CARE dataset. The generalization of the model is further verified on the WORD dataset. Extensive experiments demonstrate that the proposed U-SAM outperforms state-of-the-art methods on these two datasets. These experiments can serve as the baseline for future research and clinical application development.

ConKI: Contrastive Knowledge Injection for Multimodal Sentiment Analysis

Multimodal Sentiment Analysis leverages multimodal signals to detect the sentiment of a speaker. Previous approaches concentrate on performing multimodal fusion and representation learning based on general knowledge obtained from pretrained models, which neglects the effect of domain-specific knowledge. In this paper, we propose Contrastive Knowledge Injection (ConKI) for multimodal sentiment analysis, where specific-knowledge representations for each modality can be learned together with general knowledge representations via knowledge injection based on an adapter architecture. In addition, ConKI uses a hierarchical contrastive learning procedure performed between knowledge types within every single modality, across modalities within each sample, and across samples to facilitate the effective learning of the proposed representations, hence improving multimodal sentiment predictions. The experiments on three popular multimodal sentiment analysis benchmarks show that ConKI outperforms all prior methods on a variety of performance metrics.