An artificially intelligent magnetic resonance spectroscopy quantification method: Comparison between QNet and LCModel on the cloud computing platform CloudBrain-MRS

Objctives: This work aimed to statistically compare the metabolite quantification of human brain magnetic resonance spectroscopy (MRS) between the deep learning method QNet and the classical method LCModel through an easy-to-use intelligent cloud computing platform CloudBrain-MRS. Materials and Methods: In this retrospective study, two 3 T MRI scanners Philips Ingenia and Achieva collected 61 and 46 in vivo 1H magnetic resonance (MR) spectra of healthy participants, respectively, from the brain region of pregenual anterior cingulate cortex from September to October 2021. The analyses of Bland-Altman, Pearson correlation and reasonability were performed to assess the degree of agreement, linear correlation and reasonability between the two quantification methods. Results: Fifteen healthy volunteers (12 females and 3 males, age range: 21-35 years, mean age/standard deviation = 27.4/3.9 years) were recruited. The analyses of Bland-Altman, Pearson correlation and reasonability showed high to good consistency and very strong to moderate correlation between the two methods for quantification of total N-acetylaspartate (tNAA), total choline (tCho), and inositol (Ins) (relative half interval of limits of agreement = 3.04%, 9.3%, and 18.5%, respectively; Pearson correlation coefficient r = 0.775, 0.927, and 0.469, respectively). In addition, quantification results of QNet are more likely to be closer to the previous reported average values than those of LCModel. Conclusion: There were high or good degrees of consistency between the quantification results of QNet and LCModel for tNAA, tCho, and Ins, and QNet generally has more reasonable quantification than LCModel.

Distance and Hop-wise Structures Encoding Enhanced Graph Attention Networks

Numerous works have proven that existing neighbor-averaging Graph Neural Networks cannot efficiently catch structure features, and many works show that injecting structure, distance, position or spatial features can significantly improve performance of GNNs, however, injecting overall structure and distance into GNNs is an intuitive but remaining untouched idea. In this work, we shed light on the direction. We first extracting hop-wise structure information and compute distance distributional information, gathering with node's intrinsic features, embedding them into same vector space and then adding them up. The derived embedding vectors are then fed into GATs(like GAT, AGDN) and then Correct and Smooth, experiments show that the DHSEGATs achieve competitive result. The code is available at https://github.com/hzg0601/DHSEGATs.