CAMEL2: Enhancing weakly supervised learning for histopathology images by incorporating the significance ratio

Histopathology image analysis plays a crucial role in cancer diagnosis. However, training a clinically applicable segmentation algorithm requires pathologists to engage in labour-intensive labelling. In contrast, weakly supervised learning methods, which only require coarse-grained labels at the image level, can significantly reduce the labeling efforts. Unfortunately, while these methods perform reasonably well in slide-level prediction, their ability to locate cancerous regions, which is essential for many clinical applications, remains unsatisfactory. Previously, we proposed CAMEL, which achieves comparable results to those of fully supervised baselines in pixel-level segmentation. However, CAMEL requires 1,280x1,280 image-level binary annotations for positive WSIs. Here, we present CAMEL2, by introducing a threshold of the cancerous ratio for positive bags, it allows us to better utilize the information, consequently enabling us to scale up the image-level setting from 1,280x1,280 to 5,120x5,120 while maintaining the accuracy. Our results with various datasets, demonstrate that CAMEL2, with the help of 5,120x5,120 image-level binary annotations, which are easy to annotate, achieves comparable performance to that of a fully supervised baseline in both instance- and slide-level classifications.

Deep Learning-based Time-varying Channel Estimation for RIS Assisted Communication

Reconfigurable intelligent surface (RIS) is considered as a revolutionary technology for future wireless communication networks. In this letter, we consider the acquisition of the time-varying cascaded channels, which is a challenging task due to the massive number of passive RIS elements and the small channel coherence time. To reduce the pilot overhead, a deep learning-based channel extrapolation is implemented over both antenna and time domains. We divide the neural network into two parts, i.e., the time-domain and the antenna-domain extrapolation networks, where the neural ordinary differential equations (ODE) are utilized. In the former, ODE accurately describes the dynamics of the RIS channels and improves the recurrent neural network's performance of time series reconstruction. In the latter, ODE is resorted to modify the relations among different data layers in a feedforward neural network. We cascade the two networks and jointly train them. Simulation results show that the proposed scheme can effectively extrapolate the cascaded RIS channels in high mobility scenario.

Deep Learning Based Antenna-time Domain Channel Extrapolation for Hybrid mmWave Massive MIMO

In a time-varying massive multiple-input multipleoutput (MIMO) system, the acquisition of the downlink channel state information at the base station (BS) is a very challenging task due to the prohibitively high overheads associated with downlink training and uplink feedback. In this paper, we consider the hybrid precoding structure at BS and examine the antennatime domain channel extrapolation. We design a latent ordinary differential equation (ODE)-based network under the variational auto-encoder (VAE) framework to learn the mapping function from the partial uplink channels to the full downlink ones at the BS side. Specifically, the gated recurrent unit is adopted for the encoder and the fully-connected neural network is used for the decoder. The end-to-end learning is utilized to optimize the network parameters. Simulation results show that the designed network can efficiently infer the full downlink channels from the partial uplink ones, which can significantly reduce the channel training overhead.

Deep Learning Based RIS Channel Extrapolation with Element-grouping

Reconfigurable intelligent surface (RIS) is considered as a revolutionary technology for future wireless communication networks. In this letter, we consider the acquisition of the cascaded channels, which is a challenging task due to the massive number of passive RIS elements. To reduce the pilot overhead, we adopt the element-grouping strategy, where each element in one group shares the same reflection coefficient and is assumed to have the same channel condition. We analyze the channel interference caused by the element-grouping strategy and further design two deep learning based networks. The first one aims to refine the partial channels by eliminating the interference, while the second one tries to extrapolate the full channels from the refined partial channels. We cascade the two networks and jointly train them. Simulation results show that the proposed scheme provides significant gain compared to the conventional element-grouping method without interference elimination.

Deep Learning Based Antenna Selection for Channel Extrapolation in FDD Massive MIMO

In massive multiple-input multiple-output (MIMO) systems, the large number of antennas would bring a great challenge for the acquisition of the accurate channel state information, especially in the frequency division duplex mode. To overcome the bottleneck of the limited number of radio links in hybrid beamforming, we utilize the neural networks (NNs) to capture the inherent connection between the uplink and downlink channel data sets and extrapolate the downlink channels from a subset of the uplink channel state information. We study the antenna subset selection problem in order to achieve the best channel extrapolation and decrease the data size of NNs. The probabilistic sampling theory is utilized to approximate the discrete antenna selection as a continuous and differentiable function, which makes the back propagation of the deep learning feasible. Then, we design the proper off-line training strategy to optimize both the antenna selection pattern and the extrapolation NNs. Finally, numerical results are presented to verify the effectiveness of our proposed massive MIMO channel extrapolation algorithm.

Deep Learning Optimized Sparse Antenna Activation for Reconfigurable Intelligent Surface Assisted Communication

To capture the communications gain of the massive radiating elements with low power cost, the conventional reconfigurable intelligent surface (RIS) usually works in passive mode. However, due to the cascaded channel structure and the lack of signal processing ability, it is difficult for RIS to obtain the individual channel state information and optimize the beamforming vector. In this paper, we add signal processing units for a few antennas at RIS to partially acquire the channels. To solve the crucial active antenna selection problem, we construct an active antenna selection network that utilizes the probabilistic sampling theory to select the optimal locations of these active antennas. With this active antenna selection network, we further design two deep learning (DL) based schemes, i.e., the channel extrapolation scheme and the beam searching scheme, to enable the RIS communication system. The former utilizes the selection network and a convolutional neural network to extrapolate the full channels from the partial channels received by the active RIS antennas, while the latter adopts a fully-connected neural network to achieve the direct mapping between the partial channels and the optimal beamforming vector with maximal transmission rate. Simulation results are provided to demonstrate the effectiveness of the designed DL-based schemes.

CAMEL: A Weakly Supervised Learning Framework for Histopathology Image Segmentation

Histopathology image analysis plays a critical role in cancer diagnosis and treatment. To automatically segment the cancerous regions, fully supervised segmentation algorithms require labor-intensive and time-consuming labeling at the pixel level. In this research, we propose CAMEL, a weakly supervised learning framework for histopathology image segmentation using only image-level labels. Using multiple instance learning (MIL)-based label enrichment, CAMEL splits the image into latticed instances and automatically generates instance-level labels. After label enrichment, the instance-level labels are further assigned to the corresponding pixels, producing the approximate pixel-level labels and making fully supervised training of segmentation models possible. CAMEL achieves comparable performance with the fully supervised approaches in both instance-level classification and pixel-level segmentation on CAMELYON16 and a colorectal adenoma dataset. Moreover, the generality of the automatic labeling methodology may benefit future weakly supervised learning studies for histopathology image analysis.