MpoxVLM: A Vision-Language Model for Diagnosing Skin Lesions from Mpox Virus Infection

In the aftermath of the COVID-19 pandemic and amid accelerating climate change, emerging infectious diseases, particularly those arising from zoonotic spillover, remain a global threat. Mpox (caused by the monkeypox virus) is a notable example of a zoonotic infection that often goes undiagnosed, especially as its rash progresses through stages, complicating detection across diverse populations with different presentations. In August 2024, the WHO Director-General declared the mpox outbreak a public health emergency of international concern for a second time. Despite the deployment of deep learning techniques for detecting diseases from skin lesion images, a robust and publicly accessible foundation model for mpox diagnosis is still lacking due to the unavailability of open-source mpox skin lesion images, multimodal clinical data, and specialized training pipelines. To address this gap, we propose MpoxVLM, a vision-language model (VLM) designed to detect mpox by analyzing both skin lesion images and patient clinical information. MpoxVLM integrates the CLIP visual encoder, an enhanced Vision Transformer (ViT) classifier for skin lesions, and LLaMA-2-7B models, pre-trained and fine-tuned on visual instruction-following question-answer pairs from our newly released mpox skin lesion dataset. Our work achieves 90.38% accuracy for mpox detection, offering a promising pathway to improve early diagnostic accuracy in combating mpox.

ViTASD: Robust Vision Transformer Baselines for Autism Spectrum Disorder Facial Diagnosis

Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder with very high prevalence around the world. Research progress in the field of ASD facial analysis in pediatric patients has been hindered due to a lack of well-established baselines. In this paper, we propose the use of the Vision Transformer (ViT) for the computational analysis of pediatric ASD. The presented model, known as ViTASD, distills knowledge from large facial expression datasets and offers model structure transferability. Specifically, ViTASD employs a vanilla ViT to extract features from patients' face images and adopts a lightweight decoder with a Gaussian Process layer to enhance the robustness for ASD analysis. Extensive experiments conducted on standard ASD facial analysis benchmarks show that our method outperforms all of the representative approaches in ASD facial analysis, while the ViTASD-L achieves a new state-of-the-art. Our code and pretrained models are available at https://github.com/IrohXu/ViTASD.

Improving Computed Tomography (CT) Reconstruction via 3D Shape Induction

Chest computed tomography (CT) imaging adds valuable insight in the diagnosis and management of pulmonary infectious diseases, like tuberculosis (TB). However, due to the cost and resource limitations, only X-ray images may be available for initial diagnosis or follow up comparison imaging during treatment. Due to their projective nature, X-rays images may be more difficult to interpret by clinicians. The lack of publicly available paired X-ray and CT image datasets makes it challenging to train a 3D reconstruction model. In addition, Chest X-ray radiology may rely on different device modalities with varying image quality and there may be variation in underlying population disease spectrum that creates diversity in inputs. We propose shape induction, that is, learning the shape of 3D CT from X-ray without CT supervision, as a novel technique to incorporate realistic X-ray distributions during training of a reconstruction model. Our experiments demonstrate that this process improves both the perceptual quality of generated CT and the accuracy of down-stream classification of pulmonary infectious diseases.

Improving Tuberculosis (TB) Prediction using Synthetically Generated Computed Tomography (CT) Images

The evaluation of infectious disease processes on radiologic images is an important and challenging task in medical image analysis. Pulmonary infections can often be best imaged and evaluated through computed tomography (CT) scans, which are often not available in low-resource environments and difficult to obtain for critically ill patients. On the other hand, X-ray, a different type of imaging procedure, is inexpensive, often available at the bedside and more widely available, but offers a simpler, two dimensional image. We show that by relying on a model that learns to generate CT images from X-rays synthetically, we can improve the automatic disease classification accuracy and provide clinicians with a different look at the pulmonary disease process. Specifically, we investigate Tuberculosis (TB), a deadly bacterial infectious disease that predominantly affects the lungs, but also other organ systems. We show that relying on synthetically generated CT improves TB identification by 7.50% and distinguishes TB properties up to 12.16% better than the X-ray baseline.