STANet: A Novel Spatio-Temporal Aggregation Network for Depression Classification with Small and Unbalanced FMRI Data

Accurate diagnosis of depression is crucial for timely implementation of optimal treatments, preventing complications and reducing the risk of suicide. Traditional methods rely on self-report questionnaires and clinical assessment, lacking objective biomarkers. Combining fMRI with artificial intelligence can enhance depression diagnosis by integrating neuroimaging indicators. However, the specificity of fMRI acquisition for depression often results in unbalanced and small datasets, challenging the sensitivity and accuracy of classification models. In this study, we propose the Spatio-Temporal Aggregation Network (STANet) for diagnosing depression by integrating CNN and RNN to capture both temporal and spatial features of brain activity. STANet comprises the following steps:(1) Aggregate spatio-temporal information via ICA. (2) Utilize multi-scale deep convolution to capture detailed features. (3) Balance data using the SMOTE to generate new samples for minority classes. (4) Employ the AFGRU classifier, which combines Fourier transformation with GRU, to capture long-term dependencies, with an adaptive weight assignment mechanism to enhance model generalization. The experimental results demonstrate that STANet achieves superior depression diagnostic performance with 82.38% accuracy and a 90.72% AUC. The STFA module enhances classification by capturing deeper features at multiple scales. The AFGRU classifier, with adaptive weights and stacked GRU, attains higher accuracy and AUC. SMOTE outperforms other oversampling methods. Additionally, spatio-temporal aggregated features achieve better performance compared to using only temporal or spatial features. STANet outperforms traditional or deep learning classifiers, and functional connectivity-based classifiers, as demonstrated by ten-fold cross-validation.

Neural Modulation Alteration to Positive and Negative Emotions in Depressed Patients: Insights from fMRI Using Positive/Negative Emotion Atlas

Background: Although it has been noticed that depressed patients show differences in processing emotions, the precise neural modulation mechanisms of positive and negative emotions remain elusive. FMRI is a cutting-edge medical imaging technology renowned for its high spatial resolution and dynamic temporal information, making it particularly suitable for the neural dynamics of depression research. Methods: To address this gap, our study firstly leveraged fMRI to delineate activated regions associated with positive and negative emotions in healthy individuals, resulting in the creation of positive emotion atlas (PEA) and negative emotion atlas (NEA). Subsequently, we examined neuroimaging changes in depression patients using these atlases and evaluated their diagnostic performance based on machine learning. Results: Our findings demonstrate that the classification accuracy of depressed patients based on PEA and NEA exceeded 0.70, a notable improvement compared to the whole-brain atlases. Furthermore, ALFF analysis unveiled significant differences between depressed patients and healthy controls in eight functional clusters during the NEA, focusing on the left cuneus, cingulate gyrus, and superior parietal lobule. In contrast, the PEA revealed more pronounced differences across fifteen clusters, involving the right fusiform gyrus, parahippocampal gyrus, and inferior parietal lobule. Limitations: Due to the limited sample size and subtypes of depressed patients, the efficacy may need further validation in future. Conclusions: These findings emphasize the complex interplay between emotion modulation and depression, showcasing significant alterations in both PEA and NEA among depression patients. This research enhances our understanding of emotion modulation in depression, with implications for diagnosis and treatment evaluation.

A Tale of Single-channel Electroencephalogram: Devices, Datasets, Signal Processing, Applications, and Future Directions

Single-channel electroencephalogram (EEG) is a cost-effective, comfortable, and non-invasive method for monitoring brain activity, widely adopted by researchers, consumers, and clinicians. The increasing number and proportion of articles on single-channel EEG underscore its growing potential. This paper provides a comprehensive review of single-channel EEG, focusing on development trends, devices, datasets, signal processing methods, recent applications, and future directions. Definitions of bipolar and unipolar configurations in single-channel EEG are clarified to guide future advancements. Applications mainly span sleep staging, emotion recognition, educational research, and clinical diagnosis. Ongoing advancements of single-channel EEG in AI-based EEG generation techniques suggest potential parity or superiority over multichannel EEG performance.

MHNet: Multi-view High-order Network for Diagnosing Neurodevelopmental Disorders Using Resting-state fMRI

Background: Deep learning models have shown promise in diagnosing neurodevelopmental disorders (NDD) like ASD and ADHD. However, many models either use graph neural networks (GNN) to construct single-level brain functional networks (BFNs) or employ spatial convolution filtering for local information extraction from rs-fMRI data, often neglecting high-order features crucial for NDD classification. Methods: We introduce a Multi-view High-order Network (MHNet) to capture hierarchical and high-order features from multi-view BFNs derived from rs-fMRI data for NDD prediction. MHNet has two branches: the Euclidean Space Features Extraction (ESFE) module and the Non-Euclidean Space Features Extraction (Non-ESFE) module, followed by a Feature Fusion-based Classification (FFC) module for NDD identification. ESFE includes a Functional Connectivity Generation (FCG) module and a High-order Convolutional Neural Network (HCNN) module to extract local and high-order features from BFNs in Euclidean space. Non-ESFE comprises a Generic Internet-like Brain Hierarchical Network Generation (G-IBHN-G) module and a High-order Graph Neural Network (HGNN) module to capture topological and high-order features in non-Euclidean space. Results: Experiments on three public datasets show that MHNet outperforms state-of-the-art methods using both AAL1 and Brainnetome Atlas templates. Extensive ablation studies confirm the superiority of MHNet and the effectiveness of using multi-view fMRI information and high-order features. Our study also offers atlas options for constructing more sophisticated hierarchical networks and explains the association between key brain regions and NDD. Conclusion: MHNet leverages multi-view feature learning from both Euclidean and non-Euclidean spaces, incorporating high-order information from BFNs to enhance NDD classification performance.

You Only Acquire Sparse-channel (YOAS): A Unified Framework for Dense-channel EEG Generation

High-precision acquisition of dense-channel electroencephalogram (EEG) signals is often impeded by the costliness and lack of portability of equipment. In contrast, generating dense-channel EEG signals effectively from sparse channels shows promise and economic viability. However, sparse-channel EEG poses challenges such as reduced spatial resolution, information loss, signal mixing, and heightened susceptibility to noise and interference. To address these challenges, we first theoretically formulate the dense-channel EEG generation problem as by optimizing a set of cross-channel EEG signal generation problems. Then, we propose the YOAS framework for generating dense-channel data from sparse-channel EEG signals. The YOAS totally consists of four sequential stages: Data Preparation, Data Preprocessing, Biased-EEG Generation, and Synthetic EEG Generation. Data Preparation and Preprocessing carefully consider the distribution of EEG electrodes and low signal-to-noise ratio problem of EEG signals. Biased-EEG Generation includes sub-modules of BiasEEGGanFormer and BiasEEGDiffFormer, which facilitate long-term feature extraction with attention and generate signals by combining electrode position alignment with diffusion model, respectively. Synthetic EEG Generation synthesizes the final signals, employing a deduction paradigm for multi-channel EEG generation. Extensive experiments confirmed YOAS's feasibility, efficiency, and theoretical validity, even remarkably enhancing data discernibility. This breakthrough in dense-channel EEG signal generation from sparse-channel data opens new avenues for exploration in EEG signal processing and application.

MM-GTUNets: Unified Multi-Modal Graph Deep Learning for Brain Disorders Prediction

Graph deep learning (GDL) has demonstrated impressive performance in predicting population-based brain disorders (BDs) through the integration of both imaging and non-imaging data. However, the effectiveness of GDL based methods heavily depends on the quality of modeling the multi-modal population graphs and tends to degrade as the graph scale increases. Furthermore, these methods often constrain interactions between imaging and non-imaging data to node-edge interactions within the graph, overlooking complex inter-modal correlations, leading to suboptimal outcomes. To overcome these challenges, we propose MM-GTUNets, an end-to-end graph transformer based multi-modal graph deep learning (MMGDL) framework designed for brain disorders prediction at large scale. Specifically, to effectively leverage rich multi-modal information related to diseases, we introduce Modality Reward Representation Learning (MRRL) which adaptively constructs population graphs using a reward system. Additionally, we employ variational autoencoder to reconstruct latent representations of non-imaging features aligned with imaging features. Based on this, we propose Adaptive Cross-Modal Graph Learning (ACMGL), which captures critical modality-specific and modality-shared features through a unified GTUNet encoder taking advantages of Graph UNet and Graph Transformer, and feature fusion module. We validated our method on two public multi-modal datasets ABIDE and ADHD-200, demonstrating its superior performance in diagnosing BDs. Our code is available at https://github.com/NZWANG/MM-GTUNets.

MSHCNet: Multi-Stream Hybridized Convolutional Networks with Mixed Statistics in Euclidean/Non-Euclidean Spaces and Its Application to Hyperspectral Image Classification

It is well known that hyperspectral images (HSI) contain rich spatial-spectral contextual information, and how to effectively combine both spectral and spatial information using DNN for HSI classification has become a new research hotspot. Compared with CNN with square kernels, GCN have exhibited exciting potential to model spatial contextual structure and conduct flexible convolution on arbitrarily irregular image regions. However, current GCN only using first-order spectral-spatial signatures can result in boundary blurring and isolated misclassification. To address these, we first designed the graph-based second-order pooling (GSOP) operation to obtain contextual nodes information in non-Euclidean space for GCN. Further, we proposed a novel multi-stream hybridized convolutional network (MSHCNet) with combination of first and second order statistics in Euclidean/non-Euclidean spaces to learn and fuse multi-view complementary information to segment HSIs. Specifically, our MSHCNet adopted four parallel streams, which contained G-stream, utilizing the irregular correlation between adjacent land covers in terms of first-order graph in non-Euclidean space; C-stream, adopting convolution operator to learn regular spatial-spectral features in Euclidean space; N-stream, combining first and second order features to learn representative and discriminative regular spatial-spectral features of Euclidean space; S-stream, using GSOP to capture boundary correlations and obtain graph representations from all nodes in graphs of non-Euclidean space. Besides, these feature representations learned from four different streams were fused to integrate the multi-view complementary information for HSI classification. Finally, we evaluated our proposed MSHCNet on three hyperspectral datasets, and experimental results demonstrated that our method significantly outperformed state-of-the-art eight methods.

CSC-Unet: A Novel Convolutional Sparse Coding Strategy based Neural Network for Semantic Segmentation

It is a challenging task to accurately perform semantic segmentation due to the complexity of real picture scenes. Many semantic segmentation methods based on traditional deep learning insufficiently captured the semantic and appearance information of images, which put limit on their generality and robustness for various application scenes. In this paper, we proposed a novel strategy that reformulated the popularly-used convolution operation to multi-layer convolutional sparse coding block to ease the aforementioned deficiency. This strategy can be possibly used to significantly improve the segmentation performance of any semantic segmentation model that involves convolutional operations. To prove the effectiveness of our idea, we chose the widely-used U-Net model for the demonstration purpose, and we designed CSC-Unet model series based on U-Net. Through extensive analysis and experiments, we provided credible evidence showing that the multi-layer convolutional sparse coding block enables semantic segmentation model to converge faster, can extract finer semantic and appearance information of images, and improve the ability to recover spatial detail information. The best CSC-Unet model significantly outperforms the results of the original U-Net on three public datasets with different scenarios, i.e., 87.14% vs. 84.71% on DeepCrack dataset, 68.91% vs. 67.09% on Nuclei dataset, and 53.68% vs. 48.82% on CamVid dataset, respectively.