Physics-informed Score-based Diffusion Model for Limited-angle Reconstruction of Cardiac Computed Tomography

Cardiac computed tomography (CT) has emerged as a major imaging modality for the diagnosis and monitoring of cardiovascular diseases. High temporal resolution is essential to ensure diagnostic accuracy. Limited-angle data acquisition can reduce scan time and improve temporal resolution, but typically leads to severe image degradation and motivates for improved reconstruction techniques. In this paper, we propose a novel physics-informed score-based diffusion model (PSDM) for limited-angle reconstruction of cardiac CT. At the sampling time, we combine a data prior from a diffusion model and a model prior obtained via an iterative algorithm and Fourier fusion to further enhance the image quality. Specifically, our approach integrates the primal-dual hybrid gradient (PDHG) algorithm with score-based diffusion models, thereby enabling us to reconstruct high-quality cardiac CT images from limited-angle data. The numerical simulations and real data experiments confirm the effectiveness of our proposed approach.

Deep Few-view High-resolution Photon-counting Extremity CT at Halved Dose for a Clinical Trial

The latest X-ray photon-counting computed tomography (PCCT) for extremity allows multi-energy high-resolution (HR) imaging for tissue characterization and material decomposition. However, both radiation dose and imaging speed need improvement for contrast-enhanced and other studies. Despite the success of deep learning methods for 2D few-view reconstruction, applying them to HR volumetric reconstruction of extremity scans for clinical diagnosis has been limited due to GPU memory constraints, training data scarcity, and domain gap issues. In this paper, we propose a deep learning-based approach for PCCT image reconstruction at halved dose and doubled speed in a New Zealand clinical trial. Particularly, we present a patch-based volumetric refinement network to alleviate the GPU memory limitation, train network with synthetic data, and use model-based iterative refinement to bridge the gap between synthetic and real-world data. The simulation and phantom experiments demonstrate consistently improved results under different acquisition conditions on both in- and off-domain structures using a fixed network. The image quality of 8 patients from the clinical trial are evaluated by three radiologists in comparison with the standard image reconstruction with a full-view dataset. It is shown that our proposed approach is essentially identical to or better than the clinical benchmark in terms of diagnostic image quality scores. Our approach has a great potential to improve the safety and efficiency of PCCT without compromising image quality.

LoMAE: Low-level Vision Masked Autoencoders for Low-dose CT Denoising

Low-dose computed tomography (LDCT) offers reduced X-ray radiation exposure but at the cost of compromised image quality, characterized by increased noise and artifacts. Recently, transformer models emerged as a promising avenue to enhance LDCT image quality. However, the success of such models relies on a large amount of paired noisy and clean images, which are often scarce in clinical settings. In the fields of computer vision and natural language processing, masked autoencoders (MAE) have been recognized as an effective label-free self-pretraining method for transformers, due to their exceptional feature representation ability. However, the original pretraining and fine-tuning design fails to work in low-level vision tasks like denoising. In response to this challenge, we redesign the classical encoder-decoder learning model and facilitate a simple yet effective low-level vision MAE, referred to as LoMAE, tailored to address the LDCT denoising problem. Moreover, we introduce an MAE-GradCAM method to shed light on the latent learning mechanisms of the MAE/LoMAE. Additionally, we explore the LoMAE's robustness and generability across a variety of noise levels. Experiments results show that the proposed LoMAE can enhance the transformer's denoising performance and greatly relieve the dependence on the ground truth clean data. It also demonstrates remarkable robustness and generalizability over a spectrum of noise levels.

Two-and-a-half Order Score-based Model for Solving 3D Ill-posed Inverse Problems

Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are crucial technologies in the field of medical imaging. Score-based models have proven to be effective in addressing different inverse problems encountered in CT and MRI, such as sparse-view CT and fast MRI reconstruction. However, these models face challenges in achieving accurate three dimensional (3D) volumetric reconstruction. The existing score-based models primarily focus on reconstructing two dimensional (2D) data distribution, leading to inconsistencies between adjacent slices in the reconstructed 3D volumetric images. To overcome this limitation, we propose a novel two-and-a-half order score-based model (TOSM). During the training phase, our TOSM learns data distributions in 2D space, which reduces the complexity of training compared to directly working on 3D volumes. However, in the reconstruction phase, the TOSM updates the data distribution in 3D space, utilizing complementary scores along three directions (sagittal, coronal, and transaxial) to achieve a more precise reconstruction. The development of TOSM is built on robust theoretical principles, ensuring its reliability and efficacy. Through extensive experimentation on large-scale sparse-view CT and fast MRI datasets, our method demonstrates remarkable advancements and attains state-of-the-art results in solving 3D ill-posed inverse problems. Notably, the proposed TOSM effectively addresses the inter-slice inconsistency issue, resulting in high-quality 3D volumetric reconstruction.

Masked Autoencoders for Low dose CT denoising

Low-dose computed tomography (LDCT) reduces the X-ray radiation but compromises image quality with more noises and artifacts. A plethora of transformer models have been developed recently to improve LDCT image quality. However, the success of a transformer model relies on a large amount of paired noisy and clean data, which is often unavailable in clinical applications. In computer vision and natural language processing fields, masked autoencoders (MAE) have been proposed as an effective label-free self-pretraining method for transformers, due to its excellent feature representation ability. Here, we redesign the classical encoder-decoder learning model to match the denoising task and apply it to LDCT denoising problem. The MAE can leverage the unlabeled data and facilitate structural preservation for the LDCT denoising model when ground truth data are missing. Experiments on the Mayo dataset validate that the MAE can boost the transformer's denoising performance and relieve the dependence on the ground truth data.

Spectral2Spectral: Image-spectral Similarity Assisted Spectral CT Deep Reconstruction without Reference

The photon-counting detector (PCD) based spectral computed tomography attracts much more attentions since it has the capability to provide more accurate identification and quantitative analysis for biomedical materials. The limited number of photons within narrow energy-bin leads to low signal-noise ratio data. The existing supervised deep reconstruction networks for CT reconstruction are difficult to address these challenges. In this paper, we propose an iterative deep reconstruction network to synergize model and data priors into a unified framework, named as Spectral2Spectral. Our Spectral2Spectral employs an unsupervised deep training strategy to obtain high-quality images from noisy data with an end-to-end fashion. The structural similarity prior within image-spectral domain is refined as a regularization term to further constrain the network training. The weights of neural network are automatically updated to capture image features and structures with iterative process. Three large-scale preclinical datasets experiments demonstrate that the Spectral2spectral reconstruct better image quality than other state-of-the-art methods.

SQ-Swin: a Pretrained Siamese Quadratic Swin Transformer for Lettuce Browning Prediction

Packaged fresh-cut lettuce is widely consumed as a major component of vegetable salad owing to its high nutrition, freshness, and convenience. However, enzymatic browning discoloration on lettuce cut edges significantly reduces product quality and shelf life. While there are many research and breeding efforts underway to minimize browning, the progress is hindered by the lack of a rapid and reliable methodology to evaluate browning. Current methods to identify and quantify browning are either too subjective, labor intensive, or inaccurate. In this paper, we report a deep learning model for lettuce browning prediction. To the best of our knowledge, it is the first-of-its-kind on deep learning for lettuce browning prediction using a pretrained Siamese Quadratic Swin (SQ-Swin) transformer with several highlights. First, our model includes quadratic features in the transformer model which is more powerful to incorporate real-world representations than the linear transformer. Second, a multi-scale training strategy is proposed to augment the data and explore more of the inherent self-similarity of the lettuce images. Third, the proposed model uses a siamese architecture which learns the inter-relations among the limited training samples. Fourth, the model is pretrained on the ImageNet and then trained with the reptile meta-learning algorithm to learn higher-order gradients than a regular one. Experiment results on the fresh-cut lettuce datasets show that the proposed SQ-Swin outperforms the traditional methods and other deep learning-based backbones.

CTformer: Convolution-free Token2Token Dilated Vision Transformer for Low-dose CT Denoising

Low-dose computed tomography (LDCT) denoising is an important problem in CT research. Compared to the normal dose CT (NDCT), LDCT images are subjected to severe noise and artifacts. Recently in many studies, vision transformers have shown superior feature representation ability over convolutional neural networks (CNNs). However, unlike CNNs, the potential of vision transformers in LDCT denoising was little explored so far. To fill this gap, we propose a Convolution-free Token2Token Dilated Vision Transformer for low-dose CT denoising. The CTformer uses a more powerful token rearrangement to encompass local contextual information and thus avoids convolution. It also dilates and shifts feature maps to capture longer-range interaction. We interpret the CTformer by statically inspecting patterns of its internal attention maps and dynamically tracing the hierarchical attention flow with an explanatory graph. Furthermore, an overlapped inference mechanism is introduced to effectively eliminate the boundary artifacts that are common for encoder-decoder-based denoising models. Experimental results on Mayo LDCT dataset suggest that the CTformer outperforms the state-of-the-art denoising methods with a low computation overhead.

Manifoldron: Direct Space Partition via Manifold Discovery

A neural network with the widely-used ReLU activation has been shown to partition the sample space into many convex polytopes for prediction. However, the parameterized way a neural network and other machine learning models use to partition the space has imperfections, e.g., the compromised interpretability for complex models, the inflexibility in decision boundary construction due to the generic character of the model, and the risk of being trapped into shortcut solutions. In contrast, although the non-parameterized models can adorably avoid or downplay these issues, they are usually insufficiently powerful either due to over-simplification or the failure to accommodate the manifold structures of data. In this context, we first propose a new type of machine learning models referred to as Manifoldron that directly derives decision boundaries from data and partitions the space via manifold structure discovery. Then, we systematically analyze the key characteristics of the Manifoldron including interpretability, manifold characterization capability, and its link to neural networks. The experimental results on 9 small and 11 large datasets demonstrate that the proposed Manifoldron performs competitively compared to the mainstream machine learning models. We have shared our code https://github.com/wdayang/Manifoldron for free download and evaluation.

AI-Enabled Ultra-Low-Dose CT Reconstruction

By the ALARA (As Low As Reasonably Achievable) principle, ultra-low-dose CT reconstruction is a holy grail to minimize cancer risks and genetic damages, especially for children. With the development of medical CT technologies, the iterative algorithms are widely used to reconstruct decent CT images from a low-dose scan. Recently, artificial intelligence (AI) techniques have shown a great promise in further reducing CT radiation dose to the next level. In this paper, we demonstrate that AI-powered CT reconstruction offers diagnostic image quality at an ultra-low-dose level comparable to that of radiography. Specifically, here we develop a Split Unrolled Grid-like Alternative Reconstruction (SUGAR) network, in which deep learning, physical modeling and image prior are integrated. The reconstruction results from clinical datasets show that excellent images can be reconstructed using SUGAR from 36 projections. This approach has a potential to change future healthcare.