Medical Video Generation for Disease Progression Simulation

Modeling disease progression is crucial for improving the quality and efficacy of clinical diagnosis and prognosis, but it is often hindered by a lack of longitudinal medical image monitoring for individual patients. To address this challenge, we propose the first Medical Video Generation (MVG) framework that enables controlled manipulation of disease-related image and video features, allowing precise, realistic, and personalized simulations of disease progression. Our approach begins by leveraging large language models (LLMs) to recaption prompt for disease trajectory. Next, a controllable multi-round diffusion model simulates the disease progression state for each patient, creating realistic intermediate disease state sequence. Finally, a diffusion-based video transition generation model interpolates disease progression between these states. We validate our framework across three medical imaging domains: chest X-ray, fundus photography, and skin image. Our results demonstrate that MVG significantly outperforms baseline models in generating coherent and clinically plausible disease trajectories. Two user studies by veteran physicians, provide further validation and insights into the clinical utility of the generated sequences. MVG has the potential to assist healthcare providers in modeling disease trajectories, interpolating missing medical image data, and enhancing medical education through realistic, dynamic visualizations of disease progression.

On-Board Vision-Language Models for Personalized Autonomous Vehicle Motion Control: System Design and Real-World Validation

Personalized driving refers to an autonomous vehicle's ability to adapt its driving behavior or control strategies to match individual users' preferences and driving styles while maintaining safety and comfort standards. However, existing works either fail to capture every individual preference precisely or become computationally inefficient as the user base expands. Vision-Language Models (VLMs) offer promising solutions to this front through their natural language understanding and scene reasoning capabilities. In this work, we propose a lightweight yet effective on-board VLM framework that provides low-latency personalized driving performance while maintaining strong reasoning capabilities. Our solution incorporates a Retrieval-Augmented Generation (RAG)-based memory module that enables continuous learning of individual driving preferences through human feedback. Through comprehensive real-world vehicle deployment and experiments, our system has demonstrated the ability to provide safe, comfortable, and personalized driving experiences across various scenarios and significantly reduce takeover rates by up to 76.9%. To the best of our knowledge, this work represents the first end-to-end VLM-based motion control system in real-world autonomous vehicles.

MpoxVLM: A Vision-Language Model for Diagnosing Skin Lesions from Mpox Virus Infection

In the aftermath of the COVID-19 pandemic and amid accelerating climate change, emerging infectious diseases, particularly those arising from zoonotic spillover, remain a global threat. Mpox (caused by the monkeypox virus) is a notable example of a zoonotic infection that often goes undiagnosed, especially as its rash progresses through stages, complicating detection across diverse populations with different presentations. In August 2024, the WHO Director-General declared the mpox outbreak a public health emergency of international concern for a second time. Despite the deployment of deep learning techniques for detecting diseases from skin lesion images, a robust and publicly accessible foundation model for mpox diagnosis is still lacking due to the unavailability of open-source mpox skin lesion images, multimodal clinical data, and specialized training pipelines. To address this gap, we propose MpoxVLM, a vision-language model (VLM) designed to detect mpox by analyzing both skin lesion images and patient clinical information. MpoxVLM integrates the CLIP visual encoder, an enhanced Vision Transformer (ViT) classifier for skin lesions, and LLaMA-2-7B models, pre-trained and fine-tuned on visual instruction-following question-answer pairs from our newly released mpox skin lesion dataset. Our work achieves 90.38% accuracy for mpox detection, offering a promising pathway to improve early diagnostic accuracy in combating mpox.

Benchmarking Spurious Bias in Few-Shot Image Classifiers

Few-shot image classifiers are designed to recognize and classify new data with minimal supervision and limited data but often show reliance on spurious correlations between classes and spurious attributes, known as spurious bias. Spurious correlations commonly hold in certain samples and few-shot classifiers can suffer from spurious bias induced from them. There is an absence of an automatic benchmarking system to assess the robustness of few-shot classifiers against spurious bias. In this paper, we propose a systematic and rigorous benchmark framework, termed FewSTAB, to fairly demonstrate and quantify varied degrees of robustness of few-shot classifiers to spurious bias. FewSTAB creates few-shot evaluation tasks with biased attributes so that using them for predictions can demonstrate poor performance. To construct these tasks, we propose attribute-based sample selection strategies based on a pre-trained vision-language model, eliminating the need for manual dataset curation. This allows FewSTAB to automatically benchmark spurious bias using any existing test data. FewSTAB offers evaluation results in a new dimension along with a new design guideline for building robust classifiers. Moreover, it can benchmark spurious bias in varied degrees and enable designs for varied degrees of robustness. Its effectiveness is demonstrated through experiments on ten few-shot learning methods across three datasets. We hope our framework can inspire new designs of robust few-shot classifiers. Our code is available at https://github.com/gtzheng/FewSTAB.

MM-SpuBench: Towards Better Understanding of Spurious Biases in Multimodal LLMs

Spurious bias, a tendency to use spurious correlations between non-essential input attributes and target variables for predictions, has revealed a severe robustness pitfall in deep learning models trained on single modality data. Multimodal Large Language Models (MLLMs), which integrate both vision and language models, have demonstrated strong capability in joint vision-language understanding. However, whether spurious biases are prevalent in MLLMs remains under-explored. We mitigate this gap by analyzing the spurious biases in a multimodal setting, uncovering the specific test data patterns that can manifest this problem when biases in the vision model cascade into the alignment between visual and text tokens in MLLMs. To better understand this problem, we introduce MM-SpuBench, a comprehensive visual question-answering (VQA) benchmark designed to evaluate MLLMs' reliance on nine distinct categories of spurious correlations from five open-source image datasets. The VQA dataset is built from human-understandable concept information (attributes). Leveraging this benchmark, we conduct a thorough evaluation of current state-of-the-art MLLMs. Our findings illuminate the persistence of the reliance on spurious correlations from these models and underscore the urge for new methodologies to mitigate spurious biases. To support the MLLM robustness research, we release our VQA benchmark at https://huggingface.co/datasets/mmbench/MM-SpuBench.

Spuriousness-Aware Meta-Learning for Learning Robust Classifiers

Spurious correlations are brittle associations between certain attributes of inputs and target variables, such as the correlation between an image background and an object class. Deep image classifiers often leverage them for predictions, leading to poor generalization on the data where the correlations do not hold. Mitigating the impact of spurious correlations is crucial towards robust model generalization, but it often requires annotations of the spurious correlations in data -- a strong assumption in practice. In this paper, we propose a novel learning framework based on meta-learning, termed SPUME -- SPUriousness-aware MEta-learning, to train an image classifier to be robust to spurious correlations. We design the framework to iteratively detect and mitigate the spurious correlations that the classifier excessively relies on for predictions. To achieve this, we first propose to utilize a pre-trained vision-language model to extract text-format attributes from images. These attributes enable us to curate data with various class-attribute correlations, and we formulate a novel metric to measure the degree of these correlations' spuriousness. Then, to mitigate the reliance on spurious correlations, we propose a meta-learning strategy in which the support (training) sets and query (test) sets in tasks are curated with different spurious correlations that have high degrees of spuriousness. By meta-training the classifier on these spuriousness-aware meta-learning tasks, our classifier can learn to be invariant to the spurious correlations. We demonstrate that our method is robust to spurious correlations without knowing them a priori and achieves the best on five benchmark datasets with different robustness measures.

What is the Visual Cognition Gap between Humans and Multimodal LLMs?

Recently, Multimodal Large Language Models (MLLMs) have shown great promise in language-guided perceptual tasks such as recognition, segmentation, and object detection. However, their effectiveness in addressing visual cognition problems that require high-level reasoning is not well-established. One such challenge is abstract visual reasoning (AVR) -- the cognitive ability to discern relationships among patterns in a set of images and extrapolate to predict subsequent patterns. This skill is crucial during the early neurodevelopmental stages of children. Inspired by the AVR tasks in Raven's Progressive Matrices (RPM) and Wechsler Intelligence Scale for Children (WISC), we propose a new dataset MaRs-VQA and a new benchmark VCog-Bench containing three datasets to evaluate the zero-shot AVR capability of MLLMs and compare their performance with existing human intelligent investigation. Our comparative experiments with different open-source and closed-source MLLMs on the VCog-Bench revealed a gap between MLLMs and human intelligence, highlighting the visual cognitive limitations of current MLLMs. We believe that the public release of VCog-Bench, consisting of MaRs-VQA, and the inference pipeline will drive progress toward the next generation of MLLMs with human-like visual cognition abilities.

Learning Robust Classifiers with Self-Guided Spurious Correlation Mitigation

Deep neural classifiers tend to rely on spurious correlations between spurious attributes of inputs and targets to make predictions, which could jeopardize their generalization capability. Training classifiers robust to spurious correlations typically relies on annotations of spurious correlations in data, which are often expensive to get. In this paper, we tackle an annotation-free setting and propose a self-guided spurious correlation mitigation framework. Our framework automatically constructs fine-grained training labels tailored for a classifier obtained with empirical risk minimization to improve its robustness against spurious correlations. The fine-grained training labels are formulated with different prediction behaviors of the classifier identified in a novel spuriousness embedding space. We construct the space with automatically detected conceptual attributes and a novel spuriousness metric which measures how likely a class-attribute correlation is exploited for predictions. We demonstrate that training the classifier to distinguish different prediction behaviors reduces its reliance on spurious correlations without knowing them a priori and outperforms prior methods on five real-world datasets.

Spurious Correlations in Machine Learning: A Survey

Machine learning systems are known to be sensitive to spurious correlations between biased features of the inputs (e.g., background, texture, and secondary objects) and the corresponding labels. These features and their correlations with the labels are known as "spurious" because they tend to change with shifts in real-world data distributions, which can negatively impact the model's generalization and robustness. In this survey, we provide a comprehensive review of this issue, along with a taxonomy of current state-of-the-art methods for addressing spurious correlations in machine learning models. Additionally, we summarize existing datasets, benchmarks, and metrics to aid future research. The paper concludes with a discussion of the recent advancements and future research challenges in this field, aiming to provide valuable insights for researchers in the related domains.

LaMPilot: An Open Benchmark Dataset for Autonomous Driving with Language Model Programs

We present LaMPilot, a novel framework for planning in the field of autonomous driving, rethinking the task as a code-generation process that leverages established behavioral primitives. This approach aims to address the challenge of interpreting and executing spontaneous user instructions such as "overtake the car ahead," which have typically posed difficulties for existing frameworks. We introduce the LaMPilot benchmark specifically designed to quantitatively evaluate the efficacy of Large Language Models (LLMs) in translating human directives into actionable driving policies. We then evaluate a wide range of state-of-the-art code generation language models on tasks from the LaMPilot Benchmark. The results of the experiments showed that GPT-4, with human feedback, achieved an impressive task completion rate of 92.7% and a minimal collision rate of 0.9%. To encourage further investigation in this area, our code and dataset will be made available.