Physics-Integrated Inference for Signal Recovery in Non-Gaussian Regimes

High-performance room-temperature sensing is often limited by non-stationary $1/f$ fluctuations and non-Gaussian stochasticity. In spintronic devices, thermally activated Néel switching creates heavy-tailed noise that masks weak signals, defeating linear filters optimized for Gaussian statistics. Here, we introduce a physics-integrated inference framework that decouples signal morphology from stochastic transients using a hierarchical 1D CNN-GRU topology. By learning the temporal signatures of Néel relaxation, this architecture reduces the Noise Equivalent Differential Temperature (NEDT) of spintronic Poisson bolometers by a factor of six (233.78 mK to 40.44 mK), effectively elevating room-temperature sensitivity toward cryogenic limits. We demonstrate the framework's universality across the electromagnetic and biological spectrum, achieving a 9-fold error suppression in Radar tracking, a 40\% uncertainty reduction in LiDAR, and a 15.56 dB SNR enhancement in ECG. This hardware-inference coupling recovers deterministic signals from fluctuation-dominated regimes, enabling near-ideal detection limits in noisy edge environments.

UniPACT: A Multimodal Framework for Prognostic Question Answering on Raw ECG and Structured EHR

Accurate clinical prognosis requires synthesizing structured Electronic Health Records (EHRs) with real-time physiological signals like the Electrocardiogram (ECG). Large Language Models (LLMs) offer a powerful reasoning engine for this task but struggle to natively process these heterogeneous, non-textual data types. To address this, we propose UniPACT (Unified Prognostic Question Answering for Clinical Time-series), a unified framework for prognostic question answering that bridges this modality gap. UniPACT's core contribution is a structured prompting mechanism that converts numerical EHR data into semantically rich text. This textualized patient context is then fused with representations learned directly from raw ECG waveforms, enabling an LLM to reason over both modalities holistically. We evaluate UniPACT on the comprehensive MDS-ED benchmark, it achieves a state-of-the-art mean AUROC of 89.37% across a diverse set of prognostic tasks including diagnosis, deterioration, ICU admission, and mortality, outperforming specialized baselines. Further analysis demonstrates that our multimodal, multi-task approach is critical for performance and provides robustness in missing data scenarios.

How Much Temporal Modeling is Enough? A Systematic Study of Hybrid CNN-RNN Architectures for Multi-Label ECG Classification

Accurate multi-label classification of electrocardiogram (ECG) signals remains challenging due to the coexistence of multiple cardiac conditions, pronounced class imbalance, and long-range temporal dependencies in multi-lead recordings. Although recent studies increasingly rely on deep and stacked recurrent architectures, the necessity and clinical justification of such architectural complexity have not been rigorously examined. In this work, we perform a systematic comparative evaluation of convolutional neural networks (CNNs) combined with multiple recurrent configurations, including LSTM, GRU, Bidirectional LSTM (BiLSTM), and their stacked variants, for multi-label ECG classification on the PTB-XL dataset comprising 23 diagnostic categories. The CNN component serves as a morphology-driven baseline, while recurrent layers are progressively integrated to assess their contribution to temporal modeling and generalization performance. Experimental results indicate that a CNN integrated with a single BiLSTM layer achieves the most favorable trade-off between predictive performance and model complexity. This configuration attains superior Hamming loss (0.0338), macro-AUPRC (0.4715), micro-F1 score (0.6979), and subset accuracy (0.5723) compared with deeper recurrent combinations. Although stacked recurrent models occasionally improve recall for specific rare classes, our results provide empirical evidence that increasing recurrent depth yields diminishing returns and may degrade generalization due to reduced precision and overfitting. These findings suggest that architectural alignment with the intrinsic temporal structure of ECG signals, rather than increased recurrent depth, is a key determinant of robust performance and clinically relevant deployment.

Beat-ssl: Capturing Local ECG Morphology through Heartbeat-level Contrastive Learning with Soft Targets

Obtaining labelled ECG data for developing supervised models is challenging. Contrastive learning (CL) has emerged as a promising pretraining approach that enables effective transfer learning with limited labelled data. However, existing CL frameworks either focus solely on global context or fail to exploit ECG-specific characteristics. Furthermore, these methods rely on hard contrastive targets, which may not adequately capture the continuous nature of feature similarity in ECG signals. In this paper, we propose Beat-SSL, a contrastive learning framework that performs dual-context learning through both rhythm-level and heartbeat-level contrasting with soft targets. We evaluated our pretrained model on two downstream tasks: 1) multilabel classification for global rhythm assessment, and 2) ECG segmentation to assess its capacity to learn representations across both contexts. We conducted an ablation study and compared the best configuration with three other methods, including one ECG foundation model. Despite the foundation model's broader pretraining, Beat-SSL reached 93% of its performance in multilabel classification task and surpassed all other methods in the segmentation task by 4%.

Adaptive Non-Uniform Sampling of Bandlimited Signals via Algorithm-Encoder Co-Design

We propose an adaptive non-uniform sampling framework for bandlimited signals based on an algorithm-encoder co-design perspective. By revisiting the convergence analysis of iterative reconstruction algorithms for non-uniform measurements, we derive a local, energy-based sufficient condition that governs reconstruction behavior as a function of the signal and derivative energies within each sampling interval. Unlike classical approaches that impose a global Nyquist-type bound on the inter-sample spacing, the proposed condition permits large gaps in slowly varying regions while enforcing denser sampling only where the signal exhibits rapid temporal variation. Building on this theoretical insight, we design a variable-bias, variable-threshold integrate-and-fire time encoding machine (VBT-IF-TEM) whose firing mechanism is explicitly shaped to enforce the derived local convergence condition. To ensure robustness, a shifted-signal formulation is introduced to suppress excessive firing in regions where the magnitude of the signal amplitude is close to zero or the local signal energy approaches zero. Using the proposed encoder, an analog signal is discretely represented by time encodings and signal averages, enabling perfect reconstruction via a standard iterative algorithm even when the local sampling rate falls below the Nyquist rate. Simulation results on synthetic signals and experiments on ultrasonic guided-wave and ECG signals demonstrate that the proposed framework achieves substantial reductions in sampling density compared to uniform sampling and conventional IF-TEMs, while maintaining accurate reconstruction. The results further highlight a controllable tradeoff between sampling density, reconstruction accuracy, and convergence behavior, which can be navigated through adaptive parameter selection.

Experience with Single Domain Generalization in Real World Medical Imaging Deployments

A desirable property of any deployed artificial intelligence is generalization across domains, i.e. data generation distribution under a specific acquisition condition. In medical imagining applications the most coveted property for effective deployment is Single Domain Generalization (SDG), which addresses the challenge of training a model on a single domain to ensure it generalizes well to unseen target domains. In multi-center studies, differences in scanners and imaging protocols introduce domain shifts that exacerbate variability in rare class characteristics. This paper presents our experience on SDG in real life deployment for two exemplary medical imaging case studies on seizure onset zone detection using fMRI data, and stress electrocardiogram based coronary artery detection. Utilizing the commonly used application of diabetic retinopathy, we first demonstrate that state-of-the-art SDG techniques fail to achieve generalized performance across data domains. We then develop a generic expert knowledge integrated deep learning technique DL+EKE and instantiate it for the DR application and show that DL+EKE outperforms SOTA SDG methods on DR. We then deploy instances of DL+EKE technique on the two real world examples of stress ECG and resting state (rs)-fMRI and discuss issues faced with SDG techniques.

ECGomics: An Open Platform for AI-ECG Digital Biomarker Discovery

Background: Conventional electrocardiogram (ECG) analysis faces a persistent dichotomy: expert-driven features ensure interpretability but lack sensitivity to latent patterns, while deep learning offers high accuracy but functions as a black box with high data dependency. We introduce ECGomics, a systematic paradigm and open-source platform for the multidimensional deconstruction of cardiac signals into digital biomarker. Methods: Inspired by the taxonomic rigor of genomics, ECGomics deconstructs cardiac activity across four dimensions: Structural, Intensity, Functional, and Comparative. This taxonomy synergizes expert-defined morphological rules with data-driven latent representations, effectively bridging the gap between handcrafted features and deep learning embeddings. Results: We operationalized this framework into a scalable ecosystem consisting of a web-based research platform and a mobile-integrated solution (https://github.com/PKUDigitalHealth/ECGomics). The web platform facilitates high-throughput analysis via precision parameter configuration, high-fidelity data ingestion, and 12-lead visualization, allowing for the systematic extraction of biomarkers across the four ECGomics dimensions. Complementarily, the mobile interface, integrated with portable sensors and a cloud-based engine, enables real-time signal acquisition and near-instantaneous delivery of structured diagnostic reports. This dual-interface architecture successfully transitions ECGomics from theoretical discovery to decentralized, real-world health management, ensuring professional-grade monitoring in diverse clinical and home-based settings. Conclusion: ECGomics harmonizes diagnostic precision, interpretability, and data efficiency. By providing a deployable software ecosystem, this paradigm establishes a robust foundation for digital biomarker discovery and personalized cardiovascular medicine.

An AI-IoT Based Smart Wheelchair with Gesture-Controlled Mobility, Deep Learning-Based Obstacle Detection, Multi-Sensor Health Monitoring, and Emergency Alert System

The growing number of differently-abled and elderly individuals demands affordable, intelligent wheelchairs that combine safe navigation with health monitoring. Traditional wheelchairs lack dynamic features, and many smart alternatives remain costly, single-modality, and limited in health integration. Motivated by the pressing demand for advanced, personalized, and affordable assistive technologies, we propose a comprehensive AI-IoT based smart wheelchair system that incorporates glove-based gesture control for hands-free navigation, real-time object detection using YOLOv8 with auditory feedback for obstacle avoidance, and ultrasonic for immediate collision avoidance. Vital signs (heart rate, SpO$_2$, ECG, temperature) are continuously monitored, uploaded to ThingSpeak, and trigger email alerts for critical conditions. Built on a modular and low-cost architecture, the gesture control achieved a 95.5\% success rate, ultrasonic obstacle detection reached 94\% accuracy, and YOLOv8-based object detection delivered 91.5\% Precision, 90.2\% Recall, and a 90.8\% F1-score. This integrated, multi-modal approach offers a practical, scalable, and affordable solution, significantly enhancing user autonomy, safety, and independence by bridging the gap between innovative research and real-world deployment.

Inter-patient ECG Arrhythmia Classification with LGNs and LUTNs

Deep Differentiable Logic Gate Networks (LGNs) and Lookup Table Networks (LUTNs) are demonstrated to be suitable for the automatic classification of electrocardiograms (ECGs) using the inter-patient paradigm. The methods are benchmarked using the MIT-BIH arrhythmia data set, achieving up to 94.28% accuracy and a $jκ$ index of 0.683 on a four-class classification problem. Our models use between 2.89k and 6.17k FLOPs, including preprocessing and readout, which is three to six orders of magnitude less compared to SOTA methods. A novel preprocessing method is utilized that attains superior performance compared to existing methods for both the mixed-patient and inter-patient paradigms. In addition, a novel method for training the Lookup Tables (LUTs) in LUTNs is devised that uses the Boolean equation of a multiplexer (MUX). Additionally, rate coding was utilized for the first time in these LGNs and LUTNs, enhancing the performance of LGNs. Furthermore, it is the first time that LGNs and LUTNs have been benchmarked on the MIT-BIH arrhythmia dataset using the inter-patient paradigm. Using an Artix 7 FPGA, between 2000 and 2990 LUTs were needed, and between 5 to 7 mW (i.e. 50 pJ to 70 pJ per inference) was estimated for running these models. The performance in terms of both accuracy and $jκ$-index is significantly higher compared to previous LGN results. These positive results suggest that one can utilize LGNs and LUTNs for the detection of arrhythmias at extremely low power and high speeds in heart implants or wearable devices, even for patients not included in the training set.

Enhancing Imbalanced Electrocardiogram Classification: A Novel Approach Integrating Data Augmentation through Wavelet Transform and Interclass Fusion

Imbalanced electrocardiogram (ECG) data hampers the efficacy and resilience of algorithms in the automated processing and interpretation of cardiovascular diagnostic information, which in turn impedes deep learning-based ECG classification. Notably, certain cardiac conditions that are infrequently encountered are disproportionately underrepresented in these datasets. Although algorithmic generation and oversampling of specific ECG signal types can mitigate class skew, there is a lack of consensus regarding the effectiveness of such techniques in ECG classification. Furthermore, the methodologies and scenarios of ECG acquisition introduce noise, further complicating the processing of ECG data. This paper presents a significantly enhanced ECG classifier that simultaneously addresses both class imbalance and noise-related challenges in ECG analysis, as observed in the CPSC 2018 dataset. Specifically, we propose the application of feature fusion based on the wavelet transform, with a focus on wavelet transform-based interclass fusion, to generate the training feature library and the test set feature library. Subsequently, the original training and test data are amalgamated with their respective feature databases, resulting in more balanced training and test datasets. Employing this approach, our ECG model achieves recognition accuracies of up to 99%, 98%, 97%, 98%, 96%, 92%, and 93% for Normal, AF, I-AVB, LBBB, RBBB, PAC, PVC, STD, and STE, respectively. Furthermore, the average recognition accuracy for these categories ranges between 92\% and 98\%. Notably, our proposed data fusion methodology surpasses any known algorithms in terms of ECG classification accuracy in the CPSC 2018 dataset.