Generating Seamless Virtual Immunohistochemical Whole Slide Images with Content and Color Consistency

Immunohistochemical (IHC) stains play a vital role in a pathologist's analysis of medical images, providing crucial diagnostic information for various diseases. Virtual staining from hematoxylin and eosin (H&E)-stained whole slide images (WSIs) allows the automatic production of other useful IHC stains without the expensive physical staining process. However, current virtual WSI generation methods based on tile-wise processing often suffer from inconsistencies in content, texture, and color at tile boundaries. These inconsistencies lead to artifacts that compromise image quality and potentially hinder accurate clinical assessment and diagnoses. To address this limitation, we propose a novel consistent WSI synthesis network, CC-WSI-Net, that extends GAN models to produce seamless synthetic whole slide images. Our CC-WSI-Net integrates a content- and color-consistency supervisor, ensuring consistency across tiles and facilitating the generation of seamless synthetic WSIs while ensuring Sox10 immunohistochemistry accuracy in melanocyte detection. We validate our method through extensive image-quality analyses, objective detection assessments, and a subjective survey with pathologists. By generating high-quality synthetic WSIs, our method opens doors for advanced virtual staining techniques with broader applications in research and clinical care.

Machine Learning-Based Research on the Adaptability of Adolescents to Online Education

With the rapid advancement of internet technology, the adaptability of adolescents to online learning has emerged as a focal point of interest within the educational sphere. However, the academic community's efforts to develop predictive models for adolescent online learning adaptability require further refinement and expansion. Utilizing data from the "Chinese Adolescent Online Education Survey" spanning the years 2014 to 2016, this study implements five machine learning algorithms - logistic regression, K-nearest neighbors, random forest, XGBoost, and CatBoost - to analyze the factors influencing adolescent online learning adaptability and to determine the model best suited for prediction. The research reveals that the duration of courses, the financial status of the family, and age are the primary factors affecting students' adaptability in online learning environments. Additionally, age significantly impacts students' adaptive capacities. Among the predictive models, the random forest, XGBoost, and CatBoost algorithms demonstrate superior forecasting capabilities, with the random forest model being particularly adept at capturing the characteristics of students' adaptability.

Attention Mechanism and Context Modeling System for Text Mining Machine Translation

This paper advances a novel architectural schema anchored upon the Transformer paradigm and innovatively amalgamates the K-means categorization algorithm to augment the contextual apprehension capabilities of the schema. The transformer model performs well in machine translation tasks due to its parallel computing power and multi-head attention mechanism. However, it may encounter contextual ambiguity or ignore local features when dealing with highly complex language structures. To circumvent this constraint, this exposition incorporates the K-Means algorithm, which is used to stratify the lexis and idioms of the input textual matter, thereby facilitating superior identification and preservation of the local structure and contextual intelligence of the language. The advantage of this combination is that K-Means can automatically discover the topic or concept regions in the text, which may be directly related to translation quality. Consequently, the schema contrived herein enlists K-Means as a preparatory phase antecedent to the Transformer and recalibrates the multi-head attention weights to assist in the discrimination of lexis and idioms bearing analogous semantics or functionalities. This ensures the schema accords heightened regard to the contextual intelligence embodied by these clusters during the training phase, rather than merely focusing on locational intelligence.

Adversarial Purification of Information Masking

Adversarial attacks meticulously generate minuscule, imperceptible perturbations to images to deceive neural networks. Counteracting these, adversarial purification methods seek to transform adversarial input samples into clean output images to defend against adversarial attacks. Nonetheless, extent generative models fail to effectively eliminate adversarial perturbations, yielding less-than-ideal purification results. We emphasize the potential threat of residual adversarial perturbations to target models, quantitatively establishing a relationship between perturbation scale and attack capability. Notably, the residual perturbations on the purified image primarily stem from the same-position patch and similar patches of the adversarial sample. We propose a novel adversarial purification approach named Information Mask Purification (IMPure), aims to extensively eliminate adversarial perturbations. To obtain an adversarial sample, we first mask part of the patches information, then reconstruct the patches to resist adversarial perturbations from the patches. We reconstruct all patches in parallel to obtain a cohesive image. Then, in order to protect the purified samples against potential similar regional perturbations, we simulate this risk by randomly mixing the purified samples with the input samples before inputting them into the feature extraction network. Finally, we establish a combined constraint of pixel loss and perceptual loss to augment the model's reconstruction adaptability. Extensive experiments on the ImageNet dataset with three classifier models demonstrate that our approach achieves state-of-the-art results against nine adversarial attack methods. Implementation code and pre-trained weights can be accessed at \textcolor{blue}{https://github.com/NoWindButRain/IMPure}.

Block shuffling learning for Deepfake Detection

Although the deepfake detection based on convolutional neural network has achieved good results, the detection results show that these detectors show obvious performance degradation when the input images undergo some common transformations (like resizing, blurring), which indicates that the generalization ability of the detector is insufficient. In this paper, we propose a novel block shuffling learning method to solve this problem. Specifically, we divide the images into blocks and then introduce the random shuffling to intra-block and inter-block. Intra-block shuffling increases the robustness of the detector and we also propose an adversarial loss algorithm to overcome the over-fitting problem brought by the noise introduced by shuffling. Moreover, we encourage the detector to focus on finding differences among the local features through inter-block shuffling, and reconstruct the spatial layout of the blocks to model the semantic associations between them. Especially, our method can be easily integrated with various CNN models. Extensive experiments show that our proposed method achieves state-of-the-art performance in forgery face detection, including good generalization ability in the face of common image transformations.