Generalizable Single-Source Cross-modality Medical Image Segmentation via Invariant Causal Mechanisms

Single-source domain generalization (SDG) aims to learn a model from a single source domain that can generalize well on unseen target domains. This is an important task in computer vision, particularly relevant to medical imaging where domain shifts are common. In this work, we consider a challenging yet practical setting: SDG for cross-modality medical image segmentation. We combine causality-inspired theoretical insights on learning domain-invariant representations with recent advancements in diffusion-based augmentation to improve generalization across diverse imaging modalities. Guided by the ``intervention-augmentation equivariant'' principle, we use controlled diffusion models (DMs) to simulate diverse imaging styles while preserving the content, leveraging rich generative priors in large-scale pretrained DMs to comprehensively perturb the multidimensional style variable. Extensive experiments on challenging cross-modality segmentation tasks demonstrate that our approach consistently outperforms state-of-the-art SDG methods across three distinct anatomies and imaging modalities. The source code is available at \href{https://github.com/ratschlab/ICMSeg}{https://github.com/ratschlab/ICMSeg}.

Safe Deep RL for Intraoperative Planning of Pedicle Screw Placement

Spinal fusion surgery requires highly accurate implantation of pedicle screw implants, which must be conducted in critical proximity to vital structures with a limited view of anatomy. Robotic surgery systems have been proposed to improve placement accuracy, however, state-of-the-art systems suffer from the limitations of open-loop approaches, as they follow traditional concepts of preoperative planning and intraoperative registration, without real-time recalculation of the surgical plan. In this paper, we propose an intraoperative planning approach for robotic spine surgery that leverages real-time observation for drill path planning based on Safe Deep Reinforcement Learning (DRL). The main contributions of our method are (1) the capability to guarantee safe actions by introducing an uncertainty-aware distance-based safety filter; and (2) the ability to compensate for incomplete intraoperative anatomical information, by encoding a-priori knowledge about anatomical structures with a network pre-trained on high-fidelity anatomical models. Planning quality was assessed by quantitative comparison with the gold standard (GS) drill planning. In experiments with 5 models derived from real magnetic resonance imaging (MRI) data, our approach was capable of achieving 90% bone penetration with respect to the GS while satisfying safety requirements, even under observation and motion uncertainty. To the best of our knowledge, our approach is the first safe DRL approach focusing on orthopedic surgeries.

Unified Data Collection for Visual-Inertial Calibration via Deep Reinforcement Learning

Visual-inertial sensors have a wide range of applications in robotics. However, good performance often requires different sophisticated motion routines to accurately calibrate camera intrinsics and inter-sensor extrinsics. This work presents a novel formulation to learn a motion policy to be executed on a robot arm for automatic data collection for calibrating intrinsics and extrinsics jointly. Our approach models the calibration process compactly using model-free deep reinforcement learning to derive a policy that guides the motions of a robotic arm holding the sensor to efficiently collect measurements that can be used for both camera intrinsic calibration and camera-IMU extrinsic calibration. Given the current pose and collected measurements, the learned policy generates the subsequent transformation that optimizes sensor calibration accuracy. The evaluations in simulation and on a real robotic system show that our learned policy generates favorable motion trajectories and collects enough measurements efficiently that yield the desired intrinsics and extrinsics with short path lengths. In simulation we are able to perform calibrations 10 times faster than hand-crafted policies, which transfers to a real-world speed up of 3 times over a human expert.

Learning Trajectories for Visual-Inertial System Calibration via Model-based Heuristic Deep Reinforcement Learning

Visual-inertial systems rely on precise calibrations of both camera intrinsics and inter-sensor extrinsics, which typically require manually performing complex motions in front of a calibration target. In this work we present a novel approach to obtain favorable trajectories for visual-inertial system calibration, using model-based deep reinforcement learning. Our key contribution is to model the calibration process as a Markov decision process and then use model-based deep reinforcement learning with particle swarm optimization to establish a sequence of calibration trajectories to be performed by a robot arm. Our experiments show that while maintaining similar or shorter path lengths, the trajectories generated by our learned policy result in lower calibration errors compared to random or handcrafted trajectories.