MedMimic: Physician-Inspired Multimodal Fusion for Early Diagnosis of Fever of Unknown Origin

Fever of unknown origin FUO remains a diagnostic challenge. MedMimic is introduced as a multimodal framework inspired by real-world diagnostic processes. It uses pretrained models such as DINOv2, Vision Transformer, and ResNet-18 to convert high-dimensional 18F-FDG PET/CT imaging into low-dimensional, semantically meaningful features. A learnable self-attention-based fusion network then integrates these imaging features with clinical data for classification. Using 416 FUO patient cases from Sichuan University West China Hospital from 2017 to 2023, the multimodal fusion classification network MFCN achieved macro-AUROC scores ranging from 0.8654 to 0.9291 across seven tasks, outperforming conventional machine learning and single-modality deep learning methods. Ablation studies and five-fold cross-validation further validated its effectiveness. By combining the strengths of pretrained large models and deep learning, MedMimic offers a promising solution for disease classification.

MM-Retinal V2: Transfer an Elite Knowledge Spark into Fundus Vision-Language Pretraining

Vision-language pretraining (VLP) has been investigated to generalize across diverse downstream tasks for fundus image analysis. Although recent methods showcase promising achievements, they significantly rely on large-scale private image-text data but pay less attention to the pretraining manner, which limits their further advancements. In this work, we introduce MM-Retinal V2, a high-quality image-text paired dataset comprising CFP, FFA, and OCT image modalities. Then, we propose a novel fundus vision-language pretraining model, namely KeepFIT V2, which is pretrained by integrating knowledge from the elite data spark into categorical public datasets. Specifically, a preliminary textual pretraining is adopted to equip the text encoder with primarily ophthalmic textual knowledge. Moreover, a hybrid image-text knowledge injection module is designed for knowledge transfer, which is essentially based on a combination of global semantic concepts from contrastive learning and local appearance details from generative learning. Extensive experiments across zero-shot, few-shot, and linear probing settings highlight the generalization and transferability of KeepFIT V2, delivering performance competitive to state-of-the-art fundus VLP models trained on large-scale private image-text datasets. Our dataset and model are publicly available via https://github.com/lxirich/MM-Retinal.

A Post-Processing-Based Fair Federated Learning Framework

Federated Learning (FL) allows collaborative model training among distributed parties without pooling local datasets at a central server. However, the distributed nature of FL poses challenges in training fair federated learning models. The existing techniques are often limited in offering fairness flexibility to clients and performance. We formally define and empirically analyze a simple and intuitive post-processing-based framework to improve group fairness in FL systems. This framework can be divided into two stages: a standard FL training stage followed by a completely decentralized local debiasing stage. In the first stage, a global model is trained without fairness constraints using a standard federated learning algorithm (e.g. FedAvg). In the second stage, each client applies fairness post-processing on the global model using their respective local dataset. This allows for customized fairness improvements based on clients' desired and context-guided fairness requirements. We demonstrate two well-established post-processing techniques in this framework: model output post-processing and final layer fine-tuning. We evaluate the framework against three common baselines on four different datasets, including tabular, signal, and image data, each with varying levels of data heterogeneity across clients. Our work shows that this framework not only simplifies fairness implementation in FL but also provides significant fairness improvements with minimal accuracy loss or even accuracy gain, across data modalities and machine learning methods, being especially effective in more heterogeneous settings.

On Learning Representations for Tabular Data Distillation

Dataset distillation generates a small set of information-rich instances from a large dataset, resulting in reduced storage requirements, privacy or copyright risks, and computational costs for downstream modeling, though much of the research has focused on the image data modality. We study tabular data distillation, which brings in novel challenges such as the inherent feature heterogeneity and the common use of non-differentiable learning models (such as decision tree ensembles and nearest-neighbor predictors). To mitigate these challenges, we present $\texttt{TDColER}$, a tabular data distillation framework via column embeddings-based representation learning. To evaluate this framework, we also present a tabular data distillation benchmark, ${{\sf \small TDBench}}$. Based on an elaborate evaluation on ${{\sf \small TDBench}}$, resulting in 226,890 distilled datasets and 548,880 models trained on them, we demonstrate that $\texttt{TDColER}$ is able to boost the distilled data quality of off-the-shelf distillation schemes by 0.5-143% across 7 different tabular learning models.

Computational Protein Science in the Era of Large Language Models (LLMs)

Considering the significance of proteins, computational protein science has always been a critical scientific field, dedicated to revealing knowledge and developing applications within the protein sequence-structure-function paradigm. In the last few decades, Artificial Intelligence (AI) has made significant impacts in computational protein science, leading to notable successes in specific protein modeling tasks. However, those previous AI models still meet limitations, such as the difficulty in comprehending the semantics of protein sequences, and the inability to generalize across a wide range of protein modeling tasks. Recently, LLMs have emerged as a milestone in AI due to their unprecedented language processing & generalization capability. They can promote comprehensive progress in fields rather than solving individual tasks. As a result, researchers have actively introduced LLM techniques in computational protein science, developing protein Language Models (pLMs) that skillfully grasp the foundational knowledge of proteins and can be effectively generalized to solve a diversity of sequence-structure-function reasoning problems. While witnessing prosperous developments, it's necessary to present a systematic overview of computational protein science empowered by LLM techniques. First, we summarize existing pLMs into categories based on their mastered protein knowledge, i.e., underlying sequence patterns, explicit structural and functional information, and external scientific languages. Second, we introduce the utilization and adaptation of pLMs, highlighting their remarkable achievements in promoting protein structure prediction, protein function prediction, and protein design studies. Then, we describe the practical application of pLMs in antibody design, enzyme design, and drug discovery. Finally, we specifically discuss the promising future directions in this fast-growing field.

Make Domain Shift a Catastrophic Forgetting Alleviator in Class-Incremental Learning

In the realm of class-incremental learning (CIL), alleviating the catastrophic forgetting problem is a pivotal challenge. This paper discovers a counter-intuitive observation: by incorporating domain shift into CIL tasks, the forgetting rate is significantly reduced. Our comprehensive studies demonstrate that incorporating domain shift leads to a clearer separation in the feature distribution across tasks and helps reduce parameter interference during the learning process. Inspired by this observation, we propose a simple yet effective method named DisCo to deal with CIL tasks. DisCo introduces a lightweight prototype pool that utilizes contrastive learning to promote distinct feature distributions for the current task relative to previous ones, effectively mitigating interference across tasks. DisCo can be easily integrated into existing state-of-the-art class-incremental learning methods. Experimental results show that incorporating our method into various CIL methods achieves substantial performance improvements, validating the benefits of our approach in enhancing class-incremental learning by separating feature representation and reducing interference. These findings illustrate that DisCo can serve as a robust fashion for future research in class-incremental learning.

FaceLift: Single Image to 3D Head with View Generation and GS-LRM

We present FaceLift, a feed-forward approach for rapid, high-quality, 360-degree head reconstruction from a single image. Our pipeline begins by employing a multi-view latent diffusion model that generates consistent side and back views of the head from a single facial input. These generated views then serve as input to a GS-LRM reconstructor, which produces a comprehensive 3D representation using Gaussian splats. To train our system, we develop a dataset of multi-view renderings using synthetic 3D human head as-sets. The diffusion-based multi-view generator is trained exclusively on synthetic head images, while the GS-LRM reconstructor undergoes initial training on Objaverse followed by fine-tuning on synthetic head data. FaceLift excels at preserving identity and maintaining view consistency across views. Despite being trained solely on synthetic data, FaceLift demonstrates remarkable generalization to real-world images. Through extensive qualitative and quantitative evaluations, we show that FaceLift outperforms state-of-the-art methods in 3D head reconstruction, highlighting its practical applicability and robust performance on real-world images. In addition to single image reconstruction, FaceLift supports video inputs for 4D novel view synthesis and seamlessly integrates with 2D reanimation techniques to enable 3D facial animation. Project page: https://weijielyu.github.io/FaceLift.

DMesh++: An Efficient Differentiable Mesh for Complex Shapes

Recent probabilistic methods for 3D triangular meshes capture diverse shapes by differentiable mesh connectivity, but face high computational costs with increased shape details. We introduce a new differentiable mesh processing method in 2D and 3D that addresses this challenge and efficiently handles meshes with intricate structures. Additionally, we present an algorithm that adapts the mesh resolution to local geometry in 2D for efficient representation. We demonstrate the effectiveness of our approach on 2D point cloud and 3D multi-view reconstruction tasks. Visit our project page (https://sonsang.github.io/dmesh2-project) for source code and supplementary material.

Learnable Prompting SAM-induced Knowledge Distillation for Semi-supervised Medical Image Segmentation

The limited availability of labeled data has driven advancements in semi-supervised learning for medical image segmentation. Modern large-scale models tailored for general segmentation, such as the Segment Anything Model (SAM), have revealed robust generalization capabilities. However, applying these models directly to medical image segmentation still exposes performance degradation. In this paper, we propose a learnable prompting SAM-induced Knowledge distillation framework (KnowSAM) for semi-supervised medical image segmentation. Firstly, we propose a Multi-view Co-training (MC) strategy that employs two distinct sub-networks to employ a co-teaching paradigm, resulting in more robust outcomes. Secondly, we present a Learnable Prompt Strategy (LPS) to dynamically produce dense prompts and integrate an adapter to fine-tune SAM specifically for medical image segmentation tasks. Moreover, we propose SAM-induced Knowledge Distillation (SKD) to transfer useful knowledge from SAM to two sub-networks, enabling them to learn from SAM's predictions and alleviate the effects of incorrect pseudo-labels during training. Notably, the predictions generated by our subnets are used to produce mask prompts for SAM, facilitating effective inter-module information exchange. Extensive experimental results on various medical segmentation tasks demonstrate that our model outperforms the state-of-the-art semi-supervised segmentation approaches. Crucially, our SAM distillation framework can be seamlessly integrated into other semi-supervised segmentation methods to enhance performance. The code will be released upon acceptance of this manuscript at: https://github.com/taozh2017/KnowSAM

EvTTC: An Event Camera Dataset for Time-to-Collision Estimation

Time-to-Collision (TTC) estimation lies in the core of the forward collision warning (FCW) functionality, which is key to all Automatic Emergency Braking (AEB) systems. Although the success of solutions using frame-based cameras (e.g., Mobileye's solutions) has been witnessed in normal situations, some extreme cases, such as the sudden variation in the relative speed of leading vehicles and the sudden appearance of pedestrians, still pose significant risks that cannot be handled. This is due to the inherent imaging principles of frame-based cameras, where the time interval between adjacent exposures introduces considerable system latency to AEB. Event cameras, as a novel bio-inspired sensor, offer ultra-high temporal resolution and can asynchronously report brightness changes at the microsecond level. To explore the potential of event cameras in the above-mentioned challenging cases, we propose EvTTC, which is, to the best of our knowledge, the first multi-sensor dataset focusing on TTC tasks under high-relative-speed scenarios. EvTTC consists of data collected using standard cameras and event cameras, covering various potential collision scenarios in daily driving and involving multiple collision objects. Additionally, LiDAR and GNSS/INS measurements are provided for the calculation of ground-truth TTC. Considering the high cost of testing TTC algorithms on full-scale mobile platforms, we also provide a small-scale TTC testbed for experimental validation and data augmentation. All the data and the design of the testbed are open sourced, and they can serve as a benchmark that will facilitate the development of vision-based TTC techniques.