Physics-informed Score-based Diffusion Model for Limited-angle Reconstruction of Cardiac Computed Tomography

Cardiac computed tomography (CT) has emerged as a major imaging modality for the diagnosis and monitoring of cardiovascular diseases. High temporal resolution is essential to ensure diagnostic accuracy. Limited-angle data acquisition can reduce scan time and improve temporal resolution, but typically leads to severe image degradation and motivates for improved reconstruction techniques. In this paper, we propose a novel physics-informed score-based diffusion model (PSDM) for limited-angle reconstruction of cardiac CT. At the sampling time, we combine a data prior from a diffusion model and a model prior obtained via an iterative algorithm and Fourier fusion to further enhance the image quality. Specifically, our approach integrates the primal-dual hybrid gradient (PDHG) algorithm with score-based diffusion models, thereby enabling us to reconstruct high-quality cardiac CT images from limited-angle data. The numerical simulations and real data experiments confirm the effectiveness of our proposed approach.

LoMAE: Low-level Vision Masked Autoencoders for Low-dose CT Denoising

Low-dose computed tomography (LDCT) offers reduced X-ray radiation exposure but at the cost of compromised image quality, characterized by increased noise and artifacts. Recently, transformer models emerged as a promising avenue to enhance LDCT image quality. However, the success of such models relies on a large amount of paired noisy and clean images, which are often scarce in clinical settings. In the fields of computer vision and natural language processing, masked autoencoders (MAE) have been recognized as an effective label-free self-pretraining method for transformers, due to their exceptional feature representation ability. However, the original pretraining and fine-tuning design fails to work in low-level vision tasks like denoising. In response to this challenge, we redesign the classical encoder-decoder learning model and facilitate a simple yet effective low-level vision MAE, referred to as LoMAE, tailored to address the LDCT denoising problem. Moreover, we introduce an MAE-GradCAM method to shed light on the latent learning mechanisms of the MAE/LoMAE. Additionally, we explore the LoMAE's robustness and generability across a variety of noise levels. Experiments results show that the proposed LoMAE can enhance the transformer's denoising performance and greatly relieve the dependence on the ground truth clean data. It also demonstrates remarkable robustness and generalizability over a spectrum of noise levels.

Reduced Deep Convolutional Activation Features (R-DeCAF) in Histopathology Images to Improve the Classification Performance for Breast Cancer Diagnosis

Breast cancer is the second most common cancer among women worldwide. Diagnosis of breast cancer by the pathologists is a time-consuming procedure and subjective. Computer aided diagnosis frameworks are utilized to relieve pathologist workload by classifying the data automatically, in which deep convolutional neural networks (CNNs) are effective solutions. The features extracted from activation layer of pre-trained CNNs are called deep convolutional activation features (DeCAF). In this paper, we have analyzed that all DeCAF features are not necessarily led to a higher accuracy in the classification task and dimension reduction plays an important role. Therefore, different dimension reduction methods are applied to achieve an effective combination of features by capturing the essence of DeCAF features. To this purpose, we have proposed reduced deep convolutional activation features (R-DeCAF). In this framework, pre-trained CNNs such as AlexNet, VGG-16 and VGG-19 are utilized in transfer learning mode as feature extractors. DeCAF features are extracted from the first fully connected layer of the mentioned CNNs and support vector machine has been used for binary classification. Among linear and nonlinear dimensionality reduction algorithms, linear approaches such as principal component analysis (PCA) represent a better combination among deep features and lead to a higher accuracy in the classification task using small number of features considering specific amount of cumulative explained variance (CEV) of features. The proposed method is validated using experimental BreakHis dataset. Comprehensive results show improvement in the classification accuracy up to 4.3% with less computational time. Best achieved accuracy is 91.13% for 400x data with feature vector size (FVS) of 23 and CEV equals to 0.15 using pre-trained AlexNet as feature extractor and PCA as feature reduction algorithm.