PICS in Pics: Physics Informed Contour Selection for Rapid Image Segmentation

Effective training of deep image segmentation models is challenging due to the need for abundant, high-quality annotations. Generating annotations is laborious and time-consuming for human experts, especially in medical image segmentation. To facilitate image annotation, we introduce Physics Informed Contour Selection (PICS) - an interpretable, physics-informed algorithm for rapid image segmentation without relying on labeled data. PICS draws inspiration from physics-informed neural networks (PINNs) and an active contour model called snake. It is fast and computationally lightweight because it employs cubic splines instead of a deep neural network as a basis function. Its training parameters are physically interpretable because they directly represent control knots of the segmentation curve. Traditional snakes involve minimization of the edge-based loss functionals by deriving the Euler-Lagrange equation followed by its numerical solution. However, PICS directly minimizes the loss functional, bypassing the Euler Lagrange equations. It is the first snake variant to minimize a region-based loss function instead of traditional edge-based loss functions. PICS uniquely models the three-dimensional (3D) segmentation process with an unsteady partial differential equation (PDE), which allows accelerated segmentation via transfer learning. To demonstrate its effectiveness, we apply PICS for 3D segmentation of the left ventricle on a publicly available cardiac dataset. While doing so, we also introduce a new convexity-preserving loss term that encodes the shape information of the left ventricle to enhance PICS's segmentation quality. Overall, PICS presents several novelties in network architecture, transfer learning, and physics-inspired losses for image segmentation, thereby showing promising outcomes and potential for further refinement.

PARSE challenge 2022: Pulmonary Arteries Segmentation using Swin U-Net Transformer(Swin UNETR) and U-Net

In this work, we present our proposed method to segment the pulmonary arteries from the CT scans using Swin UNETR and U-Net-based deep neural network architecture. Six models, three models based on Swin UNETR, and three models based on 3D U-net with residual units were ensemble using a weighted average to make the final segmentation masks. Our team achieved a multi-level dice score of 84.36 percent through this method. The code of our work is available on the following link: https://github.com/akansh12/parse2022. This work is part of the MICCAI PARSE 2022 challenge.

Brain Tumor Segmentation and Survival Prediction using Automatic Hard mining in 3D CNN Architecture

We utilize 3-D fully convolutional neural networks (CNN) to segment gliomas and its constituents from multimodal Magnetic Resonance Images (MRI). The architecture uses dense connectivity patterns to reduce the number of weights and residual connections and is initialized with weights obtained from training this model with BraTS 2018 dataset. Hard mining is done during training to train for the difficult cases of segmentation tasks by increasing the dice similarity coefficient (DSC) threshold to choose the hard cases as epoch increases. On the BraTS2020 validation data (n = 125), this architecture achieved a tumor core, whole tumor, and active tumor dice of 0.744, 0.876, 0.714,respectively. On the test dataset, we get an increment in DSC of tumor core and active tumor by approximately 7%. In terms of DSC, our network performances on the BraTS 2020 test data are 0.775, 0.815, and 0.85 for enhancing tumor, tumor core, and whole tumor, respectively. Overall survival of a subject is determined using conventional machine learning from rediomics features obtained using a generated segmentation mask. Our approach has achieved 0.448 and 0.452 as the accuracy on the validation and test dataset.

Abstracting Deep Neural Networks into Concept Graphs for Concept Level Interpretability

The black-box nature of deep learning models prevents them from being completely trusted in domains like biomedicine. Most explainability techniques do not capture the concept-based reasoning that human beings follow. In this work, we attempt to understand the behavior of trained models that perform image processing tasks in the medical domain by building a graphical representation of the concepts they learn. Extracting such a graphical representation of the model's behavior on an abstract, higher conceptual level would unravel the learnings of these models and would help us to evaluate the steps taken by the model for predictions. We show the application of our proposed implementation on two biomedical problems - brain tumor segmentation and fundus image classification. We provide an alternative graphical representation of the model by formulating a \textit{concept level graph} as discussed above, which makes the problem of intervention to find active inference trails more tractable. Understanding these trails would provide an understanding of the hierarchy of the decision-making process followed by the model. [As well as overall nature of model]. Our framework is available at \url{https://github.com/koriavinash1/BioExp}

Distangling Biological Noise in Cellular Images with a focus on Explainability

The cost of some drugs and medical treatments has risen in recent years that many patients are having to go without. A classification project could make researchers more efficient. One of the more surprising reasons behind the cost is how long it takes to bring new treatments to market. Despite improvements in technology and science, research and development continues to lag. In fact, finding new treatment takes, on average, more than 10 years and costs hundreds of millions of dollars. In turn, greatly decreasing the cost of treatments can make ensure these treatments get to patients faster. This work aims at solving a part of this problem by creating a cellular image classification model which can decipher the genetic perturbations in cell (occurring naturally or artificially). Another interesting question addressed is what makes the deep-learning model decide in a particular fashion, which can further help in demystifying the mechanism of action of certain perturbations and paves a way towards the explainability of the deep-learning model. We show the results of Grad-CAM visualizations and make a case for the significance of certain features over others. Further we discuss how these significant features are pivotal in extracting useful diagnostic information from the deep-learning model.

Structurally aware bidirectional unpaired image to image translation between CT and MR

Magnetic Resonance (MR) Imaging and Computed Tomography (CT) are the primary diagnostic imaging modalities quite frequently used for surgical planning and analysis. A general problem with medical imaging is that the acquisition process is quite expensive and time-consuming. Deep learning techniques like generative adversarial networks (GANs) can help us to leverage the possibility of an image to image translation between multiple imaging modalities, which in turn helps in saving time and cost. These techniques will help to conduct surgical planning under CT with the feedback of MRI information. While previous studies have shown paired and unpaired image synthesis from MR to CT, image synthesis from CT to MR still remains a challenge, since it involves the addition of extra tissue information. In this manuscript, we have implemented two different variations of Generative Adversarial Networks exploiting the cycling consistency and structural similarity between both CT and MR image modalities on a pelvis dataset, thus facilitating a bidirectional exchange of content and style between these image modalities. The proposed GANs translate the input medical images by different mechanisms, and hence generated images not only appears realistic but also performs well across various comparison metrics, and these images have also been cross verified with a radiologist. The radiologist verification has shown that slight variations in generated MR and CT images may not be exactly the same as their true counterpart but it can be used for medical purposes.

2018 Robotic Scene Segmentation Challenge

In 2015 we began a sub-challenge at the EndoVis workshop at MICCAI in Munich using endoscope images of ex-vivo tissue with automatically generated annotations from robot forward kinematics and instrument CAD models. However, the limited background variation and simple motion rendered the dataset uninformative in learning about which techniques would be suitable for segmentation in real surgery. In 2017, at the same workshop in Quebec we introduced the robotic instrument segmentation dataset with 10 teams participating in the challenge to perform binary, articulating parts and type segmentation of da Vinci instruments. This challenge included realistic instrument motion and more complex porcine tissue as background and was widely addressed with modifications on U-Nets and other popular CNN architectures. In 2018 we added to the complexity by introducing a set of anatomical objects and medical devices to the segmented classes. To avoid over-complicating the challenge, we continued with porcine data which is dramatically simpler than human tissue due to the lack of fatty tissue occluding many organs.

A Generalized Deep Learning Framework for Whole-Slide Image Segmentation and Analysis

Histopathology tissue analysis is considered the gold standard in cancer diagnosis and prognosis. Given the large size of these images and the increase in the number of potential cancer cases, an automated solution as an aid to histopathologists is highly desirable. In the recent past, deep learning-based techniques have provided state of the art results in a wide variety of image analysis tasks, including analysis of digitized slides. However, the size of images and variability in histopathology tasks makes it a challenge to develop an integrated framework for histopathology image analysis. We propose a deep learning-based framework for histopathology tissue analysis. We demonstrate the generalizability of our framework, including training and inference, on several open-source datasets, which include CAMELYON (breast cancer metastases), DigestPath (colon cancer), and PAIP (liver cancer) datasets. We discuss multiple types of uncertainties pertaining to data and model, namely aleatoric and epistemic, respectively. Simultaneously, we demonstrate our model generalization across different data distribution by evaluating some samples on TCGA data. On CAMELYON16 test data (n=139) for the task of lesion detection, the FROC score achieved was 0.86 and in the CAMELYON17 test-data (n=500) for the task of pN-staging the Cohen's kappa score achieved was 0.9090 (third in the open leaderboard). On DigestPath test data (n=212) for the task of tumor segmentation, a Dice score of 0.782 was achieved (fourth in the challenge). On PAIP test data (n=40) for the task of viable tumor segmentation, a Jaccard Index of 0.75 (third in the challenge) was achieved, and for viable tumor burden, a score of 0.633 was achieved (second in the challenge). Our entire framework and related documentation are freely available at GitHub and PyPi.

Demystifying Brain Tumour Segmentation Networks: Interpretability and Uncertainty Analysis

The accurate automatic segmentation of gliomas and its intra-tumoral structures is important not only for treatment planning but also for follow-up evaluations. Several methods based on 2D and 3D Deep Neural Networks (DNN) have been developed to segment brain tumors and to classify different categories of tumors from different MRI modalities. However, these networks are often black-box models and do not provide any evidence regarding the process they take to perform this task. Increasing transparency and interpretability of such deep learning techniques are necessary for the complete integration of such methods into medical practice. In this paper, we explore various techniques to explain the functional organization of brain tumor segmentation models and to extract visualizations of internal concepts to understand how these networks achieve highly accurate tumor segmentations. We use the BraTS 2018 dataset to train three different networks with standard architectures and outline similarities and differences in the process that these networks take to segment brain tumors. We show that brain tumor segmentation networks learn certain human-understandable disentangled concepts on a filter level. We also show that they take a top-down or hierarchical approach to localizing the different parts of the tumor. We then extract visualizations of some internal feature maps and also provide a measure of uncertainty with regards to the outputs of the models to give additional qualitative evidence about the predictions of these networks. We believe that the emergence of such human-understandable organization and concepts might aid in the acceptance and integration of such methods in medical diagnosis.

Enhanced Optic Disk and Cup Segmentation with Glaucoma Screening from Fundus Images using Position encoded CNNs

In this manuscript, we present a robust method for glaucoma screening from fundus images using an ensemble of convolutional neural networks (CNNs). The pipeline comprises of first segmenting the optic disk and optic cup from the fundus image, then extracting a patch centered around the optic disk and subsequently feeding to the classification network to differentiate the image as diseased or healthy. In the segmentation network, apart from the image, we make use of spatial co-ordinate (X \& Y) space so as to learn the structure of interest better. The classification network is composed of a DenseNet201 and a ResNet18 which were pre-trained on a large cohort of natural images. On the REFUGE validation data (n=400), the segmentation network achieved a dice score of 0.88 and 0.64 for optic disc and optic cup respectively. For the tasking differentiating images affected with glaucoma from healthy images, the area under the ROC curve was observed to be 0.85.