EyeCLIP: A visual-language foundation model for multi-modal ophthalmic image analysis

Early detection of eye diseases like glaucoma, macular degeneration, and diabetic retinopathy is crucial for preventing vision loss. While artificial intelligence (AI) foundation models hold significant promise for addressing these challenges, existing ophthalmic foundation models primarily focus on a single modality, whereas diagnosing eye diseases requires multiple modalities. A critical yet often overlooked aspect is harnessing the multi-view information across various modalities for the same patient. Additionally, due to the long-tail nature of ophthalmic diseases, standard fully supervised or unsupervised learning approaches often struggle. Therefore, it is essential to integrate clinical text to capture a broader spectrum of diseases. We propose EyeCLIP, a visual-language foundation model developed using over 2.77 million multi-modal ophthalmology images with partial text data. To fully leverage the large multi-modal unlabeled and labeled data, we introduced a pretraining strategy that combines self-supervised reconstructions, multi-modal image contrastive learning, and image-text contrastive learning to learn a shared representation of multiple modalities. Through evaluation using 14 benchmark datasets, EyeCLIP can be transferred to a wide range of downstream tasks involving ocular and systemic diseases, achieving state-of-the-art performance in disease classification, visual question answering, and cross-modal retrieval. EyeCLIP represents a significant advancement over previous methods, especially showcasing few-shot, even zero-shot capabilities in real-world long-tail scenarios.

Low-Complexity SVM Signal Recovery in Bandwidth-Limited 100Gb/s PAM4 PON Upstream

We proposed a low-complexity SVM-based signal recovery algorithm and evaluated it in 100G-PON with 25G-class devices. For the first time, it experimentally achieved 24 dB power budget @ FEC threshold 1E-3 over 40 km SMF, improving receiver sensitivity over 2 dB compared to FFE&DFE.

LUT-boosted CDR and Equalization for Burst-mode 50/100 Gbit/s Bandwidth-limited Flexible PON

We proposed and experimentally demonstrated a look-up table boosted fast CDR and equalization scheme for the burst-mode 50/100 Gbps bandwidth-limited flexible PON, requiring no preamble for convergence and achieved the same bit error rate performance as in the case of long preambles.

Masked Contrastive Reconstruction for Cross-modal Medical Image-Report Retrieval

Cross-modal medical image-report retrieval task plays a significant role in clinical diagnosis and various medical generative tasks. Eliminating heterogeneity between different modalities to enhance semantic consistency is the key challenge of this task. The current Vision-Language Pretraining (VLP) models, with cross-modal contrastive learning and masked reconstruction as joint training tasks, can effectively enhance the performance of cross-modal retrieval. This framework typically employs dual-stream inputs, using unmasked data for cross-modal contrastive learning and masked data for reconstruction. However, due to task competition and information interference caused by significant differences between the inputs of the two proxy tasks, the effectiveness of representation learning for intra-modal and cross-modal features is limited. In this paper, we propose an efficient VLP framework named Masked Contrastive and Reconstruction (MCR), which takes masked data as the sole input for both tasks. This enhances task connections, reducing information interference and competition between them, while also substantially decreasing the required GPU memory and training time. Moreover, we introduce a new modality alignment strategy named Mapping before Aggregation (MbA). Unlike previous methods, MbA maps different modalities to a common feature space before conducting local feature aggregation, thereby reducing the loss of fine-grained semantic information necessary for improved modality alignment. Qualitative and quantitative experiments conducted on the MIMIC-CXR dataset validate the effectiveness of our approach, demonstrating state-of-the-art performance in medical cross-modal retrieval tasks.

Learning from Noisy Labels Generated by Extremely Point Annotations for OCT Fluid Segmentation

Automatic segmentation of fluid in OCT (Optical Coherence Tomography) images is beneficial for ophthalmologists to make an accurate diagnosis. Currently, data-driven convolutional neural networks (CNNs) have achieved great success in OCT fluid segmentation. However, obtaining pixel-level masks of OCT images is time-consuming and requires expertise. The popular weakly-supervised strategy is to generate noisy pseudo-labels from weak annotations, but the noise information introduced may mislead the model training. To address this issue, (i) we propose a superpixel-guided method for generating noisy labels from weak point annotations, called Point to Noisy by Superpixel (PNS), which limits the network from over-fitting noise by assigning low confidence to suspiciously noisy label pixels, and (ii) we propose a Two-Stage Mean-Teacher-assisted Confident Learning (2SMTCL) method based on MTCL for multi-category OCT fluid segmentation, which alleviates the uncertainty and computing power consumption introduced by the real-time characterization noise of MTCL. For evaluation, we have constructed a 2D OCT fluid segmentation dataset. Compared with other state-of-art label-denoising methods, comprehensive experimental results demonstrate that the proposed method can achieve excellent performance in OCT fluid segmentation as well as label denoising. Our study provides an efficient, accurate, and practical solution for fluid segmentation of OCT images, which is expected to have a positive impact on the diagnosis and treatment of patients in the field of ophthalmology.

Dispensed Transformer Network for Unsupervised Domain Adaptation

Accurate segmentation is a crucial step in medical image analysis and applying supervised machine learning to segment the organs or lesions has been substantiated effective. However, it is costly to perform data annotation that provides ground truth labels for training the supervised algorithms, and the high variance of data that comes from different domains tends to severely degrade system performance over cross-site or cross-modality datasets. To mitigate this problem, a novel unsupervised domain adaptation (UDA) method named dispensed Transformer network (DTNet) is introduced in this paper. Our novel DTNet contains three modules. First, a dispensed residual transformer block is designed, which realizes global attention by dispensed interleaving operation and deals with the excessive computational cost and GPU memory usage of the Transformer. Second, a multi-scale consistency regularization is proposed to alleviate the loss of details in the low-resolution output for better feature alignment. Finally, a feature ranking discriminator is introduced to automatically assign different weights to domain-gap features to lessen the feature distribution distance, reducing the performance shift of two domains. The proposed method is evaluated on large fluorescein angiography (FA) retinal nonperfusion (RNP) cross-site dataset with 676 images and a wide used cross-modality dataset from the MM-WHS challenge. Extensive results demonstrate that our proposed network achieves the best performance in comparison with several state-of-the-art techniques.

DeepTracker: Visualizing the Training Process of Convolutional Neural Networks

Deep convolutional neural networks (CNNs) have achieved remarkable success in various fields. However, training an excellent CNN is practically a trial-and-error process that consumes a tremendous amount of time and computer resources. To accelerate the training process and reduce the number of trials, experts need to understand what has occurred in the training process and why the resulting CNN behaves as such. However, current popular training platforms, such as TensorFlow, only provide very little and general information, such as training/validation errors, which is far from enough to serve this purpose. To bridge this gap and help domain experts with their training tasks in a practical environment, we propose a visual analytics system, DeepTracker, to facilitate the exploration of the rich dynamics of CNN training processes and to identify the unusual patterns that are hidden behind the huge amount of training log. Specifically,we combine a hierarchical index mechanism and a set of hierarchical small multiples to help experts explore the entire training log from different levels of detail. We also introduce a novel cube-style visualization to reveal the complex correlations among multiple types of heterogeneous training data including neuron weights, validation images, and training iterations. Three case studies are conducted to demonstrate how DeepTracker provides its users with valuable knowledge in an industry-level CNN training process, namely in our case, training ResNet-50 on the ImageNet dataset. We show that our method can be easily applied to other state-of-the-art "very deep" CNN models.