C^2M-DoT: Cross-modal consistent multi-view medical report generation with domain transfer network

In clinical scenarios, multiple medical images with different views are usually generated simultaneously, and these images have high semantic consistency. However, most existing medical report generation methods only consider single-view data. The rich multi-view mutual information of medical images can help generate more accurate reports, however, the dependence of multi-view models on multi-view data in the inference stage severely limits their application in clinical practice. In addition, word-level optimization based on numbers ignores the semantics of reports and medical images, and the generated reports often cannot achieve good performance. Therefore, we propose a cross-modal consistent multi-view medical report generation with a domain transfer network (C^2M-DoT). Specifically, (i) a semantic-based multi-view contrastive learning medical report generation framework is adopted to utilize cross-view information to learn the semantic representation of lesions; (ii) a domain transfer network is further proposed to ensure that the multi-view report generation model can still achieve good inference performance under single-view input; (iii) meanwhile, optimization using a cross-modal consistency loss facilitates the generation of textual reports that are semantically consistent with medical images. Extensive experimental studies on two public benchmark datasets demonstrate that C^2M-DoT substantially outperforms state-of-the-art baselines in all metrics. Ablation studies also confirmed the validity and necessity of each component in C^2M-DoT.

AMLP:Adaptive Masking Lesion Patches for Self-supervised Medical Image Segmentation

Self-supervised masked image modeling has shown promising results on natural images. However, directly applying such methods to medical images remains challenging. This difficulty stems from the complexity and distinct characteristics of lesions compared to natural images, which impedes effective representation learning. Additionally, conventional high fixed masking ratios restrict reconstructing fine lesion details, limiting the scope of learnable information. To tackle these limitations, we propose a novel self-supervised medical image segmentation framework, Adaptive Masking Lesion Patches (AMLP). Specifically, we design a Masked Patch Selection (MPS) strategy to identify and focus learning on patches containing lesions. Lesion regions are scarce yet critical, making their precise reconstruction vital. To reduce misclassification of lesion and background patches caused by unsupervised clustering in MPS, we introduce an Attention Reconstruction Loss (ARL) to focus on hard-to-reconstruct patches likely depicting lesions. We further propose a Category Consistency Loss (CCL) to refine patch categorization based on reconstruction difficulty, strengthening distinction between lesions and background. Moreover, we develop an Adaptive Masking Ratio (AMR) strategy that gradually increases the masking ratio to expand reconstructible information and improve learning. Extensive experiments on two medical segmentation datasets demonstrate AMLP's superior performance compared to existing self-supervised approaches. The proposed strategies effectively address limitations in applying masked modeling to medical images, tailored to capturing fine lesion details vital for segmentation tasks.

MvCo-DoT:Multi-View Contrastive Domain Transfer Network for Medical Report Generation

In clinical scenarios, multiple medical images with different views are usually generated at the same time, and they have high semantic consistency. However, the existing medical report generation methods cannot exploit the rich multi-view mutual information of medical images. Therefore, in this work, we propose the first multi-view medical report generation model, called MvCo-DoT. Specifically, MvCo-DoT first propose a multi-view contrastive learning (MvCo) strategy to help the deep reinforcement learning based model utilize the consistency of multi-view inputs for better model learning. Then, to close the performance gaps of using multi-view and single-view inputs, a domain transfer network is further proposed to ensure MvCo-DoT achieve almost the same performance as multi-view inputs using only single-view inputs.Extensive experiments on the IU X-Ray public dataset show that MvCo-DoT outperforms the SOTA medical report generation baselines in all metrics.

MPS-AMS: Masked Patches Selection and Adaptive Masking Strategy Based Self-Supervised Medical Image Segmentation

Existing self-supervised learning methods based on contrastive learning and masked image modeling have demonstrated impressive performances. However, current masked image modeling methods are mainly utilized in natural images, and their applications in medical images are relatively lacking. Besides, their fixed high masking strategy limits the upper bound of conditional mutual information, and the gradient noise is considerable, making less the learned representation information. Motivated by these limitations, in this paper, we propose masked patches selection and adaptive masking strategy based self-supervised medical image segmentation method, named MPS-AMS. We leverage the masked patches selection strategy to choose masked patches with lesions to obtain more lesion representation information, and the adaptive masking strategy is utilized to help learn more mutual information and improve performance further. Extensive experiments on three public medical image segmentation datasets (BUSI, Hecktor, and Brats2018) show that our proposed method greatly outperforms the state-of-the-art self-supervised baselines.

Multi-Head Feature Pyramid Networks for Breast Mass Detection

Analysis of X-ray images is one of the main tools to diagnose breast cancer. The ability to quickly and accurately detect the location of masses from the huge amount of image data is the key to reducing the morbidity and mortality of breast cancer. Currently, the main factor limiting the accuracy of breast mass detection is the unequal focus on the mass boxes, leading the network to focus too much on larger masses at the expense of smaller ones. In the paper, we propose the multi-head feature pyramid module (MHFPN) to solve the problem of unbalanced focus of target boxes during feature map fusion and design a multi-head breast mass detection network (MBMDnet). Experimental studies show that, comparing to the SOTA detection baselines, our method improves by 6.58% (in AP@50) and 5.4% (in TPR@50) on the commonly used INbreast dataset, while about 6-8% improvements (in AP@20) are also observed on the public MIAS and BCS-DBT datasets.

Incremental Predictive Coding: A Parallel and Fully Automatic Learning Algorithm

Neuroscience-inspired models, such as predictive coding, have the potential to play an important role in the future of machine intelligence. However, they are not yet used in industrial applications due to some limitations, such as the lack of efficiency. In this work, we address this by proposing incremental predictive coding (iPC), a variation of the original framework derived from the incremental expectation maximization algorithm, where every operation can be performed in parallel without external control. We show both theoretically and empirically that iPC is much faster than the original algorithm originally developed by Rao and Ballard, while maintaining performance comparable to backpropagation in image classification tasks. This work impacts several areas, has general applications in computational neuroscience and machine learning, and specific applications in scenarios where automatization and parallelization are important, such as distributed computing and implementations of deep learning models on analog and neuromorphic chips.

PCA: Semi-supervised Segmentation with Patch Confidence Adversarial Training

Deep learning based semi-supervised learning (SSL) methods have achieved strong performance in medical image segmentation, which can alleviate doctors' expensive annotation by utilizing a large amount of unlabeled data. Unlike most existing semi-supervised learning methods, adversarial training based methods distinguish samples from different sources by learning the data distribution of the segmentation map, leading the segmenter to generate more accurate predictions. We argue that the current performance restrictions for such approaches are the problems of feature extraction and learning preference. In this paper, we propose a new semi-supervised adversarial method called Patch Confidence Adversarial Training (PCA) for medical image segmentation. Rather than single scalar classification results or pixel-level confidence maps, our proposed discriminator creates patch confidence maps and classifies them at the scale of the patches. The prediction of unlabeled data learns the pixel structure and context information in each patch to get enough gradient feedback, which aids the discriminator in convergent to an optimal state and improves semi-supervised segmentation performance. Furthermore, at the discriminator's input, we supplement semantic information constraints on images, making it simpler for unlabeled data to fit the expected data distribution. Extensive experiments on the Automated Cardiac Diagnosis Challenge (ACDC) 2017 dataset and the Brain Tumor Segmentation (BraTS) 2019 challenge dataset show that our method outperforms the state-of-the-art semi-supervised methods, which demonstrates its effectiveness for medical image segmentation.

Associative Memories via Predictive Coding

Associative memories in the brain receive and store patterns of activity registered by the sensory neurons, and are able to retrieve them when necessary. Due to their importance in human intelligence, computational models of associative memories have been developed for several decades now. They include autoassociative memories, which allow for storing data points and retrieving a stored data point $s$ when provided with a noisy or partial variant of $s$, and heteroassociative memories, able to store and recall multi-modal data. In this paper, we present a novel neural model for realizing associative memories, based on a hierarchical generative network that receives external stimuli via sensory neurons. This model is trained using predictive coding, an error-based learning algorithm inspired by information processing in the cortex. To test the capabilities of this model, we perform multiple retrieval experiments from both corrupted and incomplete data points. In an extensive comparison, we show that this new model outperforms in retrieval accuracy and robustness popular associative memory models, such as autoencoders trained via backpropagation, and modern Hopfield networks. In particular, in completing partial data points, our model achieves remarkable results on natural image datasets, such as ImageNet, with a surprisingly high accuracy, even when only a tiny fraction of pixels of the original images is presented. Furthermore, we show that this method is able to handle multi-modal data, retrieving images from descriptions, and vice versa. We conclude by discussing the possible impact of this work in the neuroscience community, by showing that our model provides a plausible framework to study learning and retrieval of memories in the brain, as it closely mimics the behavior of the hippocampus as a memory index and generative model.

RSG: A Simple but Effective Module for Learning Imbalanced Datasets

Imbalanced datasets widely exist in practice and area great challenge for training deep neural models with agood generalization on infrequent classes. In this work, wepropose a new rare-class sample generator (RSG) to solvethis problem. RSG aims to generate some new samplesfor rare classes during training, and it has in particularthe following advantages: (1) it is convenient to use andhighly versatile, because it can be easily integrated intoany kind of convolutional neural network, and it works wellwhen combined with different loss functions, and (2) it isonly used during the training phase, and therefore, no ad-ditional burden is imposed on deep neural networks duringthe testing phase. In extensive experimental evaluations, weverify the effectiveness of RSG. Furthermore, by leveragingRSG, we obtain competitive results on Imbalanced CIFARand new state-of-the-art results on Places-LT, ImageNet-LT, and iNaturalist 2018. The source code is available at https://github.com/Jianf-Wang/RSG.

Predictive Coding Can Do Exact Backpropagation on Any Neural Network

Intersecting neuroscience and deep learning has brought benefits and developments to both fields for several decades, which help to both understand how learning works in the brain, and to achieve the state-of-the-art performances in different AI benchmarks. Backpropagation (BP) is the most widely adopted method for the training of artificial neural networks, which, however, is often criticized for its biological implausibility (e.g., lack of local update rules for the parameters). Therefore, biologically plausible learning methods (e.g., inference learning (IL)) that rely on predictive coding (a framework for describing information processing in the brain) are increasingly studied. Recent works prove that IL can approximate BP up to a certain margin on multilayer perceptrons (MLPs), and asymptotically on any other complex model, and that zero-divergence inference learning (Z-IL), a variant of IL, is able to exactly implement BP on MLPs. However, the recent literature shows also that there is no biologically plausible method yet that can exactly replicate the weight update of BP on complex models. To fill this gap, in this paper, we generalize (IL and) Z-IL by directly defining them on computational graphs. To our knowledge, this is the first biologically plausible algorithm that is shown to be equivalent to BP in the way of updating parameters on any neural network, and it is thus a great breakthrough for the interdisciplinary research of neuroscience and deep learning.