Unconstrained Salient and Camouflaged Object Detection

Visual Salient Object Detection (SOD) and Camouflaged Object Detection (COD) are two interrelated yet distinct tasks. Both tasks model the human visual system's ability to perceive the presence of objects. The traditional SOD datasets and methods are designed for scenes where only salient objects are present, similarly, COD datasets and methods are designed for scenes where only camouflaged objects are present. However, scenes where both salient and camouflaged objects coexist, or where neither is present, are not considered. This simplifies the existing research on SOD and COD. In this paper, to explore a more generalized approach to SOD and COD, we introduce a benchmark called Unconstrained Salient and Camouflaged Object Detection (USCOD), which supports the simultaneous detection of salient and camouflaged objects in unconstrained scenes, regardless of their presence. Towards this, we construct a large-scale dataset, CS12K, that encompasses a variety of scenes, including four distinct types: only salient objects, only camouflaged objects, both, and neither. In our benchmark experiments, we identify a major challenge in USCOD: distinguishing between salient and camouflaged objects within the same scene. To address this challenge, we propose USCNet, a baseline model for USCOD that decouples the learning of attribute distinction from mask reconstruction. The model incorporates an APG module, which learns both sample-generic and sample-specific features to enhance the attribute differentiation between salient and camouflaged objects. Furthermore, to evaluate models' ability to distinguish between salient and camouflaged objects, we design a metric called Camouflage-Saliency Confusion Score (CSCS). The proposed method achieves state-of-the-art performance on the newly introduced USCOD task. The code and dataset will be publicly available.

Benchmarking and Enhancing Surgical Phase Recognition Models for Robotic-Assisted Esophagectomy

Robotic-assisted minimally invasive esophagectomy (RAMIE) is a recognized treatment for esophageal cancer, offering better patient outcomes compared to open surgery and traditional minimally invasive surgery. RAMIE is highly complex, spanning multiple anatomical areas and involving repetitive phases and non-sequential phase transitions. Our goal is to leverage deep learning for surgical phase recognition in RAMIE to provide intraoperative support to surgeons. To achieve this, we have developed a new surgical phase recognition dataset comprising 27 videos. Using this dataset, we conducted a comparative analysis of state-of-the-art surgical phase recognition models. To more effectively capture the temporal dynamics of this complex procedure, we developed a novel deep learning model featuring an encoder-decoder structure with causal hierarchical attention, which demonstrates superior performance compared to existing models.

Benchmarking Pretrained Attention-based Models for Real-Time Recognition in Robot-Assisted Esophagectomy

Esophageal cancer is among the most common types of cancer worldwide. It is traditionally treated using open esophagectomy, but in recent years, robot-assisted minimally invasive esophagectomy (RAMIE) has emerged as a promising alternative. However, robot-assisted surgery can be challenging for novice surgeons, as they often suffer from a loss of spatial orientation. Computer-aided anatomy recognition holds promise for improving surgical navigation, but research in this area remains limited. In this study, we developed a comprehensive dataset for semantic segmentation in RAMIE, featuring the largest collection of vital anatomical structures and surgical instruments to date. Handling this diverse set of classes presents challenges, including class imbalance and the recognition of complex structures such as nerves. This study aims to understand the challenges and limitations of current state-of-the-art algorithms on this novel dataset and problem. Therefore, we benchmarked eight real-time deep learning models using two pretraining datasets. We assessed both traditional and attention-based networks, hypothesizing that attention-based networks better capture global patterns and address challenges such as occlusion caused by blood or other tissues. The benchmark includes our RAMIE dataset and the publicly available CholecSeg8k dataset, enabling a thorough assessment of surgical segmentation tasks. Our findings indicate that pretraining on ADE20k, a dataset for semantic segmentation, is more effective than pretraining on ImageNet. Furthermore, attention-based models outperform traditional convolutional neural networks, with SegNeXt and Mask2Former achieving higher Dice scores, and Mask2Former additionally excelling in average symmetric surface distance.

Exploring the Effect of Dataset Diversity in Self-Supervised Learning for Surgical Computer Vision

Over the past decade, computer vision applications in minimally invasive surgery have rapidly increased. Despite this growth, the impact of surgical computer vision remains limited compared to other medical fields like pathology and radiology, primarily due to the scarcity of representative annotated data. Whereas transfer learning from large annotated datasets such as ImageNet has been conventionally the norm to achieve high-performing models, recent advancements in self-supervised learning (SSL) have demonstrated superior performance. In medical image analysis, in-domain SSL pretraining has already been shown to outperform ImageNet-based initialization. Although unlabeled data in the field of surgical computer vision is abundant, the diversity within this data is limited. This study investigates the role of dataset diversity in SSL for surgical computer vision, comparing procedure-specific datasets against a more heterogeneous general surgical dataset across three different downstream surgical applications. The obtained results show that using solely procedure-specific data can lead to substantial improvements of 13.8%, 9.5%, and 36.8% compared to ImageNet pretraining. However, extending this data with more heterogeneous surgical data further increases performance by an additional 5.0%, 5.2%, and 2.5%, suggesting that increasing diversity within SSL data is beneficial for model performance. The code and pretrained model weights are made publicly available at https://github.com/TimJaspers0801/SurgeNet.

HMAMP: Hypervolume-Driven Multi-Objective Antimicrobial Peptides Design

Antimicrobial peptides (AMPs) have exhibited unprecedented potential as biomaterials in combating multidrug-resistant bacteria. Despite the increasing adoption of artificial intelligence for novel AMP design, challenges pertaining to conflicting attributes such as activity, hemolysis, and toxicity have significantly impeded the progress of researchers. This paper introduces a paradigm shift by considering multiple attributes in AMP design. Presented herein is a novel approach termed Hypervolume-driven Multi-objective Antimicrobial Peptide Design (HMAMP), which prioritizes the simultaneous optimization of multiple attributes of AMPs. By synergizing reinforcement learning and a gradient descent algorithm rooted in the hypervolume maximization concept, HMAMP effectively expands exploration space and mitigates the issue of pattern collapse. This method generates a wide array of prospective AMP candidates that strike a balance among diverse attributes. Furthermore, we pinpoint knee points along the Pareto front of these candidate AMPs. Empirical results across five benchmark models substantiate that HMAMP-designed AMPs exhibit competitive performance and heightened diversity. A detailed analysis of the helical structures and molecular dynamics simulations for ten potential candidate AMPs validates the superiority of HMAMP in the realm of multi-objective AMP design. The ability of HMAMP to systematically craft AMPs considering multiple attributes marks a pioneering milestone, establishing a universal computational framework for the multi-objective design of AMPs.

Synthetic Data in AI: Challenges, Applications, and Ethical Implications

In the rapidly evolving field of artificial intelligence, the creation and utilization of synthetic datasets have become increasingly significant. This report delves into the multifaceted aspects of synthetic data, particularly emphasizing the challenges and potential biases these datasets may harbor. It explores the methodologies behind synthetic data generation, spanning traditional statistical models to advanced deep learning techniques, and examines their applications across diverse domains. The report also critically addresses the ethical considerations and legal implications associated with synthetic datasets, highlighting the urgent need for mechanisms to ensure fairness, mitigate biases, and uphold ethical standards in AI development.