Time Matters: Examine Temporal Effects on Biomedical Language Models

Time roots in applying language models for biomedical applications: models are trained on historical data and will be deployed for new or future data, which may vary from training data. While increasing biomedical tasks have employed state-of-the-art language models, there are very few studies have examined temporal effects on biomedical models when data usually shifts across development and deployment. This study fills the gap by statistically probing relations between language model performance and data shifts across three biomedical tasks. We deploy diverse metrics to evaluate model performance, distance methods to measure data drifts, and statistical methods to quantify temporal effects on biomedical language models. Our study shows that time matters for deploying biomedical language models, while the degree of performance degradation varies by biomedical tasks and statistical quantification approaches. We believe this study can establish a solid benchmark to evaluate and assess temporal effects on deploying biomedical language models.

Length-Aware Multi-Kernel Transformer for Long Document Classification

Lengthy documents pose a unique challenge to neural language models due to substantial memory consumption. While existing state-of-the-art (SOTA) models segment long texts into equal-length snippets (e.g., 128 tokens per snippet) or deploy sparse attention networks, these methods have new challenges of context fragmentation and generalizability due to sentence boundaries and varying text lengths. For example, our empirical analysis has shown that SOTA models consistently overfit one set of lengthy documents (e.g., 2000 tokens) while performing worse on texts with other lengths (e.g., 1000 or 4000). In this study, we propose a Length-Aware Multi-Kernel Transformer (LAMKIT) to address the new challenges for the long document classification. LAMKIT encodes lengthy documents by diverse transformer-based kernels for bridging context boundaries and vectorizes text length by the kernels to promote model robustness over varying document lengths. Experiments on five standard benchmarks from health and law domains show LAMKIT outperforms SOTA models up to an absolute 10.9% improvement. We conduct extensive ablation analyses to examine model robustness and effectiveness over varying document lengths.

Chain-of-Interaction: Enhancing Large Language Models for Psychiatric Behavior Understanding by Dyadic Contexts

Automatic coding patient behaviors is essential to support decision making for psychotherapists during the motivational interviewing (MI), a collaborative communication intervention approach to address psychiatric issues, such as alcohol and drug addiction. While the behavior coding task has rapidly adapted machine learning to predict patient states during the MI sessions, lacking of domain-specific knowledge and overlooking patient-therapist interactions are major challenges in developing and deploying those models in real practice. To encounter those challenges, we introduce the Chain-of-Interaction (CoI) prompting method aiming to contextualize large language models (LLMs) for psychiatric decision support by the dyadic interactions. The CoI prompting approach systematically breaks down the coding task into three key reasoning steps, extract patient engagement, learn therapist question strategies, and integrates dyadic interactions between patients and therapists. This approach enables large language models to leverage the coding scheme, patient state, and domain knowledge for patient behavioral coding. Experiments on real-world datasets can prove the effectiveness and flexibility of our prompting method with multiple state-of-the-art LLMs over existing prompting baselines. We have conducted extensive ablation analysis and demonstrate the critical role of dyadic interactions in applying LLMs for psychotherapy behavior understanding.

Semantic-Aware Transformation-Invariant RoI Align

Great progress has been made in learning-based object detection methods in the last decade. Two-stage detectors often have higher detection accuracy than one-stage detectors, due to the use of region of interest (RoI) feature extractors which extract transformation-invariant RoI features for different RoI proposals, making refinement of bounding boxes and prediction of object categories more robust and accurate. However, previous RoI feature extractors can only extract invariant features under limited transformations. In this paper, we propose a novel RoI feature extractor, termed Semantic RoI Align (SRA), which is capable of extracting invariant RoI features under a variety of transformations for two-stage detectors. Specifically, we propose a semantic attention module to adaptively determine different sampling areas by leveraging the global and local semantic relationship within the RoI. We also propose a Dynamic Feature Sampler which dynamically samples features based on the RoI aspect ratio to enhance the efficiency of SRA, and a new position embedding, \ie Area Embedding, to provide more accurate position information for SRA through an improved sampling area representation. Experiments show that our model significantly outperforms baseline models with slight computational overhead. In addition, it shows excellent generalization ability and can be used to improve performance with various state-of-the-art backbones and detection methods.

Token Imbalance Adaptation for Radiology Report Generation

Imbalanced token distributions naturally exist in text documents, leading neural language models to overfit on frequent tokens. The token imbalance may dampen the robustness of radiology report generators, as complex medical terms appear less frequently but reflect more medical information. In this study, we demonstrate how current state-of-the-art models fail to generate infrequent tokens on two standard benchmark datasets (IU X-RAY and MIMIC-CXR) of radiology report generation. % However, no prior study has proposed methods to adapt infrequent tokens for text generators feeding with medical images. To solve the challenge, we propose the \textbf{T}oken \textbf{Im}balance Adapt\textbf{er} (\textit{TIMER}), aiming to improve generation robustness on infrequent tokens. The model automatically leverages token imbalance by an unlikelihood loss and dynamically optimizes generation processes to augment infrequent tokens. We compare our approach with multiple state-of-the-art methods on the two benchmarks. Experiments demonstrate the effectiveness of our approach in enhancing model robustness overall and infrequent tokens. Our ablation analysis shows that our reinforcement learning method has a major effect in adapting token imbalance for radiology report generation.

Semi-supervised Body Parsing and Pose Estimation for Enhancing Infant General Movement Assessment

General movement assessment (GMA) of infant movement videos (IMVs) is an effective method for early detection of cerebral palsy (CP) in infants. We demonstrate in this paper that end-to-end trainable neural networks for image sequence recognition can be applied to achieve good results in GMA, and more importantly, augmenting raw video with infant body parsing and pose estimation information can significantly improve performance. To solve the problem of efficiently utilizing partially labeled IMVs for body parsing, we propose a semi-supervised model, termed SiamParseNet (SPN), which consists of two branches, one for intra-frame body parts segmentation and another for inter-frame label propagation. During training, the two branches are jointly trained by alternating between using input pairs of only labeled frames and input of both labeled and unlabeled frames. We also investigate training data augmentation by proposing a factorized video generative adversarial network (FVGAN) to synthesize novel labeled frames for training. When testing, we employ a multi-source inference mechanism, where the final result for a test frame is either obtained via the segmentation branch or via propagation from a nearby key frame. We conduct extensive experiments for body parsing using SPN on two infant movement video datasets, where SPN coupled with FVGAN achieves state-of-the-art performance. We further demonstrate that SPN can be easily adapted to the infant pose estimation task with superior performance. Last but not least, we explore the clinical application of our method for GMA. We collected a new clinical IMV dataset with GMA annotations, and our experiments show that SPN models for body parsing and pose estimation trained on the first two datasets generalize well to the new clinical dataset and their results can significantly boost the CRNN-based GMA prediction performance.

End-to-end Graph-constrained Vectorized Floorplan Generation with Panoptic Refinement

The automatic generation of floorplans given user inputs has great potential in architectural design and has recently been explored in the computer vision community. However, the majority of existing methods synthesize floorplans in the format of rasterized images, which are difficult to edit or customize. In this paper, we aim to synthesize floorplans as sequences of 1-D vectors, which eases user interaction and design customization. To generate high fidelity vectorized floorplans, we propose a novel two-stage framework, including a draft stage and a multi-round refining stage. In the first stage, we encode the room connectivity graph input by users with a graph convolutional network (GCN), then apply an autoregressive transformer network to generate an initial floorplan sequence. To polish the initial design and generate more visually appealing floorplans, we further propose a novel panoptic refinement network(PRN) composed of a GCN and a transformer network. The PRN takes the initial generated sequence as input and refines the floorplan design while encouraging the correct room connectivity with our proposed geometric loss. We have conducted extensive experiments on a real-world floorplan dataset, and the results show that our method achieves state-of-the-art performance under different settings and evaluation metrics.

Asymmetry Disentanglement Network for Interpretable Acute Ischemic Stroke Infarct Segmentation in Non-Contrast CT Scans

Accurate infarct segmentation in non-contrast CT (NCCT) images is a crucial step toward computer-aided acute ischemic stroke (AIS) assessment. In clinical practice, bilateral symmetric comparison of brain hemispheres is usually used to locate pathological abnormalities. Recent research has explored asymmetries to assist with AIS segmentation. However, most previous symmetry-based work mixed different types of asymmetries when evaluating their contribution to AIS. In this paper, we propose a novel Asymmetry Disentanglement Network (ADN) to automatically separate pathological asymmetries and intrinsic anatomical asymmetries in NCCTs for more effective and interpretable AIS segmentation. ADN first performs asymmetry disentanglement based on input NCCTs, which produces different types of 3D asymmetry maps. Then a synthetic, intrinsic-asymmetry-compensated and pathology-asymmetry-salient NCCT volume is generated and later used as input to a segmentation network. The training of ADN incorporates domain knowledge and adopts a tissue-type aware regularization loss function to encourage clinically-meaningful pathological asymmetry extraction. Coupled with an unsupervised 3D transformation network, ADN achieves state-of-the-art AIS segmentation performance on a public NCCT dataset. In addition to the superior performance, we believe the learned clinically-interpretable asymmetry maps can also provide insights towards a better understanding of AIS assessment. Our code is available at https://github.com/nihaomiao/MICCAI22_ADN.

Patcher: Patch Transformers with Mixture of Experts for Precise Medical Image Segmentation

We present a new encoder-decoder Vision Transformer architecture, Patcher, for medical image segmentation. Unlike standard Vision Transformers, it employs Patcher blocks that segment an image into large patches, each of which is further divided into small patches. Transformers are applied to the small patches within a large patch, which constrains the receptive field of each pixel. We intentionally make the large patches overlap to enhance intra-patch communication. The encoder employs a cascade of Patcher blocks with increasing receptive fields to extract features from local to global levels. This design allows Patcher to benefit from both the coarse-to-fine feature extraction common in CNNs and the superior spatial relationship modeling of Transformers. We also propose a new mixture-of-experts (MoE) based decoder, which treats the feature maps from the encoder as experts and selects a suitable set of expert features to predict the label for each pixel. The use of MoE enables better specializations of the expert features and reduces interference between them during inference. Extensive experiments demonstrate that Patcher outperforms state-of-the-art Transformer- and CNN-based approaches significantly on stroke lesion segmentation and polyp segmentation. Code for Patcher will be released with publication to facilitate future research.

Unsupervised Reinforcement Adaptation for Class-Imbalanced Text Classification

Class imbalance naturally exists when train and test models in different domains. Unsupervised domain adaptation (UDA) augments model performance with only accessible annotations from the source domain and unlabeled data from the target domain. However, existing state-of-the-art UDA models learn domain-invariant representations and evaluate primarily on class-balanced data across domains. In this work, we propose an unsupervised domain adaptation approach via reinforcement learning that jointly leverages feature variants and imbalanced labels across domains. We experiment with the text classification task for its easily accessible datasets and compare the proposed method with five baselines. Experiments on three datasets prove that our proposed method can effectively learn robust domain-invariant representations and successfully adapt text classifiers on imbalanced classes over domains. The code is available at https://github.com/woqingdoua/ImbalanceClass.