Towards Motion Compensation in Autonomous Robotic Subretinal Injections

Exudative (wet) age-related macular degeneration (AMD) is a leading cause of vision loss in older adults, typically treated with intravitreal injections. Emerging therapies, such as subretinal injections of stem cells, gene therapy, small molecules or RPE cells require precise delivery to avoid damaging delicate retinal structures. Autonomous robotic systems can potentially offer the necessary precision for these procedures. This paper presents a novel approach for motion compensation in robotic subretinal injections, utilizing real-time Optical Coherence Tomography (OCT). The proposed method leverages B$^{5}$-scans, a rapid acquisition of small-volume OCT data, for dynamic tracking of retinal motion along the Z-axis, compensating for physiological movements such as breathing and heartbeat. Validation experiments on \textit{ex vivo} porcine eyes revealed challenges in maintaining a consistent tool-to-retina distance, with deviations of up to 200 $\mu m$ for 100 $\mu m$ amplitude motions and over 80 $\mu m$ for 25 $\mu m$ amplitude motions over one minute. Subretinal injections faced additional difficulties, with horizontal shifts causing the needle to move off-target and inject into the vitreous. These results highlight the need for improved motion prediction and horizontal stability to enhance the accuracy and safety of robotic subretinal procedures.

Real-time Deformation-aware Control for Autonomous Robotic Subretinal Injection under iOCT Guidance

Robotic platforms provide repeatable and precise tool positioning that significantly enhances retinal microsurgery. Integration of such systems with intraoperative optical coherence tomography (iOCT) enables image-guided robotic interventions, allowing to autonomously perform advanced treatment possibilities, such as injecting therapeutic agents into the subretinal space. Yet, tissue deformations due to tool-tissue interactions are a major challenge in autonomous iOCT-guided robotic subretinal injection, impacting correct needle positioning and, thus, the outcome of the procedure. This paper presents a novel method for autonomous subretinal injection under iOCT guidance that considers tissue deformations during the insertion procedure. This is achieved through real-time segmentation and 3D reconstruction of the surgical scene from densely sampled iOCT B-scans, which we refer to as B5-scans, to monitor the positioning of the instrument regarding a virtual target layer defined at a relative position between the ILM and RPE. Our experiments on ex-vivo porcine eyes demonstrate dynamic adjustment of the insertion depth and overall improved accuracy in needle positioning compared to previous autonomous insertion approaches. Compared to a 35% success rate in subretinal bleb generation with previous approaches, our proposed method reliably and robustly created subretinal blebs in all our experiments.

Bimanual Manipulation of Steady Hand Eye Robots with Adaptive Sclera Force Control: Cooperative vs. Teleoperation Strategies

Performing intricate eye microsurgery, such as retinal vein cannulation (RVC), as a potential treatment for retinal vein occlusion (RVO), without the assistance of a surgical robotic system is very challenging to do safely. The main limitation has to do with the physiological hand tremor of surgeons. Robot-assisted eye surgery technology may resolve the problems of hand tremors and fatigue and improve the safety and precision of RVC. The Steady-Hand Eye Robot (SHER) is an admittance-based robotic system that can filter out hand tremors and enables ophthalmologists to manipulate a surgical instrument inside the eye cooperatively. However, the admittance-based cooperative control mode does not address crucial safety considerations, such as minimizing contact force between the surgical instrument and the sclera surface to prevent tissue damage. An adaptive sclera force control algorithm was proposed to address this limitation using an FBG-based force-sensing tool to measure and minimize the tool-sclera interaction force. Additionally, features like haptic feedback or hand motion scaling, which can improve the safety and precision of surgery, require a teleoperation control framework. We implemented a bimanual adaptive teleoperation (BMAT) control mode using SHER 2.0 and SHER 2.1 and compared its performance with a bimanual adaptive cooperative (BMAC) mode. Both BMAT and BMAC modes were tested in sitting and standing postures during a vessel-following experiment under a surgical microscope. It is shown, for the first time to the best of our knowledge in robot-assisted retinal surgery, that integrating the adaptive sclera force control algorithm with the bimanual teleoperation framework enables surgeons to safely perform bimanual telemanipulation of the eye without over-stretching it, even in the absence of registration between the two robots.

Cooperative vs. Teleoperation Control of the Steady Hand Eye Robot with Adaptive Sclera Force Control: A Comparative Study

A surgeon's physiological hand tremor can significantly impact the outcome of delicate and precise retinal surgery, such as retinal vein cannulation (RVC) and epiretinal membrane peeling. Robot-assisted eye surgery technology provides ophthalmologists with advanced capabilities such as hand tremor cancellation, hand motion scaling, and safety constraints that enable them to perform these otherwise challenging and high-risk surgeries with high precision and safety. Steady-Hand Eye Robot (SHER) with cooperative control mode can filter out surgeon's hand tremor, yet another important safety feature, that is, minimizing the contact force between the surgical instrument and sclera surface for avoiding tissue damage cannot be met in this control mode. Also, other capabilities, such as hand motion scaling and haptic feedback, require a teleoperation control framework. In this work, for the first time, we implemented a teleoperation control mode incorporated with an adaptive sclera force control algorithm using a PHANTOM Omni haptic device and a force-sensing surgical instrument equipped with Fiber Bragg Grating (FBG) sensors attached to the SHER 2.1 end-effector. This adaptive sclera force control algorithm allows the robot to dynamically minimize the tool-sclera contact force. Moreover, for the first time, we compared the performance of the proposed adaptive teleoperation mode with the cooperative mode by conducting a vessel-following experiment inside an eye phantom under a microscope.

Human-Robot Interaction in Retinal Surgery: A Comparative Study of Serial and Parallel Cooperative Robots

Cooperative robots for intraocular surgery allow surgeons to perform vitreoretinal surgery with high precision and stability. Several robot structural designs have shown capabilities to perform these surgeries. This research investigates the comparative performance of a serial and parallel cooperative-controlled robot in completing a retinal vessel-following task, with a focus on human-robot interaction performance and user experience. Our results indicate that despite differences in robot structure and interaction forces and torques, the two robots exhibited similar levels of performance in terms of general robot-to-patient interaction and average operating time. These findings have implications for the development and implementation of surgical robotics, suggesting that both serial and parallel cooperative-controlled robots can be effective for vitreoretinal surgery tasks.

Using an Improved Output Feedback MPC Approach for Developing a Haptic Virtual Training System

Haptic training simulators generally consist of three major components, namely a human operator, a haptic interface, and a virtual environment. Appropriate dynamic modeling of each of these components can have far-reaching implications for the whole system's performance improvement in terms of transparency, the analogy to the real environment, and stability. In this paper, we developed a virtual-based haptic training simulator for Endoscopic Sinus Surgery (ESS) by doing a dynamic characterization of the phenomenological sinus tissue fracture in the virtual environment, using an input-constrained linear parametric variable model. A parallel robot manipulator equipped with a calibrated force sensor is employed as a haptic interface. A lumped five-parameter single-degree-of-freedom mass-stiffness-damping impedance model is assigned to the operator's arm dynamic. A robust online output feedback quasi-min-max model predictive control (MPC) framework is proposed to stabilize the system during the switching between the piecewise linear dynamics of the virtual environment. The simulations and the experimental results demonstrate the effectiveness of the proposed control algorithm in terms of robustness and convergence to the desired impedance quantities.

A Virtual-Based Haptic Endoscopic Sinus Surgery (ESS) Training System: from Development to Validation

Simulated training platforms offer a suitable avenue for surgical students and professionals to build and improve upon their skills, without the hassle of traditional training methods. To enhance the degree of realistic interaction paradigms of training simulators, great work has been done to both model simulated anatomy in more realistic fashion, as well as providing appropriate haptic feedback to the trainee. As such, this chapter seeks to discuss the ongoing research being conducted on haptic feedback-incorporated simulators specifically for Endoscopic Sinus Surgery (ESS). This chapter offers a brief comparative analysis of some EES simulators, in addition to a deeper quantitative and qualitative look into our approach to designing and prototyping a complete virtual-based haptic EES training platform.

A Data-Driven Model with Hysteresis Compensation for I2RIS Robot

Retinal microsurgery is a high-precision surgery performed on an exceedingly delicate tissue. It now requires extensively trained and highly skilled surgeons. Given the restricted range of instrument motion in the confined intraocular space, and also potentially restricting instrument contact with the sclera, snake-like robots may prove to be a promising technology to provide surgeons with greater flexibility, dexterity, space access, and positioning accuracy during retinal procedures requiring high precision and advantageous tooltip approach angles, such as retinal vein cannulation and epiretinal membrane peeling. Kinematics modeling of these robots is an essential step toward accurate position control, however, as opposed to conventional manipulators, modeling of these robots does not follow a straightforward method due to their complex mechanical structure and actuation mechanisms. Especially, in wire-driven snake-like robots, the hysteresis problem due to the wire tension condition can have a significant impact on the positioning accuracy of these robots. In this paper, we proposed an experimental kinematics model with a hysteresis compensation algorithm using the probabilistic Gaussian mixture models (GMM) Gaussian mixture regression (GMR) approach. Experimental results on the two-degree-of-freedom (DOF) integrated robotic intraocular snake (I2RIS) show that the proposed model provides 0.4 deg accuracy, which is an overall 60% and 70% of improvement for yaw and pitch degrees of freedom, respectively, compared to a previous model of this robot.

Design and Fabrication of a Fiber Bragg Grating Shape Sensor for Shape Reconstruction of a Continuum Manipulator

Continuum dexterous manipulators (CDMs) are suitable for performing tasks in a constrained environment due to their high dexterity and maneuverability. Despite the inherent advantages of CDMs in minimally invasive surgery, real-time control of CDMs' shape during non-constant curvature bending is still challenging. This study presents a novel approach for the design and fabrication of a large deflection fiber Bragg grating (FBG) shape sensor embedded within the lumens inside the walls of a CDM with a large instrument channel. The shape sensor consisted of two fibers, each with three FBG nodes. A shape-sensing model was introduced to reconstruct the centerline of the CDM based on FBG wavelengths. Different experiments, including shape sensor tests and CDM shape reconstruction tests, were conducted to assess the overall accuracy of the shape sensing. The FBG sensor evaluation results revealed the linear curvature-wavelength relationship with the large curvature detection of 0.045 mm at a 90 degrees bending angle and a sensitivity of up to 5.50 nm/mm in each bending direction. The CDM's shape reconstruction experiments in a free environment demonstrated the shape tracking accuracy of 0.216+-0.126 mm for positive/negative deflections. Also, the CDM shape reconstruction error for three cases of bending with obstacles were observed to be 0.436+-0.370 mm for the proximal case, 0.485+-0.418 mm for the middle case, and 0.312+-0.261 mm for the distal case. This study indicates the adequate performance of the FBG sensor and the effectiveness of the model for tracking the shape of the large-deflection CDM with nonconstant-curvature bending for minimally-invasive orthopaedic applications.