Knowledge-driven AI-generated data for accurate and interpretable breast ultrasound diagnoses

Data-driven deep learning models have shown great capabilities to assist radiologists in breast ultrasound (US) diagnoses. However, their effectiveness is limited by the long-tail distribution of training data, which leads to inaccuracies in rare cases. In this study, we address a long-standing challenge of improving the diagnostic model performance on rare cases using long-tailed data. Specifically, we introduce a pipeline, TAILOR, that builds a knowledge-driven generative model to produce tailored synthetic data. The generative model, using 3,749 lesions as source data, can generate millions of breast-US images, especially for error-prone rare cases. The generated data can be further used to build a diagnostic model for accurate and interpretable diagnoses. In the prospective external evaluation, our diagnostic model outperforms the average performance of nine radiologists by 33.5% in specificity with the same sensitivity, improving their performance by providing predictions with an interpretable decision-making process. Moreover, on ductal carcinoma in situ (DCIS), our diagnostic model outperforms all radiologists by a large margin, with only 34 DCIS lesions in the source data. We believe that TAILOR can potentially be extended to various diseases and imaging modalities.

Mining Negative Temporal Contexts For False Positive Suppression In Real-Time Ultrasound Lesion Detection

During ultrasonic scanning processes, real-time lesion detection can assist radiologists in accurate cancer diagnosis. However, this essential task remains challenging and underexplored. General-purpose real-time object detection models can mistakenly report obvious false positives (FPs) when applied to ultrasound videos, potentially misleading junior radiologists. One key issue is their failure to utilize negative symptoms in previous frames, denoted as negative temporal contexts (NTC). To address this issue, we propose to extract contexts from previous frames, including NTC, with the guidance of inverse optical flow. By aggregating extracted contexts, we endow the model with the ability to suppress FPs by leveraging NTC. We call the resulting model UltraDet. The proposed UltraDet demonstrates significant improvement over previous state-of-the-arts and achieves real-time inference speed. To facilitate future research, we will release the code, checkpoints, and high-quality labels of the CVA-BUS dataset used in our experiments.

DETRs with Hybrid Matching

One-to-one set matching is a key design for DETR to establish its end-to-end capability, so that object detection does not require a hand-crafted NMS (non-maximum suppression) method to remove duplicate detections. This end-to-end signature is important for the versatility of DETR, and it has been generalized to a wide range of visual problems, including instance/semantic segmentation, human pose estimation, and point cloud/multi-view-images based detection, etc. However, we note that because there are too few queries assigned as positive samples, the one-to-one set matching significantly reduces the training efficiency of positive samples. This paper proposes a simple yet effective method based on a hybrid matching scheme that combines the original one-to-one matching branch with auxiliary queries that use one-to-many matching loss during training. This hybrid strategy has been shown to significantly improve training efficiency and improve accuracy. In inference, only the original one-to-one match branch is used, thus maintaining the end-to-end merit and the same inference efficiency of DETR. The method is named $\mathcal{H}$-DETR, and it shows that a wide range of representative DETR methods can be consistently improved across a wide range of visual tasks, including Deformable-DETR, 3DETR/PETRv2, PETR, and TransTrack, among others. Code will be available at: https://github.com/HDETR