Generalizing AI-driven Assessment of Immunohistochemistry across Immunostains and Cancer Types: A Universal Immunohistochemistry Analyzer

Despite advancements in methodologies, immunohistochemistry (IHC) remains the most utilized ancillary test for histopathologic and companion diagnostics in targeted therapies. However, objective IHC assessment poses challenges. Artificial intelligence (AI) has emerged as a potential solution, yet its development requires extensive training for each cancer and IHC type, limiting versatility. We developed a Universal IHC (UIHC) analyzer, an AI model for interpreting IHC images regardless of tumor or IHC types, using training datasets from various cancers stained for PD-L1 and/or HER2. This multi-cohort trained model outperforms conventional single-cohort models in interpreting unseen IHCs (Kappa score 0.578 vs. up to 0.509) and consistently shows superior performance across different positive staining cutoff values. Qualitative analysis reveals that UIHC effectively clusters patches based on expression levels. The UIHC model also quantitatively assesses c-MET expression with MET mutations, representing a significant advancement in AI application in the era of personalized medicine and accumulating novel biomarkers.

Unsupervised Change Detection Based on Image Reconstruction Loss

To train the change detector, bi-temporal images taken at different times in the same area are used. However, collecting labeled bi-temporal images is expensive and time consuming. To solve this problem, various unsupervised change detection methods have been proposed, but they still require unlabeled bi-temporal images. In this paper, we propose unsupervised change detection based on image reconstruction loss using only unlabeled single temporal single image. The image reconstruction model is trained to reconstruct the original source image by receiving the source image and the photometrically transformed source image as a pair. During inference, the model receives bi-temporal images as the input, and tries to reconstruct one of the inputs. The changed region between bi-temporal images shows high reconstruction loss. Our change detector showed significant performance in various change detection benchmark datasets even though only a single temporal single source image was used. The code and trained models will be publicly available for reproducibility.

Using Self-Supervised Pretext Tasks for Active Learning

Labeling a large set of data is expensive. Active learning aims to tackle this problem by asking to annotate only the most informative data from the unlabeled set. We propose a novel active learning approach that utilizes self-supervised pretext tasks and a unique data sampler to select data that are both difficult and representative. We discover that the loss of a simple self-supervised pretext task, such as rotation prediction, is closely correlated to the downstream task loss. The pretext task learner is trained on the unlabeled set, and the unlabeled data are sorted and grouped into batches by their pretext task losses. In each iteration, the main task model is used to sample the most uncertain data in a batch to be annotated. We evaluate our method on various image classification and segmentation benchmarks and achieve compelling performances on CIFAR10, Caltech-101, ImageNet, and CityScapes.

Studying the Effects of Self-Attention for Medical Image Analysis

When the trained physician interprets medical images, they understand the clinical importance of visual features. By applying cognitive attention, they apply greater focus onto clinically relevant regions while disregarding unnecessary features. The use of computer vision to automate the classification of medical images is widely studied. However, the standard convolutional neural network (CNN) does not necessarily employ subconscious feature relevancy evaluation techniques similar to the trained medical specialist and evaluates features more generally. Self-attention mechanisms enable CNNs to focus more on semantically important regions or aggregated relevant context with long-range dependencies. By using attention, medical image analysis systems can potentially become more robust by focusing on more important clinical feature regions. In this paper, we provide a comprehensive comparison of various state-of-the-art self-attention mechanisms across multiple medical image analysis tasks. Through both quantitative and qualitative evaluations along with a clinical user-centric survey study, we aim to provide a deeper understanding of the effects of self-attention in medical computer vision tasks.

Exploiting Features with Split-and-Share Module

Deep convolutional neural networks (CNNs) have shown state-of-the-art performances in various computer vision tasks. Advances on CNN architectures have focused mainly on designing convolutional blocks of the feature extractors, but less on the classifiers that exploit extracted features. In this work, we propose Split-and-Share Module (SSM),a classifier that splits a given feature into parts, which are partially shared by multiple sub-classifiers. Our intuition is that the more the features are shared, the more common they will become, and SSM can encourage such structural characteristics in the split features. SSM can be easily integrated into any architecture without bells and whistles. We have extensively validated the efficacy of SSM on ImageNet-1K classification task, andSSM has shown consistent and significant improvements over baseline architectures. In addition, we analyze the effect of SSM using the Grad-CAM visualization.

Learning Visual Context by Comparison

Finding diseases from an X-ray image is an important yet highly challenging task. Current methods for solving this task exploit various characteristics of the chest X-ray image, but one of the most important characteristics is still missing: the necessity of comparison between related regions in an image. In this paper, we present Attend-and-Compare Module (ACM) for capturing the difference between an object of interest and its corresponding context. We show that explicit difference modeling can be very helpful in tasks that require direct comparison between locations from afar. This module can be plugged into existing deep learning models. For evaluation, we apply our module to three chest X-ray recognition tasks and COCO object detection & segmentation tasks and observe consistent improvements across tasks. The code is available at https://github.com/mk-minchul/attend-and-compare.

Sequential Feature Filtering Classifier

We propose Sequential Feature Filtering Classifier (FFC), a simple but effective classifier for convolutional neural networks (CNNs). With sequential LayerNorm and ReLU, FFC zeroes out low-activation units and preserves high-activation units. The sequential feature filtering process generates multiple features, which are fed into a shared classifier for multiple outputs. FFC can be applied to any CNNs with a classifier, and significantly improves performances with negligible overhead. We extensively validate the efficacy of FFC on various tasks: ImageNet-1K classification, MS COCO detection, Cityscapes segmentation, and HMDB51 action recognition. Moreover, we empirically show that FFC can further improve performances upon other techniques, including attention modules and augmentation techniques. The code and models will be publicly available.

Reducing Domain Gap via Style-Agnostic Networks

Deep learning models often fail to maintain their performance on new test domains. This problem has been regarded as a critical limitation of deep learning for real-world applications. One of the main causes of this vulnerability to domain changes is that the model tends to be biased to image styles (i.e. textures). To tackle this problem, we propose Style-Agnostic Networks (SagNets) to encourage the model to focus more on image contents (i.e. shapes) shared across domains but ignore image styles. SagNets consist of three novel techniques: style adversarial learning, style blending and style consistency learning, each of which prevents the model from making decisions based upon style information. In collaboration with a few additional training techniques and an ensemble of several model variants, the proposed method won the 1st place in the semi-supervised domain adaptation task of the Visual Domain Adaptation 2019 (VisDA-2019) Challenge.

CBAM: Convolutional Block Attention Module

We propose Convolutional Block Attention Module (CBAM), a simple yet effective attention module for feed-forward convolutional neural networks. Given an intermediate feature map, our module sequentially infers attention maps along two separate dimensions, channel and spatial, then the attention maps are multiplied to the input feature map for adaptive feature refinement. Because CBAM is a lightweight and general module, it can be integrated into any CNN architectures seamlessly with negligible overheads and is end-to-end trainable along with base CNNs. We validate our CBAM through extensive experiments on ImageNet-1K, MS~COCO detection, and VOC~2007 detection datasets. Our experiments show consistent improvements in classification and detection performances with various models, demonstrating the wide applicability of CBAM. The code and models will be publicly available.

BAM: Bottleneck Attention Module

Recent advances in deep neural networks have been developed via architecture search for stronger representational power. In this work, we focus on the effect of attention in general deep neural networks. We propose a simple and effective attention module, named Bottleneck Attention Module (BAM), that can be integrated with any feed-forward convolutional neural networks. Our module infers an attention map along two separate pathways, channel and spatial. We place our module at each bottleneck of models where the downsampling of feature maps occurs. Our module constructs a hierarchical attention at bottlenecks with a number of parameters and it is trainable in an end-to-end manner jointly with any feed-forward models. We validate our BAM through extensive experiments on CIFAR-100, ImageNet-1K, VOC 2007 and MS COCO benchmarks. Our experiments show consistent improvement in classification and detection performances with various models, demonstrating the wide applicability of BAM. The code and models will be publicly available.