Efficient Knowledge Infusion via KG-LLM Alignment

To tackle the problem of domain-specific knowledge scarcity within large language models (LLMs), knowledge graph-retrievalaugmented method has been proven to be an effective and efficient technique for knowledge infusion. However, existing approaches face two primary challenges: knowledge mismatch between public available knowledge graphs and the specific domain of the task at hand, and poor information compliance of LLMs with knowledge graphs. In this paper, we leverage a small set of labeled samples and a large-scale corpus to efficiently construct domain-specific knowledge graphs by an LLM, addressing the issue of knowledge mismatch. Additionally, we propose a three-stage KG-LLM alignment strategyto enhance the LLM's capability to utilize information from knowledge graphs. We conduct experiments with a limited-sample setting on two biomedical question-answering datasets, and the results demonstrate that our approach outperforms existing baselines.

Effective Classification of MicroRNA Precursors Using Combinatorial Feature Mining and AdaBoost Algorithms

MicroRNAs (miRNAs) are non-coding RNAs with approximately 22 nucleotides (nt) that are derived from precursor molecules. These precursor molecules or pre-miRNAs often fold into stem-loop hairpin structures. However, a large number of sequences with pre-miRNA-like hairpins can be found in genomes. It is a challenge to distinguish the real pre-miRNAs from other hairpin sequences with similar stem-loops (referred to as pseudo pre-miRNAs). Several computational methods have been developed to tackle this challenge. In this paper we propose a new method, called MirID, for identifying and classifying microRNA precursors. We collect 74 features from the sequences and secondary structures of pre-miRNAs; some of these features are taken from our previous studies on non-coding RNA prediction while others were suggested in the literature. We develop a combinatorial feature mining algorithm to identify suitable feature sets. These feature sets are then used to train support vector machines to obtain classification models, based on which classifier ensemble is constructed. Finally we use an AdaBoost algorithm to further enhance the accuracy of the classifier ensemble. Experimental results on a variety of species demonstrate the good performance of the proposed method, and its superiority over existing tools.