Trajectory Flow Matching with Applications to Clinical Time Series Modeling

Modeling stochastic and irregularly sampled time series is a challenging problem found in a wide range of applications, especially in medicine. Neural stochastic differential equations (Neural SDEs) are an attractive modeling technique for this problem, which parameterize the drift and diffusion terms of an SDE with neural networks. However, current algorithms for training Neural SDEs require backpropagation through the SDE dynamics, greatly limiting their scalability and stability. To address this, we propose Trajectory Flow Matching (TFM), which trains a Neural SDE in a simulation-free manner, bypassing backpropagation through the dynamics. TFM leverages the flow matching technique from generative modeling to model time series. In this work we first establish necessary conditions for TFM to learn time series data. Next, we present a reparameterization trick which improves training stability. Finally, we adapt TFM to the clinical time series setting, demonstrating improved performance on three clinical time series datasets both in terms of absolute performance and uncertainty prediction.

Customized Retrieval Augmented Generation and Benchmarking for EDA Tool Documentation QA

Retrieval augmented generation (RAG) enhances the accuracy and reliability of generative AI models by sourcing factual information from external databases, which is extensively employed in document-grounded question-answering (QA) tasks. Off-the-shelf RAG flows are well pretrained on general-purpose documents, yet they encounter significant challenges when being applied to knowledge-intensive vertical domains, such as electronic design automation (EDA). This paper addresses such issue by proposing a customized RAG framework along with three domain-specific techniques for EDA tool documentation QA, including a contrastive learning scheme for text embedding model fine-tuning, a reranker distilled from proprietary LLM, and a generative LLM fine-tuned with high-quality domain corpus. Furthermore, we have developed and released a documentation QA evaluation benchmark, ORD-QA, for OpenROAD, an advanced RTL-to-GDSII design platform. Experimental results demonstrate that our proposed RAG flow and techniques have achieved superior performance on ORD-QA as well as on a commercial tool, compared with state-of-the-arts. The ORD-QA benchmark and the training dataset for our customized RAG flow are open-source at https://github.com/lesliepy99/RAG-EDA.

UniZero: Generalized and Efficient Planning with Scalable Latent World Models

Learning predictive world models is essential for enhancing the planning capabilities of reinforcement learning agents. Notably, the MuZero-style algorithms, based on the value equivalence principle and Monte Carlo Tree Search (MCTS), have achieved superhuman performance in various domains. However, in environments that require capturing long-term dependencies, MuZero's performance deteriorates rapidly. We identify that this is partially due to the \textit{entanglement} of latent representations with historical information, which results in incompatibility with the auxiliary self-supervised state regularization. To overcome this limitation, we present \textit{UniZero}, a novel approach that \textit{disentangles} latent states from implicit latent history using a transformer-based latent world model. By concurrently predicting latent dynamics and decision-oriented quantities conditioned on the learned latent history, UniZero enables joint optimization of the long-horizon world model and policy, facilitating broader and more efficient planning in latent space. We demonstrate that UniZero, even with single-frame inputs, matches or surpasses the performance of MuZero-style algorithms on the Atari 100k benchmark. Furthermore, it significantly outperforms prior baselines in benchmarks that require long-term memory. Lastly, we validate the effectiveness and scalability of our design choices through extensive ablation studies, visual analyses, and multi-task learning results. The code is available at \textcolor{magenta}{https://github.com/opendilab/LightZero}.

ReZero: Boosting MCTS-based Algorithms by Just-in-Time and Speedy Reanalyze

MCTS-based algorithms, such as MuZero and its derivatives, have achieved widespread success in various decision-making domains. These algorithms employ the reanalyze process to enhance sample efficiency, albeit at the expense of significant wall-clock time consumption. To address this issue, we propose a general approach named ReZero to boost MCTS-based algorithms. Specifically, we propose a new scheme that simplifies data collecting and reanalyzing, which significantly reduces the search cost while guarantees the performance as well. Furthermore, to accelerate each search process, we conceive a method to reuse the subsequent information in the trajectory. The corresponding analysis conducted on the bandit model also provides auxiliary theoretical substantiation for our design. Experiments conducted on Atari environments and board games demonstrates that ReZero substantially improves training speed while maintaining high sample efficiency. The code is available as part of the LightZero benchmark at https://github.com/opendilab/LightZero.

Assessing the Usability of GutGPT: A Simulation Study of an AI Clinical Decision Support System for Gastrointestinal Bleeding Risk

Applications of large language models (LLMs) like ChatGPT have potential to enhance clinical decision support through conversational interfaces. However, challenges of human-algorithmic interaction and clinician trust are poorly understood. GutGPT, a LLM for gastrointestinal (GI) bleeding risk prediction and management guidance, was deployed in clinical simulation scenarios alongside the electronic health record (EHR) with emergency medicine physicians, internal medicine physicians, and medical students to evaluate its effect on physician acceptance and trust in AI clinical decision support systems (AI-CDSS). GutGPT provides risk predictions from a validated machine learning model and evidence-based answers by querying extracted clinical guidelines. Participants were randomized to GutGPT and an interactive dashboard, or the interactive dashboard and a search engine. Surveys and educational assessments taken before and after measured technology acceptance and content mastery. Preliminary results showed mixed effects on acceptance after using GutGPT compared to the dashboard or search engine but appeared to improve content mastery based on simulation performance. Overall, this study demonstrates LLMs like GutGPT could enhance effective AI-CDSS if implemented optimally and paired with interactive interfaces.

LightZero: A Unified Benchmark for Monte Carlo Tree Search in General Sequential Decision Scenarios

Building agents based on tree-search planning capabilities with learned models has achieved remarkable success in classic decision-making problems, such as Go and Atari. However, it has been deemed challenging or even infeasible to extend Monte Carlo Tree Search (MCTS) based algorithms to diverse real-world applications, especially when these environments involve complex action spaces and significant simulation costs, or inherent stochasticity. In this work, we introduce LightZero, the first unified benchmark for deploying MCTS/MuZero in general sequential decision scenarios. Specificially, we summarize the most critical challenges in designing a general MCTS-style decision-making solver, then decompose the tightly-coupled algorithm and system design of tree-search RL methods into distinct sub-modules. By incorporating more appropriate exploration and optimization strategies, we can significantly enhance these sub-modules and construct powerful LightZero agents to tackle tasks across a wide range of domains, such as board games, Atari, MuJoCo, MiniGrid and GoBigger. Detailed benchmark results reveal the significant potential of such methods in building scalable and efficient decision intelligence. The code is available as part of OpenDILab at https://github.com/opendilab/LightZero.

Context-Based Soft Actor Critic for Environments with Non-stationary Dynamics

The performance of deep reinforcement learning methods prone to degenerate when applied to environments with non-stationary dynamics. In this paper, we utilize the latent context recurrent encoders motivated by recent Meta-RL materials, and propose the Latent Context-based Soft Actor Critic (LC-SAC) method to address aforementioned issues. By minimizing the contrastive prediction loss function, the learned context variables capture the information of the environment dynamics and the recent behavior of the agent. Then combined with the soft policy iteration paradigm, the LC-SAC method alternates between soft policy evaluation and soft policy improvement until it converges to the optimal policy. Experimental results show that the performance of LC-SAC is significantly better than the SAC algorithm on the MetaWorld ML1 tasks whose dynamics changes drasticly among different episodes, and is comparable to SAC on the continuous control benchmark task MuJoCo whose dynamics changes slowly or doesn't change between different episodes. In addition, we also conduct relevant experiments to determine the impact of different hyperparameter settings on the performance of the LC-SAC algorithm and give the reasonable suggestions of hyperparameter setting.

Decomposed Soft Actor-Critic Method for Cooperative Multi-Agent Reinforcement Learning

Deep reinforcement learning methods have shown great performance on many challenging cooperative multi-agent tasks. Two main promising research directions are multi-agent value function decomposition and multi-agent policy gradients. In this paper, we propose a new decomposed multi-agent soft actor-critic (mSAC) method, which effectively combines the advantages of the aforementioned two methods. The main modules include decomposed Q network architecture, discrete probabilistic policy and counterfactual advantage function (optinal). Theoretically, mSAC supports efficient off-policy learning and addresses credit assignment problem partially in both discrete and continuous action spaces. Tested on StarCraft II micromanagement cooperative multiagent benchmark, we empirically investigate the performance of mSAC against its variants and analyze the effects of the different components. Experimental results demonstrate that mSAC significantly outperforms policy-based approach COMA, and achieves competitive results with SOTA value-based approach Qmix on most tasks in terms of asymptotic perfomance metric. In addition, mSAC achieves pretty good results on large action space tasks, such as 2c_vs_64zg and MMM2.